Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity

Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy

(2020) Saleha Anwar et al.   Biomedicines

HPLC-MS/MS analysis of ilimaquinone and its application in a pharmacokinetic study in rats

(2019) Heebin Son et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ROS Induced by KillerRed Targeting Mitochondria (mtKR) Enhances Apoptosis Caused by Radiation via Cyt c/Caspase-3 Pathway

(2019) Xin Li et al.   Oxidative Medicine and Cellular Longevity

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats

(2019) Heebin Son et al.   Marine Drugs

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance

(2019) Xing Huang et al.   Autophagy

Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity

(2019) Choong-Hwan Kwak et al.   Cancers

Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors

(2019) Hanna Cho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis

(2019) Benjamin L. Woolbright et al.   MOLECULAR CANCER THERAPEUTICS

Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone

(2018) Johayra Simithy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

(2018) Ching-Wen Chang et al.   Cell Death & Disease

Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer

(2018) Zheng Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase

(2018) Tereza Golias et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation

(2018) Meng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Water-extracted branch of Cinnamomum cassia promotes lung cancer cell apoptosis by inhibiting pyruvate dehydrogenase kinase activity

(2018) Eun-Ji Lee et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Expression of enzymes related to glucose metabolism in non-small cell lung cancer and prognosis

(2017) Alexandra Giatromanolaki et al.   EXPERIMENTAL LUNG RESEARCH

Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth

(2017) Tae-Wook Chung et al.   JOURNAL OF ETHNOPHARMACOLOGY

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

(2017) Giulia Cesi et al.   Molecular Cancer

The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism

(2017) Guang Shi et al.   Cell Reports

PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer

(2016) Tao Liu et al.   ONCOLOGY REPORTS

Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea

(2015) Shi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification

(2015) W. Sun et al.   CANCER RESEARCH

Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents

(2015) Shao-Lin Zhang et al.   DRUG DISCOVERY TODAY

The Warburg effect: Evolving interpretations of an established concept

(2015) Xiaozhuo Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

(2015) Wen Zhang et al.   International Journal of Biological Sciences

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents

(2015) Elise Saunier et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

(2015) Hyun-Young Lee et al.   Marine Drugs

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

(2015) Nam Ho Jeoung   Diabetes & Metabolism Journal

Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK–CHOP signaling pathways

(2014) Minh Truong Do et al.   FOOD AND CHEMICAL TOXICOLOGY

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

(2013) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

(2010) James J. La Clair   NATURAL PRODUCT REPORTS

A new structural class of S-adenosylhomocysteine hydrolase inhibitors

(2009) Byung Gyu Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY