Article
Multidisciplinary Sciences
Yixin Wen, Feng Xu, Yang Liu, Kaining Zhi, Junfeng Tan, Yong Jiang, Minghui Li, Hui Zhang
Summary: This study investigated the clinical outcomes of preserving or excising the infrapatellar fat pad (IPFP) during anterior cruciate ligament reconstruction (ACLR). The results showed that preserving IPFP led to more significant improvements in anterior knee pain and knee joint function compared to excising IPFP. Surgeons should avoid excising IPFP as much as possible to ensure the effectiveness of ACLR.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Braun, Frank Zaucke, Marco Brenneis, Anna E. Rapp, Patrizia Pollinger, Rebecca Sohn, Zsuzsa Jenei-Lanzl, Andrea Meurer
Summary: In recent years, there has been increasing research interest in the infrapatellar fat pad (IFP). It is believed to play a role in the development and progression of knee osteoarthritis (OA) through its interactions with the synovium, articular cartilage, and subchondral bone. While IFP is (partially) resected in most total knee arthroplasties (TKA), there is currently no clear guideline in favor of or against this practice.
Article
Orthopedics
Junjie Xu, Zipeng Ye, Kang Han, Ting Zheng, Tianlun Zhang, Shikui Dong, Jia Jiang, Xiaoyu Yan, Jiangyu Cai, Jinzhong Zhao
Summary: This study evaluated the effect of exosomes derived from infrapatellar fat pad (IPFP) mesenchymal stromal cells (MSCs) on tendon-bone healing and intra-articular graft remodeling after anterior cruciate ligament reconstruction (ACLR) in a rat model. The results demonstrated that IPFP MSC-derived exosomes accelerated tendon-bone healing and intra-articular graft remodeling, possibly through the immunomodulation of macrophage polarization.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chiara Giulia Fontanella, Elisa Belluzzi, Assunta Pozzuoli, Manuela Scioni, Eleonora Olivotto, Davide Reale, Pietro Ruggieri, Raffaele De Caro, Roberta Ramonda, Emanuele Luigi Carniel, Marta Favero, Veronica Macchi
Summary: This study analyzed the role of infrapatellar fat pad (IFP) and suprapatellar fat pad (SFP) in knee osteoarthritis (OA) using magnetic resonance (MR) imaging. The results showed differences in the characteristics of these tissues among different patient groups, supporting their importance in the pathology and progression of OA.
Article
Immunology
Shuhe Ma, Kosaku Murakami, Rintaro Saito, Hiromu Ito, Koichi Murata, Kohei Nishitani, Motomu Hashimoto, Masao Tanaka, Masahi Taniguchi, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Koichiro Ohmura, Akio Morinobu, Tsuneyo Mimori
Summary: This study identified differences in the quantity and quality of CD14-positive cells in the infrapatellar fat pads and subcutaneous fat tissues of OA and RA patients. Patients treated with bDMARDs showed a higher ratio of CD14(++)CD80(+) cells/CD14(++)CD163(+) cells in the IFP, indicating localized inflammation. This suggests that adipose tissue-derived innate immune cells could be a potential target for new therapeutic strategies in inflammatory joint diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Elena Stocco, Elisa Belluzzi, Martina Contran, Rafael Boscolo-Berto, Edgardo Picardi, Diego Guidolin, Chiara Giulia Fontanella, Eleonora Olivotto, Giuseppe Filardo, Giulia Borile, Filippo Romanato, Roberta Ramonda, Pietro Ruggieri, Marta Favero, Andrea Porzionato, Raffaele De Caro, Veronica Macchi
Summary: The infrapatellar fat pad (IFP) plays an important role in knee osteoarthritis, with age affecting its tissue characteristics even in the absence of pathological conditions. Differences were observed between the young group and elderly group in terms of collagen III levels and adipocyte size. Additionally, aging was associated with a decrease in total collagen deposition in the IFP tissue.
FRONTIERS IN MEDICINE
(2021)
Article
Engineering, Biomedical
Junjun Yang, Xin Wang, Yahan Fan, Xiongbo Song, Jiangyi Wu, Zhenlan Fu, Tao Li, Yang Huang, ZheXiong Tang, Shuo Meng, Na Liu, Jiajia Chen, Pingju Liu, Liu Yang, Xiaoyuan Gong, Cheng Chen
Summary: Intra-articular injection of tropoelastin (TE) improves the adhesion, migration, and chondrogenic differentiation of mesenchymal stem cells (MSCs) and enhances matrix synthesis of osteoarthritic chondrocytes (OACs). In vitro experiments demonstrate that TE enhances MSCs adhesion through activation of specific pathways. In vivo experiments show that intra-articular injection of TE-MSCs suspension increases MSCs survival rate and improves histology scores of joint tissues.
BIOACTIVE MATERIALS
(2022)
Article
Immunology
Zhiwen Li, Shiyong Zhang, Guping Mao, Yiyang Xu, Yunze Kang, Linli Zheng, Dianbo Long, Weishen Chen, Minghui Gu, Zhiqi Zhang, Yan Kang, Puyi Sheng, Ziji Zhang
Summary: ACL plays an important role in knee homeostasis and disease progression. Degeneration of the ACL alters knee joint homeostasis and influences the microenvironment, contributing to the progression of KOA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peter Kreitmaier, Young-Chan Park, Diane Swift, Arthur Gilly, J. Mark Wilkinson, Eleftheria Zeggini
Summary: This study examines the DNA methylation profiles of infrapatellar fat pad and blood samples from osteoarthritis patients, revealing widespread epigenetic differences. The researchers produce the first genome-wide methylation quantitative trait locus map and provide insights into the molecular mechanisms of osteoarthritis.
HUMAN MOLECULAR GENETICS
(2023)
Article
Chemistry, Multidisciplinary
Bingyang Dai, Yuwei Zhu, Xu Li, Zuru Liang, Shunxiang Xu, Shian Zhang, Zhe Zhang, Shanshan Bai, Wenxue Tong, Mingde Cao, Ye Li, Xiaobo Zhu, Wei Liu, Yuantao Zhang, Liang Chang, Patrick Shu-hang Yung, Kevin Ki-wai Ho, Jiankun Xu, To Ngai, Ling Qin
Summary: The study investigates the role of infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) progression and identifies dysregulated osteopontin (OPN) and integrin beta 3 signaling in OA specimens. The study demonstrates that IPFP-derived OPN plays a role in OA progression, including chondrocyte hypertrophy and IPFP fibrosis. An injectable nanogel, (RGD-)Nanogel/siRNA Cd61, is developed to target integrins and effectively alleviate cartilage degeneration and subchondral bone mass in OA mice.
Article
Pharmacology & Pharmacy
Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang, Chunli Wang
Summary: This study demonstrated that Hesperetin (HPT) has chondroprotective and anti-inflammatory effects on chondrocytes through the AMPK signaling pathway, inhibiting TNF-alpha-induced cartilage degradation and promoting chondrocyte proliferation. RNA sequencing identified potential molecular targets, with 549 differentially expressed genes, and highlighted the importance of the AMPK pathway in mediating HPT's protective effects. Overall, HPT shows promise as a natural drug for osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jie-Ting Li, Ni Zeng, Zhi-Peng Yan, Tao Liao, Xin Chen, Guo-Xin Ni
Summary: The metabolic changes in rat serum after an ACL injury were closely related to disturbances in energy metabolism and amino acid metabolism, which may contribute to the pathogenesis of posttraumatic osteoarthritis.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yumei Cao, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Weiren Lan, Guangfeng Ruan, Jia Li, Zhaohua Zhu, Weiyu Han, Su'an Tang, Changhai Ding
Summary: Infrapatellar fat pad (IPFP) is associated with the progression of knee osteoarthritis (OA), as it secretes small extracellular vesicles (sEVs) that promote cartilage destruction and cellular senescence. The let-7b-5p and let-7c-5p in IPFP-sEVs directly decrease the negative regulator of senescence, lamin B receptor (LBR). This study uncovers the function and mechanism of IPFP-sEVs in the progression of OA, providing a potential strategy for OA therapy.
Review
Biochemistry & Molecular Biology
Parviz Vahedi, Rana Moghaddamshahabi, Thomas J. Webster, Ayse Ceren Calikoglu Koyuncu, Elham Ahmadian, Wasim S. Khan, Ali Jimale Mohamed, Aziz Eftekhari
Summary: Cartilage damage is often difficult to repair, and current treatment strategies are inadequate. Autologous mesenchymal stem cells are considered a promising therapeutic approach for cartilage regeneration, as they possess robust cartilaginous production capacity and are easy to isolate and expand without causing morbidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Qin Ye, Dong He, Xiaonan Ding, Yajie Wang, Yuguo Wei, Jing Liu
Summary: This study evaluated the infrapatellar fat pad (IFP) in knee osteoarthritis (KOA) using radiomics and developed a radiomic signature for assessing IFP in KOA progression. The results showed that radiomic alterations in IFP were associated with the severity and structural abnormalities of KOA.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Ramesh Nadarajah, Peter Ludman, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milasinovic, Chris P. Gale
Summary: The aim of this study is to identify international patterns in the management of NSTEMI and compare them with the 2015 ESC Guidelines. By collecting data from 3620 NSTEMI patients in 287 centers across 59 countries, this study will provide unique insights into the contemporary management of NSTEMI patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Engineering, Biomedical
Ilaria Toniolo, Maria Vittoria Mascolini, Emanuele Luigi Carniel, Chiara Giulia Fontanella
Summary: Artificial sphincters (ASs) are used to replace the function of biological sphincters in cases of severe urinary and fecal incontinence and gastroesophageal reflux disease. However, commercial ASs currently have sub-optimal clinical outcomes due to device malfunction and side effects on biological tissues. It is important to investigate the interaction between biological tissues and ASs and develop innovative AS designs.
Article
Computer Science, Interdisciplinary Applications
Ilaria Toniolo, Alice Berardo, Michel Gagner, Mirto Foletto, Emanuele Luigi Carniel
Summary: This study investigated the mechanism of gastro-oesophageal reflux disease (GERD) using computational models. It found that laparoscopic sleeve gastrectomy could induce de novo GERD and worsen pre-existing GERD. Variables such as the His-angle, antral dimension, and bolus viscosity were found to affect reflux increase.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Chiara Giulia Fontanella, Emanuele Luigi Carniel, Andrea Parpaiola, Marco Toia, Arturo Nicola Natali
Summary: The biomechanical response of bone tissues is crucial for understanding the functional response of dental implants, especially in cases of misfit. The interaction between surgical procedures and healing phases primarily depends on bone tissue response, which is influenced by specific loadings. This pilot study aims to define a method for biomechanical investigation and highlight the need to integrate clinical knowledge with biomechanical analysis to interpret osseointegration.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Angelo Di Vincenzo, Marika Crescenzi, Marnie Granzotto, Sara Zancaner, Roberto Fabris, Mirto Foletto, Luca Prevedello, Federico Capone, Roberto Vettor, Marco Rossato
Summary: This study investigated the basal INSL5 plasma levels in morbidly obese subjects before and after laparoscopic sleeve gastrectomy. The results showed that obese subjects had elevated INSL5 levels before surgery, which were positively correlated with BMI, fat mass, and leptin levels. After surgery, INSL5 levels significantly decreased, and there was no expression of the INSL5 gene in human adipose tissue. These findings suggest that the reduction of INSL5 levels after bariatric surgery may contribute to appetite reduction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Camilla Costa, Stefano Piaserico, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
Summary: Psoriasis is a chronic inflammatory disease characterized by skin lesions. It is more prevalent and severe in obese individuals. Insulin stimulates the production of IL-23 by human adipocytes, which may explain the association between psoriasis and obesity.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Medicine, General & Internal
Carmelo Pirri, Nina Pirri, Diego Guidolin, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Carla Stecco
Summary: Recent studies have found an association between thoracolumbar fascia thickness and reduced gliding in patients with lower back pain. This study aimed to measure and compare the thickness of thoracolumbar fascia in chronic non-specific lower back pain patients and healthy individuals using ultrasound imaging. The results showed that lower back pain patients had a loss of anisotropy in the thoracolumbar fascia, with a homogeneous increase in thickness and a loss of adaptability in the transverse direction.
Article
Biochemistry & Molecular Biology
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
Summary: In this study, the effects of sex steroids on the expression of inflammatory mediators in human-derived adipocytes were evaluated. The results showed that non-aromatizable androgen DHT and the aromatase inhibitor anastrozole in combination with testosterone significantly enhanced the expression of inflammatory cytokines induced by LPS. These results confirm the involvement of sex hormones in adipose tissue inflammation and suggest a specific role for non-aromatizable androgens as amplificatory sex hormones of the inflammatory response.
Article
Computer Science, Interdisciplinary Applications
Maria Vittoria Mascolini, Chiara Giulia Fontanella, Alice Berardo, Emanuele Luigi Carniel
Summary: This study used computational fluid dynamics to analyze the influence of a catheter on male lower urinary tract functionality. The results showed that the catheter affected urine flow and supported the use of clinical uroflow studies to reduce diagnostic uncertainty.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Rheumatology
Giacomo Cozzi, Laura Scagnellato, Mariagrazia Lorenzin, Edoardo Savarino, Fabiana Zingone, Francesca Ometto, Marta Favero, Andrea Doria, Stephan R. Vavricka, Roberta Ramonda
Summary: Spondyloarthritis (SpA) is a group of chronic inflammatory diseases affecting the axial and peripheral joints, tendons, and entheses. Inflammatory bowel disease (IBD) is strongly associated with SpA and has significant impacts on patients' quality of life. Effective treatment requires close collaboration between gastroenterologists and rheumatologists to identify and manage joint and intestinal manifestations, and current drug options for both conditions remain limited.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sofia Pettenuzzo, Alessandro Arduino, Elisa Belluzzi, Assunta Pozzuoli, Chiara Giulia Fontanella, Pietro Ruggieri, Valentina Salomoni, Carmelo Majorana, Alice Berardo
Summary: Biomechanical studies are expanding into various fields, playing crucial roles in the development, growth, and disease processes of organs and tissues. However, challenges exist in analyzing the passive response of cells due to cell variability, complex procedures, and different models. This review aims to provide important information on experimental techniques, results, models, and factors influencing the structural and mechanical changes in chondrocytes and chondrons.
Article
Health Care Sciences & Services
Carlo Biz, Assunta Pozzuoli, Elisa Belluzzi, Davide Scucchiari, Nicola Luigi Bragazzi, Alessandro Rossin, Mariachiara Cerchiaro, Pietro Ruggieri
Summary: This study compared the clinical and radiographic outcomes of operative and non-operative treatment for acute displaced midshaft clavicle fractures (ADMCFs), and verified the effectiveness of the institutional treatment protocol. The results showed that conservative treatment had better clinical outcomes, while return to sports was longer in the surgical group. However, both groups achieved good mid-term clinical results without any signs of non-union.
