Editorial Material
Cardiac & Cardiovascular Systems
William A. E. Parker, Robert F. Storey
Summary: This editorial discusses the efficacy of Ticagrelor monotherapy in patients with chronic kidney disease undergoing interventional procedures.
EUROPEAN HEART JOURNAL
(2021)
Article
Clinical Neurology
Lili Sun, Shuzhen Wang, Yun Song, Wei Zhao, Meimei Zheng, Hao Yin, Jun Zhang, Yao Meng, Wei Wang, Ju Han
Summary: This study compared the efficacy and safety outcomes of aspirin-ticagrelor and aspirin-clopidogrel regimens in patients undergoing intracranial stenting. The results showed no significant difference in the rate of ischemic vascular events between the two groups at 180 days. There was also no difference in bleeding risk, total restenosis, or symptomatic restenosis at follow-up.
FRONTIERS IN NEUROLOGY
(2023)
Article
Hematology
Yunnan Zhang, Yi Zhang, Xiujin Shi, Baidi Lin, Jialun Han, Yifan Wang, Jialin Yan, Wenxing Peng, Wenzheng Li, Ze Zheng, Yang Lin
Summary: This study found that in ACS patients without CYP2C19 loss-of-function alleles, clopidogrel was not associated with a higher risk of MACCEs compared to ticagrelor. This suggests that clopidogrel can be used as an alternative P2Y12 inhibitor in CYP2C19 LOF noncarriers, potentially reducing medical expenses and adverse reactions caused by more potent P2Y12 inhibitors in these patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Yongjun Wang, Yuesong Pan, Hao Li, Pierre Amarenco, Hans Denison, Scott R. Evans, Anders Himmelmann, Stefan James, Mikael Knutsson, Per Ladenvall, Carlos A. Molina, S. Claiborne Johnston
Summary: This study investigated the short-term benefits and risks of ticagrelor with aspirin in patients with acute mild-moderate ischemic stroke or high-risk TIA. The results showed that ticagrelor significantly reduced major ischemic events from the first week and continued throughout the 30-day treatment period, while the risk of major hemorrhage increased in the first week and remained relatively stable thereafter.
Article
Medicine, General & Internal
Erik Bjorklund, Carl Johan Malm, Susanne J. Nielsen, Emma C. Hansson, Hans Tygesen, Birgitta S. Romlin, Andreas Martinsson, Elmir Omerovic, Aldina Pivodic, Anders Jeppsson
Summary: This study compared clinical outcomes of patients with acute coronary syndrome treated with aspirin and ticagrelor vs aspirin alone after artery bypass grafting. The results showed that dual antiplatelet therapy did not significantly reduce major adverse cardiovascular events compared with aspirin monotherapy, but was associated with an increased risk of major bleeding. Further research is needed to determine optimal antiplatelet therapy in this group.
Article
Cardiac & Cardiovascular Systems
Ziwei Xi, Jianan Li, Hong Qiu, Tingting Guo, Yong Wang, Yang Li, Jianfeng Zheng, Kefei Dou, Bo Xu, Yongjian Wu, Shubin Qiao, Weixian Yang, Yuejin Yang, Runlin Gao
Summary: This study demonstrates that in patients with SCAD undergoing complex PCI, ticagrelor can significantly reduce the risk of adverse cardiovascular events compared to clopidogrel, without an increased risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yunnan Zhang, Wenxing Peng, Xiujin Shi, Jialun Han, Yifan Wang, Zhenwei Fang, Yang Lin
Summary: This study compared the clinical outcomes of clopidogrel and ticagrelor in older patients with acute coronary syndrome. The findings suggest that clopidogrel and ticagrelor have comparable clinical benefits in patients aged 65 and above, with clopidogrel associated with a lower risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yonggu Lee, Jeong-Hun Shin, Suk Min Seo, Ik Jun Choi, Jong-Young Lee, Jun-Won Lee, Mahn-Won Park, Tae Soo Kang, Woong Gil Choi, Ki-Hyun Jeon, Hong-Seok Lim, Hyung Joon Joo, Sang Jae Rhee, Jae-Bin Seo, Myung Soo Park, Sang-Ho Park, Young-Hyo Lim
Summary: This study investigated the influence of early ticagrelor dose reduction on clinical outcomes in Korean patients undergoing percutaneous coronary intervention. The results showed that reducing ticagrelor dose within 6 months after PCI is feasible and safe, even in patients with complex lesions harboring a high ischemic event risk.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Christina L. Marcaccio, Priya B. Patel, Patric Liang, Vinamr Rastogi, Lars Stangenberg, Jeffrey Jim, Peter A. Schneider, Marc L. Schermerhorn
Summary: The study findings indicate that compared to aspirin/clopidogrel, aspirin/ticagrelor may potentially reduce the risk of stroke/death in specific cases involving carotid artery stenting and carotid artery revascularization procedures when protamine is used, while also increasing the risk of bleeding.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Pharmacology & Pharmacy
Yaxin Liu, Yun Kuang, Min Hai, Cheng Cui, Dongyang Liu, Guoping Yang
Summary: The exposure to ticagrelor is higher in East Asians, resulting in an increased risk of bleeding. A population pharmacokinetic model was developed and machine learning methods were used to construct bleeding risk models. The Random Forest model performed the best and a lower bleeding risk ticagrelor regimen can be obtained using this model.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Clinical Neurology
Jean Papaxanthos, Federico Cagnazzo, Francois-Louis Collemiche, Xavier Barreau, Razvan Alexandru Radu, Florent Gariel, Imad Derraz, Gregory Gascou, Carlos Riquelme, Ivan Ferreira, Pierre-Henri Lefevre, Jerome Berge, Vincent Costalat, Cyril Dargazanli, Gaultier Marnat
Summary: Ticagrelor with aspirin and clopidogrel with aspirin have similar efficacy and safety in the treatment of intracranial aneurysms with flowdiverter.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Guiomar Mendieta, Shamir Mehta, Usman Baber, Dominick J. Angiolillo, Carlo Briguori, David Cohen, Timothy Collier, George Dangas, Dariusz Dudek, Javier Escaned, Robert Gil, Birgit Vogel, Davide Cao, Alessandro Spirito, Kurt Huber, Adnan Kastrati, Upendra Kaul, Ran Kornowski, Mitchell W. Krucoff, Vijay Kunadian, David J. Moliterno, E. Magnus Ohman, Gennaro Sardella, Samantha Sartori, Samin Sharma, Richard Shlofmitz, P. Gabriel Steg, Ya-Ling Han, Stuart Pocock, C. Michael Gibson, Roxana Mehran
Summary: In high-risk patients, ticagrelor monotherapy reduces bleeding events without increasing the risk of ischemic events compared to dual antiplatelet therapy. The benefit of ticagrelor monotherapy is consistent across different bleeding and ischemic risk levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Felice Gragnano, Elisabetta Moscarella, Paolo Calabro, Arturo Cesaro, Pia Clara Pafundi, Alfonso Ielasi, Giuseppe Patti, Ilaria Cavallari, Emilia Antonucci, Plinio Cirillo, Pasquale Pignatelli, Gualtiero Palareti, Francesco Pelliccia, Carlo Gaudio, Ferdinando Carlo Sasso, Vittorio Pengo, Paolo Gresele, Rossella Marcucci
Summary: In patients with acute coronary syndrome and high bleeding risk, there was no significant difference in ischemic and bleeding events at 1 year between those treated with clopidogrel and ticagrelor. The duration of dual antiplatelet therapy, rather than the specific type of therapy, was associated with long-term outcomes.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Cell Biology
Ziwei Xi, Zifeng Qiu, Jianan Li, Hong Qiu, Tingting Guo, Yong Wang, Jianfeng Zheng, Yanan Gao, Runlin Gao
Summary: This study compares the clinical outcomes of clopidogrel and ticagrelor in elderly East Asian patients with acute coronary syndrome (ACS). The results show that ticagrelor does not reduce the risk of the primary efficacy outcome compared to clopidogrel, but it is associated with a significantly higher risk of all-cause death and major bleeding.
Article
Cardiac & Cardiovascular Systems
Anoop N. Koshy, Gennaro Giustino, Samantha Sartori, Htoo Kyaw, Mayank Yadav, Zhongjie Zhang, Amit Hooda, Ali Farooq, Parasuram Krishnamoorthy, Joseph M. Sweeny, Sahil Khera, Gregory W. Serrao, Raman Sharma, Javed Suleman, George Dangas, Annapoorna S. Kini, Roxana Mehran, Samin K. Sharma
Summary: This study compared the efficacy and safety of ticagrelor and prasugrel in a real-world patient population undergoing percutaneous coronary intervention (PCI). The results showed no difference in the risk of death or myocardial infarction (MI) between ticagrelor and prasugrel groups, but the ticagrelor cohort had significantly lower rates of target vessel revascularization without differences in stroke or bleeding.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Environmental Sciences
Sylwester Rogula, Aleksandra Gasecka, Tomasz Mazurek, Eliano Pio Navarese, Lukasz Szarpak, Krzysztof J. Filipiak
Summary: The prevalence of chronic kidney disease is increasing due to aging population and risk factors. Impaired renal function increases the risk of bleeding and thrombosis. Vitamin K antagonists and direct oral anticoagulants are two groups of drugs for preventing thromboembolic events, and DOACs have pleiotropic effects and comparable efficacy and safety in patients with CKD.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Szymon Jonik, Michal Marchel, Marcin Grabowski, Grzegorz Opolski, Tomasz Mazurek
Summary: This manuscript provides a comprehensive summary of the role of gastrointestinal hormones GIP and GLP-1 in atherosclerosis and coronary artery disease. The study suggests that GIP and GLP-1 are expressed in various human tissues and are associated with inflammation, atherosclerosis, and myocardial ischemia. In animal models, GIP and GLP-1 improve endothelial function and reduce macrophage infiltration in atherosclerotic plaques. In humans, GIP and GLP-1 have both pro-atherosclerotic and anti-atherosclerotic effects. Clinical trials have shown that GLP-1 analogs can significantly reduce cardiovascular events in patients with type 2 diabetes. However, more research is needed to understand the metabolism of GIP in acute myocardial ischemia and stable coronary artery disease.
Article
Biology
Michal Konwerski, Aleksandra Gasecka, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
Summary: Epicardial adipose tissue (EAT) is a significant risk factor for cardiovascular diseases (CVDs) and may impact the course of COVID-19. Novel therapies targeting EAT could revolutionize the prognosis in CVDs.
Article
Hematology
Ceren Eyileten, Aleksandra Gasecka, Anna Nowak, Joanna Jarosz-Popek, Marta Wolska, Al-Medina Dizdarevic, Irene M. Lang, Marek Postula, Marcin Ufnal, Jolanta M. Siller-Matula
Summary: This study found that higher SDMA concentration was associated with lower platelet reactivity and major/minor bleeding events in ACS patients receiving DAPT. Therefore, SDMA has the potential to serve as a biomarker for individualization of antiplatelet therapy in ACS patients at high risk of bleeding complications.
THROMBOSIS RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ceren Eyileten, Zofia Wicik, Disha Keshwani, Faisal Aziz, Felix Aberer, Peter N. Pferschy, Norbert J. Tripolt, Caren Sourij, Barbara Prietl, Florian Pruller, Dirk von Lewinski, Salvatore De Rosa, Jolanta M. Siller-Matula, Marek Postula, Harald Sourij
Summary: Hypoglycemia was found to influence the expression of miRNAs related to diabetes and platelet activation. These findings suggest that miRNAs could potentially serve as biomarkers for platelet activation in patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ceren Eyileten, Zofia Wicik, Sergio N. Simoes, David C. Martins-Jr, Krzysztof Klos, Wojciech Wlodarczyk, Alice Assinger, Dariusz Soldacki, Andrzej Chcialowski, Jolanta M. Siller-Matula, Marek Postula
Summary: By utilizing bioinformatic and co-expression analysis, this study identified and validated miRNAs associated with thrombosis in COVID-19 patients, which can serve as potential diagnostic and prognostic biomarkers for disease severity. The findings contribute to our understanding of the pathogenesis of COVID-19 and the identification of novel predictive markers.
Article
Cardiac & Cardiovascular Systems
Mandeep S. Sidhu, Karen P. Alexander, Zhen Huang, Roy O. Mathew, Jonathan D. Newman, Sean M. O'Brien, Patricia A. Pellikka, Radmila Lyubarova, Olga Bockeria, Carlo Briguori, Evgeny L. Kretov, Tomasz Mazurek, Francesco Orso, Marek F. Roik, Chakkanalil Sajeev, Evgeny Shutov, Frank W. Rockhold, David Borrego, Stephen Balter, Gregg W. Stone, Bernard R. Chaitman, Shaun G. Goodman, Jerome L. Fleg, Harmony R. Reynolds, David J. Maron, Judith S. Hochman, Sripal Bangalore
Summary: In the ISCHEMIA-CKD study, patients with advanced chronic kidney disease and chronic coronary disease had similar all-cause mortality rates with initial invasive or conservative strategies. This secondary analysis aimed to determine whether an initial invasive strategy reduced the incidence of cardiovascular or non-cardiovascular causes of death. The results showed no significant difference in the cause-specific death rates between the two treatment strategies.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Multidisciplinary Sciences
Szczepan Wiecha, Przemyslaw Seweryn Kasiak, Igor Cieslinski, Tim Takken, Tomasz Palka, Beat Knechtle, Pantelis T. Nikolaidis, Lukasz A. Malek, Marek Postula, Artur Mamcarz, Daniel Sliz
Summary: This study compared predicted VO2max (pVO2max) with directly measured VO2max and found that the accuracy of available prediction models has not been validated in endurance athletes. The models underestimated pVO2max in younger and higher trained athletes, and overestimated pVO2max in older and lower trained athletes. These models should only be used as a supplemental method for physicians and new models need to be developed for clinical practice and sports diagnostics.
Article
Cardiac & Cardiovascular Systems
Aleksandra Gasecka, Oliwia Fidali, Aleksandra Klebukowska, Karolina Jasinska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postula, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
Summary: This study investigates the association between plasma concentrations of gut metabolites and major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI). The findings suggest that increased levels of trimethylamine-N-oxide (TMAO) may be an independent predictor of MACCE and contribute to post-AMI cardiac dysfunction.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)
Review
Biochemistry & Molecular Biology
Chiara Siracusa, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postula, Salvatore De Rosa
Summary: Lack of timely intervention strategies for acute ischemic stroke due to limited understanding of underlying mechanisms. Circular RNAs involved in pathophysiological processes of ischemic stroke, providing potential therapeutic targets and clinical biomarkers.
Article
Biology
Szczepan Wiecha, Przemyslaw Seweryn Kasiak, Piotr Szwed, Tomasz Kowalski, Igor Cieslinski, Marek Postula, Andrzej Klusiewicz, Herbert Loellgen
Summary: This study aimed to develop prediction models for VO2max based on submaximal exercise variables or somatic variables in endurance athletes. The study found that VO2 at anaerobic threshold and respiratory compensation point were the most important variables in the exercise equations, while body weight and body fat had the highest impact on the somatic equation. The derived models were accurate and replicable, providing valuable tools for estimating VO2max in sport and clinical settings.
Article
Biochemistry & Molecular Biology
Gloria M. M. Gager, Ceren Eyileten, Marek Postula, Anna Nowak, Aleksandra Gasecka, Bernd Jilma, Jolanta M. M. Siller-Matula
Summary: This study investigated the relationship between blood-derived microRNAs (miRNAs) and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The expression of miR-223 was found to be associated with improved long-term survival in NSTE-ACS patients. This hypothesis-generating study suggests that miR-223 may be a suitable predictor for long-term all-cause mortality.
Review
Health Care Sciences & Services
Chiara Siracusa, Niccolo Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa
Summary: Despite improvements in diagnosis and treatment, ischemic stroke remains a challenge with significant morbidity and mortality. The identification of high-risk individuals, timely diagnosis, recognition of different clinical forms, treatment response assessment, and prognostic evaluation are unmet clinical needs. This article provides an overview of circular RNAs as potential biomarkers in stroke, aiming to gather comprehensive information on this promising class of molecules.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Szymon Jonik, Maria Boszko, Elena Sztemberg, Dominik Lepecki, Bartlomiej Grodzinski, Marcin Mikusek-Pham Van, Michal Marchel, Janusz Kochman, Mariusz Kusmierczyk, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
Summary: This study investigates the impact of the COVID-19 pandemic on the functioning of the Heart Team. The results show a decrease in the number of meetings and consulted patients, as well as changes in treatment strategies, suggesting a significant impact of the pandemic on the Heart Team.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jakub Maksym, Agnieszka Kaplon-Cieslicka, Piotr Scislo, Zenon Huczek, Michal Marchel, Radoslaw Piatkowski, Janusz Kochman, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
Summary: This study investigated the safety and efficacy of LAAC procedure followed by antiplatelet therapy in a high-risk population. The results showed that this treatment strategy was safe and effective in high-risk patients. Peri-procedural complications and treatment endpoints were evaluated.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)
