Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Catarina Almeida-Ferreira, Rafael Silva-Teixeira, Ana Cristina Goncalves, Carlos Miguel Marto, Ana Bela Sarmento-Ribeiro, Francisco Caramelo, Maria Filomena Botelho, Mafalda Laranjo
Summary: This study evaluated the therapeutic potential of cold atmospheric plasma (CAP) in breast cancer cells with distinct histological features and found that apoptosis was the most prevalent type of cell death. In addition, CAP treatment inhibited cell replication ability and antioxidative activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Helena Motaln, Nina Recek, Boris Rogelj
Summary: This review examines the potential use of cold atmospheric plasma in medicine, particularly its beneficial effects on tumor reduction in oncology. It discusses the cellular changes and impacts on main cellular processes, such as proliferation, migration, protein degradation, and various forms of cell death, especially in the oncology field of plasma medicine.
Article
Materials Science, Multidisciplinary
Shichen Zhang, Zhengqiang Li, Zhimin Xu, Yixin Tang, Congcong Duan, Huanyan Dai, Xinyu Dai, Xin Wei, Yan Liu, Caina Xu, Bing Han
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of head and neck cancer. Traditional treatments can have negative effects on physiological functions and appearance. This article discusses the use of reactive oxygen species (ROS)-based cancer therapy and summarizes various nanotherapeutics for HNSCC, including photodynamic therapy, sonodynamic therapy, radiation therapy, and chemodynamic therapy. The challenges and future directions for these treatments are also discussed.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Sun-Ja Kim, Min-Jeong Seong, Jong-Jin Mun, Jin-Hee Bae, Hea-Min Joh, Tae-Hun Chung
Summary: This study compared the effects of cold atmospheric plasma (CAP) on non-cancerous and melanoma cells. The results showed that melanoma cells were more sensitive to CAP treatment and produced more reactive oxygen and nitrogen species (RONS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Chemical
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: Cold atmospheric pressure plasmas (CAPPs) have attracted increasing attention in the field of medicine, particularly in oncology. The selective anticancer characteristics of CAPP make it a promising application for treating skin cancers. Research on the effects of CAPP on skin cancers has provided insights into potential new treatments and the complex interactions between reactive species and cellular components.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
Article
Engineering, Environmental
Hangbo Xu, Cao Fang, Qing Huang
Summary: A novel approach using cold atmospheric-pressure plasma (CAP) and plasma-activated water (PAW) was employed to efficiently remove aflatoxin B-1 (AFB(1)), a highly toxic metabolite from Aspergillus flavus (A. flavus). CAP could effectively degrade AFB(1), while PAW produced by CAP further removed AFB(1) with longer treatment time. The dominant reactive species involved in the degradation process were hydroxyl radical (center dot OH) in CAP treatment and singlet oxygen (O-1(2)) in PAW treatment.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Physics, Applied
Maksudbek Yusupov, Debbie Dewaele, Pankaj Attri, Umedjon Khalilov, Frank Sobott, Annemie Bogaerts
Summary: This study unravels the possible mechanisms of oligosaccharide oxidation induced by cold atmospheric plasma (CAP), providing atomic-level insight into the onset of plasma-induced removal of biofilms.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Stefania Magnano, Patricia Hannon Barroeta, Ronan Duffy, Jeff O'Sullivan, Daniela M. Zisterer
Summary: The study evaluated the role of autophagy in mediating cisplatin resistance in oral squamous cell carcinoma (OSCC) cells. Results demonstrated that cisplatin induces both apoptosis and autophagy in OSCC cells through the ROS/JNK pathway. However, autophagy did not play a significant role in acquired resistance to cisplatin or have a pro-survival effect in the cells. This suggests a complex interplay between apoptosis and autophagy pathways in OSCC.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Som V. Thomas, Krista Dienger-Stambaugh, Michael Jordan, Yuxin Wang, Jason Hammonds, Paul Spearman, Donglu Shi
Summary: A Cold Atmospheric Plasma (CAP) apparatus was developed and tested for its ability to kill SARS-CoV-2 using pseudotyped viral infectivity assays. The reactive species generated by the plasma system were fully characterized, revealing the presence of various reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the plasma plume. Virus killing experiments showed that CAP treatment significantly reduced SARS-CoV-2 infectivity after 8 seconds, with further enhancement of killing observed with longer exposures of 15-120 seconds. The efficacy of killing was correlated with the type, intensity, energy, and frequency of the reactive species. These results demonstrate the effective use of cold plasma for virus inactivation through ROS and RNS under ambient conditions.
BIOENGINEERING-BASEL
(2023)
Article
Food Science & Technology
Shanrui Li, Xiaolong Wang, Lian Li, Jun Liu, Yunhan Ding, Tong Zhao, Yuantao Zhang
Summary: In this study, the authors used Reactive Molecular Dynamics (RMD) simulation to investigate the detoxification pathways of the mycotoxin DON induced by reactive oxygen species (ROS). It was found that ROS can modify toxicologically important functional groups of DON through various reactions, reducing its toxicity and providing theoretical understanding for plasma degradation of mycotoxins in the future.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hee-Kyun Oh, Seunggon Jung, Hong-Ju Park, Yeong-Joon Park, Min-Suk Kook
Article
Surgery
Seunggon Jung, Hee-Kyun Oh, Hong-Ju Park, Min-Suk Kook
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Article
Biotechnology & Applied Microbiology
Jung-Pyo Park, Hye Joo Shin, Suk-Gyun Park, Hee-Kyun Oh, Choong-Ho Choi, Hong-Ju Park, Min-Suk Kook, Seung-Ho Ohk
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Do-Young Choi, Tae-Yeong Bak, Young-Hyoun Hwang, Seong-Won Yang, Sang-Chul Jung, Min-Suk Kook, Byung-Hoon Kim
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2015)
Article
Dentistry, Oral Surgery & Medicine
Su-Yeoun Jang, Kwang Chung, Seunggon Jung, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook
Article
Dentistry, Oral Surgery & Medicine
Min-Suk Kook, Seunggon Jung, Hong-Ju Park, Hee-Kyun Oh, Sun-Youl Ryu, Jin-Hyoung Cho, Jae-Seo Lee, Suk-Ja Yoon, Min-Soo Kim, Hyo-Keun Shin
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2014)
Article
Surgery
Hee-Kyun Oh, Hong-Ju Park, Je-Seok Oh, Seunggon Jung, Min-Suk Kook
JOURNAL OF CRANIOFACIAL SURGERY
(2014)
Article
Materials Science, Multidisciplinary
M. -J. Hwang, H. -R. Choi, M. -S. Kook, H. -J. Song, Y. -J. Park
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
(2015)
Article
Chemistry, Physical
Seunggon Jung, Hee-Kyun Oh, Myung-Sun Kim, Ki-Young Lee, Hongju Park, Min-Suk Kook
Article
Chemistry, Physical
Min-Suk Kook, Chang-Min Lee, Young-Il Jeong, Byung-Hoon Kim
Article
Biochemistry & Molecular Biology
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim
Summary: Folic acid-conjugated nanophotosensitizers showed ROS-sensitive properties and could be delivered to cancer cells via a folate receptor-mediated pathway, making them promising candidates for targeted photodynamic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Sung-Ok Hong, Min-Suk Kook, Young-IL Jeong, Min-Ju Park, Seong-Won Yang, Byung-Hoon Kim
Summary: Ce6-incorporated COSthPBAP nanophotosensitizers showed effective photodynamic therapy (PDT) in oral cancer cells with tumor-specific delivery capacity and fluorescence imaging.
Article
Biochemistry & Molecular Biology
Kaengwon Yoon, Seunggon Jung, Jaeyoung Ryu, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook
Summary: ROS-sensitive polymer nanoparticles were synthesized for tumor targeting of doxorubicin. The nanoparticles showed ROS sensitivity and cytotoxicity against both sensitive and resistant cancer cells. In vivo studies demonstrated that the nanoparticles had higher antitumor efficacy and accumulated effectively in tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kaeng Won Yoon, Suk-Ja Yoon, Byung-Cheol Kang, Young-Hee Kim, Min Suk Kook, Jae-Seo Lee, Juan Martin Palomo
IMAGING SCIENCE IN DENTISTRY
(2014)