Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 158, Issue -, Pages 9-17Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.04.116
Keywords
Electrospinning; Chitosan; Metal-organic framework; Wound dressing
Funding
- National Natural Science Foundation of China [31771093]
- Project of International Collaboration of Jilin Province [201180414085GH]
- Fundamental Research Funds for the Central Universities
- Program for JLU Science and Technology Innovative Research Team [2017TD-27, 2019TD-36]
- Jilin Provincial Industrial Innovation Program [2016C024]
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Developing wound dressing that inhibits bacterial infection for treating complex wound healing processes has been a research hotspot. Here, we report the fabrication of Cu-MOFs (HKUST-1) incorporated electrospun chitosan/polyvinyl alcohol (HKUST-1/chitosan/PVA) fibers through the blending electrospinning for wound therapy. HKUST-1/chitosan/PVA fibers displayed satisfying physical properties, such as mechanical property, water uptake, water vapor transmission rate, etc. Cytotoxicity test indicated that HKUST-1/chitosan/PVA fibers were biocompatible and could support cell adhesion. Due to the HKUST-1 incorporation, HKUST-1/chitosan/PVA fibers exhibited the good antibacterial activity against Escherichia coli and Staphylococcus aureus with 99% antibacterial efficiency. Furthermore, in animal studies, compared with commercial chitosan dressings and chitosan/PVA fibers, HKUST-1/chitosan/PVA fibers were more efficient to heal the wound with less inflammation. In summary, the HKUST-1/chitosan/PVA fibers with good physicochemical property, biocompatibility and antibacterial property is an excellent wound dressing for full-thickness skin repair. (C) 2020 Elsevier B.V. All rights reserved.
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