Journal
INFECTION
Volume 49, Issue 1, Pages 181-186Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s15010-020-01526-0
Keywords
Dalbavancin; Bacteremia; Intravascular infection; Suppressive therapy; LVAD; Endocarditis
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Funding
- Projekt DEAL
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Four cases of Gram-positive bacteremia originating from intravascular sources, including left ventricular assist devices, transfemoral aortic valve implantation, and prosthetic aortic valves, were effectively suppressed with dalbavancin therapy without significant side effects.
We present four cases with Gram-positive bacteremia (pathogens: MRSAn = 1, Enterococcusspp.n = 3) due to an intravascular source (left ventricular assist device:n = 2, transfemoral aortic valve implantationn = 1, prosthetic aortic valve:n = 1) where no curative treatment was available. These patients received indefinite, chronic suppressive (palliative) therapy with dalbavancin (500 mg weekly or 1000 mg biweekly regimens). Outcomes and clinical characteristics are described; treatment was effective in suppression of bacteremia in all patients over several months (range: 1 to more than 12 months), we observed no relevant side effects.
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