Article
Immunology
Tengfei Zhu, Ming Kong, Chen Li, Changwei Shao
Summary: This study investigated the role of exosomal miRNAs in Chinese tongue sole's response to Vibrio harveyi infection. The results demonstrated the important regulatory roles of exosomal miRNAs in the inflammatory and immune responses, and their potential as biomarkers for the prognosis and diagnosis of infection in teleost fish.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Mina Ahangarzadeh, Hossein Houshmand, Mansour Torfi Mozanzadeh, Shapour Kakoolaki, Samira Nazemroaya, Abolfazl Sepahdari, Rahim Peyghan, Ashkan Ajdari, Ayeh Sadat Sadr
Summary: This study developed and evaluated a killed polyvalent vaccine against important bacterial diseases in Asian seabass. The vaccinated fish showed higher survival rates, antibody titers, and enhanced immune parameters compared to the control group.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Shun Zhou, Ying Li, Jingyuan Yi, Xujia Zheng, Qing Huang, Lin Su, Baoshan Guo, Zongrui Yang, Yunji Xiu
Summary: In this study, FKCs and VVGs vaccines were developed to prevent vibriosis in S. maximus caused by V. vulnificus. The immune response induced by the vaccines was analyzed using transcriptome data, and it was found that both vaccines activated innate and adaptive immune-related genes. VVGs vaccine induced a stronger immune response compared to FKCs vaccine.
JOURNAL OF FISH DISEASES
(2022)
Article
Pharmacology & Pharmacy
Zhe Chen, Chaoyang Meng, Junhua Mai, Yongbin Liu, Hangwen Li, Haifa Shen
Summary: This study demonstrates that a lipid-formulated RNA vaccine composed of a protamine/mRNA core and a lipid shell is highly effective in promoting cytotoxic CD8 T cell responses and mediating anti-tumor immunity. Both the mRNA core and lipid shell are necessary for stimulating the expression of type I interferons and inflammatory cytokines in dendritic cells. The expression of interferon relies exclusively on STING, and the antitumor activity of the mRNA vaccine is compromised in mice with a defective Sting gene. Thus, the mRNA vaccine induces STING-dependent antitumor immunity.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Ruth Montero, Justin Tze Ho Chan, Bernd Koellner, Roman Kuchta, Jakub Vyslouzil, Peter Podhorec, Astrid Sibylle Holzer, Tomas Korytar
Summary: Poly lactic-co-glycolic acid (PLGA) particles can serve as carriers for drugs and vaccine antigens in fishes, and the immune system of common carp recognizes and reacts to PLGA microparticles. PLGA particles can play a dual role as both antigen and drug carriers in fishes.
Article
Immunology
Shaswath S. Chandrasekar, Yashdeep Phanse, Rachel E. Hildebrand, Mostafa Hanafy, Chia-Wei Wu, Chungyi H. Hansen, Jorge E. Osorio, M. Suresh, Adel M. Talaat
Summary: The study demonstrated that using a heterologous immunization strategy can induce neutralizing antibodies against SARS-CoV-2 in mice, showing potential for a protective vaccine. This approach also induced polyfunctional T-cell responses, while the homologous plasmid vaccine strategy mainly led to local T-cell responses.
Article
Microbiology
Minjeong Nam, Seung Gyu Yun, Sang-wook Kim, Chris Gunwoo Kim, Jae Hyun Cha, Cheonghwa Lee, Seunghyuk Kang, Seul Gi Park, Sun Bean Kim, Ki-Byung Lee, You-Seung Chung, Myung-Hyun Nam, Chang Kyu Lee, Yunjung Cho
Summary: This study investigated the impact of age, sex, and vaccine type on humoral and cellular immune responses after vaccination against SARS-CoV-2. The results showed that there were differences in immune responses based on age, sex, and vaccine type, with mix-and-match and mRNA vaccines inducing stronger immune responses. Furthermore, the levels of RBD antibodies and neutralizing antibodies could be used to predict the presence of cellular immune responses.
MICROBIOLOGY SPECTRUM
(2022)
Review
Immunology
Pooja Choudhary, Donaldson Magloire, Glenn Hamonic, Heather L. Wilson
Summary: The immune system in the upper reproductive tract provides protection against pathogens and immune tolerance against sperm and fetus. The timing of exposure to pathogens is most likely during estrus and breeding when the cervix is semi-permissive. The goal of intrauterine immunization is to induce local or systemic immunity and/or promote passive protection for suckling offspring.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yu-ming Peng, Jian-jun Tao, Su-fang Kuang, Ming Jiang, Xuan-xian Peng, Hui Li
Summary: This study identified potential polyvalent vaccine candidates against bacterial infections by constructing DNA vaccines from extracellular secretory proteins of Vibrio alginolyticus. Three of the vaccines showed cross-immune protective effects against various bacterial infections, indicating the possibility of using extracellular secretory proteome as an antigen pool for identifying cross-protective immunogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
My Dang, Trung Cao, Ignacio Vasquez, Ahmed Hossain, Hajarooba Gnanagobal, Surendra Kumar, Jennifer R. Hall, Jennifer Monk, Danny Boyce, Jillian Westcott, Javier Santander
Summary: The study evaluated the efficacy of orally delivered V. anguillarum bacterin on lumpfish and found that oral immunization was ineffective, while intraperitoneal delivery provided protection against vibriosis. This indicates that orally administered bacterin did not reach deep lymphoid tissues, rendering oral immunization ineffective.
Article
Multidisciplinary Sciences
Xiaoxiao Dong, Boye Li, Boyang Yu, Tian Chen, Qin Hu, Bo Peng, Wang Sheng
Summary: Poria cocos polysaccharide (PCP) enhances antigen-specific antibody levels, CD8(+) T cell cytotoxicity, and Th-1 type cytokine production in mice, suggesting its potential as a vaccine adjuvant.
Article
Biotechnology & Applied Microbiology
Na Young Kim, Won Rak Son, Min Hoon Lee, Hong Seok Choi, Jun Young Choi, Young Jo Song, Chi Ho Yu, Dong Hyun Song, Gyeung Haeng Hur, Seong Tae Jeong, Sung Youl Hong, Young Kee Shin, Sungho Shin
Summary: This study developed a synthetic dual-pathogen DNA vaccine for anthrax and botulism, which elicited high levels of antibody response and provided over 50% protection against both pathogens. The study suggests a prospective approach for developing emergency vaccines that can be distributed on a massive scale in response to biothreat emergencies or infectious disease outbreaks.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Weina Sun, Yonghong Liu, Fatima Amanat, Irene Gonzalez-Dominguez, Stephen McCroskery, Stefan Slamanig, Lynda Coughlan, Victoria Rosado, Nicholas Lemus, Sonia Jangra, Raveen Rathnasinghe, Michael Schotsaert, Jose L. Martinez, Kaori Sano, Ignacio Mena, Bruce L. Innis, Ponthip Wirachwong, Duong Huu Thai, Ricardo Das Neves Oliveira, Rami Scharf, Richard Hjorth, Rama Raghunandan, Florian Krammer, Adolfo Garcia-Sastre, Peter Palese
Summary: The rapid development of COVID-19 vaccines has been crucial in mitigating the spread of SARS-CoV-2, but equitable allocation of vaccines is necessary to limit global impact and the emergence of variants. A Newcastle disease virus-based COVID-19 vaccine candidate has been developed, inducing protective immunity in various animal models.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Yixin Wu, Huicong Zhang, Liuxian Meng, Fusheng Li, Changyuan Yu
Summary: This study compares the immune responses of SARS-CoV-2 mRNA and recombinant protein vaccines, showing that both vaccines can elicit high levels of antibody responses, but with bias towards different IgG subtypes. Additionally, the mRNA vaccine induces stronger cellular immune responses compared to the recombinant protein vaccine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Yang, Xiao-li Yang, Yu-bin Su, Xuan-xian Peng, Hui Li
Summary: Vaccines are safe and effective in controlling bacterial diseases in the aquaculture industry and align with green farming. A novel approach of preparing live-attenuated V. alginolyticus vaccine using high magnesium concentration to attenuate virulence was developed. Metabolomic analysis revealed enhanced TCA cycle and increased fumarate as crucial pathways and biomarkers in vaccine-mediated and survival fish.
FRONTIERS IN IMMUNOLOGY
(2021)