Article
Multidisciplinary Sciences
Bin Wang, Zhiling Li
Summary: This study investigated the association between basal luteinizing hormone (LH) and reproductive outcomes in women with polycystic ovary syndrome (PCOS) undergoing intrauterine insemination (IUI). The results showed that high levels of basal LH were associated with an increased risk of pregnancy loss and could be used to predict the success of pregnancy in PCOS women undergoing IUI.
Review
Endocrinology & Metabolism
Rosa Wartena, Mushi Matjila
Summary: The relationship between polycystic ovarian syndrome (PCOS) and recurrent pregnancy loss (RPL) is still poorly understood and requires further research. Factors that should be further investigated include the contribution of PCOS phenotypes, BMI, obesity, insulin resistance, hyperandrogenemia, SHBG, hs-CRP, CTRP6, adiponectin, plasma leptin, homocysteine, AMH, and thrombophilia to the risk of miscarriage. Other factors that need to be explored in relation to the risk of miscarriage in PCOS patients with RPL include sOB-R, PAI-Fx, and Factor-V-Leiden mutations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Hui-Ying Jie, Xiu Zhou, Ming-Peng Zhao, Min Hu, Qing-Yun Mai, Can-Quan Zhou
Summary: The study aimed to investigate whether polycystic ovary syndrome (PCOS) is an independent risk factor for pregnancy complications in women undergoing assisted reproductive technology (ART) treatment. Results showed that PCOS may increase the risk of late miscarriage, but other pregnancy outcomes were similar between PCOS patients and the control group.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Maya Sharon-Weiner, Hadar Gluska, Sivan Farladansky-Gershenabel, Hanoch Schreiber, Amir Wiser, Adrian Shulman, Anat Hershko-Klement
Summary: The study found that IVF should not be postponed following a pregnancy loss, as shorter intervals were associated with greater likelihood of live birth. Patients after biochemical or spontaneous miscarriage typically had shorter intervals to the next cycle, while those after medical or surgical miscarriages had longer intervals.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Nutrition & Dietetics
Andres Diaz-Lopez, Blanca Ribot, Josep Basora, Victoria Arija
Summary: This population-based cohort study found that women with anaemia or high haemoglobin levels in early pregnancy are at higher risk of miscarriage, with miscarriage rates of 8.4% and 10.2% respectively. Compared to women with normal Hb levels, those with anaemia and high Hb levels had a 2.11-fold and 1.83-fold increased risk of miscarriage. The study also showed a U-shaped association between Hb concentrations and miscarriage, with the lowest risk among women with Hb levels of 120-130 g/L.
Article
Obstetrics & Gynecology
Yossi Mizrachi, Gon Shoham, Milton Leong, Ron Sagiv, Eran Horowitz, Arieh Raziel, Ariel Weissman
Summary: The research revealed significant variability in the use of misoprostol for the management of early pregnancy loss (EPL) on a global scale. More high-quality research is needed to further examine the various aspects of treatment due to the differences in practice, particularly focusing on the timing and effectiveness of a second dose administration and criteria for determining treatment failure or success.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Rima K. Dhillon-Smith, Pedro Melo, Rosinder Kaur, Emily Fox, Adam Devall, Natalie Woodhead, Arri Coomarasamy
Summary: Miscarriage can have devastating physical and psychological impacts, but there are lifestyle and therapeutic interventions available to prevent it.
FERTILITY AND STERILITY
(2023)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Dana B. McQueen, Kruti P. Maniar, Anne Hutchinson, Rafael Confino, Lia Bernardi, Mary Ellen Pavone
Summary: The study aimed to develop diagnostic criteria for chronic endometritis and compare its prevalence between women with recurrent pregnancy loss (RPL) and controls. Results showed that with strict diagnostic criteria, the prevalence of chronic endometritis was significantly higher in women with RPL, indicating an association between chronic endometritis and RPL.
FERTILITY AND STERILITY
(2021)
Article
Public, Environmental & Occupational Health
Diana C. Goncalves Mendes, Ana Fonseca, Monica S. Cameirao
Summary: A quarter of pregnancies worldwide end in early pregnancy loss, causing trauma and negative mental health responses for many women. This study aimed to characterize the psychological impact of early pregnancy loss in Portugal. An online survey was conducted, and it was found that a significant proportion of women still experienced clinical symptoms of mental health disorders even 3 years after the loss. Timely intervention and monitoring are crucial for those women in need.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Carmen Conroy, Tanya Jain, Sheila K. Mody
Summary: This study aimed to explore how patients emotionally cope with early pregnancy loss (EPL) and assess the interest in a peer EPL support program with a self-compassion component. The findings suggest that therapy and in-person support groups are helpful but sometimes inaccessible, social media support groups can create a sense of solidarity initially but may trigger negative emotions in the long term, support from a peer who has experienced EPL is valuable, developing self-compassion is important in coping with EPL, and there is a demand for emotional and informational support following EPL.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Obstetrics & Gynecology
Roberto Matorras, Jose Ignacio Pijoan, Lucia Lainz, Maria Diaz-Nunez, Hector Sainz, Silvia Perez-Fernandez, Dayana Moreira
Summary: The purpose of this systematic review and meta-analysis was to evaluate the risk of miscarriage in IVF cycles in women with polycystic ovary syndrome (PCOS). The results showed that women with PCOS had a significantly increased risk of miscarriage in IVF pregnancies, including total miscarriage, preclinical miscarriage, and early miscarriage. This increased risk was observed in both Chinese and Western populations.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Emergency Medicine
Arden McAllister, Britt Lang, Anne Flynn, Zachary F. Meisel, Alice Abernathy, Mary D. Sammel, Courtney A. Schreiber
Summary: This study aimed to assess the prevalence of Critical or Emergent patient classification among pregnant patients in the Emergency Department and identified risk factors such as history of ectopic pregnancy, heavy bleeding, and prior ED visits during the current pregnancy for patients requiring emergency-level care. The majority of pregnant patients presenting with early pregnancy complaints were discharged without intervention.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Genetics & Heredity
Mahmoud Salama, M. Lambertini, M. S. Christianson, Y. Jayasinghe, A. Anazodo, M. De Vos, F. Amant, C. Stern, L. Appiah, T. L. Woodard, R. A. Anderson, L. M. Westphal, R. E. Leach, K. A. Rodriguez-Wallberg, P. Patrizio, Teresa K. Woodruff
Summary: This study compared oncofertility practices for breast cancer in limited versus optimum resource settings and found higher scores in optimum resource settings, with commonly used methods including egg freezing and embryo freezing, while some new technologies are still in the early stages of clinical research.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Editorial Material
Obstetrics & Gynecology
Ezgi Darici, Christophe Blockeel, Shari Mackens
Summary: Chronic endometritis is an infectious or inflammatory process that disrupts the correct implantation of embryos. Its prevalence ranges from 2% to almost 60%, with a higher suspicion in women with recurrent early pregnancy loss and recurrent implantation failure. The impact of chronic endometritis on reproductive outcomes following IVF is uncertain due to the lack of convincing data showing improvement after diagnosis and treatment. This article critically evaluates current diagnostic methods, treatments, and patient populations for chronic endometritis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
P. Drakopoulos, F. Di Guardo, L. Boudry, S. Mackens, M. De Vos, G. Verheyen, H. Tournaye, C. Blockeel
Summary: The dose or type of gonadotropin does not affect the reproductive outcomes of poor responders undergoing MNC-IVF.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Panagiotis Drakopoulos, Yakoub Khalaf, Sandro C. Esteves, Nikolaos P. Polyzos, Sesh K. Sunkara, Daniel Shapiro, Botros Rizk, Hong Ye, Michael Costello, Yulia Koloda, Bruno Salle, Monica Lispi, Thomas D'Hooghe, Antonio La Marca
Summary: A high ovarian response refers to a greater number of follicles and/or oocytes compared to a normal response. It can be diagnosed before oocyte pick-up when there are >18-20 follicles ≥11-12 mm, or after oocyte pick-up when >18-20 oocytes have been retrieved. Women with a high response are at high risk of ovarian hyperstimulation syndrome (OHSS). Appropriate management strategies, such as individualized gonadotropin dosing, monitoring, and choice of protocols, can greatly reduce the risk of high response.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, Michel De Vos, Ferdinando D'Amico, Kristine Paridaens, Gaurang Daftary, Robert Dudkowiak, Laurent Peyrin-Biroulet, Silvio Danese
Summary: This study investigated the level of knowledge among health care professionals and patients about the impact of inflammatory bowel disease (IBD) on fertility. The results showed that health care professionals had good knowledge, while patients had poor knowledge. The study also revealed a lack of understanding among patients regarding the impact on sexual function and reproductive outcomes. The findings highlight the importance of improving education for both health care professionals and patients regarding fertility and sexual function in IBD.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Obstetrics & Gynecology
Lan N. Vuong, Toan D. Pham, Tuong M. Ho, Michel De Vos
Summary: Oocyte in vitro maturation (IVM) has been considered as an alternative to conventional ovarian stimulation (COS) for subfertile women with polycystic ovary syndrome. Our systematic review found that the live birth rate after IVM was not significantly lower compared to COS, regardless of the stage of transferred embryos. While there may be a potentially higher rate of hypertensive disorders during pregnancy, there were no significant differences in obstetric or perinatal complications between IVM and COS.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Filipa Rafael, Maria Dias Rodrigues, Jose Bellver, Mariana Canelas-Pais, Nicolas Garrido, Juan A. Garcia-Velasco, Sergio Reis Soares, Samuel Santos-Ribeiro
Summary: For women with infertility and overweight/obesity, delaying infertility treatment to promote weight loss should consider female age. Substantial weight loss in a short period of time (3 months) seems to provide any benefit, particularly for women over 38 years old.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
F. Blavier, D. Grobet, C. Duflos, R. Rayssiguier, N. Ranisavljevic, M. Duport Percier, A. Rodriguez, C. Blockeel, S. Santos-Ribeiro, G. Faron, L. Gucciardo, F. Fuchs
Summary: Compared to the standard clinical approach, retrospective implementation of the new medical software in a gynaecological emergency unit was correlated with more accurate diagnosis and more cost-effective management.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Shari Mackens, Francisca Pais, Panagiotis Drakopoulos, Samah Amghizar, Caroline Roelens, Lisbet Van Landuyt, Herman Tournaye, Michel De Vos, Christophe Blockeel
Summary: This retrospective cohort study aimed to investigate whether additional oral dydrogesterone supplementation improves reproductive outcomes in patients with low serum progesterone concentrations during frozen embryo transfer (FET) after artificial endometrial preparation. The study found that the live birth rate was comparable between patients who received additional oral dydrogesterone supplementation and those who continued with the routine protocol.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Endocrinology & Metabolism
Anders Juul, Claus H. Gravholt, Michel De Vos, Ekaterina Koledova, Martine Cools
Summary: Diagnosis and management of individuals with differences of sex development (DSD) due to numerical or structural variations of sex chromosomes (NSVSC) is challenging. Girls with Turner syndrome (45X) may have varying phenotypic features. Individuals with 45,X/46,XY chromosomal mosaicism may have Turner syndrome-like features and short stature. Newborn screening for sex chromosome variations could be possible but requires further analysis. Comprehensive healthcare and fertility assessment are important for individuals with NSVSC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
P. Verdyck, G. Altarescu, S. Santos-Ribeiro, C. Vrettou, U. Koehler, G. Griesinger, V Goossens, C. Magli, C. Albanese, M. Parriego, L. Coll, R. Ron-El, K. Sermon, J. Traeger-Synodinos
Summary: The study found that known chromosome segregation errors accounted for 90.4% of abnormal chromosome copy numbers in polar bodies of oocytes from women of advanced maternal age. These errors were associated with impaired embryo development.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Robert B. Gilchrist, Tuong M. Ho, Michel De Vos, Flor Sanchez, Sergio Romero, William L. Ledger, Ellen Anckaert, Lan N. Vuong, Johan Smitz
Summary: Recent advances in understanding oocyte biology and ovulation from animal studies have led to the development of biphasic IVM approaches, which involve pre-culturing immature oocytes before routine in vitro maturation. This novel procedure has the potential to significantly impact human ART practices. This review examines the scientific advances in ovarian biology, biphasic IVM procedures, and reports on outcomes from animal and clinical human data.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Pietro Santulli, Christophe Blockeel, Mathilde Bourdon, Giovanni Coticchio, Alison Campbell, Michel De Vos, Kirsten Tryde Macklon, Anja Pinborg, Juan A. Garcia-Velasco
Summary: While there is extensive research on fertility preservation in women with malignant diseases, there is limited research on the role of fertility preservation in non-malignant conditions. This includes various benign gynaecological conditions that may affect reproductive potential. Currently, there is insufficient data to develop guidelines for clinical practice in fertility preservation for women with benign gynaecological conditions.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Samuel Santos-Ribeiro, Catarina M. Godinho, Sergio Reis-Soares
Summary: Frozen embryo transfers (FET) are gaining popularity in assisted reproductive technology (ART) due to advancements in cryopreservation techniques and the 'freeze-all' strategy. The debate between artificial or natural cycles for FET preparation continues, but natural cycle FETs offer promising outcomes and increased convenience for patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)