Article
Immunology
Ramon Cortez, Luana N. Moreira, Marina Padilha, Mariana D. Bibas, Ricardo K. Toma, Gilda Porta, Carla R. Taddei
Summary: Studies have shown that the composition of intestinal microbiome in pediatric patients with primary sclerosing cholangitis (PSC) is influenced by disease, age, and disease activity status, highlighting significant differences in microbiome between PSC patients. Specific genera Veillonella and Megasphaera have increased relative abundance depending on age at diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mikal Jacob Hole, Kristin Kaasen Jorgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer-Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Gotz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov
Summary: This study investigated the characteristics of the gut microbiota in patients with primary sclerosing cholangitis (PSC) and found several features associated with PSC, including an expansion of Proteobacteria and increased variability. Furthermore, certain genera and the presence of the pathobiont Klebsiella were associated with reduced survival in PSC patients, and concomitant inflammatory bowel disease (IBD) was associated with reduced levels of Akkermansia.
Review
Nutrition & Dietetics
Andreas Blesl, Vanessa Stadlbauer
Summary: The gut-liver axis is a crucial physiological interplay between the gut and liver, with disruptions playing a key role in the evolution and progression of chronic cholestatic liver diseases. Key features of this cycle include the gut microbiome, gut barrier, bacterial translocation, and bile acid metabolism. Understanding of the alterations in the gut-liver axis has significantly increased, influencing the pathogenesis and outcome of these diseases. Therapeutic implications and future scientific objectives are also outlined in this review.
Article
Gastroenterology & Hepatology
Martin Kummen, Louise B. Thingholm, Malte C. Ruhlemann, Kristian Holm, Simen H. Hansen, Lucas Moitinho-Silva, Timur Liwinski, Roman Zenouzi, Christopher Storm-Larsen, Oyvind Midttun, Adrian McCann, Per M. Ueland, Marte L. Hoivik, Mette Vesterhus, Marius Troseid, Matthias Laudes, Wolfgang Lieb, Tom H. Karlsen, Corinna Bang, Christoph Schramm, Andre Franke, Johannes R. Hov
Summary: The study found significant functional differences in the gut microbiome of PSC patients, including microbial metabolism of essential nutrients. Changes in related circulating metabolites associated with disease course suggest that microbial functions may be relevant for the disease process in PSC.
Review
Gastroenterology & Hepatology
Johannes R. Hov, Tom H. Karlsen
Summary: This Review explores the links between Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), and the mechanisms related to the gut-liver axis. It is found that the gut microbiota in people with PSC differs from that of healthy individuals, but the specific microbial factors that differentiate PSC from IBD without PSC are poorly understood. The potential existence of a specific unknown factor related to the gut-liver axis as a cause of PSC is postulated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Kai Markus Schneider, Lena Susanna Candels, Johannes R. Hov, Maiju Myllys, Reham Hassan, Carolin Victoria Schneider, Annika Wahlstrom, Antje Mohs, Sebastian Zuehlke, Lijun Liao, Carsten Elfers, Konrad Kilic, Marcus Henricsson, Antonio Molinaro, Maximilian Hatting, Ayham Zaza, Dirk Drasdo, Mick Frissen, A. Sloan Devlin, Eric J. C. Galvez, Till Strowig, Tom H. Karlsen, Jan G. Hengstler, Hanns-Ulrich Marschall, Ahmed Ghallab, Christian Trautwein
Summary: Patients with PSC display alterations in gut microbiota and bile acid composition, which play a role in disease pathogenesis.
Article
Medicine, Research & Experimental
Tejinder Pal Singh, Saurabh Kadyan, Harisha Devi, Gwoncheol Park, Ravinder Nagpal
Summary: The gut plays a significant role in regulating the physiology of various organs in the body, including the liver. The communication between the gut and liver is bidirectional, with gut-derived products being transported to the liver through the portal vein, triggering responses from the liver. Maintaining a healthy gut microbiome is crucial for the homeostasis of the gut-liver axis, while disturbances in this axis can lead to liver disorders. This article discusses the functional characteristics of a healthy gut-liver axis and explores the role of gut dysbiosis in liver diseases, as well as potential therapeutic approaches.
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Review
Nutrition & Dietetics
Eleuterio A. Sanchez Romero, Erika Melendez Oliva, Jose Luis Alonso Perez, Sebastian Martin Perez, Silvia Turroni, Lorenzo Marchese, Jorge Hugo Villafane
Summary: This study aimed to review the association between gut microbiome and pain in OA patients and found only three out of 2084 studies supported a relationship, but the results were not conclusive. It also highlighted the lack of high-quality studies and significant technique disparities, making it impossible to draw firm conclusions on the topic.
Article
Gastroenterology & Hepatology
Omar Y. Mousa, Brian D. Juran, Bryan M. McCauley, Mette N. Vesterhus, Trine Folseraas, Coleman T. Turgeon, Ahmad H. Ali, Erik M. Schlicht, Elizabeth J. Atkinson, Chang Hu, Denise Harnois, Elizabeth J. Carey, Andrea A. Gossard, Devin Oglesbee, John E. Eaton, Nicholas F. LaRusso, Gregory J. Gores, Tom H. Karlsen, Konstantinos N. Lazaridis
Summary: In patients with PSC, alterations in plasma BA consistent with cholestasis, UDCA treatment, and IBD were observed. BA profiles were able to predict future hepatic decompensation, demonstrating the clinical potential of BA profiling for use in clinical trials.
Review
Gastroenterology & Hepatology
Blaine Caslin, Kailey Mohler, Shreya Thiagarajan, Esther Melamed
Summary: Alcohol may have complex effects on autoimmune diseases, with potential pro-inflammatory and anti-inflammatory properties. These effects may be related to factors such as the dose, duration, type, cultural background, and sex of alcohol consumption.
Article
Gastroenterology & Hepatology
Federica Del Chierico, Sabrina Cardile, Valerio Baldelli, Tommaso Alterio, Sofia Reddel, Matteo Bramuzzo, Daniela Knafelz, Sara Lega, Fiammetta Bracci, Giuliano Torre, Giuseppe Maggiore, Lorenza Putignani
Summary: This study reveals the dysbiosis of gut microbiota and mycobiota in pediatric patients with PSC-UC, showing an increase in pro-inflammatory pathobionts and a reduction in anti-inflammatory commensals.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medical Laboratory Technology
Angela R. Shih, Dilara Hatipoglu, Robert Wilechansky, Reece Goiffon, Vikram Deshpande, Joseph Misdraji, Raymond T. Chung
Summary: Some critically ill COVID-19 patients may experience significant and persistent cholestatic injury, with radiographic and histologic evidence of secondary sclerosing cholangitis, which could be a long-term sequelae of COVID-19 acute illness.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Review
Biology
Salvatore Pezzino, Maria Sofia, Gloria Faletra, Chiara Mazzone, Giorgia Litrico, Gaetano La Greca, Saverio Latteri
Summary: Non-alcoholic fatty liver disease (NAFLD) is a prevalent and poorly-understood liver disease with increasing incidence worldwide. Recent research suggests that dysbiosis of the gut microbiome may play a significant role in the pathogenesis of NAFLD by disrupting the gut-liver axis. This review examines the impact of altered gut microbiome on the progression of NAFLD, focusing on the pathological mechanisms and the role of gut-liver axis disruption.
Article
Microbiology
Bassam Abomoelak, Veronica Pemberton, Chirajyoti Deb, Stephani Campion, Michelle Vinson, Jennifer Mauck, Joseph Manipadam, Sailendharan Sudakaran, Samit Patel, Miguel Saps, Hesham A. El Enshasy, Theodoros Varzakas, Devendra Mehta
Summary: This prospective longitudinal study revealed distinct differences in gut microbiome between pediatric patients with functional abdominal pain disorders (FAPDs) and healthy controls, with variations observed not only in bacterial populations but also in diversity levels. The severity of symptoms in patients was found to be correlated with the gut microbiome, highlighting a potential relationship between the two. Additionally, the Faecalibacterium/Bacteroides ratio may serve as a promising diagnostic biomarker for FAPDs.
Meeting Abstract
Gastroenterology & Hepatology
Y. Lapidot, R. Nosenko, B. Gayshis, M. Likhter, D. Ben-Ami, T. Engel, R. Margalit, I. Kalisky, P. Weiss, V. Ella, O. Cohen-Ezra, Y. Davidov, O. Koren, M. Safran, Z. B. Ari
JOURNAL OF HEPATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran, Ziv Ben-Ari
MOLECULAR MEDICINE
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Yelena Lapidot, Shira Ben-Simon, Oranit Cohen-ezra, Yana Davidov, Peretz Weiss, Mariya Likhter, Ella Veitsman, Omry Koren, Michal Safran, Ziv Ben Ari
JOURNAL OF HEPATOLOGY
(2019)
Article
Microbiology
Yelena Lapidot, Amnon Amir, Rita Nosenko, Atara Uzan-Yulzari, Ella Veitsman, Oranit Cohen-Ezra, Yana Davidov, Peretz Weiss, Tanya Bradichevski, Shlomo Segev, Omry Koren, Michal Safran, Ziv Ben-Ari
Article
Nutrition & Dietetics
Yelena Lapidot, Leah Reshef, Rebecca Goldsmith, Wasef Na'amnih, Eias Kassem, Asher Ornoy, Uri Gophna, Khitam Muhsen
Summary: The study found that the intestinal microbiome of preadolescents is associated with socioeconomic status, body mass index (BMI), and dietary intake, particularly with higher consumption of polyunsaturated fatty acids. This suggests that tailored interventions during these crucial years have the potential to improve health disparities throughout the lifespan.
Article
Gastroenterology & Hepatology
Yelena Lapidot, Leah Reshef, Dani Cohen, Khitam Muhsen
Summary: This study found that H. pylori infection in healthy children is significantly associated with altered intestinal microbiome structure, and socioeconomic factors can also impact both H. pylori infection and intestinal diversity and composition in childhood. These findings have clinical significance for understanding the role of H. pylori infection and other intestinal microbes in health and disease.
Article
Biotechnology & Applied Microbiology
Yelena Lapidot, Leah Reshef, Mayan Maya, Dani Cohen, Uri Gophna, Khitam Muhsen
Summary: This study aimed to investigate the impacts of household environmental and socioeconomic factors on the gut microbiome of school-age children. By analyzing stool samples from 176 Israeli Arab children aged six to nine years from three villages of different socioeconomic status, differences in microbial composition and metabolic pathways were identified. Living in a low socioeconomic status village and high household crowding were associated with increased bacterial richness and significant differences in microbial composition and metabolic pathways.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Health Care Sciences & Services
Khitam Muhsen, Wasef Na'aminh, Yelena Lapidot, Sophy Goren, Yonatan Amir, Saritte Perlman, Manfred S. Green, Gabriel Chodick, Dani Cohen
Summary: This study in Israel reveals that ethnic and religious minorities as well as low socioeconomic status communities bear a higher burden of COVID-19 and have lower vaccine uptake, indicating the presence of social inequalities.
LANCET REGIONAL HEALTH-EUROPE
(2021)