Article
Medicine, General & Internal
Yuexi Liu, Meng Ni, Fanfan Huang, Qiuying Gu, Yao Xiao, Xinyue Du
Summary: This study aimed to evaluate the prognostic effect of neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer (EOC) patients with different histological subtypes. The study found that NACT showed an inferior overall survival (OS) and cause-specific survival (CSS) in high-grade serous carcinoma (HGSC) patients, while it served as a protective factor in clear cell carcinoma and carcinosarcoma. For other histological subtypes, primary debulking surgery (PDS) showed a survival benefit over NACT in certain models. Therefore, the prognostic effect of NACT in advanced EOC differed according to pathological subtypes, with NACT being a risk factor for HGSC but potentially beneficial for less common subtypes.
Article
Oncology
Jin He, Richard D. Schulick, Marco Del Chiaro
Summary: The definition of BRPC should consider biological and conditional dimensions in addition to the anatomic relationship between the tumor and vessels. Neoadjuvant chemotherapy and surgery are associated with improved outcomes of BRPC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Antoni Llueca, Maria Victoria Ibanez, Pedro Cascales, Antonio Gil-Moreno, Vicente Bebia, Jordi Ponce, Sergi Fernandez, Alvaro Arjona-Sanchez, Juan Carlos Muruzabal, Nadia Veiga, Berta Diaz-Feijoo, Cristina Celada, Juan Gilabert-Estelles, Cristina Aghababyan, Alicia Calero, Javier Lacueva, Juan Jose Segura, Karina Maiocchi, Sara Llorca, Alvaro Villarin, Maria Teresa Climent, Katty Delgado, Anna Serra, Luis Gomez-Quiles, Maria Llueca
Summary: This study examines the data collected from 11 tertiary hospitals in Spain and uses a statistical technique called propensity score matching to reproduce the effects of a prospective study using retrospective data. The study found that the addition of hyperthermic chemotherapy after interval cytoreductive surgery is safe and improves disease-free survival in patients with advanced ovarian cancer. Therefore, the addition of hyperthermic chemotherapy is beneficial for these patients.
Article
Oncology
Sabrina Piedimonte, Rachel Kim, Marcus Q. Bernardini, Eshetu G. Atenafu, Mitchell Clark, Stephanie Lheureux, Taymaa May
Summary: The study aims to validate the effectiveness of the KELIM score in patients with high grade serous ovarian cancer undergoing neoadjuvant chemotherapy (NACT) and to explore its correlation with cytoreduction outcome, platinum sensitivity, progression free survival (PFS), and overall survival (OS). The results showed that patients with a KELIM score less than 1 were more likely to have platinum-resistant disease and worse PFS and OS compared to those with a KELIM score of 1. The KELIM score can serve as a useful tool in predicting chemotherapy response and aiding treatment decision-making.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Shi-Ping Yang, Jian-Xian Chen, Jing-Ying Xu, Jian Lei, San-Gang Wu, Juan Zhou
Summary: The study suggests that primary debulking surgery may be the optimal procedure for the majority of advanced epithelial ovarian cancer patients, aiming for complete resection of all residual diseases.
Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Oncology
Derman Basaran, Thomas Boerner, Jessa Suhner, Dib Sassine, Ying Liu, Rachel N. Grisham, William P. Tew, Ginger J. Gardner, Oliver Zivanovic, Yukio Sonoda, Kara Long Roche, Dennis S. Chi, Nadeem R. Abu-Rustum, Gerald A. Soff, Elizabeth L. Jewell
Summary: The study aimed to determine the incidence of VTE in patients receiving neoadjuvant chemotherapy for ovarian cancer, finding that FIGO stage IV disease was the only factor associated with increased risk for new-onset VTE.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Alexandra L. Martin, Christelle M. Colin-Leitzinger, Sweta K. Sinha, Jing-Yi Chern, Lauren C. Peres
Summary: The impact of obesity on frontline carboplatin dosing in epithelial ovarian cancer patients was investigated in this study. The underdosing of carboplatin was more common among obese patients, and it was associated with worse survival in patients with serous tumors in the neoadjuvant setting. It is crucial to provide appropriate weight-based dosing of carboplatin in order to improve outcomes in this patient population.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Nicole D. Fleming, Shannon N. Westin, J. Alejandro Rauh-Hain, Pamela T. Soliman, Bryan M. Fellman, Robert L. Coleman, Larissa A. Meyer, Aaron Shafer, Lauren P. Cobb, Amir Jazaeri, Karen H. Lu, Anil K. Sood
Summary: This study evaluated factors associated with response to neoadjuvant chemotherapy and interval tumor reductive surgery in patients with advanced ovarian cancer. Factors such as age, comorbidity index, ECOG status, and laparoscopic assessment were found to correlate with a patient reaching interval surgery. Patients with lower CA-125 levels at interval surgery had higher rates of complete resection and improved progression-free survival.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, General & Internal
Patrick M. Forde, Jonathan Spicer, Shun Lu, Mariano Provencio, Tetsuya Mitsudomi, Mark M. Awad, Enriqueta Felip, Stephen R. Broderick, Julie R. Brahmer, Scott J. Swanson, Keith Kerr, Changli Wang, Tudor-Eliade Ciuleanu, Gene B. Saylors, Fumihiro Tanaka, Hiroyuki Ito, Ke-Neng Chen, Moishe Liberman, Everett E. Vokes, Janis M. Taube, Cecile Dorange, Junliang Cai, Joseph Fiore, Anthony Jarkowski, David Balli, Mark Sausen, Dimple Pandya, Christophe Y. Calvet, Nicolas Girard
Summary: In patients with resectable non-small-cell lung cancer (NSCLC), neoadjuvant nivolumab plus chemotherapy resulted in significantly longer event-free survival and a higher percentage of patients with a pathological complete response than chemotherapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Oncology
Ami Patel, Puja Iyer, Shinya Matsuzaki, Koji Matsuo, Anil K. Sood, Nicole D. Fleming
Summary: Epithelial ovarian cancer is a deadly cancer in women, often diagnosed at an advanced stage. While historically patients underwent primary tumor reductive surgery followed by chemotherapy, neoadjuvant chemotherapy followed by interval tumor reductive surgery is now an alternative approach for advanced-stage patients. Identifying patients who can benefit most from this approach is crucial for personalized treatment.
Letter
Medicine, General & Internal
Tawee Tanvetyanon
Summary: This article reports that neoadjuvant treatment with nivolumab does not impede the feasibility of lung cancer surgery, but some patients had their surgeries canceled due to disease progression after treatment, which is concerning as they could have been cured through surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Leah A. Marsh, Teresa H. Kim, Mingyan Zhang, Kari Kubalanza, Charisse Liz Treece, Dana Chase, Sanaz Memarzadeh, Ritu Salani, Beth Karlan, Jianyu Rao, Gottfried E. Konecny
Summary: The study validates the three-tier chemotherapy response score (CRS) as a surrogate marker for survival in ovarian cancer (OC) patients who underwent neoadjuvant chemotherapy (NACT). The results show that pathologic response is associated with improved progression-free survival (PFS) and overall survival (OS).
GYNECOLOGIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Sunghoon Joo, Eun Sook Ko, Soonhwan Kwon, Eunjoo Jeon, Hyungsik Jung, Ji-Yeon Kim, Myung Jin Chung, Young-Hyuck Im
Summary: The study developed a deep learning model that integrates clinical information and MRI images to predict pathologic complete response to neoadjuvant chemotherapy in breast cancer patients. The model trained on all datasets showed better performance compared to using only clinical information.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ji Hyun Kim, Hyeong In Ha, Min Hae Kim, Mi Ra Han, Sang-Yoon Park, Myong Cheol Lim
Summary: By modifying institutional procedures for intraperitoneal chemotherapy (IP), including insertion of an IP port in a neutral abdominal position, daily irrigation of the peritoneal cavity with warmed dextrose fluid, and intravenous infusion of cisplatin after left colonic surgery, the completion rate of IP chemotherapy in patients with ovarian cancer was improved, even after left colonic surgery. An average of 63.0% of patients completed all six cycles of IP chemotherapy, with the most common toxicities being gastrointestinal issues and neutropenia. Further studies are needed to confirm the impact of these modifications on survival outcomes.
Article
Oncology
Koji Matsuo, Andrew Vallejo, Syem K. Barakzai, David J. Nusbaum, Hiroko Machida, Marcia A. Ciccone, Lynda D. Roman
Summary: This population-based retrospective cohort study examined characteristics and survival of patients who developed secondary ovarian cancer after external beam radiotherapy (EBRT) for a prior nonovarian pelvic malignancy. Results showed that 215 (1.3 per 1000) patients developed secondary ovarian cancer after EBRT, and these patients had decreased overall survival compared to those with ovarian cancer who did not receive prior EBRT.
Article
Obstetrics & Gynecology
Ariane C. C. Youssefzadeh, Amin Tavakoli, Viraj R. R. Panchal, Rachel S. S. Mandelbaum, Joseph G. G. Ouzounian, Koji Matsuo
Summary: This retrospective cohort study examined the recent incidence trends and characteristics of shoulder dystocia. The study found that the incidence of shoulder dystocia increased from 21.0 to 24.6 per 1000 deliveries during the study period. Risk factors for shoulder dystocia include diabetes mellitus, large for gestational age, and vacuum-assisted delivery.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Letter
Obstetrics & Gynecology
Shinya Matsuzaki, Takeya Hara, Masayuki Endo, Tadashi Kimura
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Genetics & Heredity
Alexandra M. M. McGough, Kaitlin A. A. Doody, Olivia B. B. Foy, Chelsey A. A. Harris, Rachel S. S. Mandelbaum, Koji Matsuo, Richard J. J. Paulson
Summary: This study examined patient and hospital characteristics related to seasonal fluctuation in in vitro fertilization (IVF) in the USA. The findings suggest that there are differences in patient characteristics, such as age and income, for IVF performed in different seasons.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Letter
Oncology
Pavan K. Mann, Alesandra R. Rau, Rachel S. Mandelbaum, Lynda D. Roman, Koji Matsuo
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Yukio Suzuki, Ling Chen, June Y. Hou, Caryn M. St Clair, Fady Khoury-Collado, Alexandre Buckley de Meritens, Koji Matsuo, Alexander Melamed, Dawn L. Hershman, Jason D. Wright
Summary: The use of progestin therapy for premenopausal patients with endometrial intraepithelial neoplasia has increased over time, and the use of progestin-releasing intrauterine devices (IUDs) is also on the rise. Progestin-releasing IUDs may be associated with a lower rate of hysterectomy and a similar rate of venous thromboembolism (VTE) compared with oral progestin therapy.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Surgery
Koji Matsuo, Katharine M. Ciesielski, Rachel S. Mandelbaum, Matthew Y. W. Lee, Jooya D. Neda, Lynda D. Roman, Jason D. Wright
Summary: Based on a retrospective study, there is significant variability in lymph node evaluation during minimally invasive hysterectomy for endometrial hyperplasia in an ambulatory surgery setting, which is associated with histology type, hysterectomy modality, patient factors, and hospital parameters. This suggests the need for developing clinical practice guidelines.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura, Michihide Maeda, Shinya Matsuzaki, Tsuyoshi Hisa, Shoji Kamiura, Toshitaka Morishima, Isao Miyashiro
Summary: A population-based study was conducted to investigate the efficacy of minimally invasive surgery in the treatment of uterine-confined and node-negative cervical cancer in Japan. The results showed that there was no difference in survival outcomes between minimally invasive surgery and open surgery in Japanese patients with FIGO 2018 stage I cervical cancer.
Review
Biochemistry & Molecular Biology
Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Hitomi Sakaguchi, Mamoru Kakuda, Misooja Lee, Yuki Takemoto, Harue Hayashida, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: The placenta has important physiological functions and complications related to abnormal placentas are not well studied. This study reviewed 48 studies published between 1974 and 2022 to determine the outcomes and prevalence of patients with abnormal placentas. The cumulative prevalence of different types of abnormal placentas was reported, along with their associations with adverse pregnancy outcomes.
Article
Obstetrics & Gynecology
Alesandra R. Rau, Ariane C. Youssefzadeh, Shinya Matsuzaki, Rachel S. Mandelbaum, Joseph G. Ouzounian, Koji Matsuo
Summary: This study examined the incidence, characteristics, and outcomes of patients with incidentally diagnosed placenta accreta spectrum during term vaginal delivery. It was found that unsuspected placenta accreta spectrum is rare but associated with significant morbidity. There is a significant association between uterine anomalies and placenta accreta spectrum, which requires further investigation.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Viraj R. Panchal, Alesandra R. Rau, Rachel S. Mandelbaum, Caroline J. Violette, Chelsy A. Harris, Doerthe Brueggmann, Shinya Matsuzaki, Joseph G. Ouzounian, Koji Matsuo
Summary: This study used nationwide data to describe the characteristics and outcomes of pregnancies with a retained intrauterine device. The results showed that these pregnancies are uncommon but may be associated with high-risk pregnancy characteristics and outcomes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Chelsey A. Harris, Rachel S. Mandelbaum, Alesandra R. Rau, Bonnie B. Song, Maximilian Klar, Joseph G. Ouzounian, Richard J. Paulson, Lynda D. Roman, Koji Matsuo
Summary: This study aimed to investigate the preferred contraceptive option or method of sterilization chosen by pregnant patients with malignancy at the time of hospital delivery. The results showed that there were differences in contraceptive choices among pregnant patients with different types of malignancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Letter
Obstetrics & Gynecology
Koji Matsuo, Ling Chen, Katina Robison, Maximilian Klar, Lynda D. Roman, Jason D. Wright
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Oncology
Hitomi Sakaguchi-Mukaida, Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Satoki Deguchi, Mina Sakata, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: This systematic review examines the effectiveness of neoadjuvant chemotherapy (NACT) for women with malignant ovarian germ cell tumors (MOGCT). The results indicate that NACT is used in approximately 40% of advanced MOGCT cases with a response rate of 95.8%. The uterine preservation rate is around 70% and the cumulative resumed menstruation rate is 100%. Comparisons with primary debulking surgery show similar overall survival, disease-free survival, recurrence rate, and adverse event rate from chemotherapy.
Editorial Material
Medicine, General & Internal
Shinya Matsuzaki, Michihide Maeda, Tsuyoshi Hisa, Shoji Kamiura
Summary: In recent years, the number of minimally invasive surgeries (MIS) has been increasing. However, it is important to recognize a specific postoperative complication of MIS, such as a port-site hernia. Persistent postoperative ileus after MIS is rare and should be recognized as a probable sign of a port-site hernia.
CLINICAL CASE REPORTS
(2023)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)