Behavioral States

A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep

(2020) Elisabeth Maluck et al.   PLOS BIOLOGY

Odorant Receptor Inhibition Is Fundamental to Odor Encoding

(2020) Patrick Pfister et al.   CURRENT BIOLOGY

A salt-induced kinase is required for the metabolic regulation of sleep

(2020) Jeremy J. Grubbs et al.   PLOS BIOLOGY

C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization

(2020) Leigh R. Wexler et al.   CURRENT BIOLOGY

Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

(2020) Nathan Cermak et al.   eLife

Feeding state sculpts a circuit for sensory valence in Caenorhabditis elegans

(2019) Sophie Rengarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel Multimodal Circuits Control an Innate Foraging Behavior

(2019) Alejandro López-Cruz et al.   NEURON

Quantitative imaging of sleep behavior in Caenorhabditis elegans and larval Drosophila melanogaster

(2019) Matthew A. Churgin et al.   Nature Protocols

Environmental Programming of Adult Foraging Behavior in C. elegans

(2019) Sreeparna Pradhan et al.   CURRENT BIOLOGY

A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

(2019) Wagner Steuer Costa et al.   Nature Communications

A microfluidic-induced C. elegans sleep state

(2019) Daniel L. Gonzales et al.   Nature Communications

Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep

(2018) Heather L. Bennett et al.   BMC NEUROSCIENCE

FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans

(2018) Ingrid Buntschuh et al.   PLoS One

Satiety behavior is regulated by ASI/ASH reciprocal antagonism

(2018) Kristen C. Davis et al.   Scientific Reports

Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans

(2018) Susanne Skora et al.   Cell Reports

Glia Modulate a Neuronal Circuit for Locomotion Suppression during Sleep in C. elegans

(2018) Menachem Katz et al.   Cell Reports

Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans

(2018) Michael P. O’Donnell et al.   PLoS Genetics

Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans

(2018) Rosalind Hussey et al.   PLoS Genetics

PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans

(2018) Zoë A Hilbert et al.   eLife

An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans

(2018) Yee Lian Chew et al.   NEURON

ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors

(2018) Jeffrey L. Rhoades et al.   CELL

Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegans

(2018) Yin Wu et al.   CURRENT BIOLOGY

Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans

(2017) Hilary DeBardeleben et al.   GENETICS

Food responsiveness regulates episodic behavioral states in Caenorhabditis elegans

(2017) Richard J. McCloskey et al.   JOURNAL OF NEUROPHYSIOLOGY

Antagonistic Serotonergic and Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior in Caenorhabditis elegans

(2017) Matthew A. Churgin et al.   JOURNAL OF NEUROSCIENCE

The ETS-5 transcription factor regulates activity states inCaenorhabditis elegansby controlling satiety

(2017) Vaida Juozaityte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A global brain state underliesC. eleganssleep behavior

(2017) Annika L. A. Nichols et al.   SCIENCE

A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism

(2017) Lavinia Palamiuc et al.   Nature Communications

Genetic and neuronal regulation of sleep by neuropeptide VF

(2017) Daniel A Lee et al.   eLife

The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans

(2017) Michael J Iannacone et al.   eLife

Bmal1 function in skeletal muscle regulates sleep

(2017) J Christopher Ehlen et al.   eLife

Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans

(2017) Hilary DeBardeleben et al.   GENETICS

A Video Method to Study Drosophila Sleep

(2017) John E. Zimmerman et al.   SLEEP

Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit

(2016) Sha Liu et al.   CELL

C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides

(2016) Ravi D. Nath et al.   CURRENT BIOLOGY

The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion

(2016) D. Chen et al.   GENETICS

A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans

(2016) A. L. Fry et al.   GENETICS

Balancing selection shapes density-dependent foraging behaviour

(2016) Joshua S. Greene et al.   NATURE

Forward-genetics analysis of sleep in randomly mutagenized mice

(2016) Hiromasa Funato et al.   NATURE

A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States

(2016) Cindy N. Chiu et al.   NEURON

Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans

(2016) D. Dipon Ghosh et al.   NEURON

Hunger-Driven Motivational State Competition

(2016) C. Joseph Burnett et al.   NEURON

Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila

(2016) Christine Dubowy et al.   SLEEP

Call it Worm Sleep

(2016) Nicholas F. Trojanowski et al.   TRENDS IN NEUROSCIENCES

Pan-neuronal screening in Caenorhabditis elegans reveals asymmetric dynamics of AWC neurons is critical for thermal avoidance behavior

(2016) Ippei Kotera et al.   eLife

AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

(2016) Moloud Ahmadi et al.   eLife

Neuroendocrine modulation sustains the C. elegans forward motor state

(2016) Maria A Lim et al.   eLife

A cellular and regulatory map of the GABAergic nervous system of C. elegans

(2016) Marie Gendrel et al.   eLife

Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila

(2016) Christine Dubowy et al.   SLEEP

Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster

(2015) Glen Seidner et al.   CURRENT BIOLOGY

Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States

(2015) N. F. Trojanowski et al.   JOURNAL OF NEUROSCIENCE

Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans

(2015) Adam J. Calhoun et al.   NEURON

Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans

(2015) Min Guo et al.   Nature Communications

Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release

(2015) Seungwon Choi et al.   PLoS Genetics

An opioid-like system regulating feeding behavior in C. elegans

(2015) Mi Cheong Cheong et al.   eLife

Decoding a neural circuit controlling global animal state in C. elegans

(2015) Patrick Laurent et al.   eLife

Multilevel Modulation of a Sensory Motor Circuit during C. elegans Sleep and Arousal

(2014) Julie Y. Cho et al.   CELL

Cellular Stress Induces a Protective Sleep-like State in C. elegans

(2014) Andrew J. Hill et al.   CURRENT BIOLOGY

FMRFamide-like FLP-13 Neuropeptides Promote Quiescence following Heat Stress in Caenorhabditis elegans

(2014) Matthew D. Nelson et al.   CURRENT BIOLOGY

Mechanistic analysis of the search behaviour of Caenorhabditis elegans

(2014) L. C. M. Salvador et al.   Journal of the Royal Society Interface

Measurements of behavioral quiescence in Caenorhabditis elegans

(2014) Stanislav Nagy et al.   METHODS

Extensive Oscillatory Gene Expression during C. elegans Larval Development

(2014) Gert-Jan Hendriks et al.   MOLECULAR CELL

Presynaptic Partners of Dorsal Raphe Serotonergic and GABAergic Neurons

(2014) Brandon Weissbourd et al.   NEURON

Gene Expression Changes of Caenorhabditis elegans Larvae during Molting and Sleep-Like Lethargus

(2014) Michal Turek et al.   PLoS One

Deep Conservation of Genes Required for Both Drosophila melanogaster and Caenorhabditis elegans Sleep Includes a Role for Dopaminergic Signaling

(2014) Komudi Singh et al.   SLEEP

VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans

(2014) Amanda L. Fry et al.   Nature Communications

Loss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal Secretions

(2014) Katherine A. Cunningham et al.   PLoS Genetics

Maximally informative foraging by Caenorhabditis elegans

(2014) Adam J Calhoun et al.   eLife

Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

(2014) Stanislav Nagy et al.   eLife

Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans

(2014) J. B. George-Raizen et al.   Biology Open

The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor

(2013) Jarred Sanders et al.   BMC NEUROSCIENCE

Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response

(2013) Emma Watson et al.   CELL

Serotonin and the Neuropeptide PDF Initiate and Extend Opposing Behavioral States in C. elegans

(2013) Steven W. Flavell et al.   CELL

An Integrated Serotonin and Octopamine Neuronal Circuit Directs the Release of an Endocrine Signal to Control C. elegans Body Fat

(2013) Tallie Noble et al.   Cell Metabolism

DAF-16/FOXO Regulates Homeostasis of Essential Sleep-like Behavior during Larval Transitions in C. elegans

(2013) Robert J. Driver et al.   CURRENT BIOLOGY

An AP2 Transcription Factor Is Required for a Sleep-Active Neuron to Induce Sleep-like Quiescence in C. elegans

(2013) Michal Turek et al.   CURRENT BIOLOGY

ASI Regulates Satiety Quiescence in C. elegans

(2013) T. Gallagher et al.   JOURNAL OF NEUROSCIENCE

Analysis of NPR-1 Reveals a Circuit Mechanism for Behavioral Quiescence in C. elegans

(2013) Seungwon Choi et al.   NEURON

Hypothalamic Survival Circuits: Blueprints for Purposive Behaviors

(2013) Scott M. Sternson   NEURON

The Geometry of Locomotive Behavioral States in C. elegans

(2013) Thomas Gallagher et al.   PLoS One

The Microarchitecture of C. elegans Behavior during Lethargus: Homeostatic Bout Dynamics, a Typical Body Posture, and Regulation by a Central Neuron

(2013) Shachar Iwanir et al.   SLEEP

Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans

(2013) Bo-mi Song et al.   eLife

A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

(2013) Stanislav Nagy et al.   eLife

SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance inCaenorhabditiselegans

(2012) C. Jee et al.   GENES BRAIN AND BEHAVIOR

PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans

(2012) Arantza Barrios et al.   NATURE NEUROSCIENCE

Peptide Neuromodulation in Invertebrate Model Systems

(2012) Paul H. Taghert et al.   NEURON

A Single Gene Target of an ETS-Family Transcription Factor Determines Neuronal CO2-Chemosensitivity

(2012) Julia P. Brandt et al.   PLoS One

High-Resolution Positional Tracking for Long-Term Analysis of Drosophila Sleep and Locomotion Using the “Tracker” Program

(2012) Nathan Donelson et al.   PLoS One

Oxytocin/Vasopressin-Related Peptides Have an Ancient Role in Reproductive Behavior

(2012) J. L. Garrison et al.   SCIENCE

Reduced activity of a sensory neuron during a sleep-like state in Caenorhabditis elegans

(2011) Juliane Schwarz et al.   CURRENT BIOLOGY

LIN-42/PERIOD Controls Cyclical and Developmental Progression of C. elegans Molts

(2011) Gabriela C. Monsalve et al.   CURRENT BIOLOGY

Food sensitizesC. elegansavoidance behaviours through acute dopamine signalling

(2011) Marina Ezcurra et al.   EMBO JOURNAL

Differentiation of Carbon Dioxide-Sensing Neurons inCaenorhabditiselegansRequires the ETS-5 Transcription Factor

(2011) Manon L. Guillermin et al.   GENETICS

Mapping Neuropeptide Expression by Mass Spectrometry in Single Dissected Identified Neurons from the Dorsal Ganglion of the Nematode Ascaris suum

(2010) Jessica L. Jarecki et al.   ACS Chemical Neuroscience

The Monoaminergic Modulation of Sensory-Mediated Aversive Responses in Caenorhabditis elegans Requires Glutamatergic/Peptidergic Cotransmission

(2010) G. Harris et al.   JOURNAL OF NEUROSCIENCE

Nuclear hormone receptors in nematodes: Evolution and function

(2010) Stefan Taubert et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1

(2009) Toshihisa Nomura et al.   Genes and Nutrition

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Molecular and Sensory Basis of a Food Related Two-State Behavior in C. elegans

(2009) Juliette Ben Arous et al.   PLoS One

Insulin, cGMP, and TGF-β Signals Regulate Food Intake and Quiescence in C. elegans: A Model for Satiety

(2008) Young-jai You et al.   Cell Metabolism

Neural and Molecular Dissection of a C. elegans Sensory Circuit that Regulates Fat and Feeding

(2008) Elisabeth R. Greer et al.   Cell Metabolism

Sensory Regulation of C. elegans Male Mate-Searching Behavior

(2008) Arantza Barrios et al.   CURRENT BIOLOGY

The EGL-4 PKG Acts With KIN-29 Salt-Inducible Kinase and Protein Kinase A to Regulate Chemoreceptor Gene Expression and Sensory Behaviors in Caenorhabditis elegans

(2008) Alexander M. van der Linden et al.   GENETICS

Functional Characterization of Three G Protein-coupled Receptors for Pigment Dispersing Factors inCaenorhabditis elegans

(2008) Tom Janssen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Episodic swimming behavior in the nematode C. elegans

(2008) R. Ghosh et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Lethargus is a Caenorhabditis elegans sleep-like state

(2008) David M. Raizen et al.   NATURE

PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit

(2008) Katherine M. Parisky et al.   NEURON

Acute carbon dioxide avoidance in Caenorhabditis elegans

(2008) E. A. Hallem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular correlates of sleep and wakefulness in the brain of the white-crowned sparrow

(2007) Stephany Jones et al.   JOURNAL OF NEUROCHEMISTRY