Article
Biochemistry & Molecular Biology
Hyeonyu Kim, Tatsuya Osaki, Roger D. Kamm, H. Harry Asada
Summary: This study develops an engineered muscle tissue with a coaxial three-layered tubular structure that resembles the architecture of native skeletal muscles. By remodeling the extracellular matrix, the engineered skeletal muscle tissues produced stronger contractile force and improved angiogenesis.
Article
Biotechnology & Applied Microbiology
Jizhong Yang, Jiezhang Tang, Juanli Dang, Xiangke Rong, Kai Wang, Zhaoxiang Zhang, Mengmeng Hou, Zhou Yu, Chenggang Yi
Summary: A rapid, nonchemical/enzymatic method was developed to prepare decellularized adipose matrix (M-DAM) without using detergents. Compared with the traditional chemical method, M-DAM effectively inhibits oils and cells, sustains structural and biological elements, and contains a higher level of collagen content. Higher rates of adipogenesis and angiogenesis proteins were observed, and the M-DAM showed noncytotoxicity and an ecological niche for stem cell proliferation and differentiation.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Genetics & Heredity
Hui Sheng, Yiwen Guo, Linlin Zhang, Junxing Zhang, Manning Miao, Haoyun Tan, Debao Hu, Xin Li, Xiangbin Ding, Guangpeng Li, Hong Guo
Summary: The study revealed that the MSTN gene regulates focal adhesion, PI3K-AKT, and Ribosomal pathway through the COL1A1 gene to promote muscle growth and development in bovine skeletal muscle.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Elizabeth K. Johnston, Rosalyn D. Abbott
Summary: This review systematically analyzes the process of adipose tissue development and its relationship with the vascular niche, emphasizing the importance of understanding the pathological tissue expansion of obesity and developing improved soft-tissue reconstruction techniques.
Article
Biochemistry & Molecular Biology
Simone Vumbaca, Giulio Giuliani, Valeria Fiorentini, Flavia Tortolici, Andrea Cerquone Perpetuini, Federica Riccio, Simona Sennato, Cesare Gargioli, Claudia Fuoco, Luisa Castagnoli, Gianni Cesareni
Summary: The study investigated changes in skeletal muscle secretome during regeneration process to identify potential regulatory circuits and cell-cell interactions. The analysis included profiling gene expression of various cell types and cytokines, and testing the modulation of adipogenesis and proliferation by selected cytokines. Furthermore, the study explored the interaction mediated by extracellular vesicles and their influences on cell fate during muscle regeneration.
Article
Cell & Tissue Engineering
Chuan He, Minjia Dai, Xiaojie Zhou, Jie Long, Weidong Tian, Mei Yu
Summary: Our study compared adipose tissue extract (ATE) and its further purified small extracellular vesicles (sEV-AT) in terms of characteristics, inductivity on cells, and capacity for promoting de novo adipose tissue regeneration. sEV-AT showed higher particle yield and concentrated particle size distribution, while ATE had more soluble factors and multiple peaks in particle size distribution.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Alen Faiz, Louise M. Harkness, Gavin Tjin, Victor Bernal, Peter Horvatovich, Alan James, John G. Elliot, Janette K. Burgess, Anthony W. Ashton
Summary: The study found that the ECM deposited by asthmatic and non-asthmatic ASM cells under non-stimulated conditions had similar composition and angiogenic potential, both capable of regulating the behavior of endothelial cells. This suggests that the dysregulation of airway ECM in asthma is driven by even low levels of inflammation, emphasizing the need for more effective anti-inflammatory therapies to maintain airway ECM and regulate aberrant angiogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Silvia Barbon, Elena Stocco, Martina Contran, Federico Facchin, Rafael Boscolo-Berto, Silvia Todros, Deborah Sandrin, Filippo Romanato, Piero Pavan, Veronica Macchi, Vincenzo Vindigni, Franco Bassetto, Raffaele De Caro, Andrea Porzionato
Summary: This study considers the use of cellular human diaphragm as a scaffold material for the treatment of volumetric muscle loss (VML). After decellularization through four detergent-enzymatic protocols, cells, DNA, and muscle fibers were effectively removed, while collagen/elastin and the majority of the glycosaminoglycan component were preserved. Adipose-derived stem cells cultured with decellularized samples demonstrated high viability, indicating the biosafety of the scaffolds. Acellular diaphragmatic grafts treated with SDS+Tergitol (TM) showed better collagen preservation and integrated well with host tissue upon implantation in mice.
Article
Chemistry, Multidisciplinary
Jihun Song, Gun-Jae Jeong, Tae-Jin Lee, Sung-Won Kim, Yu-Jin Kim, Suk Ho Bhang
Summary: A new method of delivering ECMs-enriched human adipose derived stem cells using a novel polymer significantly improved therapeutic angiogenesis in ischemic wound sites, enhancing blood flow and blood vessel regeneration in mouse models compared to traditional enzyme-based methods.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yaru Guo, Siqin Ma, Mingming Xu, Yan Wei, Xuehui Zhang, Ying Huang, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: Angiogenesis is crucial in tissue engineering and regenerative medicine, and the interplay between ECs and the ECM plays a significant role in tip cell specification. HtrA3 protein is shown to be involved in this process, promoting tip cell morphogenesis through ECM degradation and integrin beta 1-related signaling pathways. This study suggests that HtrA3 could potentially serve as a therapeutic agent for enhancing angiogenesis and targeting pathological angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mariela Puebla, Pablo J. Tapia, Hilda Espinoza
Summary: This review focuses on the role of astrocytes in angiogenesis, highlighting their function as scaffolds and stabilizing factors, as well as the phenotypic differences in glioblastoma. Understanding the interaction between endothelial cells and astrocytes is crucial for comprehending the process of angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yunhui Xing, Saigopalakrishna S. Yerneni, Weitao Wang, Rebecca E. Taylor, Phil G. Campbell, Xi Ren
Summary: This article describes a strategy for long-term in vivo retention of chemoselectively immobilized metabolically incorporated azido ligand-bearing extracellular vesicles (EVs) through click chemistry. The immobilized EVs exhibited enhanced therapeutic effects compared to non-immobilized EVs, promoting host cell infiltration, angiogenesis, and immunoregulatory responses.
Article
Gastroenterology & Hepatology
Guido Carpino, Vincenzo Cardinale, Alessandra Di Giamberardino, Diletta Overi, Samantha Donsante, Tania Colasanti, Gaia Amato, Gianluca Mennini, Matteo Franchitto, Fabrizio Conti, Massimo Rossi, Mara Riminucci, Eugenio Gaudio, Domenico Alvaro, Carmine Mancone
Summary: The study identified THBS1, THBS2, and PEDF released in iCCA inhibit vessel growth and promote tumor-associated lymphangiogenesis, offering potential targets for interventions to counteract the dissemination process in iCCA.
JOURNAL OF HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yucai Wang, Guangfu Wang, Hao Liu
Summary: This study provides a comprehensive review of the dynamic changes and functions of Tenascin-C (TNC) during tissue regeneration. The review highlights the multiple mechanisms of TNC at different stages of restoration, with a specific emphasis on its role in angiogenesis and wound healing.
Review
Agriculture, Dairy & Animal Science
Luis O. Tedeschi, Paul L. Greenwood, Ilan Halachmi
Summary: Advancements in precision livestock farming (PLF) over the past 20 years have been driven by remote monitoring, modern data collection methods, rapid data transfer, and vast data storage through the Internet of Things (IoT). PLF covers a wide range of areas in livestock production, and the integration of PLF with computer modeling is crucial for on-farm applicability and further improvements in animal production efficiency.
JOURNAL OF ANIMAL SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
William B. Smith, Michael L. Galyean, Robert L. Kallenbach, Paul L. Greenwood, Eric J. Scholljegerdes
Summary: Assessment of dietary intake is crucial for animal nutrition, especially in grazing environments where feed resources are not directly provided to the animal. Various methods are currently in use for estimating intake, each with its own advantages and disadvantages. Further discussions and research are needed to advance the estimation of intake for grazing livestock in the future.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Food Science & Technology
N. L. L. L. Montelli, T. I. R. C. Alvarenga, A. K. Almeida, F. A. P. Alvarenga, I. F. Furusho-Garcia, P. L. Greenwood, I. G. Pereira
Summary: The study investigated the effects of feed efficiency classifications on lamb measurements, circulating leptin and IGF-1 concentrations, and carcass traits. Results showed that more efficient lambs had higher leptin and IGF-1 levels and produced similar carcass characteristics and meat quality as less efficient lambs, with the strategic advantage of lower feed intake.
Article
Agriculture, Multidisciplinary
Reza Arablouei, Lachlan Currie, Brano Kusy, Aaron Ingham, Paul L. Greenwood, Greg Bishop-Hurley
Summary: This study focuses on the real-time classification of cattle behavior using accelerometry data on sensor nodes, with a pipeline specifically designed for embedded systems. By analyzing the statistical and spectral properties of the accelerometry data, a set of computationally efficient features are proposed, showing good classification accuracy without significant burden on system resources. The classification performance of several supervised machine-learning algorithms is examined, demonstrating the potential for efficient discriminative models to distinguish four biologically important cattle behavior classes.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2021)
Review
Agriculture, Dairy & Animal Science
Paul L. Greenwood
Summary: Beef is a high-quality source of protein with increasing global demand. Sustainability of beef industries requires efficient value-chains and production systems, which can also help reduce environmental and animal welfare impacts for provenance and social license to operate.
Article
Agriculture, Multidisciplinary
Seyedehfaezeh Hosseininoorbin, Siamak Layeghy, Brano Kusy, Raja Jurdak, Greg J. Bishop-Hurley, Paul L. Greenwood, Marius Portmann
Summary: This paper introduces a cattle behavior classification method based on time-frequency domain data representation. Experimental results show that this method efficiently reduces model size and computational complexity with only a minor decrease in classification accuracy, achieving high classification performance across different numbers of behavior classes.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2021)
Article
Food Science & Technology
Tharcilla I. R. C. Alvarenga, Mario Palendeng, Suresh Thennadil, Peter McGilchrist, Linda M. Cafe, Amelia K. Almeida, David L. Hopkins
Summary: This study suggests that there is potential to add value by identifying higher quality meat from older cattle, rather than just selling it for mincemeat in Australia. Chronological age has a greater impact on the quality of beef in the semitendinosus muscle than in the longissimus muscle. Soluble collagen is a better predictor of age than total collagen.
Article
Agriculture, Dairy & Animal Science
Tharcilla I. R. C. Alvarenga, Amelia K. K. Almeida, Malcolm McPhee, Jason P. P. Siddell, Brad Walmsley, Paul L. L. Greenwood, Matt L. L. Wolcott
Summary: Early identification of beef cattle with potential for increased marbling and improved carcass yield can lead to more rapid genetic improvement. Ultrasound predictions of intramuscular fat and subcutaneous fat can accurately predict carcass characteristics. Further investigations are needed to explore genetic improvement and management applications using newer scanning technologies.
ANIMAL PRODUCTION SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Hannah E. Salvin, Jessica E. Monk, Linda M. Cafe, Caroline Lee
Summary: There is a growing demand to raise animal welfare standards in the livestock sector, particularly in the beef industry. This perspective article discusses the benefits and challenges of using a voluntary, producer-driven benchmarking approach to improve animal welfare in Australian pasture-based beef cattle. The authors propose the need for careful consideration in the development stage to create a robust and suitable benchmarking system.
ANIMAL PRODUCTION SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
R. C. Dobos, F. A. P. Alvarenga, H. Bansi, K. L. Austin, A. J. Donaldson, R. T. Woodgate, P. L. Greenwood
Summary: This study investigated the application of geostatistical methods to assess spatial variability in sward height and dry matter yield in severely drought-affected pastures. The results showed that the intensity of grazing by cattle is not random, demonstrating the potential for improving grazing management decisions with the incorporation of this methodology into rapid pasture data collection devices.
CROP & PASTURE SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
B. J. Walmsley, L. M. Cafe, J. F. Wilkins, M. J. McPhee
Summary: The study examined the impact of selecting for different MS on carcass traits, finding that high MS can increase carcass yield without compromising eating quality predictions. Increases in MS and the myostatin mutation were associated with higher lean tissue percentages and lean : bone ratios, while decreasing fat tissue percentages.
ANIMAL PRODUCTION SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
F. A. P. Alvarenga, H. Bansi, R. C. Dobos, K. L. Austin, A. J. Donaldson, R. T. Woodgate, P. L. Greenwood
Summary: This study evaluated the performance of Angus heifers with divergent estimated breeding values for residual feed intake at pasture, finding that heifers with lower RFI-f-EBV showed better growth responses in limited grazing conditions.
ANIMAL PRODUCTION SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Margrethe Therkildsen, Paul L. Greenwood, Colin P. Starkey, Malcolm McPhee, Brad Walmsley, Jason Siddell, Geert Geesink
Summary: The texture of beef is affected by proteolysis and collagen content in the muscles, rather than the breed type. Specifically, Hereford and Angus steers had higher WBSF initially, but after aging, the difference was mainly seen between Hereford and Wagyu x Angus steers, depending on the specific muscle.
ANIMAL PRODUCTION SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Paul L. Greenwood
Summary: This study assessed the value of live goat assessments and carcass measurements for predicting dressing percentage and meat yield. The results showed that live weight combined with the best CS method had predictive value for both dressing percentage and meat yield, while hot standard carcass weight and eye-muscle depth had the best predictive value for meat yield.
ANIMAL PRODUCTION SCIENCE
(2021)
Meeting Abstract
Agriculture, Dairy & Animal Science
Paul L. Greenwood, Igor Kardailsky, Warwick B. Badgery, Gregory J. Bishop-Hurley
JOURNAL OF ANIMAL SCIENCE
(2020)