Review
Multidisciplinary Sciences
Rajesh Singh, Shradha Dutt, Priyanka Sharma, Ashok K. Sundramoorthy, Aman Dubey, Anoop Singh, Sandeep Arya
Summary: Nanotechnology has become increasingly important in the food industry, enhancing materials and structures in fields such as agriculture, food, pharmacy, and more. Applications include encapsulation and distribution of materials, flavor improvement, introduction of antibacterial nanoparticles, prolonged storage, pollutant detection, enhanced storage facilities, and consumer awareness. Nanobarcodes offer security and distribution tracking for labeled food goods. This article discusses current advances in nanotechnology in food-tech, packaging, security, and product enhancement, as well as various synthesis methods. Nanotechnology holds great potential for future advancements in food packaging with new nanomaterials and nanosensors.
Review
Environmental Sciences
Sameh S. Ali, Rania Al-Tohamy, Eleni Koutra, Mohamed S. Moawad, Michael Kornaros, Ahmed M. Mustafa, Yehia A. -G. Mahmoud, Abdelfattah Badr, Mohamed E. H. Osman, Tamer Elsamahy, Haixin Jiao, Jianzhong Sun
Summary: The high demand for sufficient and safe food, along with environmental damage caused by conventional agriculture, has led to the need for smart alternatives and more sustainable practices in food production. Nanotechnology in agriculture offers smart delivery systems for enhanced soil fertility and protection, as well as precision farming through nano-based sensors. Nanotechnology also plays a significant role in post-harvest food processing and packaging to reduce contamination and wastage, with applications including nano-remediation of wastewater, nanofertilizers, nanopesticides, and nanozymes. The review also addresses the potential risks and impacts of nanomaterials on soil, plants, and human health, while evaluating the strengths, weaknesses, opportunities, and threats of nanotechnology in agrifood applications towards sustainability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Food Science & Technology
Ramya Premanath, Jainey Puthenveettil James, Iddya Karunasagar, Eva Vankova, Vladimir Scholtz
Summary: Pathogenic bacteria in food can cause serious diseases, so preservatives are used to ensure microbial food safety. However, the negative effects of chemical preservatives have led to an increased demand for natural biopreservatives. Researchers are working to identify plant compounds with antibacterial activity against foodborne bacteria. The use of plant antimicrobials in food is challenging due to their interaction with food constituents. New approaches and technologies have been developed to incorporate plant antimicrobials into food, but more research is needed to optimize their use without affecting the sensory properties of the food.
Review
Food Science & Technology
Adriano Brandelli, Nathalie Almeida Lopes, Cristian Mauricio Barreto Pinilla
Summary: In the food sector, the dairy industry is an important economic activity that faces challenges in meeting consumer demand for natural and high quality products. To address these challenges, the application of innovative technologies, such as nanotechnology, can improve the quality and safety of dairy products. This review provides examples and promising results of using nanotechnology in dairy product preservation, including the use of nanoparticles and nanofilms. Despite the high cost and scale-up difficulties, these technologies have generated interest in the dairy industry.
Review
Food Science & Technology
Danka Bukvicki, Margherita D'Alessandro, Samantha Rossi, Lorenzo Siroli, Davide Gottardi, Giacomo Braschi, Francesca Patrignani, Rosalba Lanciotti
Summary: The use of plant extracts, such as essential oils, as alternatives to chemical additives and preservatives in food storage has gained significant attention. Essential oils are valuable sources of food preservatives due to their natural antimicrobial properties, providing a healthier alternative without compromising food quality. Combining biocontrol agents, like bacteriocin-producing LAB, with essential oils can enhance the safety and shelf life of food products while preserving their sensory and nutritional quality. This review critically examines the application of essential oils in various food sectors, as well as their combination with biocontrol agents and bacteriocins.
Review
Chemistry, Analytical
Jiaojiao Zhou, Yue Gui, Xuqin Lv, Jiangling He, Fang Xie, Jinjie Li, Jie Cai
Summary: Food safety is a major concern for public health, and nanostructured fluorescent materials have shown great potential for monitoring food quality and safety. This review discusses the application of fluorescent biosensors based on nanomaterials in analyzing various food safety issues and provides insights into future developments.
Review
Polymer Science
Punuri Jayasekhar Babu, Jagan Mohan Rao Tingirikari
Summary: Food storage and preservation present a significant challenge to the food industry. Nanotechnology offers promising solutions with unique properties of nanomaterials in terms of preservation, quality improvement, and antimicrobial effects. It holds great potential in combating foodborne pathogens and enhancing food properties.
Article
Environmental Sciences
Omar Bashir, Shakeel Ahmad Bhat, Aneela Basharat, Mahpara Qamar, Sarmad Ahmad Qamar, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: Food spoilage and safety are important concerns in the modern food sector. Nanotechnology provides novel solutions for strengthening food applications and developing functional foods. However, there are challenges in the application of nanotechnology in food sciences.
Article
Food Science & Technology
Kai Zhang, Wenhang Wang, Kaixuan Zhao, Yunhao Ma, Yang Wang, Yu Li
Summary: Nanocellulose (NC) with edible and biodegradable properties is urgently needed for food science and engineering. It has excellent physicochemical properties and potential applications in food production, processing, and packaging, promoting the development of food nanotechnology. NC can serve as a functional food ingredient and biodegradable packaging material, with various beneficial effects on health and potential for weight management and obesity prevention.
Review
Engineering, Chemical
Xiujuan Qiao, Jingyi He, Ruixi Yang, Yanhui Li, Gengjia Chen, Sanxiong Xiao, Bo Huang, Yahong Yuan, Qinglin Sheng, Tianli Yue
Summary: The growing concern over food safety incidents has led to the demand for analytical techniques that have high sensitivity, reliability, and reproducibility to prevent such incidents in a timely manner. Nanomaterials, with their unique physical and chemical properties, offer new opportunities for ensuring food quality and safety. This article outlines various nanomaterial-based sensors used for food analysis, including optical and electrochemical sensors, and discusses the current strategies and novel designs. Additionally, the article explores smartphone sensor-based point-of-care devices for home care testing, in response to the trend towards portable devices.
Review
Agriculture, Multidisciplinary
Lu Yang, Fan Wei, Jing-Min Liu, Shuo Wang
Summary: This review discusses the advances in agro-food safety inspection techniques utilizing new hybrid micro/nanoentities, such as molecular imprinting polymers integrated with quantum dots and upconversion luminescent nanoparticles. The integration of various disciplines like material science, nanotechnology, and analytical methodology shows promise in addressing emerging challenges in the field of agro-food research.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Applied
Asparshika Shruti, Nirgaman Bage, Pradip Kar
Summary: This review comprehensively studies the causes of food safety issues, the responsible analytes, remedies using various nanomaterials, the development of nanosensors, and the challenges faced in maintaining food safety standards to reduce the risk of contaminants.
Review
Chemistry, Analytical
Lelya Hilda, Maysam Salih Mutlaq, Ibrahem Waleed, Raed H. Althomali, Mohammed H. Mahdi, Sherzod Shukhratovich Abdullaev, Rajesh Singh, Hind Ali Nasser, Yasser Fakri Mustafa, Ahmed H. R. Alawadi
Summary: Over the past decade, paper-based biosensing has gained significant attention due to its advantages such as affordability and portability. However, limitations in sensitivity and selectivity have hindered its application. The use of nanomaterials to modify paper and incorporation of bioreceptors have been proposed as strategies to overcome these limitations. Paper-based genosensors have the potential for detecting various genes related to biomedical and food safety.
Article
Biotechnology & Applied Microbiology
Arun Sharma, Rajasree Ranjit, Pratibha, Nishant Kumar, Manish Kumar, Balendu Shekher Giri
Summary: Recent developments in nanotechnology-driven intelligent and active packaging materials have improved food safety by providing real-time and cost-effective contamination recognition. Nanoparticle-driven nanosensors play a crucial role in detecting and measuring environmental and microbial changes in food processing and storage. However, the migration of nanoparticles raises concerns about potential health risks. This review focuses on the application of nanoparticle-driven nanosensors in ensuring the safety and quality of packaged food.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Analytical
Xianfeng Lin, Wenyan Yu, Xinyu Tong, Changxin Li, Nuo Duan, Zhouping Wang, Shijia Wu
Summary: This review comprehensively summarizes the application of nanomaterials in the detection and control of mycotoxins. Nanomaterials with unique properties have been used to improve the sensitivity and selectivity of detection methods, as well as inhibit fungal growth and absorb and degrade mycotoxins. These methods are of great importance for safeguarding food industry safety and public health.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sebastian P. Nischwitz, Julia Fink, Marlies Schellnegger, Hanna Luze, Vladimir Bubalo, Carolin Tetyczka, Eva Roblegg, Christian Holecek, Martin Zacharias, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Persistent inflammation during wound healing is identified as a precipitating factor in the development of hypertrophic scars. However, lack of standardized models and limited evidence for therapeutic approaches hinder research progress. This study aimed to investigate scar formation mechanisms and develop a method for generating standardized hypertrophic scars through prolonged inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Adrian Rump, Carolin Tetyczka, Eva Littringer, Marie-Luise Kromrey, Robin Buelow, Eva Roblegg, Werner Weitschies, Michael Grimm
Summary: Gastroretentive dosage forms, which can release drugs inside the stomach for a prolonged period, offer advantages such as improved pharmacokinetics/bioavailability and reduced intake frequency, leading to better patient adherence. However, there are currently no gastroretentive products with proven efficacy in humans. One effective approach is the use of mucoadhesive properties to prevent gastric emptying. The adhesion time of minitablets containing Carbopol 71G NF was significantly longer compared to non-adhesive minitablets, resulting in delayed gastric emptying. However, further improvement is needed to achieve clinical benefits, and variations in gastric residence time were observed.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Christina Winter, Manuel Zettl, Jerome Mantanus, Eftychios Hadjittofis, Gerd Leitinger, Dagmar Kolb, Wen-Kai Hsiao, Martin Spoerk, Amrit Paudel, Eva Roblegg, Joana T. Pinto
Summary: The study successfully demonstrated the production of engineered microparticles with defined structures using inkjet printing technology, showing promising potential for future drug development and delivery approaches.
PHARMACEUTICAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Vesna Benkovic, Mirta Milic, Nada Orsolic, Anica Horvat Knezevic, Gordana Brozovic, Nikola Borojevic
Summary: Although both can cause DNA damage, the combined impact of volatile anesthetics halothane/sevoflurane/isoflurane and radiotherapeutic exposure on sensitive brain cells in vivo has not been previously analyzed.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2023)
Article
Environmental Sciences
Rafael Valencia-Quintana, Mirta Milic, Stefano Bonassi, Maria Antonieta Ochoa-Ocana, Victoria Campos-Pena, Maria Guadalupe Tenorio-Arvide, Guillermo Alejandro Perez-Flores, Juana Sanchez-Alarcon
Summary: This study evaluated the effect of pesticides on genetic damage to agricultural workers in Los Reyes, Michoacan, Mexico. The results showed that pesticide use poses a risk of genetic damage to agricultural workers, but measures can be taken to reduce this risk.
Article
Engineering, Biomedical
Andreia M. M. Goncalves, Filipa Leal, Anabela Moreira, Tobias Schellhorn, Veronika Hefka Blahnova, Scarlett Zeiringer, Karolina Vocetkova, Carolin Tetyczka, Aiva Simaite, Matej Buzgo, Eva Roblegg, Pedro F. F. Costa, Peter Ertl, Eva Filova, Yvonne Kohl
Summary: This study presents intestinal, skin, and pulmonary in vitro tissue models based on electrospun membranes of poly(epsilon-caprolactone) (PCL) and cellulose derivatives. The physicochemical characterization and biocompatibility of the scaffolds are evaluated using different cell types. The results show that the fibrous meshes prepared are biocompatible and have the potential to be used as substrates for in vitro epithelial tissue modeling and toxicity screening.
ADVANCED NANOBIOMED RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Manuel Zettl, Christina Winter, Jerome Mantanus, Eftychios Hadjittofis, Sandrine Rome, Gerd Leitinger, Wen-Kai Hsiao, Eva Roblegg, Joana T. Pinto, Martin Spoerk
Summary: Active pharmaceutical ingredients (APIs) with challenging shapes and reduced bioavailability can be effectively processed and improved by inkjet printing. This technique offers benefits such as maintaining particle properties, scalability, and co-processing options with excipients to enhance bioavailability. This study successfully demonstrates the optimization of particle shapes through inkjet printing, producing spherical lacosamide particles with improved flow properties compared to the bulk material. The particle size can be easily adjusted by controlling the ink volume and printing cycles.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Nutrition & Dietetics
Mirta Milic, Ivan Ozvald, Katarina Matkovic, Hrvoje Radasevic, Maja Nikolic, Dragan Bozicevic, Lidija Duh, Martina Matovinovic, Martina Bituh
Summary: This study is the first to assess DNA damage in a severely obese population using three different assays. The results showed a correlation between DNA damage levels and anthropometric measurements, severity of obesity, and elevated levels of certain biochemical parameters. BMI and BMR were also associated with decreased cell proliferation and DNA damage.
Article
Chemistry, Multidisciplinary
Atida Selmani, Ramona Jeitler, Michael Auinger, Carolin Tetyczka, Peter Banzer, Brian Kantor, Gerd Leitinger, Eva Roblegg
Summary: Biocompatible gold nanoparticles have been utilized in wound healing due to their radical scavenging activity. An acidic microenvironment is also found to promote wound healing through cell proliferation and inhibit bacterial growth. Combining these two approaches shows promising results for wound healing.
Article
Chemistry, Multidisciplinary
Claudia Meindl, Markus Absenger-Novak, Ramona Jeitler, Eva Roblegg, Eleonore Froehlich
Summary: The toxicity of inhaled nanoparticles was assessed using air-liquid interface cultures of respiratory cells and reconstructed bronchial and alveolar tissues. The results showed no significant adverse effects on the bronchial and alveolar models when exposed to nanoparticles at doses corresponding to the maximum estimated lifetime exposure of workers, except for a slight increase in interleukin 6 secretion in the alveolar model.
Article
Pharmacology & Pharmacy
Daniela Fiedler, Elisabeth Fink, Isabella Aigner, Gerd Leitinger, Walter Keller, Eva Roblegg, Johannes G. Khinast
Summary: This study proposes a new material-efficient multi-step machine learning approach for the development of a design space for spray drying proteins. By comparing the ML and DoE model predictions to protein-based validation runs, the suitability of using a surrogate material and ML for the development of a design space was investigated with demonstrated advantages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Plant Sciences
Ana Hudek Turkovic, Ksenija Durgo, Florentina Cuckovic, Ivana Ledenko, Tena Krizmanic, Arijana Martinic, Aleksandra Vojvodic Cebin, Drazenka Komes, Mirta Milic
Summary: The aim of this study was to determine the influence of rosemary and dandelion leaves aqueous extracts on oral microbiota and tongue epithelial cells, genomic damage, and H2O2-induced oxidative damage protection. The results showed that both extracts increased the adhesion of lactic acid bacteria and decreased the adhesion of bacterial pathogens to tongue epithelial cells. Rosemary extract also demonstrated a protective effect against H2O2-induced oxidative damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Laura Wiltschko, Eva Roblegg, Reingard Raml, Thomas Birngruber
Summary: The importance of plasma protein binding in drug development is recognized. However, validated methods for assessing protein binding in physiological fluids such as dermal interstitial fluid (dISF) are currently missing. This study successfully validated small volume rapid equilibrium dialysis (RED) for low protein samples, providing a tool to directly examine drug-protein binding in the biological fluid at the site of action. Small volume RED was applied to assess the effects of interstitial parameters on protein-bound drug fraction using surrogate dISF samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Scarlett Zeiringer, Laura Wiltschko, Christina Glader, Martin Reiser, Markus Absenger-Novak, Eleonore Froehlich, Eva Roblegg
Summary: In vitro intestinal models are used to investigate biological processes, drug absorption, and cytotoxicity. Synthetic hydrogel Vitrogel is found to be the best material for cell proliferation and differentiation in the model.
MOLECULAR PHARMACEUTICS
(2023)
Article
Environmental Sciences
Mahara Valverde, Adriana Granados, Mirta Milic, Marcello Ceppi, Leticia Sollano, Stefano Bonassi, Emilio Rojas
Summary: DNA damage in newborn children's cord blood cells from Mexico City is correlated with the DNA damage in their mothers, as well as the environmental exposure and complications during pregnancy. Mothers living in the southern part of the city have double DNA damage compared to those living in the northern part. This study highlights the importance of antioxidants during pregnancy and the role of the placental barrier in protecting newborns from DNA-damaging effects of pollution.