Article
Environmental Sciences
Ya-Ru Xu, Milton Talukder, Chen-Xi Li, Ying-Xin Zhao, Cong Zhang, Jing Ge, Jin-Long Li
Summary: Cadmium exposure is known to cause brain injury, but nano-selenium supplementation has been shown to alleviate the damage. The study found that nano-selenium restored the altered neuronal morphology, endoplasmic reticulum, and mitochondrial structure caused by cadmium exposure. Additionally, it was found that nano-selenium supplementation reduced Cx43 phosphorylation induced by cadmium exposure.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leonardo Oliveira Bittencourt, Rakhel Dayanne Damasceno-Silva, Walessa Alana Braganca Aragao, Luciana Eiro-Quirino, Ana Carolina Alves Oliveira, Rafael Monteiro Fernandes, Marco Aurelio M. Freire, Sabrina Carvalho Cartagenes, Aline Dionizio, Marilia Afonso Rabelo Buzalaf, Juliana Silva Cassoli, Ana Cirovic, Aleksandar Cirovic, Cristiane do Socorro Ferraz Maia, Rafael Rodrigues Lima
Summary: This study found that exposure to low doses of aluminum chloride can lead to reduced learning and memory abilities, which is associated with dysregulated protein expression and decreased cell body density in the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lina He, Jiating Zhao, Liming Wang, Quancheng Liu, Yuqin Fan, Bai Li, Yong-Liang Yu, Chunying Chen, Yu-Feng Li
Summary: Selenium, an essential trace element, is known for its antioxidant and immunity-boosting capabilities, which can have a strong antiviral effect. NanoSelenium shows potential in combating COVID-19, highlighting the importance of Selenium in fighting various viruses.
Article
Biochemistry & Molecular Biology
Sabrina G. Muller, Natalia S. Jardim, Guilherme Lutz, Gilson Zeni, Cristina W. Nogueira
Summary: This study investigated the anxiolytic-like effect of (m-CF3-PhSe)2 and its modulation of synaptic plasticity and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model. The results showed that (m-CF3-PhSe)2 abolished anxiety-like behavior, reversed neurotoxicity, and restored synaptic plasticity-related signaling. These findings suggest that (m-CF3-PhSe)2 may be a potential candidate for anxiolytic drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Ademola C. Famurewa, Nnaemeka T. Asogwa, Samson C. Ezea
Summary: This study found that sitagliptin, an antidiabetic drug, can mitigate the cerebral neurotoxicity induced by cyclophosphamide (CYP) by inhibiting inflammatory reactions and reducing oxidative stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Omar Hosea Cabrera, Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Summary: Anesthetics cause widespread neuroapoptosis and lasting cognitive impairments in the developing brains. This study shows that neonatal ketamine exposure interferes with normal neural circuit development and leads to lasting increase in excitatory synaptic transmission in the hippocampus.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Jing Chen, Fei Xiao, Lifei Chen, Zhan Zhou, Yi Wei, Yu Zhong, Li Li, Yubo Xie
Summary: An increasing number of studies have reported that the neurotoxicity of propofol may cause long-term learning and cognitive dysfunction. Hypoxic preconditioning has been shown to have neuroprotective effects, reducing the neurotoxicity of propofol. However, it is unclear whether hypoxic preconditioning reduces propofol neurotoxicity associated with ferroptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Kamilia M. Ibrahim, Samar F. Darwish, Eman M. Mantawy, Ebtehal El-demerdash
Summary: Cyclophosphamide has improved the life expectancy and quality of life of cancer patients, but it is also accompanied by various neurological complications. This review summarizes the neurotoxicity caused by cyclophosphamide and discusses potential protective agents. However, further clinical trials are needed to evaluate the therapeutic value of these agents.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Environmental Sciences
Mohammad Naderi, Pankaj Puar, Mahtab Zonouzi-Marand, Douglas P. Chivers, Som Niyogi, Raymond W. M. Kwong
Summary: Selenium is an essential micronutrient with beneficial health effects at proper levels, but can become highly toxic at slightly higher concentrations. Excessive selenium exposure may compromise the normal functioning of key proteins, neurotransmitter systems, and signaling molecules, as well as increase the risk of neurodegenerative and neuropsychiatric diseases. Despite its deleterious effects on the central nervous system, the neurotoxicity and negative behavioral outcomes of excess selenium are often overlooked.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Xuejiao Yuan, Yanfeng Zhou, Jinli Sun, Shanshan Wang, Xingjie Hu, Jiyu Li, Jing Huang, Nan Chen
Summary: Acute liver injury (ALI) is a severe liver disease characterized by sudden hepatocyte necrosis and liver function deterioration. This study develops hepatocyte-targeting self-assembling nanoparticles encapsulating an organic Selenium compound, which effectively removes reactive oxygen species (ROS) and protects hepatocyte viability. The nanoparticles, functionalized with a liver-targeting ligand, exhibit enhanced hepatocyte uptake and successfully reduce liver damage in mouse models of ALI induced by acetaminophen or carbon tetrachloride.
CELL PROLIFERATION
(2023)
Article
Chemistry, Medicinal
Qiufeng Wei, Jing Chen, Fei Xiao, Youbing Tu, Yu Zhong, Yubo Xie
Summary: High concentrations of dexmedetomidine have potential toxic effects on fetal rat hippocampal neurons, leading to neuronal apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Rekha K. Narasimhamurthy, Kamalesh D. Mumbrekar, B. S. Satish Rao
Summary: Advancements in radio diagnostic imaging tools and techniques have greatly improved the diagnosis of various pathophysiological conditions, but the effects of low dose radiation on the biological system remain unclear. Current research suggests that low dose radiation may have neurological effects on the central nervous system and further investigation is needed to understand the risks and benefits.
Article
Neurosciences
Alexis N. Webb, Kathryn M. Spiers, Gerald Falkenberg, Huiying Gu, Sai S. Dwibhashyam, Yansheng Du, Wei Zheng, Linda H. Nie
Summary: The study utilized synchrotron micro-x-ray fluorescence technique to investigate the distribution of lead and other metals in mouse brains. The results showed that lead typically deposited in localized particles of <10 um2, with a significant correlation with selenium, suggesting selenium may play a crucial role in lead-induced neurotoxicity.
Article
Environmental Sciences
Jun He, Yang Chen, Shiming Dai, Feng Chen, Yeke Wang, Ting Shi, Liang Chen, Ying Liu, Jun Chen, Ping Xie
Summary: In this study, we investigated the effects of microcystin-leucine arginine (MC-LR) on the brain lipidome profile and functions in mice. Our results showed that MC-LR led to a decline in cognitive parameters and apparent neurodegenerative changes in the prefrontal cortex. Lipidomic analyses revealed profound changes in phospholipids and sphingolipids, with region-specific trends in lipid content. Transcriptional regulations of lipid metabolism and apoptosis differed in the two brain regions, suggesting their involvement in the neurodegenerative changes. This study sheds light on the role of lipid dysfunction in the neurotoxicity mechanism of MCs.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Neurosciences
Farangis Ramezani, Maryam Ghasemi-Kasman, Nasrin Nosratiyan, Shahram Ghasemi, Farideh Feizi
Summary: This study investigated the effects of sulfur-doped g-C3N4 on cognitive function and histopathology of hippocampus in mice, showing that TCN can induce cognitive impairment partly through exacerbating impacts on neuronal loss and glial activation. Behavioral tests indicated a dose-dependent reduction in spatial learning and memory, while histological evaluations revealed increased neuronal loss and glial activation in the hippocampus of TCN treated mice.
BRAIN RESEARCH BULLETIN
(2021)