Article
Dentistry, Oral Surgery & Medicine
Turan Emre Kuzu, Kuebra Ozturk, Cem A. Gurgan, Arzu Yay, Ozge Goktepe, Alpdogan Kantarci
Summary: Objective: This study aimed to investigate the potential anti-inflammatory effect of paeoniflorin (Pae) on diabetic periodontitis and its impact on bone loss.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jyotirmaya Behera, Jessica Ison, Michael J. Voor, Neetu Tyagi
Summary: Recent evidence suggests that physical exercise has a positive impact on skeletal development and can protect against bone loss and deterioration. This study investigated the effects of exercise on bone mass and mechanical quality in mice with type 2 diabetes mellitus. The results showed that diabetes leads to a decrease in Irisin, which further contributes to bone loss through inflammation. Exercise, along with certain interventions, can restore Irisin levels and improve bone formation in diabetic mice. This study demonstrates that exercise-induced skeletal Irisin can ameliorate diabetes-associated glucose intolerance and bone loss.
Article
Dentistry, Oral Surgery & Medicine
M. B. Chavez, M. H. Tan, T. N. Kolli, C. Zachariadou, F. Farah, F. F. Mohamed, E. Y. Chu, B. L. Foster
Summary: Bone sialoprotein (BSP) is a critical factor for alveolar bone healing, and its absence disrupts multiple major pathways involved in appropriate healing.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xue Yuan, Vedanshi Amin, Tianli Zhu, Mizuho Kittaka, Yasuyoshi Ueki, Teresita M. Bellido, Hakan Turkkahraman
Summary: The aim of this study was to investigate the early effects of Type 1 diabetes mellitus (T1DM) on the periodontium. By examining diabetic mice using histology, molecular and cellular assays, it was found that gingival inflammation and soft tissue degeneration increased in the diabetic condition, but the alveolar bone was preserved through the recruitment of more osteoprogenitor cells and increased bone formation rates.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Srinivas Ayilavarapu, Abbas Doctor, Chun-Teh Lee, Gena D. Tribble, Yulun Chiu, Robin L. Weltman, Nikola Angelov
Summary: This cross-sectional study aimed to investigate the gene expression in alveolar bone of healthy individuals and those with type 2 diabetes using RNA sequencing and bioinformatics analysis. The results showed that genes involved in bone turnover were significantly downregulated in patients with diabetes, indicating potential impairment in wound healing and bone homeostasis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yangyang Cui, Hankun Zhang, Song Wang, Junzhe Lu, Jinmei He, Lanlan Liu, Weiqiang Liu
Summary: Salivary glucose is commonly used in the diagnosis of diabetes mellitus due to its non-invasive and cost-effective nature. However, salivary glucose levels can be affected by various factors, and this study investigates the impact of handling conditions and donor-dependent factors on these levels. The findings suggest that external variables should be taken into consideration when using salivary glucose as a predictive biomarker for diabetes mellitus.
Article
Dentistry, Oral Surgery & Medicine
N. Shalehin, Y. Seki, H. Takebe, S. Fujii, T. Mizoguchi, H. Nakamura, N. Yoshiba, K. Yoshiba, M. Iijima, T. Shimo, K. Irie, A. Hosoya
Summary: Gli1(+) cells in the periodontal ligament are mesenchymal stem cells capable of differentiating into osteoblasts, chondrocytes, and adipocytes. They play an important role in alveolar bone regeneration.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Physiology
Chunmei Xu, Xudong Xie, Hu Zhao, Yafei Wu, Jun Wang, Jian Q. Feng
Summary: TGF beta signaling plays critical roles in early alveolar bone formation by promoting proliferation and differentiation of periodontal ligament mesenchymal progenitor cells, impacting the formation and function of periodontal ligament. Early conditional deletion of Tgf beta r2 resulted in significant reduction in alveolar bone mass and mineral density, along with drastic defects in periodontal ligament, while late conditional deletion showed minor changes in alveolar bone.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Xianyi Meng, Ben Wielockx, Martina Rauner, Aline Bozec
Summary: Hypoxia-inducible factors (HIFs) play a crucial role in regulating bone metabolism, angiogenesis, and inflammation, with significant impact on osteoclast activity. Their tight regulation by tissue microenvironments highlights their importance in bone pathologies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Article
Biochemistry & Molecular Biology
Cristian-Ioan Craciun, Maria-Adriana Neag, Adrian Catinean, Andrei-Otto Mitre, Adriana Rusu, Cornelia Bala, Gabriela Roman, Anca-Dana Buzoianu, Dana-Maria Muntean, Anca-Elena Craciun
Summary: This review evaluates the pathogenetic association between microbiota and diabetes and explores new therapeutic agents that may modulate the microbiota. It provides new insights into the treatment of diabetes.
Article
Endocrinology & Metabolism
Jakob Kau Starup-Linde, Rikke Viggers, Bente Langdahl, Soeren Gregersen, Simon Lykkeboe, Aase Handberg, Peter Vestergaard
Summary: Osteoglycin levels were similar in patients with type 1 and type 2 diabetes, and were not correlated with glucose, HbA1c, or any other biochemical marker of bone turnover. This suggests that there is no evidence supporting the existence of an osteoglycin-bone-pancreas axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqing Li, Jiayong Zheng, Xiuling Ma, Bing Zhang, Jinyang Zhang, Wenhuan Wang, Congcong Sun, Yeping Wang, Jianqiong Zheng, Haiying Chen, Jiejing Tao, Hai Wang, Fengyi Zhang, Jinfeng Wang, Hongping Zhang
Summary: Analyzing the oral microbiota can effectively distinguish pregnant women with GDM from healthy pregnant women, providing evidence for the development of noninvasive biomarkers for GDM.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rui Zhang, Zhiwu Wu, Mingming Li, Jin Yang, Ran Cheng, Tao Hu
Summary: Inhibition of pyroptosis reduced inflammation and alveolar bone resorption in periodontitis, suggesting a potential target for alleviating periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jinhui Wang, Yanyun Xia, Jianhao Li, Wei Wang
Summary: This study investigated the role of miR-129-5p in regulating osteoblast differentiation, showing that exosomes containing miR-129-5p from the blood of DM rats inhibit osteoblast differentiation by targeting the FZD4/B-catenin signaling pathway. The findings suggest that miR-129-5p may be a regulator of BMSCs in the jaw region.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)