Article
Oncology
Haowen Jiang, Rachel L. Greathouse, Sarah Jane Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye
Summary: The Warburg effect is the major metabolic hallmark of cancer. In this study, researchers found that treating neuroblastoma cells with the mitochondrial uncoupler NEN can induce neural differentiation by altering metabolic and epigenetic pathways.
Article
Biochemistry & Molecular Biology
Marie Herrnhold, Isabel Hamp, Oliver Plettenburg, Martin Jastroch, Michaela Keuper
Summary: N-acyl amino acids (NAAs) are endogenous molecules that act as mitochondrial uncouplers in human adipocytes. While NAAs effectively induce uncoupled respiration, high concentrations of NAAs reduce adipocyte functionality and viability. Hence, the suitability of NAAs as anti-obesity agents without further chemical modifications is questionable.
Article
Biochemistry & Molecular Biology
Hanna Sarah Kutsche, Rolf Schreckenberg, Klaus-Dieter Schlueter
Summary: Uncoupling proteins UCP2 and UCP3 may have multiple functions in striated muscles, including protection against mitochondria-dependent oxidative stress, transportation of pyruvate, fatty acids, and protons, and metabolic sensing. UCP2 is mainly expressed in cardiac tissues, while UCP3 dominates in skeletal muscles.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Cell Biology
Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami
Summary: ALS is a fatal neurological disorder characterized by motor neuron degeneration. The use of larval zebrafish as a model allows for functional analysis of ALS-related proteins in vivo, providing insights into ALS pathogenesis and potential therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katalin Gyurina, Mariia Yarmak, Laszlo Sasi-Szabo, Sarolta Molnar, Gabor Mehes, Tamas Roeszer
Summary: Studying subcutaneous adipose tissues in fetuses, infants, and children, we found that UCP1-positive adipocytes are mainly located in the deep layer of adipose tissue, particularly in the abdominal wall. These UCP1-positive adipocytes develop in late fetal stage and persist throughout childhood, expressing genes related to mitochondrial biogenesis and thermogenesis. The absence of UCP1 expression in adipose tissue during the early childhood adiposity rebound phase is associated with an obesity-related gene expression signature. UCP1 expression is negatively correlated with BMI z-score and adipocyte size in infants and children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Rachael Maree Wood, Fabio Rodrigo Thewes, Milena Reynaud, Dominikus Kittemann, Claudia Kaehler Sautter, Jens Norbert Wuensche, Daniel Alexandre Neuwald
Summary: This study explored how different apple cultivars responded to anaerobic treatment and storage conditions, finding that shorter durations of anaerobic exposure allowed fruits to recover from metabolic changes. Storage under controlled atmosphere post-anoxia was more effective in maintaining fruit quality and reducing anaerobic metabolite concentrations than regular air storage.
Article
Biochemistry & Molecular Biology
Elliot Piper-Brown, Fiona Dresel, Eman Badr, Campbell W. Gourlay
Summary: Ras plays a crucial role in cell fate and its overproduction with mutations can lead to growth arrest and metabolic imbalance. The altered cell fate can be rescued by gene deletion or nutrient supplementation.
Article
Hematology
Victoria Da Silva-Diz, Bin Cao, Olga Lancho, Eric Chiles, Amer Alasadi, Maya Aleksandrova, Shirley Luo, Amartya Singh, Hanlin Tao, David Augeri, Sonia Minuzzo, Stefano Indraccolo, Hossein Khiabanian, Xiaoyang Su, Shengkan Jin, Daniel Herranz
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with high relapse rates. A newly developed mitochondrial uncoupling compound, MB1-47, inhibits leukemia cell proliferation by compromising mitochondrial energy and nucleotide biosynthesis, showcasing potential as a novel therapeutic strategy for this disease.
Article
Biochemistry & Molecular Biology
Francesco De Leonardis, Amer Ahmed, Angelo Vozza, Loredana Capobianco, Christopher L. Riley, Simona Nicole Barile, Daria Di Molfetta, Stefano Tiziani, John Digiovanni, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte
Summary: UCP3 catalyzes a strict exchange of aspartate, malate, sulphate, and phosphate, with R282Q mutation abolishing its transport activity. UCP3 differs from UCP2 in transport mode and kinetic constants.
Article
Genetics & Heredity
Ziwei You, Jieyu Wang, Faliang Li, Wei Hei, Meng Li, Xiaohong Guo, Pengfei Gao, Guoqing Cao, Chunbo Cai, Bugao Li, Yalan Yang, Rong Zhou
Summary: This study evaluated the effects of Ucp3 on myogenic differentiation, myofiber type, and energy metabolism in C2C12 cells. The results showed that Ucp3 could increase the number of myotubes and promote myogenic differentiation. Additionally, Ucp3 promoted the expression of type IIb myofiber marker genes and accelerated energy metabolism.
Review
Oncology
Mit Joshi, Bhoomika M. Patel
Summary: Cancer cachexia is a wasting syndrome driven by chronic inflammation and high energy expenditure. Uncoupling proteins (UCPs) play an important role in cancer cachexia by increasing the body's overall energy utilization. This review provides new insights into the role of UCPs in cancer cachexia and highlights their potential as a target for treating this syndrome.
Editorial Material
Medicine, General & Internal
Karuna Ganesh
Summary: Cell dissemination is a late event in tumor progression. Recent research suggests that nontransformed epithelial cells can also disseminate and colonize distant organs, which has implications for therapy and regenerative medicine.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Agronomy
Noreen Zahra, Muhammad Bilal Hafeez, Kanval Shaukat, Abdul Wahid, Sadam Hussain, Rubina Naseer, Ali Raza, Shahid Iqbal, Muhammad Farooq
Summary: Oxygen is a limiting factor for plant growth under submerged conditions, and plants have evolved various adaptations to cope with oxygen deprivation. However, metabolic reactions and molecular regulation under oxygen deprivation are not well understood. Understanding how plants respond to oxygen deficiency is crucial for developing anoxia and hypoxia tolerant varieties for flood-prone areas.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Paola Lunetti, Ruggiero Gorgoglione, Rosita Curcio, Federica Marra, Antonella Pignataro, Angelo Vozza, Christopher L. Riley, Loredana Capobianco, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte
Summary: The study reveals that DmUCP4A in fruit flies may be involved in the transport of aspartate from mitochondria to the cytosol, playing a key role in signal transmission in the central nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adam J. Trewin, Laura L. Bahr, Anmol Almast, Brandon J. Berry, Alicia Y. Wei, Thomas H. Foster, Andrew P. Wojtovich
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Biochemistry & Molecular Biology
Andrew P. Wojtovich, Brandon J. Berry, Alexander Galkin
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Genetics & Heredity
Nicholas S. Philip, Fernando Escobedo, Laura L. Bahr, Brandon J. Berry, Andrew P. Wojtovich
G3-GENES GENOMES GENETICS
(2019)
Review
Biochemistry & Molecular Biology
John O. Onukwufor, Brandon J. Berry, Andrew P. Wojtovich
Article
Biochemistry & Molecular Biology
Brandon J. Berry, Adam J. Trewin, Alexander S. Milliken, Aksana Baldzizhar, Andrea M. Amitrano, Yunki Lim, Minsoo Kim, Andrew P. Wojtovich
Review
Biochemistry & Molecular Biology
Brandon J. Berry, Andrew P. Wojtovich
Article
Cell Biology
Yunki Lim, Brandon Berry, Stephanie Viteri, Matthew McCall, Eun Chan Park, Christopher Rongo, Paul S. Brookes, Keith Nehrke
Summary: This study demonstrates that FNDC-1 plays a role in non-hypoxic mitochondrial quality control, with its loss leading to stress responses and metabolic remodeling dependent on atfs-1. These changes are prophylactic against subsequent HR injury.
Article
Geriatrics & Gerontology
Brandon J. Berry, Matt Kaeberlein
Summary: Mitochondrial dysfunction has been linked to cellular decline and biological aging. The decrease in protonmotive force with age in experimental models suggests a potential role in aging. Emerging technology allows for more precise study of mitochondria and holds promise for developing energetics approaches to combat aging.
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Brandon J. Berry
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Brandon J. J. Berry, Evan Mjelde, Fatima Carreno, Kathryn Gilham, Emily J. J. Hanson, Emily Na, Matt Kaeberlein
Summary: Dietary restriction (DR) increases lifespan in many organisms, and this study aimed to understand the mechanism behind it. They found that mitochondrial membrane potential (Delta psi(m)) plays a critical role in regulating health and longevity in response to DR. Maintaining Delta psi(m) during adulthood was essential for the longevity and health benefits of DR, as shown through genetic and pharmacological interventions in nematodes.
Article
Cell Biology
Brandon J. Berry, Anezka Vodickova, Annika Mueller-Eigner, Chen Meng, Christina Ludwig, Matt Kaeberlein, Shahaf Peleg, Andrew P. Wojtovich
Summary: This study demonstrates that increasing mitochondrial membrane potential using a light-activated proton pump improves age-related phenotypes and extends lifespan in Caenorhabditis elegans. These findings provide causal evidence that rescuing the age-related decline in mitochondrial function can slow down the aging process and promote longevity.
Meeting Abstract
Biochemistry & Molecular Biology
Tyrone Nieves, Miao He, Brandon Berry, Andrew Wojtovich
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Brandon Berry, Aksana Baldzizhar, Andrew Wojtovich
FREE RADICAL BIOLOGY AND MEDICINE
(2020)