Review
Medicine, General & Internal
Sergey S. Gutor, Robert F. Miller, Timothy S. Blackwell, Vasiliy V. Polosukhin
Summary: Patients diagnosed with environmental/occupational bronchiolitis obliterans (BO) often present with a slowly progressing respiratory symptom evolution, without acute exposure to toxins. Exertional dyspnea is the most common symptom, and standard evaluation may not be diagnostic. Lung biopsies commonly reveal pathological abnormalities in all distal lung compartments. The diagnosis of environmental/occupational BO should be considered in patients with subacute exertional dyspnea and a history of prolonged or recurrent exposure to environmental toxins. Important future areas of research include less invasive diagnostic approaches and testing of new agents for prevention and treatment.
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Immunology
Ruth P. Duecker, Ines De Mir Messa, Silvija-Pera Jerkic, Annalena Kochems, Gabriele Gottwald, Antonio Moreno-Galdo, Martin Rosewich, Lucia Gronau, Stefan Zielen, Andreas Geburtig-Chiocchetti, Hermann Kreyenberg, Ralf Schubert
Summary: This study aimed to define biomarkers for post-infectious bronchiolitis obliterans (PiBO) by analyzing the miRNA expression profile using next-generation sequencing (NGS). The results showed that patients with PiBO had decreased lung function values and increased airway inflammation compared to controls. NGS analysis revealed dysregulated miRNAs, which are involved in cytokine-cytokine receptor interaction, TGF-beta signaling, and FoxO signaling pathway. These dysregulated miRNAs may serve as potential biomarkers and therapeutic targets for PiBO.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Pediatrics
Frances Flanagan, Alicia Casey, Miguel Reyes-Mugica, Geoffrey Kurland
Summary: The article discusses the diagnosis, treatment options, and the importance of early diagnosis in PIBO.
PAEDIATRIC RESPIRATORY REVIEWS
(2022)
Review
Pediatrics
Die Liu, Jing Liu, Lipeng Zhang, Yuanmei Chen, Qi Zhang
Summary: This study conducted a systematic review and identified the strongest risk factors for PIBO, including hypoxemia, mechanical ventilation, tachypnea, and wheezing. The use of glucocorticoids, gamma-globulin, bacterial co-infection, a history of wheezing, and being male may also contribute to the development of PIBO. These factors can inform the generation of a clinical prediction model for PIBO in children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Cell Biology
Sara Bozzini, Laura Pandolfi, Elena Rossi, Simona Inghilleri, Michele Zorzetto, Giuseppina Ferrario, Stefano Di Carlo, Gianfranco Politano, Annalisa De Silvestri, Vanessa Frangipane, Michele Porzio, Romain Kessler, Fiorella Calabrese, Federica Meloni, Patrizia Morbini
Summary: Epigenetic changes, in particular miRNA deregulation, have been shown to potentially contribute to obliterative bronchiolitis (OB) development. Specific over-expression of miR-21-5p in OB lesions and its potential regulation of STAT3 expression were identified in this study, although miR-21-5p is not the sole regulator of STAT3. This research adds to the understanding of the downstream pathways of miR-21-5p in the context of OB fibrogenesis.
Review
Medicine, General & Internal
Anna Astashchanka, Joseph Ryan, Erica Lin, Brandon Nokes, Catriona Jamieson, Seth Kligerman, Atul Malhotra, Jess Mandel, Jisha Joshua
Summary: This review discusses the pulmonary complications post-HSCT, providing essential knowledge for non-pulmonary healthcare providers and emphasizing the importance of early diagnosis, treatment, and prognosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Silei Yan, Chao Sun, Kun Jiang
Summary: The study aimed to develop and validate a predictive nomogram for post-infectious bronchiolitis obliterans in severe pneumonia. The researchers retrospectively analyzed data from 228 patients and constructed a prediction nomogram. They used the least absolute shrinkage and selection operator (LASSO) regression model to optimize the selection of features and developed individual nomograms incorporating clinical factors. The nomograms showed good calibration, discrimination, and clinical utility, with a C-index of 0.907.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Duan-Rui Qiao, Guan-Yue Shan, Shuai Wang, Jun-Ya Cheng, Wei-Qun Yan, Hai-Jun Li
Summary: This article outlines the impact of hepatocellular carcinoma (HCC) on the mononuclear phagocyte system (MPS). It elaborates on how HCC reshapes MPS cell phenotype and the production of associated cytokines, as well as characterizes the function and impairment of the MPS in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Yiwen Liu, Yan Gong, Gaosi Xu
Summary: Although the multiple hits theory is widely accepted in IgA nephropathy, increasing evidence suggests that the mononuclear/macrophage system plays important roles in disease progression, but the exact mechanism is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Immunology
Sho Matsui, Tomoko Namba-Hamano, Shihomi Maeda, Jun Nakamura, Atsushi Takahashi, Jun-Ya Kaimori, Shota Fukae, Ryo Tanaka, Ayumu Taniguchi, Shigeaki Nakazawa, Kazuaki Yamanaka, Ryoichi Imamura, Norio Nonomura, Yoshitaka Isaka
Summary: A 68-year-old male patient who underwent ABO-incompatible living kidney transplantation 13 years ago developed graft dysfunction and required hemodialysis due to fluid overload. After initiation of hemodialysis, the patient was diagnosed with organized pneumonia, which was successfully treated with higher doses of prednisolone.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Biology
Yasmina Serroukh, Chunyan Gu-Trantien, Baharak Hooshiar Kashani, Matthieu Defrance, Thien-Phong Vu Manh, Abdulkader Azouz, Aurelie Detavernier, Alice Hoyois, Jishnu Das, Martin Bizet, Emeline Pollet, Tressy Tabbuso, Emilie Calonne, Klaas van Gisbergen, Marc Dalod, Francois Fuks, Stanislas Goriely, Arnaud Marchant
Article
Multidisciplinary Sciences
Nicolas Istaces, Marion Splittgerber, Viviana Lima Silva, Muriel Nguyen, Severine Thomas, Aurore Le, Younes Achouri, Emilie Calonne, Matthieu Defrance, Francois Fuks, Stanislas Goriely, Abdulkader Azouz
NATURE COMMUNICATIONS
(2019)
Article
Gastroenterology & Hepatology
Laura Weichselbaum, Abdulkader Azouz, Kinga K. Smolen, Jishnu Das, Marion Splittgerber, Antonia Lepida, Christophe Moreno, Jonas Schreiber, Thomas Serste, Eric Trepo, Frederick Libert, Thierry Gustot, Stanislas Goriely
JOURNAL OF HEPATOLOGY
(2020)
Article
Immunology
Hind Hussein, Sebastien Denanglaire, Frederic Van Gool, Abdulkader Azouz, Yousra Ajouaou, Hana El-Khatib, Guillaume Oldenhove, Oberdan Leo, Fabienne Andris
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Emmanuelle Alaluf, Benoit Vokaer, Aurelie Detavernier, Abdulkader Azouz, Marion Splittgerber, Alice Carrette, Louis Boon, Frederick Libert, Miguel Soares, Alain Le Moine, Stanislas Goriely
Article
Medicine, Research & Experimental
Assiya Assabban, Ingrid Dubois-Vedrenne, Laurye Van Maele, Rosalba Salcedo, Brittany L. Snyder, Lecong Zhou, Abdulkader Azouz, Berengere de Toeuf, Gaelle Lapouge, Caroline La, Maxime Melchior, Muriel Nguyen, Severine Thomas, Si Fan Wu, Wenqian Hu, Veronique Kruys, Cedric Blanpain, Giorgio Trinchieri, Cyril Gueydan, Perry J. Blackshear, Stanislas Goriely
Summary: Cancer is primarily caused by genomic alterations, with multiple genes regulated at the mRNA decay level, including the dysregulation of tristetraprolin (TTP) in human malignancies. TTP plays a critical role in controlling skin tumorigenesis by regulating tumor-associated inflammation and oncogenic pathways in neoplastic epidermal cells.
Article
Immunology
Aurore Le, Abdulkader Azouz, Severine Thomas, Nicolas Istaces, Muriel Nguyen, Stanislas Goriely
Summary: The study revealed that JNK1 plays a crucial role in inflammatory skin diseases, regulating the production of inflammatory cytokines by myeloid cells and the sensitivity of keratinocytes to EGFR ligands. These findings suggest that JNK1 could be a valuable therapeutic target in the treatment of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Aurore Demars, Armelle Vitali, Audrey Comein, Elodie Carlier, Abdulkader Azouz, Stanislas Goriely, Justine Smout, Veronique Flamand, Megane Van Gysel, Johan Wouters, Jan Abendroth, Thomas E. Edwards, Arnaud Machelart, Eik Hoffmann, Priscille Brodin, Xavier De Bolle, Eric Muraille
Summary: Brucellosis is a common bacterial zoonosis worldwide. The Acod1 gene plays a key role in controlling pulmonary Brucella infection in mice. The ACOD1 enzyme converts cis-aconitate to itaconate and may be a potential target for pharmacological interventions in treating early stages of pulmonary Brucella infection.
Article
Biology
Yousra Ajouaou, Abdulkader Azouz, Anaelle Taquin, Sebastien Denanglaire, Hind Hussein, Mohammad Krayem, Fabienne Andris, Muriel Moser, Stanislas Goriely, Oberdan Leo
Summary: PHD2 plays an important role in regulating Treg phenotype and function. Deficiency of PHD2 in Tregs leads to systemic inflammatory syndrome and immune dysregulation, possibly due to the function of the PHD2-HIF2α axis.
Article
Medicine, Research & Experimental
Elisa Brauns, Abdulkader Azouz, David Grimaldi, Hanxi Xiao, Severine Thomas, Muriel Nguyen, Veronique Olislagers, Ines Vu Duc, Carmen Orte Cano, Veronique Del Marmol, Pieter Pannus, Frederick Libert, Sven Saussez, Nicolas Dauby, Jishnu Das, Arnaud Marchant, Stanislas Goriely
Summary: Severe COVID-19 disease can lead to dysregulation of the myeloid compartment during acute infection. In this study, impaired cytokine production by monocytes was observed in patients with severe COVID-19 during the acute phase, but was restored in convalescent patients. However, recovered patients showed increased responsiveness to TLR1/2 ligation, suggesting different functional properties of these cells at different stages of the disease.
Article
Multidisciplinary Sciences
Guillem Sanchez Sanchez, Maria Papadopoulou, Abdulkader Azouz, Yohannes Tafesse, Archita Mishra, Jerry K. Y. Chan, Yiping Fan, Isoline Verdebout, Silvana Porco, Frederick Libert, Florent Ginhoux, Bart Vandekerckhove, Stanislas Goriely, David Vermijlen
Summary: This study examines the development of gamma delta T cells in fetal and pediatric individuals using single cell RNA gene expression and gamma delta T cell receptor sequencing. The findings reveal that fetal gamma delta thymocytes exhibit a wave-like pattern of development, while pediatric thymus generates only a small subset of effector cells. The study provides insights into the distinct programming of gamma delta T cell immunity in humans.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Charlotte Bisilliat Donnet, Valerie Acolty, Abdulkader Azouz, Anaelle Taquin, Coralie Henin, Sarah Trusso Cafarello, Sebastien Denanglaire, Massimiliano Mazzone, Guillaume Oldenhove, Oberdan Leo, Stanislas Goriely, Muriel Moser
Summary: The PHD/HIF pathway is involved in immune and inflammatory processes, including in the hypoxic tumor microenvironment. Deleting PHD2 in T lymphocytes resulted in regression of EG7-OVA tumors, which depended on HIF-1a. The enhanced control of tumor growth was associated with increased polyfunctionality of CD8+ tumor-infiltrating lymphocytes, indicating the importance of glycolysis in sustaining CTL activity.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Biology
Aurelie Detavernier, Abdulkader Azouz, Hussein Shehade, Marion Splittgerber, Laurye Van Maele, Muriel Nguyen, Severine Thomas, Younes Achouri, David Svec, Emilie Calonne, Francois Fuks, Guillaume Oldenhove, Stanislas Goriely
COMMUNICATIONS BIOLOGY
(2019)