Article
Pharmacology & Pharmacy
Edouard Charles Le Carpentier, Emmanuel Canet, Damien Masson, Maelle Martin, Guillaume Deslandes, Aurelie Gaultier, Eric Dailly, Ronan Bellouard, Matthieu Gregoire
Summary: In this study, the impact of inflammation on the pharmacokinetics of midazolam in COVID-19 patients was investigated. The results suggest that inflammation could reduce the metabolism of midazolam by CYP3A. Therefore, caution should be exercised when administering drugs metabolized by CYP3A in cases of severe inflammation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, Research & Experimental
Jae Seok Kim, Jun Young Lee, Jae Won Yang, Keum Hwa Lee, Maria Effenberger, Wladimir Szpirt, Andreas Kronbichler, Jae Il Shin
Summary: Severe COVID-19 is characterized by systemic hyper-inflammation and cytokine storm, often leading to acute respiratory distress syndrome and multiple organ failure. Treatment of COVID-19 cytokine storm is crucial, with anti-inflammatory therapies playing a significant role. Various approaches are being used, including new cytokine-targeted therapies, to address the cytokine storm associated with COVID-19.
Article
Multidisciplinary Sciences
David Garcia-Azorin, Alvaro Sierra, Javier Trigo, Ana Alberdi, Maria Blanco, Ismael Calcerrada, Ana Cornejo, Miguel Cubero, Ana Gil, Cristina Garcia-Iglesias, Ana Guiomar Lozano, Cristina Martinez Badillo, Carol Montilla, Marta Mora, Gabriela Nunez, Marina Paniagua, Carolina Perez, Maria Rojas, Marta Ruiz, Leticia Sierra, Maria Luisa Hurtado, Angel Luis Guerrero Peral
Summary: Headache occurred in 23.4% of patients with confirmed COVID-19, being more intense in females. Headache was the most frequent first symptom of COVID-19, with characteristics of being bilateral with pressing quality and typically lasting for 7 days.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Medicine, Research & Experimental
Hugh Rosen, Michael B. A. Oldstone
Summary: In this study, the researchers explored the association between S1P serum levels and the severity of COVID-19, proposing a new prognostic indicator.
EMBO MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yaqun Li, Wenjie Zhao, Jinhua Liu, Zichao Chen, Qingtao Lv, Zhen Zhang
Summary: COVID-19 pneumonia, caused by SARS-CoV-2, has disrupted the pro-inflammatory/anti-inflammatory response, leading to a need to neutralize cytokine storm. Current treatments focus on vaccines for prevention and immunomodulatory therapies to alleviate immune imbalance, with antiviral drugs and respiratory support as clinical options.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaokang He, Fei Yao, Jie Chen, Yan Wang, Xiangming Fang, Xuan Lin, Hui Long, Qiang Wang, Qingming Wu
Summary: The study found that D-dimer levels are closely related to the clinical classification and prognosis of COVID-19 patients, with a D-dimer value of 2.025 mg/L regarded as the optimal probability cutoff for predicting death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Anna Gracia-Perez-Bonfils, Kugajeevan Vigneswaran, Daniel Cuadras, Edwin Chandraharan
Summary: Research found that the saltatory pattern (SP) is almost non-existent, while the ZigZag pattern (ZZP) is more common during labor and is associated with perinatal outcomes. Newborns with ZZP during active maternal pushing had lower Apgar scores and a higher admission rate.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Satoshi Ikeda, Toshihiro Misumi, Shinyu Izumi, Keita Sakamoto, Naoki Nishimura, Shosei Ro, Koichi Fukunaga, Satoshi Okamori, Natsuo Tachikawa, Nobuyuki Miyata, Masaharu Shinkai, Masahiro Shinoda, Yasunari Miyazaki, Yuki Iijima, Takehiro Izumo, Minoru Inomata, Masaki Okamoto, Tomoyoshi Yamaguchi, Keisuke Iwabuchi, Makoto Masuda, Hiroyuki Takoi, Yoshitaka Oyamada, Shigeki Fujitani, Masamichi Mineshita, Haruyuki Ishii, Atsushi Nakagawa, Nobuhiro Yamaguchi, Makoto Hibino, Kenji Tsushima, Tatsuya Nagai, Satoru Ishikawa, Nobuhisa Ishikawa, Yasuhiro Kondoh, Yoshitaka Yamazaki, Kyoko Gocho, Tomotaka Nishizawa, Akifumi Tsuzuku, Kazuma Yagi, Yuichiro Shindo, Yuriko Takeda, Takeharu Yamanaka, Takashi Ogura
Summary: The study indicated that the use of corticosteroids in COVID-19 patients did not improve clinical status on Day 15, but reduced the time to improvement in radiological findings for all patients regardless of disease severity and also reduced the duration of invasive mechanical ventilation in patients who required intubation.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin
Summary: COVID-19, caused by viral infection, is a pandemic disease with high mortality rate, with most symptoms related to mitochondrial dysfunction. Targeting mitochondrion may offer a more rational treatment approach, and understanding the underlying causes could enhance the opportunity to treat COVID-19 effectively.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Charles Ochieng' Olwal, Nora Nghuchuzie Nganyewo, Kesego Tapela, Alexandra Lindsey Djomkam Zune, Oloche Owoicho, Yaw Bediako, Samuel Duodu
Summary: Sepsis and COVID-19 share many pathophysiological and clinical features, both leading to consumptive thrombocytopenia, coagulopathy, multi-organ dysfunction syndrome, respiratory failure, among other complications. Therefore, lessons learned from sepsis care could potentially inform on COVID-19 management.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiayu Zhang, Xuejing Ma, Fuwei Liu, Deju Zhang, Jitao Ling, Zicheng Zhu, Yixuan Chen, Pingping Yang, Yanlin Yang, Xiao Liu, Jing Zhang, Jianping Liu, Peng Yu
Summary: 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severe cases of COVID-19 are associated with a cytokine storm, characterized by elevated levels of pro-inflammatory cytokines in the bloodstream. Recent studies have shown a higher severity of necrobiosis infection in diabetic patients, as well as higher morbidity and mortality in people with chronic metabolic diseases such as diabetes. Additionally, COVID-19 may result in hyperglycemia in infected individuals. This review explores the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19, and discusses the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, several promising targeted NLRP3 inflammatory vesicle inhibitors are proposed as a basis for clinical management of patients with diabetes combined with noncoronary pneumonia.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Luis A. A. Silva-Lagos, Janesh Pillay, Matijs van Meurs, Alexandra Smink, Peter H. J. van der Voort, Paul de Vos
Summary: COVID-19 severity is associated with cytokine storm, and danger-associated molecular patterns (DAMPs) and Toll-like receptors (TLRs) can explain some gender-, weight- and age-dependent effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaul Lev, Tamar Gottesman, Gal Sahaf Levin, Doron Lederfein, Evgeny Berkov, Dror Diker, Aliza Zaidman, Amir Nutman, Tahel Ilan Ber, Alon Angel, Lior Kellerman, Eran Barash, Roy Navon, Olga Boico, Yael Israeli, Michal Rosenberg, Amir Gelman, Roy Kalfon, Einav Simon, Noa Avni, Mary Hainrichson, Oren Zarchin, Tanya M. Gottlieb, Kfir Oved, Eran Eden, Boaz Tadmor
Summary: This single-center cohort study found that IP-10 levels correlated with COVID-19 severity and admission to the intensive care unit, and corticosteroid therapy significantly decreased IP-10 levels. Serial IP-10 measurements may serve as an actionable aid in managing inflammation and guiding therapeutic decisions in COVID-19 patients.
Article
Obstetrics & Gynecology
Polan Ordas, Roberto Rodriguez, Beatriz Herrero, Ucia Deiros, Enery Gomez, Elisa Llurba, Jose Luis Bartha, Eugenia Antolin
Summary: This study analyzed changes in fetal cephalic biometry and fetoplacental circulation throughout pregnancy in fetuses with congenital heart defects. The results showed that these fetuses had smaller head size and Doppler changes, especially in cardiac defects with expected low oxygen supply.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Article
Medicine, General & Internal
Cristina Trilla, Josefina Mora, Nuria Ginjaume, Madalina Nicoleta Nan, Obdulia Alejos, Carla Dominguez, Carmen Vega, Yessenia Godinez, Monica Cruz-Lemini, Juan Parra, Elisa Llurba
Summary: This study validates and evaluates the performance of a first-trimester contingent screening process using PlGF for PE, with prophylactic LDA, for decreasing the incidence of preterm PE. The results show a significant reduction in preterm PE incidence in routine care settings.
Article
Cardiac & Cardiovascular Systems
Cristina Trilla, Cristina Luna, Silvia De Leon Socorro, Leire Rodriguez, Aina Ruiz-Romero, Josefina Mora Brugues, Taysa Benitez Delgado, Marta Fabre, Alicia Martin Martinez, Sara Ruiz-Martinez, Elisa Llurba, Daniel Oros
Summary: This study aims to determine the predictive and preventive capacity of a universal first-trimester screening model for preeclampsia by determining PlGF levels in intermediate-risk patients. The screening model is expected to achieve similar diagnostic performance as universal determination of PlGF but at a lower economic cost.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Maria Torres Toda, Mohammad Miri, Hafez Heydari, Moslem Lari Najafi, Maria Dolores Gomez-Roig, Elisa Llurba, Maria Foraster, Payam Dadvand
Summary: This study investigated the association between prenatal exposure to greenspace and lipid levels in cord blood. The results showed that increased greenspace in residential surroundings, higher residential accessibility to green space, and more use of green spaces were associated with decreased cord blood lipid levels. The findings regarding greenspace in larger buffers and the number of plant pots were inconclusive. The study also suggested a potential mediatory role of air pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Carla Dominguez-Gallardo, Nuria Ginjaume-Garcia, Johana Ullmo, Cristina Trilla, Maria Carmen Medina, Ana Vazquez, Monica Cruz-Lemini, Elisa Llurba
Summary: The objective of this study was to construct reference values for left ventricle longitudinal strain in normal fetuses using automated cardiac motion quantification software and evaluate its feasibility and reproducibility. The results showed that the assessment of LV longitudinal strain using aCMQ-QLab is feasible and reproducible, and normal ranges have been provided.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Diego F. Wyszynski, Mondira Bhattacharya, Oscar Martinez-Perez, Anthony R. Scialli, Melissa Tassinari, Naor Bar-Zeev, Cheryl Renz, Sonia Hernandez-Diaz
Summary: This study aims to compare the relative risks of obstetric, neonatal, and infant outcomes between pregnant individuals who received COVID-19 vaccines and those who did not. By collecting data through an international non-interventional cohort study, the study will determine the safety profiles of the vaccines and generate hypotheses for future research. The results will provide information for pregnant individuals and healthcare providers to make informed decisions regarding COVID-19 vaccination.
Article
Medicine, General & Internal
Carmen Garrido-Gimenez, Monica Cruz-Lemini, Francisco V. Alvarez, Madalina Nicoleta Nan, Francisco Carretero, Antonio Fernandez-Oliva, Josefina Mora, Olga Sanchez-Garcia, Alvaro Garcia-Osuna, Jaume Alijotas-Reig, Elisa Llurba
Summary: N-terminal pro-brain natriuretic peptide (NT-proBNP) and uric acid levels are increased in preeclampsia pregnancies. Using angiogenic factors for short-term prediction of preeclampsia has limitations. A machine-learning model (MLM) combining NT-proBNP, uric acid, and sFlt-1/PlGF ratio improves the prediction accuracy for preterm preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Iris Soveral, Laura Guirado, Maria C. Escobar-Diaz, Maria Jose Alcaide, Josep Maria Martinez, Victor Rodriguez-Sureda, Bart Bijnens, Eugenia Antolin, Elisa Llurba, Jose L. Bartha, Olga Gomez, Fatima Crispi
Summary: Fetal echocardiography has limited prognostic ability in evaluating left heart defects. Cord blood cardiovascular biomarkers could improve the prognostic evaluation of left heart defects. The study found that fetuses with left heart defects have distinct cord blood biomarker profiles according to their outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Virginia Engels, Margarita Medina, Eugenia Antolin, Cristina Ros, Carmina Bermejo, Nabil Manzour, Irene Pelayo, Ainara Amaro, Pilar Martinez-Ten, Cristian De-Guirior, Roberto Rodriguez, Laura Sotillo, Isabel Brotons, Reyes de la Cuesta-benjumea, Oscar Martinez, Javier Sancho, Juan Luis Alcazar
Summary: A multicenter observational study found that one in four infertile women who underwent HyFoSy examination with ExEm® foam achieved spontaneous pregnancy within the following twelve months. Couples with shorter infertility duration, unexplained infertility, and women under 35 years of age were more likely to achieve spontaneous conception after HyFoSy.
Article
Medicine, General & Internal
Carla Dominguez-Gallardo, Nuria Ginjaume-Garcia, Johana Ullmo, Antonio Fernandez-Oliva, Juan Parra, Ana Vazquez, Monica Cruz-Lemini, Elisa Llurba
Summary: This study aimed to evaluate the association between fetal growth restriction (FGR) and cardiac left-ventricle (LV) dysfunction. The global and segmental LV longitudinal strain was measured using 2D speckle tracking echocardiography (2D-STE) software, and the differences in cardiac function were compared between FGR and appropriate-for-gestational-age (AGA) fetuses. The study found that FGR fetuses had lower LV strain values, indicating subclinical cardiac dysfunction. The findings provide more insights into fetal cardiac function in cases of placental dysfunction and highlight the potential use of 2D-STE in monitoring the cardiac function of these fetuses.
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Review
Virology
Otilia Gonzalez-Vanegas, Oscar Martinez-Perez
Summary: Pregnant women with SARS-CoV-2 infection have a higher risk of maternal death, ICU admission, preterm delivery, and stillbirth. The risk of preeclampsia (PE) increases in infected pregnant women, especially in severe cases. COVID-19 and PE are likely linked through various mechanisms such as direct effects of the virus, inflammatory response, placental ischemia, myocardial injury, cytokine storm, and thrombotic microangiopathy. This paper aims to explore the similarities between PE and SARS-CoV-2 infection, using COVID-19 as a valuable study model. It highlights the potential for COVID-19-induced myocardial injury in pregnant women and its connection to increased maternal mortality rate.
Review
Obstetrics & Gynecology
Pia Espanol, Rocio Luna, Cristina Soler, Pablo Caruana, Amanda Altes-Arranz, Francisco Rodriguez, Oriol Porta, Olga Sanchez, Elisa Llurba, Ramon Rovira, Maria Virtudes Cespedes
Summary: Endometrial carcinoma, the most common gynecological malignancy in Western countries, is expected to increase in the following years due to high obesity rates in the population. Neural signaling has been identified as part of the tumor microenvironment, playing an active role in the progression and invasion of different solid tumor types. Therefore, a precise understanding of the structure and function of autonomous uterine neural innervations, as well as the influence of hormone-dependent nerves in tumor progression, is urgently needed.
Article
Obstetrics & Gynecology
Cristina Trilla, Josefina Mora, Francesca Crovetto, Fatima Crispi, Eduard Gratacos, Elisa Llurba
Summary: First-trimester SARS-CoV-2 infections are mostly asymptomatic, with a slight increase in inflammatory markers in symptomatic women. Obstetric complications were not increased, but PAPP-A levels were higher in symptomatic women.
FETAL DIAGNOSIS AND THERAPY
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)