Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy

Title
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy
Authors
Keywords
Benzylidenecyclohexenones, Thioredoxin reductase (TrxR), Reactive oxygen species (ROS), Piperlongumine, Antitumor activities
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 204, Issue -, Pages 112610
Publisher
Elsevier BV
Online
2020-07-15
DOI
10.1016/j.ejmech.2020.112610

Ask authors/readers for more resources

Reprint

Contact the author

Find Funding. Review Successful Grants.

Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.

Explore

Ask a Question. Answer a Question.

Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.

Get Started