Article
Oncology
Claire J. Han, Leorey Saligan, Adele Crouch, Matthew F. Kalady, Anne M. Noonan, Lena J. Lee, Diane Von Ah
Summary: The aim of this study was to identify subgroups of colorectal cancer survivors based on cognitive impairment and common co-occurring symptoms, and to explore the risk factors of these subgroups. Three distinct latent classes were identified based on self-reported symptoms in 64 CRC survivors. The high symptom burden group was associated with shorter time since cancer diagnosis, higher perceived stress levels, and poor emotional social support.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Michaela Patton, Victoria J. Forster, Caitlin Forbes, Mehak Stokoe, Melanie Noel, Linda E. Carlson, Kathryn A. Birnie, Kathleen Reynolds, Fiona Schulte
Summary: The study focused on describing rates and dimensions of pain, identifying patterns of chronic pain, and testing correlates of chronic pain in LTSCC. Results showed that 26% of LTSCC reported chronic pain, with factors like posttraumatic stress symptoms, age, and pain catastrophizing being significant predictors. Regular screening for chronic pain in survivors of childhood cancer is recommended for long-term follow-up care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Eric J. Chow, Sanjeev Aggarwal, David R. Doody, Richard Aplenc, Saro H. Armenian, K. Scott Baker, Smita Bhatia, Nancy Blythe, Steven D. Colan, Louis S. Constine, David R. Freyer, Lisa M. Kopp, Caroline Laverdiere, Wendy M. Leisenring, Nao Sasaki, Lynda M. Vrooman, Barbara L. Asselin, Cindy L. Schwartz, Steven E. Lipshultz
Summary: Through evaluating four randomized trials of children with acute lymphoblastic leukemia or Hodgkin lymphoma and a nonrandomized trial of patients with osteosarcoma, it was found that dexrazoxane has cardioprotective effects for survivors of childhood cancer treated with doxorubicin, even after nearly 20 years.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Agnes Dumas, Karen Milcent, Nicolas Bougas, Daniel Bejarano-Quisoboni, Chiraz El Fayech, Helene Charreire, Odile Oberlin, Catherine Patte, Julie Allard, Eric Thebault, Amel Boumaraf, Amel Belhout, Vu-Bezin Giao, Vincent Souchard, Angela Jackson, Rodrigue Allodji, Dominique Valteau-Couanet, Christelle Dufour, Gilles Vassal, Nadia Haddy, Florent De Vathaire, Brice Fresneau
Summary: The study found that patients who received combined chemotherapy and radiotherapy, had bone sarcoma, central nervous system primitive tumor, or underwent autologous hematopoietic cell transplant were more likely to attend long-term follow-up visits. Additionally, factors such as health status, medical expenses, social status, and distance from the follow-up center also influenced attendance.
Article
Oncology
Timothy J. D. Ohlsen, Huiqi Wang, David Buchbinder, I-Chan Huang, Arti D. Desai, Zhiyuan Zheng, Anne C. Kirchhoff, Elyse R. Park, Kevin Krull, Rena M. Conti, Yutaka Yasui, Wendy Leisenring, Gregory T. Armstrong, K. Robin Yabroff, Paul C. Nathan, Eric J. Chow
Summary: Adult siblings of childhood cancer survivors may experience greater aspects of financial hardship compared with the general population. Childhood cancer may adversely affect entire households, with potentially lasting implications.
Article
Anesthesiology
Perri R. Tutelman, Christine T. Chambers, Laura Cornelissen, Conrad Fernandez, Annette Flanders, Julia MacLeod, Simon B. Sherry, Sherry H. Stewart, Robin Urquhart, Sitara de Gagne, Gregory M. T. Guilcher, Javeria Hashmi, Lauren C. Heathcote, Melanie Noel, Fiona S. M. Schulte, Jennifer N. Stinson, Maya Stern
Summary: Cancer and its treatment have long-term consequences on pain and sensory processing in survivors of childhood cancer. This study utilized a standardized quantitative sensory testing protocol to quantify the differences in pain and sensory processing in survivors compared to reference data. The results showed that survivors exhibited reduced sensitivity and a significant minority experienced pain sensitization. Several risk factors for changes in sensory processing were identified. Further research is needed to understand the long-term implications of altered somatosensation in this population.
Article
Clinical Neurology
Sandra J. Weiss, Heather Flynn, Lisa Christian, Liisa Hantsoo, Teresa Lanza di Scalea, Sara L. Kornfield, Maria Muzik, Diana Simeonova, Bruce A. Cooper, Anna Strahm, Kristina M. Deligiannidis
Summary: The study identified three distinct profiles of depressive symptoms among high-risk women, including generally asymptomatic, elevated symptoms of comorbid anxiety and depression, and somatic symptoms. Financial security and greater social support were protective factors, while menstrual irregularity and stronger expression of neurovegetative symptoms characterized the different classes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Natassia Robinson, John Casement, Marc J. Gunter, Inge Huybrechts, Antonio Agudo, Miguel Rodriguez Barranco, Fabian Eichelmann, Theron Johnson, Rudolf Kaaks, Valeria Pala, Salvatore Panico, Torkjel M. Sandanger, Matthias B. Schultze, Ruth C. Travis, Rosario Tumino, Paolo Vineis, Elisabete Weiderpass, Roderick Skinner, Linda Sharp, Jill A. McKay, Gordon Strathdee
Summary: This study identifies widespread DNA methylation changes in childhood cancer patients post-treatment, which may have long-term retention. Adult survivors also exhibit epigenetic age acceleration, independent of DMR methylation. Altered methylation at the DUSP6 DMR is significantly associated with early mortality. These findings highlight the importance of these methylation changes as potential biomarkers for assessing treatment toxicity and predicting long-term health outcomes in childhood cancer survivors.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Wassim Chemaitilly, Zhenghong Li, Tara M. Brinkman, Angela Delaney, Sujuan Huang, Kari L. Bjornard, Catherine G. Lam, Carmen L. Wilson, Nicole Barnes, Karen L. Clark, Matthew J. Krasin, Monika L. Metzger, Anthony Sheyn, Michael W. Bishop, Noah D. Sabin, Rebecca M. Howell, Sara Helmig, Barry L. Shulkin, Brandon M. Triplett, Ching-Hong Pui, Amar Gajjar, Deo Kumar Srivastava, Daniel M. Green, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kristen K. Ness, Charles A. Sklar, Kevin R. Krull
Summary: This study examined the prevalence and risk factors of primary hypothyroidism in childhood cancer survivors, and found associations with physical frailty, dyslipidemia, impaired physical quality of life, and having health care insurance. The impact of thyroid hormone replacement practices on these outcomes should be further investigated.
Article
Oncology
Solveig K. Smedsland, Ragnhild S. Falk, Kristin V. Reinertsen, Cecilie E. Kiserud, Mette Brekke, Synne H. Bohn, Alv A. Dahl, Kathrine F. Vandraas
Summary: More than half of long-term breast cancer survivors suffer from medium or high burden of late effects. Younger age and systemic treatments are important risk factors for experiencing a higher symptom burden, and breast cancer survivors with these risk factors should be prioritized for closer and extended survivorship care.
Article
Oncology
Felix J. Clouth, Arturo Moncada-Torres, Gijs Geleijnse, Floortje Mols, Felice N. van Erning, Ignace H. J. T. de Hingh, Steffen C. Pauws, Lonneke V. van de Poll-Franse, Jeroen K. Vermunt
Summary: This study identified five distinct clusters of long-term colon cancer survivors with similar patterns of health-related quality of life using latent class analysis (LCA) and latent transition analysis (LTA). The clusters were stable over time and influenced by factors like time since diagnosis, age, and gender.
Article
Pediatrics
Melissa M. Hudson, Smita Bhatia, Jacqueline Casillas, Wendy Landier
Summary: Advancements in cancer therapy have improved survival rates for children, adolescents, and young adults with cancer, but they are still at risk for long-term therapy-related complications. Therefore, ongoing systematic follow-up and health counseling are crucial to early detection and intervention for potential late-onset complications, as well as promoting healthy lifestyles to reduce risks for common adult health problems. Healthcare providers play a key role in the ongoing care of childhood cancer survivors, beyond routine preventive care, health supervision, and guidance.
Article
Oncology
Rafael Gonzalez-Manzanares, Juan C. Castillo, Jose R. Molina, Martin Ruiz-Ortiz, Dolores Mesa, Soledad Ojeda, Manuel Anguita, Manuel Pan
Summary: The study found that the prevalence of LVSD detected using automated GLS was higher than that detected using LVEF in long-term childhood leukemia survivors. This suggests that GLS may be a promising tool for monitoring the cardiac health of these patients.
Article
Oncology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet Van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline Van Dulmen-den Broeder, Marry M. Van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Arend Bokenkamp, Margreet A. Veening
Summary: This study investigated the occurrence of tubular dysfunction in childhood cancer survivors who received nephrotoxic therapy. The overall prevalence of electrolyte losses in survivors was not higher compared to controls, but some survivors had an increased risk of tubular dysfunction, especially those treated with specific chemotherapeutic agents. Therefore, these patients should be closely monitored during follow-up.
Article
Dentistry, Oral Surgery & Medicine
Tushar Patni, Chun-Teh Lee, Yimei Li, Sue Kaste, Liang Zhu, Ryan Sun, Melissa M. Hudson, Kirsten K. Ness, Ana Neumann, Leslie L. Robison
Summary: This study investigated the associations between clinical, socioeconomic, and demographic factors and oral diseases in childhood cancer survivors. The results showed that survivors had a higher prevalence of microdontia, abnormal root development, hypodontia, enamel hypoplasia, xerostomia, severe gingivitis, and missing teeth compared to controls. Cancer treatment, socioeconomic factors, and access to oral health care contributed to the prevalence of dental abnormalities.
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Chemistry, Medicinal
Bichismita Sahu, Santosh Kumar Behera, Rudradip Das, Tanay Dalvi, Arnab Chowdhury, Bhaskar Dewangan, Kiran Kalia, Amit Shard
Summary: This study designed scaffolds derived from peptide nucleic acid (PNA) and conducted in-silico screening to identify a compound with similar binding affinity to RdRp. Compound 12 showed comparable pharmacokinetics to remdesivir but with significantly lower toxicity, making it a potential candidate for the treatment of COVID-19.
CURRENT COMPUTER-AIDED DRUG DESIGN
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Nursing
Ari Min, Hye Chong Hong, Sungtaek Son, Linda D. Scott
Summary: This study found that overtime has a negative effect on the alertness of rotating-shift nurses in South Korea, with night shifts having the most significant impact. Previous-day overtime hours and consecutive overtime days are associated with decreased alertness scores.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Nursing
Hye Chong Hong, Ari Min, Young Man Kim
Summary: This study aimed to systematically review and meta-analyse the prevalence of symptoms in childhood and adolescent and young adult cancer survivors. The study found that physical and psychological symptoms were common in this population, with fatigue, sleep disturbance, anxiety, and depression being the most frequently reported symptoms. These findings have important implications for future research.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Public, Environmental & Occupational Health
Ari Min, Hye Chong Hong
Summary: This study examined job characteristics profiles based on the job demand-control-support model, and found a significant association between job characteristics and presenteeism. The low-stain collective group showed the most significant reduction in presenteeism.
SAFETY AND HEALTH AT WORK
(2023)
Article
Public, Environmental & Occupational Health
Hye Chong Hong, Hyeonkyeong Lee, Suk Jeong Lee, Chang Park, Mikyung Lee
Summary: The COVID-19 pandemic has had devastating effects on health, society, economy, and politics, with long-lasting impacts. Public health efforts to reduce the spread of COVID-19 are a global priority. Public health and social measures have been shown to be effective in reducing COVID-19 transmission, but there is insufficient evidence on compliance with these measures in the general population, including Korea.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Review
Nursing
Young Man Kim, Eui Geum Oh
Summary: The purpose of this systematic review and meta-analysis was to explore the effects of pelvic floor muscle training (PFMT) on bowel function and health-related quality of life in patients who have undergone low anterior resection. The findings suggest that PFMT can reduce bowel dysfunction and enhance multiple domains of health-related quality of life.
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
(2023)
Review
Oncology
Young Man Kim, Ari Min, Hye Chong Hong
Summary: The objective of this study was to review telenursing interventions for colorectal cancer patients and determine their impact on health-related quality of life and healthcare service utilization. The findings showed that telenursing intervention had similar effects to usual care, but resulted in lower readmission rates and emergency department visits, although these differences were not statistically significant. These results suggest that telenursing interventions could be a partial alternative to face-to-face interventions for colorectal cancer patients.
SEMINARS IN ONCOLOGY NURSING
(2023)
Article
Nursing
Se Young Jang, Hee Sun Kim, Seok Hee Jeong, Young Man Kim
Summary: The aim of this study was to identify factors explaining protective behaviors against radiation exposure in perioperative nurses based on the theory of planned behavior. A cross-sectional study was conducted with 229 perioperative nurses, and data were analyzed using SPSS/WIN 23.0 and AMOS 23.0 software. The results showed that radiation protective intention, attitude, subjective norm, and perceived behavioral control were significant factors explaining 49.0% of the variance in radiation protective behaviors.
JOURNAL OF KOREAN ACADEMY OF NURSING
(2023)