Article
Cardiac & Cardiovascular Systems
Madalena D. Costa, Susan Redline, Elsayed Z. Soliman, Ary L. Goldberger, Susan R. Heckbert
Summary: Heart rate fragmentation (HRF), a marker of anomalous sinoatrial dynamics, is an independent predictor of atrial fibrillation (AF), adding value to existing predictive models and supporting the concept of electrodynamical remodeling in the prediction of AF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mathijs S. van Schie, Rongheng Liao, Nawin L. Ramdat Misier, Paul Knops, Annejet Heida, Yannick J. H. J. Taverne, Natasja M. S. de Groot
Summary: This study aimed to investigate the effect of atrial extrasystoles (AES) on myocardial electrical signals. The study found that AES could decrease the amplitude of the signals, increase the fractionation and duration, and lead to more low-voltage areas. These effects were correlated with the prematurity index and degree of aberrancy of the AES, and were more pronounced in patients with atrial fibrillation (AF).
Article
Medicine, General & Internal
Ahsan A. Khan, Rehan T. Junejo, Graham N. Thomas, James P. Fisher, Gregory Y. H. Lip
Summary: AF, regardless of hypertension, is associated with higher HRV, and may be related to vagal tone. Permanent AF has a stronger influence on HRV than paroxysmal AF, indicating autonomic involvement in permanent AF pathophysiology. Exploration of autonomic modulation on cardiovascular system is recommended for future studies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Joo Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
Summary: In patients with heart failure (HF) and atrial fibrillation (AF), those whose acute decompensation is tachycardia-mediated have better in-hospital outcomes, but similar post-discharge outcomes compared to those with sinus rhythm or AF whose decompensation is not tachycardia-mediated.
Article
Cardiac & Cardiovascular Systems
Guenseli Cubukcuoglu Deniz, Serkan Durdu, Yesim Dogan, Esra Erdemli, Hilal Ozdag, Ahmet Ruchan Akar
Summary: This study aimed to characterize the transcriptomics of atrial fibrillation in patients with chronic primary mitral regurgitation. The results showed that persistent atrial fibrillation is associated with increased expression of genes related to the transition to heart failure, structural remodeling, and cellular stress response. These findings suggest potential novel therapeutic targets for treating atrial fibrillation in patients with primary mitral regurgitation.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Lara Wagner, Fabrice F. Darche, Dierk Thomas, Patrick Lugenbiel, Panagiotis Xynogalos, Svenja Seide, Eberhard P. Scholz, Hugo A. Katus, Patrick A. Schweizer
Summary: Background modulation of the cardiac autonomic nervous system by pulmonary vein isolation (PVI) influences the sinoatrial nodal rate. Cryo-PVI causes a significant rise of sinus rate that is more pronounced in subjects with previous sinus bradycardia, with an increased risk of AF recurrence in patients with postprocedural bradycardia.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Biology
Cali Anderson, Gabriella Forte, Wei Hu, Henggui Zhang, Mark R. Boyett, Alicia D'Souza
Summary: Although the day-night rhythm in resting heart rate has traditionally been attributed to the parasympathetic nervous system, recent research shows that there is a circadian clock in the cardiac pacemaker and the rhythm in heart rate involves transcriptional remodelling of pacemaker ion channels. This study investigates the role of the sympathetic nervous system in this rhythm and finds that it directly affects pacemaker ion channel transcription. Understanding the day-night rhythm in pacemaking improves our knowledge of bradyarrhythmias during sleep.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Physiology
Nour Barazi, Nazari Polidovitch, Ryan Debi, Simona Yakobov, Robert Lakin, Peter H. Backx
Summary: The study found that heart rate and blood pressure in mice show clear circadian patterns, which are mainly influenced by physical activity and cardiac autonomic nerve system activity. The research revealed that, compared to physical activity, the cardiac autonomic nerve system plays a dominant role in circadian heart rate fluctuations, and the effects of physical activity on daily heart rate variations are remarkably small unless mice have access to running wheels.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
P. Krisai, P. Hammerle, S. Blum, P. Meyre, S. Aeschbacher, P. Melchiorre-Mayer, O. Baretella, N. Rodondi, D. Conen, S. Osswald, M. Kuhne, C. S. Zuern
Summary: The presence of atrial fibrillation (AF) on a single surface ECG is significantly associated with increased risk of mortality and hospitalizations for congestive heart failure in AF patients, suggesting that these patients are a high-risk group that may benefit from intensified treatment.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Computer Science, Information Systems
Yunendah Nur Fu'adah, Ki Moo Lim
Summary: This study proposed a one-dimensional convolutional neural network (1-D CNN) based classification system for electrocardiogram (ECG) signals to accurately diagnose atrial fibrillation (AF) and congestive heart failure (CHF). The results showed that the proposed method achieved high classification accuracy and outperformed previous studies, without the need for multiple preprocessing steps and feature extraction methods. This approach can serve as an adjunct tool for medical personnel to diagnose AF, CHF, and normal sinus rhythm (NSR).
Article
Physiology
Herbert F. Jelinek, Rohisha Tuladhar, Garland Culbreth, Gyanendra Bohara, David Cornforth, Bruce. J. West, Paolo Grigolini
Summary: The study emphasizes the importance of crucial events in physiological dynamics, where they are defined as short-term turbulence phenomena with waiting time distribution density. The index of the distribution determines the stability of the process, with healthy physiological processes being closer to the non-stationary regime. Disease progression is observed to shift the IPL index towards Gaussian statistics, providing a new index for assessing disease severity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Deshan Ma, Li Li, Wenbin Shi, Mengwei Li, Jian Zhang, Yong Fan, Yu Kang, Xiu Zhang, Pengming Yu, Qing Zhang, Zhengbo Zhang, Chien-Hung Yeh
Summary: Autonomic nervous system dysfunction is a significant characteristic of congestive heart failure patients. This study introduced HRV and MMCA-derived parameters to quantify ANS function in CHF patients and compared their clinical efficacy. The results showed that most parameters improved after treatment in SRHF patients, while only a few showed significant differences in ARHF patients. PNS function and ANS balance were recovered in all CHF patients after treatment. These metrics can be used for prognosis and therapeutic efficacy monitoring.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Health Care Sciences & Services
Matteo Gadaleta, Patrick Harrington, Eric Barnhill, Evangelos Hytopoulos, Mintu P. Turakhia, Steven R. Steinhubl, Giorgio Quer
Summary: Early identification of atrial fibrillation (AF) is crucial in reducing the risk of serious cardiovascular outcomes. This study developed a model using a deep learning approach to predict the near-term risk of AF based on electrocardiogram (ECG) data. The model showed high accuracy in predicting AF over a two-week period, providing a potential digital strategy for improving diagnosis and treatment initiation.
NPJ DIGITAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Peter Hanna, Eric Buch, Stavros Stavrakis, Christian Meyer, John D. Tompkins, Jeffrey L. Ardell, Kalyanam Shivkumar
Summary: The cardiac autonomic nervous system is crucial in cardiac physiology and disease, with therapies targeting the cardiac neuraxis showing promising results in pre-clinical and clinical studies.
CARDIOVASCULAR RESEARCH
(2021)
Article
Computer Science, Information Systems
Puneeta Marwaha, Ramesh Kumar Sunkaria, Aman Kumar
Summary: This paper investigates the suitability of multiscale entropy (MSE) technique for complexity quantification of cardiac rhythms in chronic pathological conditions. The study found that at certain time scales, MSE may provide inaccurate estimates of complexity. Although MSE efficiently discriminates between different cardiac rhythms, it fails to reveal the true complexity present in a signal.
MULTIMEDIA TOOLS AND APPLICATIONS
(2021)
Article
Physiology
Zoran Matic, Mirjana M. Platisa, Aleksandar Kalauzi, Tijana Bojic
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Nikola N. Radovanovic, Sinisa U. Pavlovic, Bratislav Kircanski, Nemanja Brankovic, Nikola Vujadinovic, Vojislav Sajic, Ana Milasinovic, Vesna Bisenic, Mirjana Zivkovic, Goran Milasinovic
Summary: This retrospective study examined the diagnostic value of ILR in 181 patients with unexplained syncope, presyncope, or palpitations suggesting cardiac arrhythmias. The results showed that ILR was able to achieve an etiological diagnosis in 54.1% of patients, especially those with recurrent palpitations. ILR should be considered as an important tool in the evaluation process of syncope.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Article
Physics, Multidisciplinary
Nikola N. Radovanovic, Sinisa U. Pavlovic, Goran Milasinovic, Mirjana M. Platisa
Summary: This study investigated the impact of CRT on the relationship between the cardiovascular and respiratory systems in heart failure patients, using signal complexity as a marker of CRT response. Results showed that differences in cardiac and respiratory rhythm complexity were associated with CRT outcomes, with responders exhibiting more stable cardio-respiratory coupling.
Article
Biochemistry & Molecular Biology
Ksenija Radotic, Daniela Djikanovic, Aleksandar Kalauzi, Gordana Tanasijevic, Vuk Maksimovic, Jelena Dragisic Maksimovic
Summary: This study investigated the interaction between silicon and lignin formation in plant cell walls. The results showed that silicon binds to the final polymer and affects its structure. Silicon may inhibit the formation of larger lignin fragments by binding to dimers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Aleksandar Kalauzi, Zoran Matic, Tijana Bojic, Mirjana M. Platisa
Summary: This study analyzed Poincare plots of electrocardiogram RR intervals to reveal their structure and complexity properties. The results showed that these plots consist of components originating from respiratory sinus arrhythmia oscillations and slow variations of the RR interval time series. The method was able to differentiate body postures and breathing regimes in healthy subjects, suggesting its potential application in patients with different pathological conditions.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Physiology
Zoran Matic, Aleksandar Kalauzi, Maximilian Moser, Mirjana M. Platisa, Mihailo Lazarevic, Tijana Bojic
Summary: This research investigates the influence of different body posture and breathing regimes on cardiorespiratory coupling, specifically focusing on the pulse respiration quotient (PRQ) as a tool to analyze the dynamic modifications. The results show that the linear features of CRC in PRQ signals are highly sensitive to posture and breathing rhythm perturbations. Furthermore, the study suggests that Stand01 state has the potential for PRQ tuning in conditions where PRQ is disturbed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Aleksandar Kalauzi, Zoran Matic, Mirjana M. Platisa, Tijana Bojic
Summary: In this study, we proposed a method to calculate the pulse respiration quotient and explored its correlations with respiratory and cardiac intervals. We found that body posture influenced the scatter plot of the correlations, while breathing regime had little effect on linear regression slopes.
BIOENGINEERING-BASEL
(2023)
Article
Physics, Multidisciplinary
Mirjana M. Platisa, Nikola N. Radovanovic, Riccardo Pernice, Chiara Bara, Sinisa U. Pavlovic, Luca Faes
Summary: The properties of cardio-respiratory coupling are affected by heart rhythm changes and nonlinear components in heart failure patients. Information theory measures, such as Granger Causality, Transfer Entropy, and Cross Entropy, are used to quantify the causal interactions between cardiac and respiratory time series. The success of cardiac resynchronization therapy is related to the information transfer between the cardiac and respiratory signals.
Proceedings Paper
Cardiac & Cardiovascular Systems
Zoran Matic, Aleksandar Kalauzi, Mirjana Platiga, Tijana Bojic
Summary: This study introduces a new measure, the inter-fractal angle (θ), which is more sensitive to perturbations like slow breathing and orthostasis compared to the traditional alpha(1)/alpha(2) ratio in detrended fluctuation analysis of physiological rhythm fluctuations.
2022 12TH CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS (ESGCO)
(2022)
Proceedings Paper
Cardiac & Cardiovascular Systems
Tijana Bojic, Zoran Maric, Mirjana Platisa, Aleksandar Kalauzi
Summary: We investigated the effects of slow breathing and orthostasis on angular indices of detrended fluctuation analysis (DFA) of RR intervals and respiration signal. By using probability density estimation (PDE), we found that these DFA angles reflected group behavioral patterns related to body posture and breathing regime, and had physiological significance.
2022 12TH CONFERENCE OF THE EUROPEAN STUDY GROUP ON CARDIOVASCULAR OSCILLATIONS (ESGCO)
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Mirjana M. Platisa, Nikola N. Radovanovic, Aleksandar Kalauzi, Sinisa Pavlovic
Summary: In this study, we applied generalized Poincare plots (gPp) analysis to analyze interbeat intervals in patients with heart failure, and compared it with other existing extended Poincare plots techniques. The results showed that gPp method has advantages over the commonly used distanced (lagged) Poincare plots analysis, as it has the potential for three-dimensional visualization of results and quantification of new multiscaling parameters.
BIOSIGNALS: PROCEEDINGS OF THE 15TH INTERNATIONAL JOINT CONFERENCE ON BIOMEDICAL ENGINEERING SYSTEMS AND TECHNOLOGIES - VOL 4: BIOSIGNALS
(2022)
Article
Endocrinology & Metabolism
Emir Muzurovic, Sanja Medenica, Milovan Kalezic, Sinisa Pavlovic
Summary: This case illustrates the interplay between electrolyte disorders and ventricular arrhythmias in primary hyperparathyroidism, emphasizing the need for caution in indicating ICD even in patients with the most serious life-threatening arrhythmias.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2021)