Article
Biochemistry & Molecular Biology
Jianing Tang, Qian Yang, Chao Mao, Desheng Xiao, Shuang Liu, Liang Xiao, Ledu Zhou, Gaosong Wu, Yongguang Tao
Summary: In this study, the researchers identified ubiquitin carboxyl terminal hydrolase L3 (UCHL3) as a deubiquitylase of Yes-associated protein (YAP) in Anaplastic thyroid carcinoma (ATC). UCHL3 stabilizes YAP through its deubiquitylation activity, and its depletion leads to decreased ATC progression, stemness, metastasis, and increased sensitivity to chemotherapy. The study also revealed that TEAD4, which binds to YAP and DNA, activates UCHL3 transcription by binding to its promoter.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Jianing Tang, Yongwen Luo, Liang Xiao
Summary: This study identified USP26 as a deubiquitinating enzyme for TAZ in anaplastic thyroid cancer (ATC) and demonstrated its significant influence on cell proliferation, migration, and invasion in ATC. Depletion of USP26 resulted in decreased TAZ protein level and affected the expression of TAZ/TEAD target genes in ATC.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
MingLiang Ning, Shaojie Qin, Jia Tian, Yuchen Wang, Qingyuan Liu
Summary: Our research demonstrated that AFAP-AS1 could promote the progression of thyroid cancer by sponging miR-155-5p through regulating the ETS1/ERK pathway. Knock-down of AFAP-AS1 inhibited cell proliferation and accelerated apoptosis in ATC cells. Additionally, AFAP-AS1 negatively regulated miR-155-5p and influenced the ETS1/ERK pathway in ATC.
Article
Biochemistry & Molecular Biology
Monika Skrzypiec-Spring, Agnieszka Sapa-Wojciechowska, Alina Rak-Pasikowska, Maciej Kaczorowski, Iwona Bil-Lula, Agnieszka Halon, Adam Szelag
Summary: This study investigated the inhibitory effect of simvastatin, a Rho-associated protein kinase (RhoA/ROCK) signaling pathway inhibitor, on matrix metalloproteinase 2 (MMP-2) activity in a rat ischemia-reperfusion injury (I/Ri) model. The results showed that simvastatin improved the contractile function of the heart and reduced MMP-2 activity in heart tissue by inhibiting the RhoA/ROCK pathway. The protective effect of simvastatin on systolic function in the acute ischemia-reperfusion model is not related to reduced MMP-2 activation but is mediated through other mechanisms associated with RhoA/ROCK pathway inhibition.
Article
Endocrinology & Metabolism
Wenjing Xu, Liwei Xie, Yingying Yang, Jiayu Xu, Shang Cai, Ye Tian
Summary: This study found that highly expressed KAT5 is associated with poor prognosis in ATC patients. The KAT5 inhibitor NU9056 can inhibit ATC cells while having no impact on normal thyroid cells. This inhibitory effect may be achieved by regulating microRNA related to NU9056.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yaraslau Padrez, Lena Golubewa, Tatsiana Kulahava, Tatyana Vladimirskaja, Galina Semenkova, Igor Adzerikho, Olga Yatsevich, Nadezda Amaegberi, Renata Karpicz, Yuri Svirko, Polina Kuzhir, Danielis Rutkauskas
Summary: We demonstrated that wide-field second harmonic generation (SHG) microscopy combined with quantitative analysis is a powerful tool for visualizing the fibrosis pathogenesis in pulmonary arterial hypertension (PAH) in a fast and label-free manner. Statistical analysis of SHG images revealed changes in collagen content and morphology in lung tissue during PAH progression.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Cardiac & Cardiovascular Systems
Johnathan Kent, Philip Erwin, Daniel Haraf, Chih-Yi Liao, Joseph Durham, Peter Angelos, Nishant Agrawal, Brandon Jackson Baird, Maria Lucia L. Madariaga
Summary: Laryngotracheal resection and reconstruction after dabrafenib/trametinib treatment has been shown to be safe and effective in locoregionally advanced BRAF v600e mutated anaplastic thyroid carcinoma. This treatment improves rates of microscopically margin-negative resection and durable locoregional control.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shu-Fu Lin, Chun-Nan Yeh, Yu-Tung Huang, Ting-Chao Chou, Richard J. Wong
Summary: The PLK inhibitor volasertib has shown potential therapeutic effects in the treatment of anaplastic thyroid cancer (ATC), either alone or in combination with sorafenib. It decreases cell viability, induces apoptosis, and exhibits mostly synergistic effects in ATC cells, suggesting it could be an effective drug for treating ATC.
Article
Cell Biology
Tong Xu, Tiefeng Jin, Xixuan Lu, Zongfu Pan, Zhuo Tan, Chuanming Zheng, Yujia Liu, Xiaoping Hu, Lisha Ba, Hao Ren, Jinming Chen, Chaozhuang Zhu, Minghua Ge, Ping Huang
Summary: By integrating 4 ATC-related datasets, 25 differentially expressed circadian rhythm genes (DE-CRGs) were identified, mainly regulating signals such as mitotic nuclear division, cytokinesis, and DNA replication.
CELLULAR SIGNALLING
(2022)
Article
Endocrinology & Metabolism
Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye
Summary: ASPM is overexpressed in ATC patients and cell lines, and it contributes to the pathogenesis of ATC through the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haoran Feng, Zhijian Jin, Juyong Liang, Qiwu Zhao, Ling Zhan, Zheyu Yang, Jiqi Yan, Jie Kuang, Xi Cheng, Weihua Qiu
Summary: The study discovered that FOXK2 plays critical roles in angiogenesis and VEGFR2 resistance in ATC by inducing VEGFA transcription. This indicates that FOXK2 could potentially serve as a new therapeutic strategy and biomarker for anti-angiogenic therapy against ATC.
Review
Biochemistry & Molecular Biology
Stephan Niland, Andrea Ximena Riscanevo, Johannes Andreas Eble
Summary: This review examines the current knowledge of the interplay of various MMPs in the context of cancer on the protein, subcellular, and cellular level, with a focus on MMP-14. It highlights the importance of a deeper understanding of functional mechanisms for the development of new prognostic and predictive markers, as well as targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ga-Yul Min, Jong-Min Park, In-Hwan Joo, Dong-Hee Kim
Summary: CSR exhibited protective effects on IL-1 beta-stimulated rat chondrocytes and MIA-induced OA model by inhibiting MMPs and ADAMTSs expression, as well as the degradation of ECM. It also suppressed MAPKs and NF-kappa B signaling pathway. In vivo, CSR and Indomethacin reduced inflammatory mediators, MMPs production and ECM degradation, improving OA severity.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Israel Aguilar-Ordonez, Fernando Perez-Villatoro, Humberto Garcia-Ortiz, Francisco Barajas-Olmos, Judith Ballesteros-Villascan, Ram Gonzalez-Buenfil, Cristobal Fresno, Alejandro Garciarrubio, Juan Carlos Fernandez-Lopez, Hugo Tovar, Enrique Hernandez-Lemus, Lorena Orozco, Xavier Soberon, Enrique Morett
Summary: This study conducted high-coverage whole genome sequencing of 76 unrelated individuals from 27 indigenous groups in Mexico, revealing novel genetic variations associated with prevalent health issues in the Mexican population. Positive selection signals and genetic stratification analysis showed distinctive population structures among Native Mexican groups, contributing to a better understanding of their genomic diversity.
Article
Genetics & Heredity
Diana Garcia-Cortes, Enrique Hernandez-Lemus, Jesus Espinal-Enriquez
Summary: Luminal A is the most common breast cancer molecular subtype in women worldwide, with characteristic yet heterogeneous alterations at the genomic and transcriptomic level. This study delves into the relationship between network topology and function in Luminal A breast cancer GCNs.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Soledad Ochoa, Guillermo de Anda-Jauregui, Enrique Hernandez-Lemus
Summary: Breast cancer is a complex and highly heterogeneous disease with different molecular subtypes. Regulation of the disease involves interactions between various mechanisms, such as transcription factor regulation, noncoding RNA regulation, and DNA methylation. Using probabilistic multilayer networks based on multi-omic data is a useful approach to understanding the molecular heterogeneity of breast cancer regulation.
FRONTIERS IN GENETICS
(2021)
Review
Physics, Multidisciplinary
Enrique Hernandez-Lemus
Summary: A random field represents the joint probability distribution of a set of random variables, with Markov fields serving as the theoretical foundation for many applications in statistical physics and probability. While Markov random fields have been used in statistical physics for a long time, their measure theoretical foundations were developed later on. Besides theoretical relevance, Markov random fields have been widely used in various fields like computational molecular biology, ecology and computer vision.
FRONTIERS IN PHYSICS
(2021)
Article
Multidisciplinary Sciences
Rodrigo Dorantes-Gilardi, Diana Garcia-Cortes, Enrique Hernandez-Lemus, Jesus Espinal-Enriquez
Summary: Gene co-expression networks (GCNs) are important analytical tools for studying the gene expression patterns associated with complex phenotypes. The association between structure and function in GCNs is a current challenge in biomedical research. Studies have shown that the majority of interactions in breast cancer networks are intra-chromosome, while inter-chromosome interactions serve as connecting bridges between clusters. Core genes in healthy networks are related to processes such as metabolism and cell cycle.
SCIENTIFIC REPORTS
(2021)
Review
Genetics & Heredity
Sergio Antonio Alcala-Corona, Santiago Sandoval-Motta, Jesus Espinal-Enriquez, Enrique Hernandez-Lemus
Summary: Network modeling plays a crucial role in studying the structure and behavior of biological systems, offering methods for exploring the relationships between components and identifying modular structures within biological networks. While traditional biology-specific methods have limited applicability, more general methods from statistical physics and network science have been developed for modularity detection in biological systems. Bridging the gap between biology and theoretical physics/network science is essential for further advancing the understanding of modularity in biological research.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Cristina Sotomayor-Vivas, Enrique Hernandez-Lemus, Rodrigo Dorantes-Gilardi
Summary: The study investigates the relationship between protein structure and function, revealing a strong correlation between structural changes and functional changes. Significant changes in protein structure are associated with functional loss, while positions that gain function through mutations tend to be structurally robust. A computational method is also proposed to predict mutation-sensitive positions using structural changes, demonstrating good predictive performance.
Article
Environmental Sciences
Mateo Carlos Galindo-Perez, Manuel Suarez, Ana Rosa Rosales-Tapia, Jose Sifuentes-Osornio, Ofelia Angulo-Guerrero, Hector Benitez-Perez, Guillermo de Anda-Jauregui, Juan Luis Diaz-de-Leon-Santiago, Enrique Hernandez-Lemus, Luis Alonso Herrera, Oliva Lopez-Arellano, Arturo Revuelta-Herrera, Rosaura Ruiz-Gutierrez, Claudia Sheinbaum-Pardo, David Kershenobich-Stalnikowitz
Summary: The evaluation of the CMU coverage strategy in the Mexico City Metropolitan Area (MCMA) found that COVID-19 infections spread from the urban center to the periphery, and as the number of cases increased and medical units became overloaded, residents traveled longer distances to seek medical care. The population residing in the urban periphery had the lowest level of accessibility to CMUs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Mauricio M. Gonzalez-Ballesteros, Carmen Mejia, Lena Ruiz-Azuara
Summary: Cancer is a heterogeneous and multifactorial disease with high mortality rates worldwide. Medicinal Inorganic Chemistry is a young field that focuses on the design, synthesis, characterization, preclinical evaluation, and mechanism of action of new inorganic compounds known as metallodrugs. Metallodrugs have the advantage of adjusting their physicochemical and stereochemical properties to bind with a wide range of targets, thus preventing the invasion and metastasis of cancer. Several metal compounds show potential in inhibiting signaling pathways associated with cancer progression.
Article
Multidisciplinary Sciences
Laura Gomez-Romero, Diana E. Alvarez-Suarez, Enrique Hernandez-Lemus, M. Veronica Ponce-Castaneda, Hugo Tovar
Summary: In this study, we analyzed a dataset of normal retina samples to identify the differentially expressed genes (DEGs) and pathways associated with retinoblastoma (Rb). We also identified the transcription factors that regulate the highest number of DEGs and proposed them as transcriptional master regulators (TMRs). Our findings suggest that aberrant expression in phototransduction and retrograde endocannabinoid signaling pathways, as well as in TMRs nuclear receptor subfamily 5 group A member 2 and hepatocyte nuclear factor 4 gamma, may be involved in the abnormal retina development associated with Rb.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Oncology
Martin Ruhle, Jesus Espinal-Enriquez, Enrique Hernandez-Lemus
Summary: This study explores the abundance and co-occurrence patterns of proteins in breast cancer cells and healthy cells. The findings suggest that these differences in proteins may be associated with relevant aspects of tumor biology. The results provide valuable information for the development of diagnostic, prognostic, and therapeutic tools for cancer.
Article
Health Care Sciences & Services
Mireya Martinez-Garcia, Adriana-Patricia Rodriguez-Hernandez, Guadalupe O. Gutierrez-Esparza, Roberto Carlos Castrejon-Perez, Enrique Hernandez-Lemus, Socorro Aida Borges-Yanez
Summary: Inequalities in oral health are influenced by social strata, and this study aimed to evaluate the association between self-reported periodontal conditions and the Social Development Index (SDI). Through a cross-sectional questionnaire, it was found that higher global scores on the SDI and quality and available space in the home (QASH) increase the probability of having bone loss. These results highlight the importance of using SDI and its indicators, particularly QASH, to further explore inequities related to privileged access to dental care in the context of periodontal diseases.
Article
Health Care Sciences & Services
Alexandra Arias-Mendoza, Jorge A. Ortega-Hernandez, Diego Araiza-Garaygordobil, Hector Gonzalez-Pacheco, Mireya Martinez-Garcia, Enrique Hernandez-Lemus, Rodrigo Gopar-Nieto, Tomas Tadeo Sandoval-Aguilar, Daniel Sierra-Lara Martinez, Salvador Mendoza-Garcia, Alfredo Altamirano-Castillo, Jose Luis Briseno-de-la-Cruz, Midori Alondra Ortega-Hernandez, Luis Alejandro Soliz-Uriona, Jorge Gaspar-Hernandez
Summary: This study compares the cost-effectiveness of pharmacoinvasive strategy (PI) and primary percutaneous intervention (pPCI) in the treatment of ST-elevation myocardial infarction (STEMI). The findings suggest that PI may be a more efficient treatment approach in regions where access to pPCI is limited or where delays are expected.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Guillermo de Anda-Jauregui, Enrique Hernandez-Lemus
Summary: Adverse drug events or reactions are often overlooked due to off-target interactions and higher order effects, but with high-throughput omic technologies and large databases, they can be studied and assessed to extract useful information. The challenge lies in extracting meaningful insights from large data sets.
2021 MEXICAN INTERNATIONAL CONFERENCE ON COMPUTER SCIENCE (ENC 2021)
(2021)
Article
Biology
Guillermo de Anda-Jauregui, Jesus Espinal-Enriquez, Enrique Hernandez-Lemus
Summary: Breast cancer is a complex, heterogeneous disease with significant impact on transcriptional regulatory programs, which can be further understood through network biology methods. The identification of cdre-miRs in breast cancer molecular subtypes suggests their potential role in controlling associated biological functions related to cancer hallmarks.