4.7 Review

The innovative potential of selenium- containing agents for fighting cancer and viral infections

Journal

DRUG DISCOVERY TODAY
Volume 26, Issue 1, Pages 256-263

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.10.014

Keywords

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Funding

  1. Saarland University's Landesforschungsforderungsprogramm [WT/2e LFFP 16/01]
  2. Erasmus+program
  3. project Epigenetic Hallmarks of Multiple Sclerosis (Epi-MS) of the VALERE 2019 Program [415]
  4. Blueprint [282510]
  5. EPICHEMBIO [CM1406]
  6. EPIGEN-MIUR-CNR
  7. MIUR [POC01_00043]
  8. Polish Statutory Research Program [N42/DBS/000027]
  9. KOHR GmbH
  10. Sapienza Ateneo Project funding scheme
  11. VALERE
  12. [MIUR20152TE5PK]
  13. [AIRC-17217]

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Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Significant advances have been made in understanding the complex biology, chemistry, and drug delivery of selenium, especially when it is included in bioactive molecules. Recent findings in selenium-based applications for cancer and viral infections treatment are summarized and critically discussed.
Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and drug delivery of this element, especially when it is included in bioactive molecules. Here, we summarize and critically discuss recent findings in the field of selenium-based applications for the treatment of cancer and viral infections. Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and drug delivery of this element, especially when it is included in bioactive molecules. Here, we summarize and critically discuss recent findings in the field of selenium-based applications for the treatment of cancer and viral infections.

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