4.7 Article

The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes

Journal

DIABETES OBESITY & METABOLISM
Volume 23, Issue 2, Pages 324-337

Publisher

WILEY
DOI: 10.1111/dom.14219

Keywords

behaviour change; carbohydrate; dietary intervention; exercise intervention; glycaemic control; obesity

Funding

  1. EU framework programme 7 (FP7/2007-2013) grant [312057]
  2. National Health and Medical Research Council - EU Collaborative Grant [AUS 8, 1067711]
  3. NZ Health Research Council [14/191]
  4. University of Auckland Faculty Research Development Fund
  5. Danish Agriculture Food Council
  6. Danish Meat and Research Institute
  7. National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK)
  8. Biotechnology and Biological Sciences Research Council (BBSRC) (UK)
  9. Engineering and Physical Sciences Research Council (EPSRC) (UK)
  10. Academy of Finland [272376, 314383, 266286, 314135]
  11. Finnish Medical Foundation
  12. Gyllenberg Foundation
  13. Novo Nordisk Foundation
  14. Finnish Diabetes Research Foundation
  15. University of Helsinki
  16. Government Research Funds for Helsinki University Hospital (FIN)
  17. Antti Wihuri Foundation (FIN)
  18. Emil Aaltonen Foundation (FIN)
  19. Juho Vainio Foundation (FIN)

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The study aimed to compare the impact of two long-term weight-maintenance diets on the incidence of type 2 diabetes after rapid weight loss. Results showed that the three-year incidence of T2D was lower than predicted and did not differ between the diets, physical activity levels, or their combination. The comprehensive protocol combining weight loss, healthy eating, and physical activity successfully reduced the risk of T2D.
Aim To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) or moderate intensity physical activity (PA), on the incidence of type 2 diabetes (T2D) after rapid weight loss. Materials and Methods A 3-year multicentre randomized trial in eight countries using a 2 x 2 diet-by-PA factorial design was conducted. Eight-week weight reduction was followed by a 3-year randomized weight-maintenance phase. In total, 2326 adults (age 25-70 years, body mass index >= 25 kg/m(2)) with prediabetes were enrolled. The primary endpoint was 3-year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1c and body weight. Results The total number of T2D cases was 62 and the cumulative incidence rate was 3.1%, with no significant differences between the two diets, PA or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Significantly fewer participants achieved normoglycaemia in the HP compared with the MP group (P < .0001). At 3 years, normoglycaemia was lowest in HP-HI (11.9%) compared with the other three groups (20.0%-21.0%, P < .05). There were no group differences in body weight change (-11% after 8-week weight reduction; -5% after 3-year weight maintenance) or in other secondary outcomes. Conclusions Three-year incidence of T2D was much lower than predicted and did not differ between diets, PA or their combination. Maintaining the target intakes of protein and GI over 3 years was difficult, but the overall protocol combining weight loss, healthy eating and PA was successful in markedly reducing the risk of T2D. This is an important clinically relevant outcome.

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