Article
Endocrinology & Metabolism
Yu Jiang, Tong Pang, Rui Shi, Wen-lei Qian, Wei-feng Yan, Yuan Li, Zhi-gang Yang
Summary: The study found that smoking is significantly associated with the presence of noncalcified, obstructive, and more extensive coronary artery plaques in diabetes patients. Furthermore, a longer smoking duration is significantly associated with a higher risk of mixed, obstructive, and more extensive plaques.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yu Jiang, Zhi-Gang Yang, Jin Wang, Rui Shi, Pei-Lun Han, Wen-Lei Qian, Wei-Feng Yan, Yuan Li
Summary: This study used clustering analysis to group T2DM patients and found differences in clinical and coronary plaque characteristics among the groups. This method has the potential to assist in clinical management and stratification of T2DM patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Ophthalmology
Pingting Zhong, Zhixi Li, Yingwen Lin, Qingsheng Peng, Manqing Huang, Lei Jiang, Cong Li, Yu Kuang, Shirong Cui, Danqing Yu, Honghua Yu, Xiaohong Yang
Summary: The study found that SCP and DCP were associated with the presence of CAD in the overall population, while DCP was associated with Gensini scores in CAD patients. Retinal microvasculature was linked to the presence and severity of coronary artery stenosis in CAD patients.
ACTA OPHTHALMOLOGICA
(2022)
Article
Cardiac & Cardiovascular Systems
Yonghui Hu, Zhiyue Yan, Zhenrui Fu, Congqing Pan
Summary: The study indicated that the presence of insomnia in T2DM patients is associated with an increased risk of hypertension and coronary artery disease. Insomnia was identified as a risk factor for HBP and CAD, suggesting that it may play a significant role in cardiovascular diseases among patients with T2DM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Ozlem Ural Fatihoglu, Sefik Gorkem Fatihoglu
Summary: This study found that patients with severe coronary artery disease showed a significant decrease in ganglion cell complex thickness, especially in the superior and inner superior nasal regions, as observed through optical coherence tomography.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Zening Jin, Bo Xu, Xingsheng Yang, Ruofei Jia, Shuai Meng, Hongyu Hu, Yue Deng, Xiaojing Cao, Yang Ruan, Jing Han, Jian Liu, Xinkai Qu, Yujie Zhou, Jian'an Wang, Guosheng Fu, Bo Yu, Yang Wang, Changdong Guan, Lei Song, Shengxian Tu, Shubin Qiao, Gregg W. Stone, FAVOR III China Study Grp
Summary: This study shows that QFR-guided lesion selection strategy improves PCI outcomes and reduces the risk of 1-year MACE in both diabetic and nondiabetic patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Bengi Ece Kurtul, Alparslan Kurtul, Fatih Yalcin
Summary: The study found a relationship between Syntax Score (SS) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients. The results showed that SS values increased gradually with the severity of DR, and both SS and duration of diabetes were independent factors for DR.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Pharmacology & Pharmacy
A. Kirankaya, S. Tugrul, S. Ozcan, O. Ince, E. Donmez, A. Atici, E. Hancioglu, E. Okuyan, I. Sahin
Summary: This study aimed to investigate the relationship between circulating lumican levels and the severity of coronary artery disease (CAD). The results showed that lumican levels were higher in the advanced CAD group and positively correlated with the Gensini score. Diabetes mellitus, EF, and lumican were found to be predictive factors for advanced CAD. Lumican levels can be used to predict the seriousness of CAD with a sensitivity rate of 64% and specificity rate of 65%.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Aldo J. Vazquez Mezquita, Federico Biavati, Volkmar Falk, Hatem Alkadhi, Reza Hajhosseiny, Pal Maurovich-Horvat, Robert Manka, Sebastian Kozerke, Matthias Stuber, Thorsten Derlin, Keith M. Channon, Ivana Isgum, Adriaan Coenen, Bernhard Foellmer, Damini Dey, Rick H. J. A. Volleberg, Felix G. Meinel, Marc R. Dweck, Jan J. Piek, Tim van de Hoef, Ulf Landmesser, Giulio Guagliumi, Andreas A. Giannopoulos, Rene M. Botnar, Ramzi Khamis, Michelle C. Williams, David E. Newby, Marc Dewey
Summary: In this Consensus Statement, clinical consensus recommendations are provided on the optimal use of different imaging techniques in various patient populations to detect and assess coronary artery stenosis and atherosclerosis. The choice of imaging modality plays a crucial role in clinical decision-making and quantification of coronary plaque. CT is recommended for ruling out obstructive stenosis and quantitative assessment of coronary plaque, while MRI can be used as a radiation-free option for non-invasive coronary angiography. PET has potential for quantifying inflammation in coronary plaque, while SPECT has limited role in clinical imaging of coronary artery stenosis and atherosclerosis. Invasive imaging modalities like intravascular ultrasonography and optical coherence tomography are important for identifying high-risk plaques.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shuren Guo, Xiaohuan Mao, Xiaohua Li, Huan Ouyang, Yuhua Gao, Liang Ming
Summary: Serum complement C1q activity is associated with obstructive CAD, higher lipid levels, and has a low value in predicting the occurrence of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Georgios Sofidis, Nikolaos Otountzidis, Nikolaos Stalikas, Efstratios Karagiannidis, Andreas S. Papazoglou, Dimitrios V. Moysidis, Eleftherios Panteris, Olga Deda, Anastasios Kartas, Thomas Zegkos, Paraskevi Daskalaki, Niki Theodoridou, Leandros Stefanopoulos, Haralambos Karvounis, Helen Gika, Georgios Theodoridis, Georgios Sianos
Summary: The study showed a significant positive correlation between the GRACE and SYNTAX scores in ACS patients. The GRACE score moderately predicted the severity of CAD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Y. Elwazir, Mohammad H. Hussein, Eman A. Toraih, Essam Al Ageeli, Safya E. Esmaeel, Manal S. Fawzy, Salwa Faisal
Summary: Variants of angiogenesis-related long non-coding RNAs (lncRNAs) may be associated with the development and severity of coronary artery disease (CAD). MIAT rs1061540 and MALAT1 rs3200401 variants are correlated with the severity of CAD and Gensini scores.
Article
Cardiac & Cardiovascular Systems
Efstratios Karagiannidis, Dimitrios Moysidis, Andreas S. Papazoglou, Eleftherios Panteris, Olga Deda, Nikolaos Stalikas, Georgios Sofidis, Anastasios Kartas, Alexandra Bekiaridou, George Giannakoulas, Helen Gika, George Theodoridis, Georgios Sianos
Summary: Diabetes mellitus (DM) and coronary artery disease (CAD) are interrelated clinical entities. There is a need for novel biomarkers and metabolomics-based prediction models to predict clinical outcomes and assess CAD complexity in the comorbid population of DM and CAD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Nutrition & Dietetics
Hongna Mu, Ruiyue Yang, Siming Wang, Wenduo Zhang, Xinyue Wang, Hongxia Li, Jun Dong, Wenxiang Chen, Xue Yu, Fusui Ji
Summary: This study found that serum BHB levels are associated with traditional risk factors and severity of CAD, with the association being more pronounced in women.
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastian Reith, Andrea Milzi, Rosalia Dettori, Nikolaus Marx, Mathias Burgmaier
CLINICAL RESEARCH IN CARDIOLOGY
(2018)
Article
Multidisciplinary Sciences
Mathias Burgmaier, Andrea Milzi, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx, Sebastian Reith
Article
Cardiac & Cardiovascular Systems
Sebastian Reith, Andrea Milzi, Enrico Domenico Lemma, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx, Mathias Burgmaier
CARDIOVASCULAR DIABETOLOGY
(2019)
Article
Biology
Andrea Milzi, Enrico Domenico Lemma, Rosalia Dettori, Kathrin Burgmaier, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier
Summary: By utilizing finite-element analysis based on OCT-generated plaque models, this study found that ruptured plaques had significantly higher maximal stress within the fibrous cap and vessel wall compared to non-ruptured plaques. Ruptures tended to occur in the vicinity of maximal stress concentrations, and stress concentrations were excellent predictors of plaque rupture, surpassing established vulnerability features like fibrous cap thickness or macrophage infiltration.
Article
Cardiac & Cardiovascular Systems
Andrea Milzi, Rosalia Dettori, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier
Summary: The study found that aQFR can effectively assess the hemodynamic relevance of non-culprit lesions in AMI patients and guide interventions for non-culprit coronary lesions, reducing staged ischemia tests by about 46.8% without a relevant loss in diagnostic efficiency.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Rosalia Dettori, Michael Frick, Kathrin Burgmaier, Richard Karl Lubberich, Martin Hellmich, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier, Andrea Milzi
Summary: QFR can predict the extent and severity of ischemia in non-culprit lesions of patients with myocardial infarction. The ratio of QFR is associated with the ischemic burden of lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Andrea Milzi, Rosalia Dettori, Richard Karl Lubberich, Kathrin Burgmaier, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier
Summary: The study investigated the relationship between anatomic left main stem (LMS) lesion parameters and quantitative flow ratio (QFR) in 53 patients with LMS disease. Results showed that the minimal luminal area of the LMS (LMS-MLA) had a consistent correlation with QFR, which could predict LMS-MLA < 6 mm(2) with very good diagnostic accuracy and LMS-MLA < 4.5 mm(2) with good accuracy. The findings suggest that QFR may be a valuable tool for assessing LMS disease, with further studies needed to validate its effectiveness in patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Andrea Milzi, Rosalia Dettori, Richard Karl Lubberich, Sebastian Reith, Michael Frick, Kathrin Burgmaier, Nikolaus Marx, Mathias Burgmaier
Summary: Myocardial infarction without obstructive coronary artery disease (MINOCA) is a condition characterized by myocardial necrosis without obstruction of major coronary arteries. This study aimed to assess coronary microvascular dysfunction (CMD) in MINOCA patients and explore its association with different subtypes of MINOCA.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Kinan Kneizeh, Andrea Milzi, Felix Vogt, Klaus Witte, Nikolaus Marx, Michael Lehrke, Mohammad Almalla, Joerg Schroeder
Summary: This study aimed to evaluate the effectiveness and safety of low-dose protamine in reducing access site-related complications during Transcatheter Aortic Valve Implantation (TAVI) compared to full-dose protamine. The results showed that patients receiving low-dose protamine had a significantly higher rate of death, life-threatening major bleeding, and major vascular complications compared to those receiving full-dose protamine, indicating that a low-dose protamine regimen may not be as effective in preventing bleeding complications in TAVI patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Rosalia Dettori, Andrea Milzi, Kathrin Burgmaier, Mohammad Almalla, Martin Hellmich, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier
CARDIOVASCULAR DIABETOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Andrea Milzi, Mathias Burgmaier, Kathrin Burgmaier, Martin Hellmich, Nikolaus Marx, Sebastian Reith
CARDIOVASCULAR DIABETOLOGY
(2017)
