Journal
CURRENT BIOLOGY
Volume 30, Issue 21, Pages 4188-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2020.08.031
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Funding
- Netherlands Organization for Scientific Research (NWO
- VICI grant) [865.13.002]
- European Union's Horizon 2020 Framework Programme for Research and Innovation [785907]
- NWO Gravitation program BRAINSCAPES: A Roadmap from Neurogenetics [NWO: 024.004.012]
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A neural pathway from prefrontal cortex (PFC) to dorsal striatum (DS) has been suggested to mediate cognitive control of behavior, including proactive inhibitory control and attention. However, a direct causal demonstration thereof is lacking. Here, we show that selective chemogenetic silencing of corticostriatal PFC neurons in rats increases premature responses. Wireless single-unit electrophysiological recordings of optogenetically identified corticostriatal PFC neurons revealed that the majority of these neurons encode behavioral trial outcome with persistent changes in firing rate. Attentional parameters were not affected by silencing corticostriatal PFC neurons, suggesting that these projection neurons encode a specific subset of cognitive behaviors. Compared to the general non-identified neuronal population in the PFC, frontostriatal neurons showed selective engagement during periods of inhibitory control. Our results demonstrate a role for corticostriatal neurons in inhibitory control and possibly suggest that distinct domains of cognitive control over behavior are encoded by specific projection neuron populations.
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