Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ziwei Li, Songren Han, Guilin Cui, Beilin Xue, Jiaxin Li, Yuhong Man, Huan Zhang, Lesheng Teng
Summary: A folic acid-targeted drug delivery system based on liposomes (FA-LP-GCK) was developed to treat rheumatoid arthritis (RA). The FA-LP-GCK showed high stability, encapsulation efficiency, and demonstrated strong anti-inflammatory and therapeutic effects in both cell and animal experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Beilei Wang, Tengteng Yuan, Liqiong Zha, Yuanxu Liu, Weidong Chen, Caiyun Zhang, Youmei Bao, Qiannian Dong
Summary: The GNA@PDA-FA SA NPs, modified with FA and coated with SA, showed enhanced antitumor effects through improved drug release, increased uptake by tumor cells, and wider distribution in liver, lung, and kidney tissues after oral administration.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Maria Anzengruber, Lisa Marie Nepustil, Fatlinda Kurtaj, Ammar Tahir, Katharina Skoll, Haider Sami, Michael Wirth, Franz Gabor
Summary: In this study, a one-step method was proposed for the preparation of nanoparticles with tailored functionalities. The results showed that the strategy could effectively control the targeting and stealth effects of the nanoparticles, and the initial ratio of the building blocks could easily fine-tune the ligand density and cell association.
Article
Pharmacology & Pharmacy
Susan Sarhadi, Seyedeh Alia Moosavian, Mohammad Mashreghi, Niloufar Rahiman, Shiva Golmohamadzadeh, Mohsen Tafaghodi, Kayvan Sadri, Jamshidkhan Chamani, Mahmoud Reza Jaafari
Summary: This study prepared B12-targeted PEGylated liposomal insulin to improve the stability and absorption of orally administered insulin. The results showed that B12-targeted liposomes were more stable than non-functionalized liposomes in the gastrointestinal environment and exhibited enhanced cellular uptake and insulin accumulation. This suggests that B12-targeted liposomes could be an effective formulation for oral delivery of insulin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Mengran Guo, Zhongshan He, Zhaohui Jin, Lingjing Huang, Jingmei Yuan, Shugang Qin, Xinchun Wang, Lili Cao, Xiangrong Song
Summary: Nanoparticles decorated with folic acid were developed for the oral treatment of atherosclerosis. These nanoparticles effectively targeted lesional macrophages in aortic plaques and significantly reduced aortic lesion, plaque, and necrotic core areas after three months of oral administration. This study provides a promising approach for the treatment of atherosclerosis.
Article
Chemistry, Multidisciplinary
Cheng Lv, Jian Ao, Ji Wang, Man Tang, An-An Liu, Dai-Wen Pang
Summary: A host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers with maintained biofunctions, which can be further multi-functionalized for tumor real-time imaging and therapy. This cell-based strategy facilitates the development and widespread application of bio-nanocarriers in targeted cancer therapy and promotes interdisciplinary studies of nanotechnology, chemistry, and virology.
Review
Nanoscience & Nanotechnology
Flavio F. Contreras-Torres, Daniel Salas-Trevino, Adolfo Soto-Dominguez, Gerardo De Jesus Garcia-Rivas
Summary: This study reviews the advantages and potential challenges of using carbon nanotubes (CNTs) in chemotherapy drug-delivery formulations. The authors focus on tumor-targeted systems prepared with hyaluronic acid and folic acid and discuss their relevance to various chemotherapy drugs. The study provides a comprehensive overview of methodologies for preparing these drug-delivery systems and discusses the opportunities and challenges of using CNTs in chemotherapeutics.
ACS APPLIED NANO MATERIALS
(2022)
Article
Oncology
Nnamdi Nwahara, Garth Abrahams, Earl Prinsloo, Tebello Nyokong
Summary: This study developed a multifunctional liposome that combines different components and functions to achieve specific treatment of tumors, demonstrating superior anti-tumor effects in hypoxic conditions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Materials Science, Biomaterials
Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui
Summary: Pectin-based drug delivery systems have great potential for oral insulin delivery. In this study, we developed folic acid (FA)-modified pectin nanoparticles (INS/DFAN) as insulin delivery vehicles through a dual-crosslinking method. INS/DFAN effectively prevented premature insulin release and enhanced insulin transepithelial transport via the FA carrier-mediated pathway. In vivo studies showed that orally-administered INS/DFAN significantly reduced blood glucose levels and improved insulin bioavailability in type I diabetic rats compared to ionic-crosslinked nanoparticles (INS/FAN). The combination of dual crosslinking and FA modification is an effective strategy for enhanced oral insulin delivery using pectin nano-vehicles.
BIOMATERIALS ADVANCES
(2022)
Review
Biochemistry & Molecular Biology
Shile Wang, Yanyu Chen, Jiancheng Guo, Qinqin Huang
Summary: Liposomes are widely studied nano-drug carriers with prominent properties such as targeted delivery, high biocompatibility, biodegradability, and low toxicity. The molecular diversity of liposome composition, including PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and cell membrane-coated biomimetic nanocarriers, provides unique physiological functions for drug delivery. This review describes liposome composition, types, preparation methods, and discusses their targeting strategies in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Thu Thi Anh Do, Santiago Grijalvo, Toyoko Imae, Maria Jose Garcia-Celma, Carlos Rodriguez-Abreu
Summary: The multifunctional rod-like CNCs-based carriers developed in this study have excellent drug-loading capacity and can be used for targeted drug delivery to tumor cells. They also exhibit fluorescence imaging and photodynamic/photothermal treatment capabilities, with pH-sensitive drug release behavior against cervical cancer cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
M. A. Sanzhakov, V. A. Kudinov, K. K. Baskaev, G. E. Morozevich, D. S. Stepanova, T. I. Torkhovskaya, Yu. A. Tereshkina, E. I. Korotkevich, E. G. Tikhonova
Summary: The study focused on constructing composite phospholipid-gold nanoparticles using soy phosphatidylcholine and a targeted ligand to enhance specific delivery into tumor cells and visualization of malignant neoplasms. In vitro and in vivo experiments demonstrated a significant increase in accumulation of the nanoparticles with a targeted fragment, showing promising potential for early diagnosis and treatment of various types of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Mehdi Afrouz, Amin Amani, Ali Eftekhari, Christophe Coudret, Sabry G. Elias, Zainab Ahmadian, Mohammad Taghi Alebrahim
Summary: The biocompatibility of nanoparticles is crucial for their clinical applications. In this study, different nanoparticles were synthesized for DNA protection and gene delivery to breast cancer cells. The results showed that these nanoparticles exhibited excellent biocompatibility and high gene transfer efficiency, making them promising materials for breast cancer therapy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Dan Liu, Qi Zhang, Jing Wang, Shuang Guan, Defu Cai, Jicheng Liu
Summary: Hyaluronic acid-coated liposomes targeted the delivery of 17-hydroxy-jolkinolide B with increased cytotoxicity and cellular uptake via CD44 receptor-mediated endocytosis. These liposomes suppressed cell migration and invasion, inhibited epithelial-mesenchymal transition, and demonstrated notable growth inhibition on tumor spheroids. In vivo experiments on mice showed strong tumor targeting and suppression abilities, making them a promising therapy for metastatic breast cancer.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Inorganic & Nuclear
M. Roeinfard, M. Zahedifar, M. Darroudi, K. Sadri, A. Khorsand Zak
Summary: The novel radiotracer featuring Graphene quantum dots (GQDs) decorated with selenium (Se) and modified with Polyethylene glycol (PEG), successfully labeled with (99m)Technetium (Tc-99m). In vivo experiments demonstrated the high stability and radioactivity of Tc-99m-GQDs, with prominent distribution in the kidneys, suggesting potential for kidney labeling and rapid clearance from the body within 24 hours.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Nastaran Barati, Fatemeh Mosaffa, Atefeh Razazan, Ali Badiee, Javad Behravan, Amin Reza Nikpoor, Seyed Mousa Motavallihaghi, Mahmoud Reza Jaafari
Summary: The study focuses on developing a nanoliposomal vaccine for HER2-overexpressing breast cancer to evaluate its immunotherapeutic effects. The findings demonstrate that the formulation is capable of eliciting CD8(+) and CD4(+) responses, inducing the synthesis of cytokines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen
Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.
Article
Cell Biology
Elham Karimi, Hanieh Azari, Ahmad Tahmasebi, Amin Reza Nikpoor, Ahmad Agha Negahi, Nima Sanadgol, Mohammad Shekari, Pegah Mousavi
Summary: This study analyzed the lncRNA-miRNA network involved in multiple sclerosis (MS) and its role in the differentiation of Th17 cells. The results showed dysregulated expression of key genes related to the pathogenesis of MS.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Parvin Zamani, Mohammad Mashreghi, Mahere Rezazade Bazaz, Farshad Mirzavi, Mehdi Barati, Fatemeh Zahedipour, Mahmoud Reza Jaafari
Summary: The study showed that a liposomal-based peptide vaccine containing AE36, PADRE, and MPL could induce significant immune responses and potential prophylactic vaccine candidacy in a mouse model of breast cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seyed Ali Nazeri, Seyed Mahdi Rezayat, Amir Amani, Jamshid Hadjati, Alireza Partoazar, Parvin Zamani, Mohammad Mashreghi, Mahmoud Reza Jaafari
Summary: In this study, liposomal formulations of both PEGylated and non-PEGylated Cyclosporine A (CsA) were prepared using a remote loading procedure to improve the tissue distribution and therapeutic efficacy of CsA. The liposomes demonstrated physicochemical stability, high drug encapsulation efficacy, and improved immunosuppressive efficiency in vitro and in vivo. They also extended the drug half-life and improved tissue distribution in animal studies. Additionally, the liposomes reduced delayed-type hypersensitivity reaction and delayed skin allograft rejection compared to CsA. Further research is required to translate this formulation into clinical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Shirin Beyranvand, Parivash Davoodian, Hesam Alizade, Hamed Gouklani, Azim Nejatizadeh, Ebrahim Eftekhar, Amin Reza Nikpoor
Summary: This study aimed to evaluate the frequency and inheritance of ACE1 I/D and ACE2 rs2285666 polymorphisms in COVID-19 patients and their impact on disease severity and cytokine levels. The results showed no significant association between ACE2 rs2285666 polymorphism genotypes and ACE1 I/D with the severity of lung involvement. However, there was a significant association between ACE1 I/D polymorphism genotypes and IL-6, WBC, and NLR levels.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Maryam Iman, Seyedeh Alia Moosavian, Parvin Zamani, Mahmoud Reza Jaafari
Summary: Active targeting of the tumor microenvironment using nucleolin-targeted PEGylated liposomal doxorubicin (AS-PLD) has shown higher therapeutic efficacy compared to traditional liposomal doxorubicin (PLD). In vitro studies demonstrated that AS-PLD exhibited increased cytotoxicity and cellular uptake in cancer cells. Additionally, competition assays confirmed the specificity of AS-PLD in targeting tumor cells. Furthermore, in vivo analysis showed higher accumulation of AS-PLD in the tumor after 72 hours post-injection, indicating its potential as an active-targeted formulation for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Hamed Hamedinasab, Ali Hossein Rezayan, Mahmoud Reza Jaafari, Mohammad Mashreghi, Hale Alvandi
Summary: N-acetylcysteine (NAC) is found to have a protective effect against liposome and chitosan-induced cell toxicity, reducing the cytotoxicity of liposome and chitosan on the A549 cell line.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Oncology
Fatemeh Zahedipour, Parvin Zamani, Mohammad Mashreghi, Mojgan Astaneh, Mojtaba Sankian, Atefeh Amiri, Khadijeh Jamialahmadi, Mahmoud Reza Jaafari
Summary: This study aimed to enhance the efficiency of peptide vaccines by using nanoliposomes. VEGFR-2-derived peptides were encapsulated in nanoliposomal formulations and injected into mice with melanoma tumors. The results showed that the nanoliposomal formulation effectively triggered immune responses, inhibited tumor growth, and improved survival rates.
CANCER NANOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Gheybi, Alireza Khooei, Azam Hoseinian, Maham Doagooyan, Kebria Houshangi, Mahmoud Reza Jaafari, Arash Papi, Zahra Khoddamipour, Amirhossein Sahebkar, Seyedeh Hoda Alavizadeh
Summary: This study aimed to use SLB nanoliposomes to combat acetaminophen-induced acute liver toxicity. Results demonstrated that SLB nanoliposomes had significant hepatoprotective effects depending on the route of administration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Maryam Kouhjani, Mahmoud Reza Jaafari, Hossein Kamali, Amirhossein Abbasi, Mohsen Tafaghodi, Seyed Ali Mousavi Shaegh
Summary: Poly lactic-co-glycolic acid (PLGA) is a suitable polymer for delivering small and macromolecule drugs. In this research, a microfluidic mixer was used to produce insulin-loaded PLGA nanoparticles (NPs) with tunable properties. The microfluidic method allowed for the production of NPs with smaller size and narrower size distribution compared to the conventional method. Additionally, the encapsulation efficiency and loading capacity of the NPs produced through the microfluidic method were significantly higher. The NPs prepared by the microfluidic method showed enhanced reduction of trans-epithelial electrical resistance values and greater paracellular permeation compared to those prepared by the conventional method.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Medicine, Research & Experimental
Pouria Rahmanian-Devin, Vahid Reza Askari, Zahra Sanei-Far, Vafa Baradaran Rahimi, Hossein Kamali, Mahmoud Reza Jaafari, Shiva Golmohammadzadeh
Summary: This study developed solid lipid nanoparticles (SLN) encapsulated noscapine (NOS) for the treatment of psoriasis. The SLN-NOS 1% formulation showed good stability, controlled release, and demonstrated significant improvements in clinical parameters and inflammatory levels.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Amin Mehrabian, Roghayyeh Vakili-Ghartavol, Mohammad Mashreghi, Sara Shokooh Saremi, Ali Badiee, Leila Arabi, Hoda Alavizadeh, Seyedeh Alia Moosavian, Mahmoud Reza Jaafari
Summary: This study developed PEGylated nanoliposomal Doxorubicin particles covalently attached to glutathione using the post-insertion technique. Compared with the pre-insertion method, the post-insertion approach was found to be simpler, faster, and more cost-effective, making it suitable for large-scale production. The results showed that nanocarriers with 40 times fewer GSH micelles significantly enhanced blood-brain barrier penetrance.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zohreh Firouzi, Mahmoud Reza Jaafari, Mojtaba Sankian, Sirwan Zare, Mohsen Tafaghodi
Summary: This study prepared a self-assembled nanomicelle as a potential vaccine candidate against tuberculosis. The nanomicelle was able to induce immune cell maturation and elicit both systemic and mucosal immune responses. The results suggest that the nanomicelle holds promise in boosting the efficacy of the BCG vaccine.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
