Journal
CLINICAL NEUROPHYSIOLOGY
Volume 131, Issue 12, Pages 2841-2850Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2020.09.013
Keywords
Parkinson's disease; Dopamine; Event-related potentials; Novelty; Cognition
Categories
Funding
- German National Academic Foundation
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Objective: Parkinson's Disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Cognitive impairments have been reported using the event-related potential (ERP) technique. Patients show reduced novelty P3 (nP3) amplitudes in oddball experiments, a response to infrequent, surprising stimuli, linked to the orienting response of the brain. The nP3 is thought to depend on dopaminergic neuronal pathways though the effect of dopaminergic medication in PD has not yet been investigated. Methods: Twenty-two patients with PD were examined on and off their regular dopaminergic medication in a novelty 3-stimulus-oddball task. Thirty-four healthy controls were also examined over two sessions, but received no medication. P3 amplitudes were compared throughout experimental conditions. Results: All participants showed sizeable novelty difference ERP effects, i.e. ndP3 amplitudes, during both testing sessions. An interaction of diagnosis, medication and testing order was also found, indicating that dopaminergic medication modulated n(d)P3 in patients with PD across the two testing sessions: We observed enhanced n(d)P3 amplitudes from PD patients who were off medication on the second testing session. Conclusion: Patients with PD 'off' medication showed ERP evidence for repetition-related enhancement of novelty responses. Dopamine depletion in neuronal pathways that are affected by mid-stage PD possibly accounts for this modulation of novelty processing. Significance: The data in this study potentially suggest that repetition effects on novelty processing in patients with PD are enhanced by dopaminergic depletion. (c) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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