Journal
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Volume 21, Issue 1, Pages 21-34Publisher
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clml.2020.08.027
Keywords
BCMA targets; Cytokine release syndrome; Refractory; Relapsed; Treatment
Categories
Funding
- NCI [R01-CA201634]
- Heinemann Foundation of Charlotte grant
- Leukemia Lymphoma Society Scholar in Clinical Research grant
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CAR-T cell therapy shows promise in treating multiple myeloma, but challenges remain in identifying target antigens and optimizing CAR constructs.
Relapsed/refractory multiple myeloma (MM) remains a significant clinical challenge, despite a wide array of approved therapeutic agents. Immunotherapy offers an advantage in this setting. Chimeric antigen receptor (CAR) modified T-cells have transformed care for patients with hematologic malignancies. CAR-T cells targeting CD-19 B-cell lymphoma cells have shown prominent activity in lymphoma and acute lymphoblastic leukemia. Recently, the CAR-T cell platform for MM demonstrated therapeutic benefit. Hence, it is rapidly progressing. The most commonly tested target for MM is the B-cell maturation antigen. Complexities involved in the generation and use of CAR-T cells for MM include the identification of appropriate target antigens that are specific, and tumor type restricted, in addition to the optimization of CAR constructs to mitigate toxicities including cytokine release syndrome. CAR-T cells hold immense promise as a therapeutic modality for the treatment of MM. In this article, we provide an updated review of clinical trials of MM-specific CAR-T cells. (C) 2020 Elsevier Inc. All rights reserved.
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