Review
Materials Science, Multidisciplinary
Ricard Aceves-Argemi, Elisabet Roca-Millan, Beatriz Gonzalez-Navarro, Antonio Mari-Roig, Eugenio Velasco-Ortega, Jose Lopez-Lopez
Summary: This systematic review analyzed the use of titanium meshes in bone regeneration, showing an average bone gain of 4.3 mm, high survival and success rates of implants, but a significant risk of mesh exposure.
Article
Dentistry, Oral Surgery & Medicine
Nada Zazou, Noha Diab, Samah Bahaa, Azza Ezz el Arab, Omniya Abdel Aziz, Hani el Nahass
Summary: This study compared the flap advancement and postoperative complications of DF, CALF, MPRI, and PRI in augmentation using titanium mesh. The CALF group showed the highest flap advancement and least complications, while the PRI group reported the highest complications. The MPRI group had the highest pain score and exposure mean.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Chemistry, Physical
Anna Bertran Faus, Jose Cordero Bayo, Eugenio Velasco-Ortega, Aina Torrejon-Moya, Francesca Fernandez-Velilla, Fernando Garcia, Jose Lopez-Lopez
Summary: This paper presents a case report on the use of customized titanium mesh for posterior vertical bone regeneration, demonstrating that this technique is feasible and predictable.
Article
Chemistry, Physical
Ayaka Takahashi, Kazuya Inoue, Naoko Imagawa-Fujimura, Keisuke Matsumoto, Kazuto Yamada, Yasuhisa Sawai, Yoichiro Nakajima, Takamitsu Mano, Nahoko Kato-Kogoe, Takaaki Ueno
Summary: This study investigates the application of additive manufacturing techniques in dental implant bone augmentation, using selective laser melting titanium mesh plates. Through surgical simulation on 14 patients, it was found that the SLM titanium mesh plate showed good adaptation with bone occupancy greater than 90%. The technique was considered useful in achieving successful bone augmentation.
Article
Chemistry, Physical
Lucio Milillo, Fabrizio Cinone, Federico Lo Presti, Dorina Lauritano, Massimo Petruzzi
Summary: In Guided Bone Regeneration (GBR), materials such as titanium foil play a crucial role in protecting blood clots, inducing bone healing, and achieving the desired results. The combination of blood clots and titanium foil barriers in different clinical settings is essential for successful outcomes in GBR procedures. The clot itself serves as a natural scaffold for ideal bone quality, while the titanium foil acts as a biocompatible and mechanically strong barrier.
Article
Materials Science, Biomaterials
Akihiro Furuhashi, Yunia Dwi Rakhmatia, Yasunori Ayukawa, Kiyoshi Koyano
Summary: The aim of this study was to investigate the use of titanium membranes incorporated in poly (lactic-co-glycolic acid) (PLGA) for guided bone regeneration. The study found that the titanium membranes significantly affected the mechanical and chemical properties, with higher release of fluvastatin in the PLGA-FS group. Micro-CT, morphometrical analysis, and histological observations showed that the TM-PLGA-FS group significantly enhanced bone formation.
REGENERATIVE BIOMATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marc Quirynen, Pierre Lahoud, Wim Teughels, Simone Cortellini, Rutger Dhondt, Reinhilde Jacobs, Andy Temmerman
Summary: Alveolar ridge resorption is a common complication after tooth extraction, requiring lateral bone augmentation. This study investigated the hypothesis that individual phenotypic dimensions may play a role in the degree of resorption.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Dan Chen, Lingling Zheng, Chao Wang, Yuanding Huang, Haitao Huang, Antonio Apicella, Guiping Hu, Lizhen Wang, Yubo Fan
Summary: The aim of this study was to evaluate the accuracy of the surgical placement of customized meshes. The results showed a certain deviation between the planned surgical placement and actual one of the mesh, with average differences of 2.69 +/- 0.70 mm and -1.41 +/- 0.90 mm in the positive and negative directions respectively, and mean difference values of the screws on the X and Y axes were 0.74 +/- 0.85 mm and 0.89 +/- 0.84 mm. However, when using a screws-position-guided template, the results were 2.38 +/- 0.69 mm and -1.30 +/- 1.13 mm, with mean difference values of the screws being 0.76 +/- 0.84 mm and 0.94 +/- 0.72 mm. There was no statistical difference between the two groups.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Engineering, Environmental
Chuchu Xu, Fanghui Wu, Jun Yang, Hui Wang, Jimin Jiang, Zhaonan Bao, Xianyan Yang, Guojing Yang, Zhongru Gou, Fuming He
Summary: This study prepared wollastonite bioceramic scaffolds with different morphologies via digital light processing, with the scaffold containing 16% CSi showing satisfactory mechanical properties and promoting the proliferation and differentiation of osteogenic stem cells. The macroporous bioceramic domes exhibited higher osteostimulate activity than metal mesh, showing potential as promising candidates to replace titanium mesh in guided bone regeneration.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Chuchu Xu, Fanghui Wu, Jun Yang, Hui Wang, Jimin Jiang, Zhaonan Bao, Xianyan Yang, Guojing Yang, Zhongru Gou, Fuming He
Summary: This study suggests that utilizing bioactive ceramics scaffolds instead of metal mesh for GBR treatment can better promote bone regeneration. The scaffold with 16% CSi content exhibits good mechanical properties and osteogenic stem cell promotion.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Songhang Li, Yuxuan Zhao, Taoran Tian, Tianxu Zhang, Yu Xie, Xiaoxiao Cai
Summary: The use of resorbable sutures for fixing a titanium mesh can achieve similar results to traditional fixation using titanium screws. Although this new fixation method can improve the efficiency of the surgery and reduce the risk of complications, the long-term clinical effects require further follow-up investigation.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yun Kee Jo, Bong-Hyuk Choi, Cong Zhou, Sang Ho Jun, Hyung Joon Cha
Summary: Titanium mesh for guided bone regeneration (GBR) has been widely used due to its mechanical properties and biocompatibility. However, soft tissue invasion and limited bioactivity often affect the outcomes of GBR treatments. In this study, a cell recognitive osteogenic barrier coating using a bioengineered mussel adhesive protein fused with Alg-Gly-Asp peptide was developed. The coating showed excellent performance in promoting bone regeneration in vitro and in vivo, making it a promising therapeutic platform for GBR treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Helene M. Arnal, Charles D. Angioni, Frederick Gaultier, Renaud Urbinelli, Istvan A. Urban
Summary: This study compared the effectiveness of a conventional guided bone regeneration (GBR) technique with a recently-reported technique on knife-edge ridges. The results showed that the new technique resulted in significantly more horizontal bone gain and stable bone loss during the healing process, regardless of the amount of grafted material.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Amely Hartmann, Helmut Hildebrandt, Zina Younan, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: This study evaluated implant survival in customized bone regeneration using patient-specific titanium mesh, finding that periodontitis plays a major role in long-term stability.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Claudia Dellavia, Elena Canciani, Gaia Pellegrini, Grazia Tommasato, Daniele Graziano, Matteo Chiapasco
Summary: This study demonstrated the successful use of customized CAD/CAM titanium mesh in combination with autologous bone chips and deproteinized bovine bone for alveolar bone regeneration. Histological analysis showed highly mineralized, well-structured newly formed tissue consisting of new lamellar bone, woven bone, osteoid matrix, and other components.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yuting Wen, Mei Zhang, Yangxue Yao, Yang Gao, Xiaolin Zhang, Yunfeng Lin, Xiaoxiao Cai
Summary: The hyperplasia and destruction of synovial tissue have a significant impact on the development of rheumatoid arthritis. Targeting anomalous synovial fibroblast and designing a high bioavailability nano drug delivery system can reduce the dosage for the treatment of rheumatoid arthritis and improve curative effect. The experiment established a nobiletin-loaded tetrahedral framework nucleic acids cargo tank which effectively alleviated the disease development of rheumatoid arthritis by reducing the invasiveness of pathological synovial fibroblast.
CHINESE CHEMICAL LETTERS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Songhang Li, Yuxuan Zhao, Taoran Tian, Tianxu Zhang, Yu Xie, Xiaoxiao Cai
Summary: The use of resorbable sutures for fixing a titanium mesh can achieve similar results to traditional fixation using titanium screws. Although this new fixation method can improve the efficiency of the surgery and reduce the risk of complications, the long-term clinical effects require further follow-up investigation.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Cell Biology
Xueping Xie, Wenjuan Ma, Guo Li, Yuxi Zhan, Li Quan, Xiaoxiao Cai
Summary: In this study, the role of tFNAs in irradiation-induced salivary gland damage was investigated. The results showed that tFNAs could promote cell proliferation, inhibit cell apoptosis, and reduce cell death caused by irradiation. Mechanism studies revealed that tFNAs inhibited cell apoptosis by regulating the Bcl-2/Bax/Caspase-3 signaling pathway and reducing inflammation-induced cell damage. Animal experiments showed that tFNAs could alleviate weight loss, increased water intake, decreased saliva production, and prolonged salivation lag time caused by irradiation, and improve salivary gland damage.
CELL PROLIFERATION
(2023)
Article
Biochemical Research Methods
Taoran Tian, Tao Zhang, Sirong Shi, Yang Gao, Xiaoxiao Cai, Yunfeng Lin
Summary: An active targeting strategy-enabled DNA tetrahedron delivery vehicle has been developed for stable drug encapsulation and stimuli-responsive on-demand release, providing a universal platform for various drug delivery requirements.
Article
Cell Biology
Yanan Lin, Yueying Jiang, Haiyu Xian, Xiaoxiao Cai, Tao Wang
Summary: In this research, the expression of the Pi3k/Akt pathway and VEGF in OSF were investigated, and their correlation was explored. It was found that the expression of Col-I increased as OSF progressed, but was downregulated in normal and moderate to advanced OSF tissues. VEGF expression correlated positively with Pi3k and Akt expression, and targeted regulation of the Pi3k/Akt pathway can induce VEGF expression and improve ischemia, ultimately treating OSF.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Nanxin Liu, Yuke Zhong, Xiaoxiao Pang, Mingzheng Li, Richard D. Cannon, Li Mei, Xiaoxiao Cai, Ping Ji
Summary: Macrophages' activation plays a crucial role in inflammation, and recent studies have identified metabolic reprogramming as a potential strategy for anti-inflammatory therapies. This study explored the anti-inflammatory effects of tetrahedral framework nucleic acid (tFNA) and discovered that it inhibits macrophage activation by reducing choline uptake. Inspired by this finding, a new tFNA-based nanomedicine called 'nano-windmill' was developed, which effectively targets slc44a1 to enhance the anti-inflammatory effects of tFNA on macrophage activation. The success of this tFNA-based nanomedicine in chronic and acute inflammatory diseases indicates its promising potential in various biological applications.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Jiajun He, Wen Chen, Xingyu Chen, Yu Xie, Yuxuan Zhao, Taoran Tian, Bin Guo, Xiaoxiao Cai
Summary: In this study, a novel compound drug system using tetrahedral framework nucleic acid (tFNA) as the carrier was developed to deliver glabridin (Gla) through the skin for the treatment of hyperpigmentation. The results demonstrated the successful treatment of hyperpigmentation using this system, which also showed efficacy in treating epidermal and superficial dermal diseases.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Xingyu Chen, Jiajun He, Yu Xie, Tianxu Zhang, Songhang Li, Yuxuan Zhao, Nan Hu, Xiaoxiao Cai
Summary: Sepsis, a deadly condition caused by immune response dysregulation, remains the leading cause of death in severely ill patients with no effective treatment available. This study investigates the role of tetrahedral framework nucleic acids (tFNAs), a novel DNA nanomaterial, in reducing organ inflammatory damage in septic mice by inhibiting pyroptosis. The results suggest tFNAs as a potential new strategy for sepsis treatment.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Yuxuan Zhao, Songhang Li, Maogeng Feng, Mei Zhang, Zhiqiang Liu, Yangxue Yao, Tianxu Zhang, Yueying Jiang, Yunfeng Lin, Xiaoxiao Cai
Summary: Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease that causes severe pain and poor quality of life. Puerarin (Pue), a natural isoflavone glycoside, shows potential in treating ONFH by promoting osteogenesis and inhibiting apoptosis of bone mesenchymal stem cells (BMSCs). However, the limitations of Pue, such as low solubility, fast degradation, and inadequate bioavailability, hinder its clinical application. In this study, tetrahedral framework nucleic acids (tFNAs) are used as carriers for Pue, resulting in a tFNA/Pue complex (TPC) that exhibits enhanced stability, biocompatibility, and tissue utilization. In vitro and in vivo models are established to investigate the effects of TPC on osteogenesis and apoptosis of BMSCs under glucocorticoid-induced conditions. The findings demonstrate that TPC can restore osteogenesis dysfunction and attenuate BMSC apoptosis through hedgehog and Akt/Bcl-2 pathways, offering a promising treatment for GC-induced ONFH.
Article
Chemistry, Multidisciplinary
Yangxue Yao, Xiaoyu Lei, Yun Wang, Geru Zhang, Hongxiao Huang, Yuxuan Zhao, Sirong Shi, Yang Gao, Xiaoxiao Cai, Shaojingya Gao, Yunfeng Lin
Summary: Diabetic peripheral neuropathy (DPN) is a major late complication of diabetes, and dysfunctional mitochondria are the key therapeutic target. In this study, a tetrahedral framework nucleic acid carrier was used to encapsulate resveratrol, resulting in enhanced stability and bioavailability. The tFNAs-RSV complex showed promising therapeutic effects in vitro and in mice models of DPN by regulating redox and energy metabolism.
Article
Chemistry, Multidisciplinary
Yu Xie, Jiajun He, Songhang Li, Xingyu Chen, Tianxu Zhang, Yuxuan Zhao, Yunfeng Lin, Xiaoxiao Cai
Summary: A transdermal drug delivery system, composed of tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA), is developed for the topical treatment of skin photodamage. The tFNAs-LA (TLA) nanocomposite exhibits excellent biocompatibility and various therapeutic effects. In both in vitro and in vivo experiments, TLA promotes tissue healing, inhibits apoptosis activation and reactive oxygen species production, and regulates inflammatory responses.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yang Gao, Shaojingya Gao, Yangxue Yao, Xiaoxiao Cai
Summary: This study evaluated the radiographic stability of bone substitute augmented outside the buccal bony arch contour in the maxillary esthetic zone. The results showed that the overaugmented bone tended to remodel into the original contour, highlighting the importance of careful observation of the anterior bone arch contour for determining implant position and bone augmentation width.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shaojingya Gao, Yao Jiang, Yangxue Yao, Songhang Li, Xiaoxiao Cai
Summary: This study aimed to introduce a minimally invasive technique for maxillary sinus floor elevation using the lateral approach (lSFE) and determine factors influencing stability of grafted area in sinus cavity. Thirty patients (30 implants) treated with lSFE using minimally invasive techniques from 2015 to 2019 were included. CBCT was used to measure bone heights (BHs) of implants before surgery, immediately after surgery (T0), 6 months after surgery (T1), and at last follow-up visit (T2). No implant failed during the 3.67±1.75 years of follow-up. Three implants exhibited perforations. BH changes showed strong correlations with each other and decreased before second-stage surgery. RBH did not significantly influence BH changes, while smoking status and type of bone graft materials were potentially influential factors. In conclusion, lSFE using minimally invasive techniques was a viable treatment option with high implant survival rate and limited bone resorption in grafted area.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Geru Zhang, Liwei Huang, Maogeng Feng, Tianxu Zhang, Yang Gao, Yangxue Yao, Songhang Li, Xiaobing Li, Yunfeng Lin
Summary: Radiation-induced oral mucositis (RIOM) is a significant public health problem affecting patients who have received radiotherapy, but there is limited research on preventing and treating RIOM. This study developed a tetrahedral framework nucleic acid drug delivery system (TFNAS) to effectively deliver Curcumin (Cur-TFNAS). Results showed that Cur-TFNAS enhanced antioxidant capacity and reduced DNA damage in oral mucosal cells, indicating its potential as a nano-shield against radiation-induced oral mucositis.