Article
Oncology
Ying Gong, Roel G. J. Klein Wolterink, Valeriia Gulaia, Silvie Cloosen, Femke A. I. Ehlers, Lotte Wieten, Yvo F. Graus, Gerard M. J. Bos, Wilfred T. V. Germeraad
Summary: The study describes a novel fully humanized anti-MUC1 antibody, which, especially after defucosylation, is a promising therapeutic candidate for cellular immunotherapy.
Article
Oncology
Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P. Basilion
Summary: Researchers have developed a new PSMA-targeting drug conjugate with potent and selective antitumor activity, showing potential to impact therapeutic management of lethal prostate cancers.
Article
Multidisciplinary Sciences
Sung Chang Lee, Jennifer S. Y. Ma, Min Soo Kim, Eduardo Laborda, Sei-Hyun Choi, Eric N. Hampton, Hwayoung Yun, Vanessa Nunez, Michelle T. Muldong, Christina N. Wu, Wenxue Ma, Anna A. Kulidjian, Christopher J. Kane, Vadim Klyushnichenko, Ashley K. Woods, Sean B. Joseph, Mike Petrassi, John Wisler, Jing Li, Christina A. M. Jamieson, Peter G. Schultz, Chan Hyuk Kim, Travis S. Young
Summary: The study introduced a unique semisynthetic bispecific antibody, CCW702, which showed specific and potent in vitro cytotoxicity, good tolerability and subcutaneous bioavailability in mice and cynomolgus monkeys, supporting a weekly dosing regimen testing in patients.
Article
Biochemistry & Molecular Biology
Aleksei E. E. Machulkin, Ekaterina A. A. Nimenko, Nikolay U. U. Zyk, Anastasiia A. A. Uspenskaia, Galina B. B. Smirnova, Irina I. I. Khan, Vadim S. S. Pokrovsky, Alexander N. N. Vaneev, Roman V. V. Timoshenko, Vugara V. V. Mamed-Nabizade, Maria V. V. Zavertkina, Alexander Erofeev, Petr Gorelkin, Alexander G. G. Majouga, Nikolay V. V. Zyk, Elena S. S. Khazanova, Elena K. K. Beloglazkina
Summary: In this study, a novel small-molecule PSMA-targeted conjugate PSMA-Abi was synthesized, which showed a preferential effect on prostate tumor cells with minimal side effects.
Article
Chemistry, Medicinal
Han Lin, Kun Zhou, Dan Li, Haofei Hong, Yuntian Xie, Liang Gong, Yu Shen, Zhifang Zhou, Jie Shi, Zhimeng Wu
Summary: Multivalent antibody-recruiting glycopolymers (MARGs) made of hyaluronic acid (HA) grafted with multiple dinitrophenol (DNP) groups have shown promising potential for targeted cancer immunotherapy. These MARGs can specifically recognize CD44-positive cancer cells and exhibit strong antibody-recruiting and tumor cell killing activities. One specific MARG, HA-[PEG(3)-DNP](8), demonstrated the best capacity for clustering antibodies and inhibiting xenograft tumor growth in animal models without causing detectable histological cytotoxicity. Given their easy access and practical synthesis approach, MARGs offer a promising avenue for cancer immunotherapy.
Article
Chemistry, Analytical
Yanbo Wang, Mingyang Wang, Haipeng Yu, Ge Wang, Pengxin Ma, Shuang Pang, Yiming Jiao, Aihua Liu
Summary: PSA is an important index for prostate cancer diagnosis and treatment. In this study, a biopanning method for PSA was established using a pIII phage display library. Two phage monoclonal antibodies specific to PSA were obtained, and an ELISA system was constructed for detecting tPSA with high accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Hersa Milawati, Yoshiyuki Manabe, Takuya Matsumoto, Masato Tsutsui, Yoshihiro Ueda, Ayane Miura, Kazuya Kabayama, Koichi Fukase
Summary: We propose a new glycan display approach using metabolic labeling and a glycan-caging strategy as an easy editing method for cell-surface glycans. This method allows the introduction of antigen glycans onto cancer cells to induce immune responses via antibody recruiting. The caging strategy prevents the capture of alpha-rhamnose (an antigen glycan) by endogenous antibodies during glycan introduction, and subsequent uncaging successfully induces immune responses. Therefore, this study presents a practical method for editing cell-surface glycocalyx under promiscuous conditions, paving the way for glycan function analysis and regulation development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Oncology
Michael Sun, Muhammad Junaid Niaz, Muhammad Obaid Niaz, Scott T. Tagawa
Summary: PSMA-targeted radionuclide therapy (TRT) is a promising investigational treatment for metastatic castration-resistant prostate cancer (mCRPC), with early studies of 177Lu-J591 and 177Lu-PSMA-617 showing favorable results. This therapy is emerging as a hopeful treatment for mCRPC.
CURRENT ONCOLOGY REPORTS
(2021)
Review
Urology & Nephrology
Jones T. Nauseef, Neil H. Bander, Scott T. Tagawa
Summary: PSMA is a clinically validated target for prostate cancer, with therapies using radioactive particles, drugs, or immune agents for treatment.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Multidisciplinary Sciences
Jeremy S. Frieling, Leticia Tordesillas, Xiomar E. Bustos, Maria Cecilia Ramello, Ryan T. Bishop, Junior E. Cianne, Sebastian A. Snedal, Tao Li, Chen Hao Lo, Janis de la Iglesia, Emiliano Roselli, Ismahene Benzaid, Xuefeng Wang, Youngchul Kim, Conor C. Lynch, Daniel Abate-Daga
Summary: We propose a combinatorial strategy using gamma 6-enriched chimeric antigen receptor (CAR) T cells and zoledronate (ZOL) for the treatment of bone metastatic castrate-resistant prostate cancer (mCRPC). In a preclinical murine model, gamma 6 CAR-T cells targeting prostate stem cell antigen (PSCA) showed significant tumor regression, increased survival, and reduced cancer-associated bone disease. Pretreatment with ZOL enhanced the activation and antitumor efficacy of gamma 6 CAR-T cells. Our findings suggest the potential use of gamma 6 CAR-T cell therapy for mCRPC treatment.
Article
Chemistry, Multidisciplinary
Chong Ou, Sunaina Kiran Prabhu, Xiao Zhang, Guanghui Zong, Qiang Yang, Lai-Xi Wang
Summary: Monoclonal antibodies are rapidly growing in use for cancer, infectious, and autoimmune disease treatment. A chemoenzymatic synthesis method was developed to create structurally well-defined conjugates of antibodies with rhamnose and alpha Gal trisaccharide clusters, enhancing targeted cell killing through CDC. These antibody-rhamnose cluster conjugates showed potent CDC activity for cancer cell killing compared to the antibody-alpha Gal trisaccharide cluster conjugates.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Yun Lee, Yong-il Kim
Summary: This study conducted a meta-analysis on the therapeutic effects of Ac-225-PSMA RLT in patients with mCRPC. The results showed that around 61% of patients had more than a 50% PSA decline and 84% of patients had any PSA decline. The common adverse events in Ac-225-PSMA RLT were xerostomia and severe hematotoxicity.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Pei-Yun Pan, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Teng-Kuang Yeh, Tsu-An Hsu, Chiung-Tong Chen, Li-Rung Huang, Lun Kelvin Tsou
Summary: This study presents a novel small molecule drug conjugate targeting immune checkpoints, which has shown significant efficacy in treating multiple types of cancer. The conjugate not only induces lasting regression of tumor growth, but also alters the tumor microenvironment and elevates specific gene expressions that were previously inaccessible with conventional treatments.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Pei-Yun Pan, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Teng-Kuang Yeh, Tsu-An Hsu, Chiung-Tong Chen, Li-Rung Huang, Lun Kelvin Tsou
Summary: This study reports a small molecule-based immune checkpoint-targeting drug delivery system, which shows great potential for cancer treatment. The system not only inhibits tumor growth effectively, but also improves the immunosuppressive tumor microenvironment, leading to enhanced therapeutic efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Indra Gandi Subramani, R. M. Ayub, Subash C. B. Gopinath, Veeradasan Perumal, M. F. M. Fathil, M. K. Md Arshad
Summary: The research introduces a novel approach using a lectin-based capacitive non-faradaic biosensor for detecting PSMA, a promising diagnostic marker for prostate cancer. The study demonstrates the potential of using PSMA expression to differentiate malignant hyperplasia from other benign prostatic diseases. By utilizing gold nanoparticles as signal amplifiers, the study successfully modified the aluminium interdigitated electrode to efficiently sense PSMA, showing a simple fabrication and quantification method for PSMA.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Multidisciplinary
Hikari Sato, Yoshiki Miyashita, Koichi Sasaki, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
Article
Biochemistry & Molecular Biology
Koichi Sasaki, Yoshiki Miyashita, Daisuke Asai, Daiki Funamoto, Kazuki Sato, Yoko Yamaguchi, Yuji Mishima, Tadafumi Iino, Shigeo Takaishi, Jun Nagano, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
Article
Multidisciplinary Sciences
Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Koichi Sasaki, Michael J. V. White, Priscilla S. Briquez, Jeffrey A. Hubbell
NATURE COMMUNICATIONS
(2018)
Article
Hematology
Jun Ishihara, Ako Ishihara, Richard D. Starke, Claire R. Peghaire, Koval E. Smith, Thomas A. J. McKinnon, Yoji Tabata, Koichi Sasaki, Michael J. V. White, Kazuto Fukunaga, Mike A. Laffan, Matthias P. Lutolf, Anna M. Randi, Jeffrey A. Hubbell
Article
Cell Biology
Jun Ishihara, Ako Ishihara, Koichi Sasaki, Steve Seung-Young Lee, John-Michael Williford, Mariko Yasui, Hiroyuki Abe, Lambert Potin, Peyman Hosseinchi, Kazuto Fukunaga, Michal M. Raczy, Laura T. Gray, Aslan Mansurov, Kiyomitsu Katsumata, Masashi Fukayama, Stephen J. Kron, Melody A. Swartz, Jeffrey A. Hubbell
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Koichi Sasaki, Jun Ishihara, Ako Ishihara, Risako Miura, Aslan Mansurov, Kazuto Fukunaga, Jeffrey A. Hubbell
Article
Pharmacology & Pharmacy
Takuma Yoshikawa, Khanh Quoc Phan, Hiroshi Tagawa, Koichi Sasaki, Haitao Feng, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Editorial Material
Multidisciplinary Sciences
Jovana V. Milic, Andreas Ehnbom, Mahlet Garedew, Paulette Vincent-Ruz, Tracy H. Schloemer, Gregory K. Hodgson, Meagan S. Oakley, Koichi Sasaki, Subhash Chander, Marc-Andre Legare, Cassandra E. Callmann, Aisha N. Bismillah, Dannie J. G. P. van Osch, Vanessa Sanchez, Nathan R. B. Boase, Dickson Mambwe, Connor W. Coley, Yuanxin Deng, Kerry N. Betz, Jesus Sanjose-Orduna, Sean Natoli, Liang Zhang, Olga Bakulina, Ehsan Fereyduni, Jazmin Ciciolil Hilario-Martinez, Lucas Busta, Arianne Hunter, Yoonsu Park, Farnaz Haidar Zadeh
Meeting Abstract
Oncology
Vipul Bhatia, Nikhil Kamat, Tiffany Pariva, Li-Ting Wu, Annabelle Tsao, Koichi Sasaki, Lauren Wiest, Ailin Zhang, Dmytro Rudoy, Lawrence True, Radhika Patel, Martine Roudier, Roman Gulati, Michael Haffner, Peter Nelson, Saul Priceman, Jun Ishihara, John Lee
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Materials Science, Biomaterials
Srinivas Balagopal, Koichi Sasaki, Pooja Kaur, Maria Nikolaidi, Jun Ishihara
Summary: CAR-T cell therapy has shown remarkable efficacy against hematological malignancies, but often leads to cytokine release syndrome. New approaches are being developed to control cytokine production and reduce the risk of this adverse event.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Koichi Sasaki, Kyohei Muguruma, Rento Osawa, Akane Fukuda, Atsuhiko Taniguchi, Akihiro Kishimura, Yoshio Hayashi, Takeshi Mori, Yoshiki Katayama
Summary: A novel Fc-binding antibody-recruiting molecule (Fc-ARM) was synthesized using the monocyclic peptide 15-Lys8Leu, which binds strongly to the Fc region to target FR-positive cancer cells. This peptide, easily synthesized, is suitable for various applications including the development of Fc-ARMs.
RSC MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hiroshi Tagawa, Katsuya Maruyama, Koichi Sasaki, Natsuki Konoue, Akihiro Kishimura, Motomu Kanai, Takeshi Mori, Kounosuke Oisaki, Yoshiki Katayama
Article
Chemistry, Multidisciplinary
Koichi Sasaki, Minori Harada, Yoshiki Miyashita, Hiroshi Tagawa, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama
Article
Materials Science, Biomaterials
Shin Yanagihara, Nozomi Kasho, Koichi Sasaki, Naoto Shironaka, Yukiya Kitayama, Eiji Yuba, Atsushi Harada
Summary: The study utilized branched beta-glucan as a naturally immune-stimulating and biocompatible material to develop multifunctional liposomal cancer vaccines that efficiently interacted with APCs and activated cells. The Aqua beta derivative-modified liposomes were pH-sensitive and capable of releasing their contents in response to weakly acidic pH, leading to efficient interaction with dendritic cells and induction of antitumor immune responses within the tumor microenvironment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)