Article
Neurosciences
Lin-Chien Lee, Ya-Yun Chen, Wei-Chi Li, Ching-Ju Yang, Ching-Hsiung Liu, Intan Low, Hsiang-Tai Chao, Li-Fen Chen, Jen-Chuen Hsieh
Summary: This study found that Asian females with primary dysmenorrhea experience a blunted response to pain during menstruation, which may be an adaptive mechanism aimed at reducing the impact of menstrual pain on the brain and inhibiting central sensitization.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Joel Castro, Jessica Maddern, Andelain Erickson, Andrea M. Harrington, Stuart M. Brierley
Summary: This study investigates the changes in sensory neurons and central nervous system processing in endometriosis patients with chronic pelvic pain. It reveals that sensory neurons innervating the reproductive tract develop mechanical hypersensitivity in endometriosis, along with neuroinflammation and sensitization of spinal circuitry. These findings provide insights into the altered pain sensitivity in endometriosis and offer a potential platform for targeted pain relief treatments.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Article
Gastroenterology & Hepatology
Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S. Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R. DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A. Houghton
Summary: This study found that patients with irritable bowel syndrome (IBS) had a stronger symptom response to small intestinal lipid infusion, which was associated with the expression of TRPV channels, suggesting that TRPV-mediated small intestinal chemosensitivity may play a role in post-meal symptoms in IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Shuai Peng, Yuan Xia, Ying Wang, Xiaoyun Yu, Zunan Wu, Li Zhang, Ke Xu, Lei Shen, Hesheng Luo
Summary: This study provides a bibliometric and visual analysis of research on abdominal pain in inflammatory bowel disease, discussing the current status, research hotspots, and future developments. The United States is the leading country in terms of article output, and gut microbiota, depression, and stress are identified as hotspots and trends in this research area. However, further exploration is needed to address outstanding issues in this field.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sergio Lopez-Estevez, Josep Manuel Lopez-Torrellardona, Marc Parera, Vicente Martinez
Summary: This study explores the validity of DSS-induced colitis in rats as a model to mimic chronic intestinal hypersensitivity. The results indicate that DSS-induced colitis can generate a long-lasting state of visceral hypersensitivity and reproduce the changes in intestinal sensitivity characteristics of inflammatory and functional gastrointestinal disorders in humans. This research is of great importance for the development of new pharmacological treatments against visceral pain.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, Research & Experimental
Sergio Lopez-Estevez, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: Sigma-1 receptors play an important role in intestinal inflammation-associated referred hyperalgesia, with knockout mice showing significant attenuation in inflammation associated hypersensitivity. The absence of sigma(1)Rs had little impact on colitis generation and progression, but did show reduction in edema and down-regulation of iNOS gene expression during the chronic phase.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Xiao Jing Wang, Jon O. Ebbert, Connor G. Loftus, Jordan K. Rosedahl, Lindsey M. Philpot
Summary: This study investigated the relationship between central sensitization syndrome (CSS) diagnoses, quality of life, symptom severity, and interactions with healthcare providers in rural community populations. The findings showed that patients with IBS often have multiple CSS disorders, which increases symptom severity and lowers quality of life. Therefore, treating multiple CSS diagnoses as a global condition may improve patient experience.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Emergency Medicine
Samer Metri, Robert Shesser, Ali Pourmand
Summary: Chronic pain is a common complaint in the emergency department. Exacerbations of chronic pain are often treated like acute pain, with imaging and analgesics. Patients may be prescribed opioids without clear explanations for their pain, leading to dissatisfaction. This case study describes a patient with chronic abdominal pain who had undergone numerous imaging studies. The patient was found to have severe central sensitization and was provided appropriate counseling and follow-up care.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Rheumatology
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Alexander Mathiessen, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Ida K. Haugen
Summary: The pathologies and symptom duration of hand osteoarthritis (OA) are related to central sensitization, with erosive hand OA potentially causing greater central sensitization. Structural and inflammatory severity are not associated with central sensitization, while symptom duration does not contribute to central sensitization.
Article
Cell Biology
Prasant Kumar Jena, Tahereh Setayesh, Lili Sheng, Jacopo Di Lucente, Lee Way Jin, Yu-Jui Yvonne Wan
Summary: The study shows that supplementing with Bifidobacterium infantis (B. infantis) and antibiotic treatment can reduce diet-induced brain inflammation and improve neuroplasticity.
Article
Multidisciplinary Sciences
Timo A. Nees, Na Wang, Pavel Adamek, Nadja Zeitzschel, Clement Verkest, Carmen La Porta, Irina Schaefer, Julie Virnich, Selin Balkaya, Vincenzo Prato, Chiara Morelli, Valerie Begay, Young Jae Lee, Anke Tappe-Theodor, Gary R. Lewin, Paul A. Heppenstall, Francisco J. Taberner, Stefan G. Lechner
Summary: In this study, Nees. et al. found that inflammation-induced upregulation of TMEM100 can sensitize silent nociceptors, leading to secondary mechanical pain hypersensitivity. They showed that TMEM100 expression is increased in silent nociceptors during inflammation, and over-expression of TMEM100 is sufficient to un-silence silent nociceptors in mice. Furthermore, they demonstrated that TMEM100 is essential for the development of secondary mechanical hypersensitivity during knee joint inflammation, and its overexpression can induce mechanical hypersensitivity in remote skin regions without causing knee joint pain. This work identifies TMEM100 as a key regulator of silent nociceptor un-silencing and uncovers its role in triggering spatially remote secondary mechanical hypersensitivity during inflammation.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Yumna El-Hakim, Shameena Bake, Kathiresh Kumar Mani, Farida Sohrabji
Summary: Brain injuries and neurological diseases can affect the gut microbiome and the gut barrier, while gut disorders like Inflammatory Bowel Syndrome can influence the development and pathology of neurodegenerative and neuropsychiatric diseases. This review explores the mechanisms behind how IBS can impact the risk and severity of neurological diseases.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Kayla Johnson, Alexis Doucette, Alexis Edwards, Aleeya Verdi, Ryan McFarland, Shelby Hulke, Amanda Fowler, Val J. Watts, Amanda H. Klein
Summary: This study found that reducing the activity or expression of adenylyl cyclase 1 can attenuate morphine tolerance and hypersensitivity, as well as provide relief for inflammatory pain.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sergey S. Panteleev, Alexandra A. Martseva, Olga A. Lyubashina
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Medicine, Research & Experimental
I. B. Sivachenko, D. S. Medvedev, I. D. Molodtsova, S. S. Panteleev, A. Yu. Sokolov, O. A. Lyubashina
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
O. A. Lyubashina, I. B. Sivachenko, S. S. Panteleev, A. D. Nozdrachev
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2016)
Article
Clinical Neurology
Olga A. Lyubashina, Sergey S. Panteleev, Alexey Y. Sokolov
JOURNAL OF NEURAL TRANSMISSION
(2017)
Review
Neurosciences
A. Y. Sokolov, A. A. Murzina, A. V. Osipchuk, O. A. Lyubashina, A. V. Amelin
NEUROCHEMICAL JOURNAL
(2017)
Article
Neurosciences
O. A. Lyubashina, I. B. Sivachenko
Article
Neurosciences
Olga A. Lyubashina, Ivan B. Sivachenko, Irina I. Busygina, Sergey S. Panteleev
BRAIN RESEARCH BULLETIN
(2018)
Article
Anesthesiology
A. Y. Sokolov, O. A. Lyubashina, R. R. Berkovich, S. S. Panteleev
EUROPEAN JOURNAL OF PAIN
(2015)
Article
Gastroenterology & Hepatology
S. S. Panteleev, I. B. Sivachenko, O. A. Lyubashina
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Neurosciences
Olga A. Lyubashina, Ivan B. Sivachenko, Boris M. Sushkevich, Irina I. Busygina
Summary: This study investigated the role of 5-HT1A receptors in supraspinal control of visceral pain in normal and post-inflammatory conditions. The results suggest a shift from anti- to pronociceptive contribution of 5-HT1A-dependent mechanisms in intestinal hypersensitivity conditions, indicating that buspirone and other 5-HT1A agonists may not be effective for relieving post-inflammatory abdominal pain.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alexey Y. Sokolov, Ivan B. Sivachenko, Sergey S. Panteleev, Olga A. Lyubashina
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Olga Lyubashina, Irina Busygina, Ivan Sivachenko, Sergey Panteleev