Review
Engineering, Biomedical
Yiting Lou, Huiming Wang, Guanchen Ye, Yongzheng Li, Chao Liu, Mengfei Yu, Binbin Ying
Summary: This review discusses the important role of periosteum in bone defect repair and regeneration, as well as the need for developing tissue-engineered periosteum (TEP). The construction strategies for TEP are explored from the perspectives of materials, mechanical properties, cell-based strategies, and combination with growth factors. Current challenges and future perspectives for TEP development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Jinsong Wang, Guobao Chen, Zhong M. Chen, Fu P. Wang, Bin Xia
Summary: The role of periosteum in the treatment of bone defects has been gradually discovered, but there are still challenges due to limited transplantable periosteum. Biomimetic periosteal scaffolds that mimic the composition and structure of natural periosteum have emerged. This article reviews the current preparation methods of biomimetic periosteal scaffolds based on various biomaterials, providing a systematic perspective for future preparation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Biophysics
Peng Liu, Tiecheng Qiu, Jiabing Liu, Xiaoxi Long, Xianwei Wang, Hemin Nie, Mengqiang Yu, Chao Ma, Nan Lin, Swee Hin Teoh, Zuyong Wang
Summary: Researchers have developed a biomimetic film with the potential to be used as a synthetic periosteum. This film, made of a blend of poly(epsilon-caprolactone) and microtantalum particles, shows enhanced surface wettability and mechanical strength. It also promotes cell proliferation, alignment, and osteogenic enhancement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Yiming Li, Michael D. Hoffman, Danielle S. W. Benoit
Summary: Decellularized allografts, commonly used for critical size bone defects, have high long-term failure rates due to lack of periosteum. Recent studies show that MMP-TEP modified allografts can effectively coordinate host neurovasculature, leading to improved bone healing outcomes.
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
Tingting Li, Liang Chen, Yu Yuan, Rengfei Shi
Summary: Bone defects may require grafting for repair, and shape memory polymers (SMPs) have gained attention in bone tissue engineering due to their excellent properties. We reviewed the various advantages of SMPs and their contribution to bone formation, especially in craniomaxillofacial and limb bones, providing new ideas for their application in bone tissue engineering.
Review
Orthopedics
Wentao Zhang, Naiguo Wang, Ming Yang, Tianze Sun, Jing Zhang, Yantao Zhao, Na Huo, Zhonghai Li
Summary: The periosteum plays a significant role in bone formation and regeneration by storing progenitor cells and acting as a source of growth factors. Tissue-engineered periosteum, produced using biomimetic methods, can significantly improve the efficacy of bone grafting and scaffold engineering. The development of bionic periosteum in tissue engineering aims to accelerate bone defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Review
Engineering, Biomedical
Tyler Potyondy, Jorge Alfredo Uquillas, Peyton J. Tebon, Batzaya Byambaa, Anwarul Hasan, Maryam Tavafoghi, Heloise Mary, George E. Aninwene, Ippokratis Pountos, Ali Khademhosseini, Nureddin Ashammakhi
Summary: The musculoskeletal system is essential for various bodily functions, and injuries may require surgery for repair. Autografts are currently the preferred treatment for tissue replacement, but face limitations in supply and donor site morbidity. 3D bioprinting technology shows promise in providing autologous tissue-like constructs for musculoskeletal repair.
Article
Cell Biology
Hai Xin, Sara Romanazzo, Eva Tomaskovic-Crook, Timothy C. Mitchell, Jui Chien Hung, Steven G. Wise, Kai Cheng, D. S. Abdullah Al Maruf, Murray J. Stokan, Timothy G. H. Manzie, Krishnan Parthasarathi, Veronica K. Y. Cheung, Ruta Gupta, Mark Ly, Carlo Pulitano, Innes K. Wise, Jeremy M. Crook, Jonathan R. Clark
Summary: We have developed an ex vivo perfusion bioreactor system to preserve surgically resected periosteal flaps, demonstrating long-term cell viability and metabolism. This proof-of-concept study paves the way for innovative bone engineering approaches using autotransplanted periosteum to enhance in vivo bone repair.
Review
Materials Science, Biomaterials
Li Gu, Rui Huang, Ni Ni, Ping Gu, Xianqun Fan
Summary: The craniofacial region, consisting of 23 bones, plays a crucial role in maintaining normal brain and eyeball position, craniofacial aesthetics, facial movements, and visual function. However, craniofacial bone defects can lead to serious dysfunction. Therefore, there is an urgent need for rapid, precise, and effective reconstruction. Recent advancements in bone tissue engineering offer hope for ideal craniofacial bone defect reconstruction. This report provides a comprehensive review of recent biomaterial advancements in craniofacial bone tissue engineering, including modifications of traditional biomaterials and development of advanced biomaterials for craniofacial reconstruction. Challenges and future prospects in biomaterial development for craniofacial applications are discussed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Hadis Gharacheh, Murat Guvendiren
Summary: Composite hydrogel bioink, formulated by incorporating human allograft bone particles in a methacrylated alginate formulation, enhances osteogenesis of adult human mesenchymal stem cells (hMSCs) for bone tissue engineering. The bioink is suitable for extrusion-based 3D bioprinting, and in vitro studies show significantly enhanced osteogenic differentiation of hMSCs cultured within the bioprinted composite scaffolds.
Article
Nanoscience & Nanotechnology
Han Sun, Yixuan Shang, Junxia Guo, Abudureheman Maihemuti, Siyu Shen, Yong Shi, Hao Liu, Junyi Che, Qing Jiang
Summary: Traditional engineered periosteal materials have difficulty in achieving high tissue adhesion, suitable cell growth, and inducing cell orientation simultaneously. In this study, a composite artificial periosteum with carbon nanotubes and oriented nanotopography surface was developed to mimic the structure of natural periosteum. This artificial periosteum showed the ability to induce cell orientation and express higher levels of osteogenic genes and proteins. In vivo experiments on a rat model demonstrated promising bone regeneration ability of the composite periosteum.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Cell & Tissue Engineering
Behnaz Banimohamad-Shotorbani, Sonia Fathi Karkan, Reza Rahbarghazi, Ahmad Mehdipour, Seyedhosein Jarolmasjed, Sepideh Saghati, Hajar Shafaei
Summary: Bone defects are common damages in human medicine, and recent advancements in cell sheet technology have offered a promising approach for osteogenesis in craniomaxillofacial (CMF) bone regeneration. The intact matrix secreted from cells provides a unique microenvironment for accelerating osteoangiogenesis. Both single-layer and multilayer cell sheets have been investigated in preclinical settings for CMF engineering, showing potential for effective bone recovery.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Polymer Science
Shuai Chang, Shaobo Wang, Zhongjun Liu, Xing Wang
Summary: Bone defects are a pressing issue in orthopedic clinics, attracting attention from the biomedical community and society. Stimulus-responsive hydrogels, as a smart biomaterial, have advantages in sensing external stimuli and providing cell adhesion, proliferation, and differentiation for precise bone defect repair.
Article
Biochemistry & Molecular Biology
Yong Li, JunKai Zhang, LiFu Chen, HaiTao Li, Jian Wang
Summary: In this study, a RADA16-W9 peptide gel scaffold was designed and its effectiveness in bone defect repair was validated through cell experiments and a mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)