IL2RG ‐deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma‐derived tumours

Cancer modeling thinks big with the pig

(2019) Ellen P. Neff   LAB ANIMAL

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Transplantation of hepatocytes from genetically engineered pigs into baboons

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2017) Stephen K Horrigan et al.   eLife

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

(2016) Jung-Taek Kang et al.   Reproductive Biology and Endocrinology

Pigs as models of human cancers

(2016) Tatiana Flisikowska et al.   THERIOGENOLOGY

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2015) Denise Chroscinski et al.   eLife

Establishing the pig as a large animal model for vaccine development against human cancer

(2015) Nana H. Overgaard et al.   Frontiers in Genetics

Epigenetic reprogramming, gene expression and in vitro development of porcine SCNT embryos are significantly improved by a histone deacetylase inhibitor—m-carboxycinnamic acid bishydroxamide (CBHA)

(2014) Yuran Song et al.   Protein & Cell

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

Il2rg Gene-Targeted Severe Combined Immunodeficiency Pigs

(2012) Shunichi Suzuki et al.   Cell Stem Cell

Beyond Mice: Genetically Modifying Larger Animals to Model Human Diseases

(2012) Xiao-Jiang Li et al.   Journal of Genetics and Genomics

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models got you puzzled?: think pig

(2011) Eric M. Walters et al.   Annals of the New York Academy of Sciences

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer

(2010) Yonglun Luo et al.   TRANSGENIC RESEARCH

Immunodeficient Mouse Strains Display Marked Variability in Growth of Human Melanoma Lung Metastases

(2009) B. M. Carreno et al.   CLINICAL CANCER RESEARCH