Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

(2020) Timothy P. Brown et al.   ONCOGENE

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

(2020) Cyril Corbet et al.   Nature Communications

A lactate-induced Snail/STAT3 pathway drives GPR81 expression in lung cancer cells

(2019) Qiang Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lactate‐fueled oxidative metabolism drives DNA methyltransferase 1‐mediated transcriptional co‐activator with PDZ binding domain protein activation

(2019) Tao Huang et al.   CANCER SCIENCE

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

(2018) Xiangrui Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

(2017) J Feng et al.   ONCOGENE

Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer

(2017) Medhi Wangpaichitr et al.   Oncotarget

Predictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape

(2016) K. A. Olaussen et al.   ANNALS OF ONCOLOGY

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation

(2016) Yi Tang et al.   NATURE CELL BIOLOGY

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

(2016) Monika Papiez et al.   Drug Design Development and Therapy

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

(2016) Yu Jin Lee et al.   Oncotarget

Lactic dehydrogenase and cancer an overview

(2015) Silvio Naviglio   Frontiers in Bioscience-Landmark

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Nivolumab in NSCLC: latest evidence and clinical potential

(2015) Raghav Sundar et al.   Therapeutic Advances in Medical Oncology

Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches

(2015) Meghan Shea et al.   Therapeutic Advances in Respiratory Disease

Targeting Multidrug Resistance Protein 1 (MRP1, ABCC1): Past, Present, and Future

(2013) Susan P.C. Cole   Annual Review of Pharmacology and Toxicology

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

(2013) Elizabeth J. Sullivan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells

(2012) Lili Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Role of hypoxia-inducible transcription factor 1α for progression and chemosensitivity of murine hepatocellular carcinoma

(2010) Katjana Daskalow et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1

(2009) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS

Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers

(2008) K. Yonesaka et al.   CLINICAL CANCER RESEARCH

MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer

(2008) T. Oguri et al.   MOLECULAR CANCER THERAPEUTICS