Overcoming acquired resistance to PD-1 inhibitor with the addition of metformin in small cell lung cancer (SCLC)

LBA1_PRNivolumab (nivo) plus ipilimumab (ipi), nivo, or placebo (pbo) as maintenance therapy in patients (pts) with extensive disease small cell lung cancer (ED-SCLC) after first-line (1L) platinum-based chemotherapy (chemo): Results from the double-blind, randomized phase III CheckMate 451 study

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Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

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EP1.04-12 Response to Combination of Metformin and Nivolumab in a NSCLC Patient Whose Disease Previously Progressed on Nivolumab

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Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

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First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

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Molecular Biomarkers of Primary and Acquired Resistance to T‐Cell‐Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions

(2017) Young Kwang Chae et al.   ONCOLOGIST

Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages

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Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial

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Repurposing metformin for cancer treatment: current clinical studies

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Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

(2015) Xinke Zhou et al.   Oncotarget

A pilot ‘window of opportunity’ neoadjuvant study of metformin in localised prostate cancer

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New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

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