Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 70, Issue 3, Pages 713-720Publisher
SPRINGER
DOI: 10.1007/s00262-020-02706-5
Keywords
SCLC; Anti-PD-1; PD-L1 antibody; NLR; PLR; SII
Categories
Funding
- National Major Research Program during the 13th Five-Year Plan [2018ZX09201013]
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In small cell lung cancer patients, NLR at 6 weeks after treatment initiation appears to be a biomarker of response to anti-PD-1/PD-L1 antibody treatment.
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) have been identified as predictors of treatment response in a variety of cancers. We conducted a retrospective analysis to investigate the usefulness of NLR, PLR and SII at baseline and at 6 weeks post-treatment as predictors of response to anti-PD-1/PD-L1 antibody treatment in small cell lung cancer (SCLC). Data of 41 SCLC patients receiving immunotherapy as second- or later-line treatment were analyzed. The overall median progression-free survival (PFS) was 5.1 months (95% CI 3.2-6.2). The median PFS was significantly longer in patients with NLR < 5 than in patients with NLR >= 5 at 6 weeks post treatment (HR = 0.29, 95%CI 0.09-0.96,P = 0.04). However, median PFS was comparable between patients with NLR < 5 and patients with NLR >= 5 at baseline (HR = 0.75, 95% CI 0.24-2.26,P = 0.56). The median PFS was similar between patients with PLR < 169 and those with PLR >= 169 at baseline (HR = 0.67, 95% CI 0.25-1.80,P = 0.43) and at 6 weeks post treatment (HR = 0.69, 95% CI 0.25-1.86,P = 0.46). No statistically different PFS was found between patients with SII < 730 and those with SII >= 730 at baseline (HR = 0.70, 95% CI 0.26-1.89,P = 0.48) and at 6 weeks post treatment (HR = 0.38, 95% CI 0.013-1.09,P = 0.07). In conclusion, NLR at 6 weeks after start of treatment appears to be a biomarker of response in the early phase in SCLC patients treated with anti-PD-1/PD-L1 antibodies as second- or later-line treatment.
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