Journal
CANCER CELL
Volume 38, Issue 4, Pages 446-448Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2020.08.011
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Funding
- NIH/NCI [R01CA238163, P50CA225450]
- American Cancer Society [RSG-18-169-01-LIB]
- Cancer Research Institute (Lloyd J. Old STAR Award)
- Mark Foundation for Cancer Research (Emerging Leader Award)
- Spanish Ministry of Economy and Innovation [SAF201789533-R]
- Team Science and Established Investigator Awards by the Melanoma Research Alliance
- Worldwide Cancer Research, Fundacion La Caixa''
- Asociacion Espanola Contra el Cancer'' (AECC)
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Lymph nodes are typically the first clinically detectable site of metastasis in melanoma, but the mechanisms that determine this preference are not well understood. An article in Nature reports that the unique composition of lymph may protect melanoma cells from ferroptosis-a form of iron-dependent cell death, thereby increasing metastatic efficiency.
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