Article
Medicine, General & Internal
Summary: This study assessed the prevalence and management of anaemia in patients undergoing major abdominal surgery in Australia and New Zealand, and found that pre-operative anaemia assessment and management were associated with lower likelihood of blood transfusion and post-operative complications.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Anesthesiology
Tom E. F. Abbott, Michael A. Gillies
Summary: Anemia is common in patients undergoing major elective surgery, with iron deficiency being the leading cause. Research on the effects of preoperative i.v. iron treatment on surgical outcomes is lacking, with the PREVENTT trial showing no difference in transfusions or deaths within 30 days post-surgery. Further studies are needed to define optimal transfusion strategies.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Review
Anesthesiology
C. Quarterman, M. Shaw, S. Hughes, V Wallace, S. Agarwal
Summary: Pre-operative anaemia is associated with higher transfusion rates and worse outcomes, while supplementation with intravenous iron can help raise hemoglobin levels in anemic patients. However, anemic patients treated with iron still have a significantly higher transfusion requirement than non-anemic patients, and may face higher risks of complications.
Article
Anesthesiology
Robert Kong, Nevil Hutchinson, Andrew Hill, Fiona Ingoldby, Nicola Skipper, Christopher Jones, Stephen Bremner, Chloe Bruce, Juliet Wright, Michael Lewis, Stanton Newman, Timothy Chevassut, David Hildick-Smith
Summary: This study demonstrates that preoperative treatment with a single dose of ferric derisomaltose and darbepoetin can significantly reduce the proportion of patients receiving perioperative blood transfusions in patients with low preoperative hemoglobin and iron deficiency, while increasing hemoglobin levels.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Surgery
J. Meyerov, M. Louis, D. K. Lee, L. Fletcher, D. Banyasz, L. F. Miles, R. Ma, S. Tosif, A. N. Koshy, D. A. Story, R. Bellomo, L. Weinberg
Summary: This retrospective cohort study found that patients with lower preoperative Hb concentrations incurred higher hospital costs during major abdominal surgery, with packed red blood cell transfusions being a principal cost driver.
Article
Anesthesiology
H. B. Kim, J. K. Shim, S. H. Ko, H. R. Kim, C. H. Lee, Y. L. Kwak
Summary: This study aimed to investigate the association between non-anaemic iron deficiency and postoperative outcomes in patients undergoing valvular heart surgery. The retrospective analysis found that patients with non-anaemic iron deficiency had lower pre-operative haemoglobin levels and slightly shorter days alive and out of hospital at postoperative day 90. However, the only factors significantly associated with reduced days alive and out of hospital at postoperative day 90 were cardiopulmonary bypass duration and intra-operative allogeneic red blood cell transfusion. Therefore, non-anaemic iron deficiency alone does not have adverse effects on valvular heart surgery outcomes when it does not increase the risk of allogeneic transfusion.
Review
Medicine, General & Internal
Abdulrahman Al-Naseem, Abdelrahman Sallam, Shamim Choudhury, Jecko Thachil
Summary: Iron deficiency without anaemia (IDWA) is more common than iron deficiency anaemia (IDA), but often poorly recognized by clinicians. Diagnosis and management of IDWA relies on various tests and treatments to correct the deficiency and prevent associated risks.
Article
Cardiac & Cardiovascular Systems
Peng Gao, Xu Wang, Peiyao Zhang, Yu Jin, Liting Bai, Wenting Wang, Yixuan Li, Jinping Liu
Summary: This study found that absolute iron deficiency was associated with preoperative anemia and cyanotic heart disease in infants undergoing cardiac surgery, and it was an independent risk factor for postoperative blood transfusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Magnus Ploug, Rasmus Kroijer, Niels Qvist, Torben Knudsen
Summary: This study reports on the experience with preoperative i.v. iron treatment in surgical colorectal cancer patients in clinical practice. The results showed that preoperative i.v. iron treatment was neither associated with a rise in Hb concentrations at the time of surgery, nor with a reduction in the likelihood of receiving perioperative RBCT in colorectal cancer patients with iron deficiency anemia.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Anesthesiology
C. R. Evans, R. Jones, G. Phillips, G. Greene, M. Phillips, R. Morris-Clarke
Summary: Cardiac surgical patients with anaemia and iron deficiency have increased morbidity and mortality post-surgery. The Cardiff Pathway successfully identifies and treats these patients, resulting in reduced blood transfusion requirements peri-operatively, with over half of successfully treated patients avoiding transfusion altogether.
Article
Surgery
Chris Triphaus, Leonie Judd, Patricia Glaser, Marie H. Goehring, Elke Schmitt, Sabine Westphal, Christoph Fuellenbach, Simone Lindau, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Summary: The study demonstrated that administering intravenous iron within 7 days before surgery effectively increased hemoglobin levels, reduced intraoperative transfusion rates, and shortened hospital stays for surgical patients with iron deficiency anemia.
Article
Anesthesiology
T. Richards, L. F. Miles, B. Clevenger, A. Keegan, S. Abeysiri, R. Rao Baikady, M. W. Besser, J. P. Browne, A. A. Klein, I. C. Macdougall, G. J. Murphy, S. D. Anker, D. Dahly, PREVENTT Trial Collaborators
Summary: In the PREVENTT trial, intravenous iron therapy did not reduce the need for blood transfusion or patient complications in those with iron deficiency anaemia undergoing major abdominal surgery. The extent of iron deficiency did not significantly affect the efficacy of intravenous iron therapy.
Article
Medicine, General & Internal
Ioana Tichil, Samara Rosenblum, Eldho Paul, Heather Cleland
Summary: Blood transfusions are crucial in the surgical management of major burn patients, with around half of transfusions related to surgical procedures and potentially influenced by blood conserving strategies. The trigger levels for transfusions in stable patients may be subject to review and reduction. Risk-adjusted analysis can support the use of blood transfusions as a valuable quality indicator in burn care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jonathon Snook, Neeraj Bhala, Ian L. P. Beales, David Cannings, Chris Kightley, Robert Ph Logan, D. Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M. Verma, Andrew F. Goddard
Summary: Iron deficiency anaemia is a major global cause of disease burden, diagnosed through blood testing and treated with iron replacement therapy. Causes include poor diet and gastrointestinal pathologies, with endoscopy and radiological scanning used for diagnosis and assessment in some cases.
Editorial Material
Anesthesiology
Daniel Bolliger, Eckhard Mauermann, Andreas Buser
Summary: Preoperative anaemia is common and associated with increased postoperative morbidity and mortality after cardiac surgery. A large Dutch cohort study supports these findings. Timely diagnosis and treatment of preoperative anaemia may help reduce postoperative risks, but the implementation of anaemia therapy remains challenging in clinical practice, and currently, there is limited evidence for its improved outcome.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
