Journal
BONE MARROW TRANSPLANTATION
Volume 56, Issue 3, Pages 536-543Publisher
SPRINGERNATURE
DOI: 10.1038/s41409-020-0983-5
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Funding
- Cure2Children Foundation, Florence, Italy
- Sankalp India Foundation, Bengaluru, India
- Italian Government
- Iraqi Kurdistan Government
- Pakistani Government
- Italian Development Cooperation Agency
- AICS, Rome, Italy
- Fondazione Umberto Veronesi, Milan, Italy
- Fondazione Monte dei Paschi, Siena, Italy
- Cassa di Risparmio di Firenze, Florence, Italy
- Institute for University Cooperation (ICU), Rome, Italy
- Associazione Volontari Servizio Internazionale (AVSI), Milan, Italy
- Comitato ML Verga, Monza, Italy
- Associazione Sostegno Ematologia Oncologia Pediatrica, Modena, Italy
- Fondazione Compagnia di San Paolo, Turin, Italy
- Heartfile, Islamabad, Pakistan
- DKMS, Tubingen, Germany
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This paper summarizes the critical issues in extending global access to BMT, based on ground experience in several MICs, discussing the requirements and cost-effectiveness of implementing BMT programs.
Severe blood disorders and cancer are the leading cause of death and disability from noncommunicable diseases in the global pediatric population and a major financial burden. The most frequent of these conditions, namely sickle cell disease and severe thalassemia, are highly curable by blood or bone marrow transplantation (BMT) which can restore a normal health-related quality of life and be cost-effective. This position paper summarizes critical issues in extending global access to BMT based on ground experience in the start-up of several BMT units in middle-income countries (MICs) across South-East Asia and the Middle East where close to 700 allogeneic BMTs have been performed over a 10-year period. Basic requirements in terms of support systems, equipment, and consumables are summarized keeping in mind WHO's model essential lists and recommendations. BMT unit setup and maintenance costs are summarized as well as those per transplant. Low-risk BMT is feasible and safe in MICs with outcomes comparable to high-income countries but at a fraction of the cost. This report might be of assistance to health care institutions in MICs interested in developing hematopoietic stem cell transplantation services and strengthening context appropriate tertiary care and higher medical education.
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