Article
Biophysics
Yangxi Zhang, Hao Wu, Han Wang, Bohan Yin, Siu Hong Dexter Wong, A. Ping Zhang, Hwa-Yaw Tam
Summary: This study presents an ultraminiature biosensor based on nanoparticles and optical fibers, capable of detecting antibodies and testing SARS-CoV-2 mimetic DNA. The biosensor offers a cost-effective solution for various applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Engineering, Electrical & Electronic
Yuchao Li, Hongbao Xin, Yao Zhang, Baojun Li
Summary: Optical manipulation and detection of nanoscale biospecimen using micro/nano optical fibers have advantages over traditional lens-based free-space techniques due to their compact structure, flexibility, high sensitivity, and sub-diffraction-limit confinement. This review covers recent advances in nanoscale manipulation and biological detection with optical fibers, including applications for biological exploration like nanoparticle delivery and detection, single-molecule trapping and sensing, and single-cell manipulation and analysis, aiming to highlight current trends and future directions in this field.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Biophysics
Tennyson Mathai, Tathagata Pal, Nayan Prakash, Soumyo Mukherji
Summary: Enrofloxacin (ENR) and its metabolite Ciprofloxacin (CIP) are effective against a broad-spectrum microbial infection, but their increased consumption has led to drug-resistant pathogens. To tackle this issue, a portable device has been developed to accurately detect the presence of CIP and ENR antibiotics in ppb concentrations.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Lipeng Pan, Mingye Zou, Fangxing Ma, Lingqing Kong, Changnan Zhang, Likun Yang, Anna Zhu, Feng Long, Xiang-Yang Liu, Naibo Lin
Summary: A compact evanescent wave detection platform is developed for the detection of fluorescence gold nanoclusters. The platform employs a simple optical system and a Si-based photodetector assembly, improving the optical efficiency and detection sensitivity. It has potential applications for fast detection of dopamine in microsamples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Electrical & Electronic
Scott Foster
Summary: Fundamental thermodynamic limits on the strain resolution of a class of fiber optic distributed acoustic sensing techniques based on optical time domain reflectometry have been derived, showing a lower limit of around 10(-14)strain/root Hz for a 2 m long (10 ns) optical pulse. These limits suggest that monitoring unmodified fiber optic cables is unlikely to achieve sensing performance comparable to engineered acoustic sensors.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Madina Shaimerdenova, Takhmina Ayupova, Zhannat Ashikbayeva, Aliya Bekmurzayeva, Wilfried Blanc, Daniele Tosi
Summary: Reflector-less biosensors based on optical fibers enable detection of refractive index variations without the need for reflective elements. In this article, the working principle and results of reflector-less biosensors fabricated through shallow tapering are presented. These biosensors offer fast fabrication (around 20 seconds) and a compact form factor.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Haixu Zhao, Shang Ren, Zhenzhe Wei, Xinhui Lou
Summary: In this study, a novel optical-fiber aptasensor was developed for the detection of Zearalenone (ZEN), a common mycotoxin pollutant in agricultural products. The aptasensor exhibited unprecedented sensitivity, high specificity, low-cost, and easy of automation, enabling the detection of ZEN at sub-picomolar levels. The sensor also demonstrated excellent specificity and regeneration capability, making it a promising tool for practical applications.
Article
Chemistry, Physical
V. Fuertes, N. Gregoire, P. Labranche, S. Gagnon, V. A. G. Rivera, S. LaRochelle, Y. Messaddeq
Summary: Alkaline earth nanoparticles grown in-situ on silica-based optical fibers hold great promise for distributed sensing applications. This study extends the previous observations on Ca-based nanoparticles to demonstrate that Sr-based nanoparticles can be suitable for fabricating low-loss Rayleigh scattering enhanced optical fibers with tunable performance. The research reveals the significant influence of preform and fiber manufacture conditions on the nanoparticle characteristics, enabling the tailoring of their features throughout the fabrication process. By improving the trade-off between Rayleigh scattering enhancement and optical losses, long-range sensing lengths from 8.6 m to 132 m are achieved.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Analytical
T. Martan, V. Prajzler, D. Mares
Summary: The paper introduces the design and development of two types of sensors for the local detection of gaseous carbon dioxide on a microscopic scale. Both sensors exhibit good linearity and sensitivity in the range of 0%-10.6% CO2 concentration. The second sensor, based on a 3 μm silica glass taper tip, is particularly suitable for laboratory testing of microorganisms and cells that actively consume gaseous carbon dioxide.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Electrical & Electronic
Zenghui Wang, Lianqin Li, Qianqian Ma, Mengjiao Wang, Qiong Wu, Baojin Peng
Summary: The study proposed an LRT sensor based on MFCR, which can measure liquid level, refractive index, and temperature by detecting sensing dips, with maximum sensitivities of 81.78pm/mm, 586.74nm/RIU, and 443.66pm/degrees C, respectively.
OPTICAL FIBER TECHNOLOGY
(2021)
Article
Chemistry, Physical
Xudong Zhao, Ni Yao, Xianghua Zhang, Lei Zhang, Guangming Tao, Zijian Li, Quan Liu, Xiujian Zhao, Yinsheng Xu
Summary: This study proposes a new approach of tapered-fiber geometry optimization to improve the evanescent efficiency of mid-infrared chalcogenide fiber sensors. The influence of fiber geometry on sensing performance is discussed, and the analysis reveals that a smaller waist radius and longer taper length lead to higher evanescent efficiency. Additionally, the investigation of waist deformation shows that increasing the waist boundary radius can decrease the sensing performance.
Review
Engineering, Electrical & Electronic
Daniele Tosi, Carlo Molardi, Marzhan Sypabekova, Wilfried Blanc
Summary: Optical Backscatter Reflectometry (OBR) is an advanced distributed sensing technique that utilizes optical fibers to detect and localize physical parameters with spatial resolution below the millimeter. By tailoring the Rayleigh scattering properties of optical fibers and enhancing backscattering contents, it is possible to create 2 and 3-dimensional sensing networks, extending OBR to multi-dimensional and even biosensing applications. This work provides a tutorial on distributed optical fiber sensors with enhanced backscattering and discusses the design of sensing networks with these fibers, while also reviewing main applications and emerging topics.
IEEE SENSORS JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Pan Tao, Kaixin Ge, Xing Dai, Danni Xue, Yang Luo, Shixun Dai, Tiefeng Xu, Tao Jiang, Peiqing Zhang
Summary: This paper proposes a fiber optic SERS sensor excited by evanescent waves for efficient detection of thiram. Silver nanocubes (Ag NCs) were prepared as SERS active substrates, which had much stronger electromagnetic field intensity than nanospheres. The combination of evanescent waves and SERS provides a new direction for the application of SERS sensors, which had great application potential in the field of pesticide residue detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Pooja Nag, Kapil Sadani, Sanjeeb Mohapatra, Suparna Mukherji, Soumyo Mukherji
Summary: Beta-lactam antibiotics are widely used in human infection therapy, but unintended exposure through food and water can lead to antibiotic-resistant bacterial pathogenesis. An optical enzymatic biosensor has been developed for rapid detection of these antibiotics in food and water samples, showing potential for wide-scale deployment.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Yinghao Song, Chii Shang, Li Ling
Summary: By manipulating the coating strategies, the research has increased the ability of TiO2-coated quartz optical fibers to generate evanescent waves, resulting in efficient degradation of organic pollutants in water.
Article
Multidisciplinary Sciences
Zhannat Ashikbayeva, Arman Aitkulov, Madina Jelbuldina, Aizhan Issatayeva, Aidana Beisenova, Carlo Molardi, Paola Saccomandi, Wilfried Blanc, Vassilis J. Inglezakis, Daniele Tosi
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Analytical
Aidana Beisenova, Aizhan Issatayeva, Zhannat Ashikbayeva, Madina Jelbuldina, Arman Aitkulov, Vassilis Inglezakis, Wilfried Blanc, Paola Saccomandi, Carlo Molardi, Daniele Tosi
Summary: The study proposes a distributed fiber optic sensor as a potential candidate for temperature monitoring during thermal ablation, with the ability to achieve 3D temperature monitoring accurately. The sensor offers high resolution, bio-compatibility, and the capability to monitor the entire ablated region effectively.
Article
Engineering, Multidisciplinary
A. Aitkulov, M. Sypabekova, C. Molardi, W. Blanc, D. Tosi
Summary: A technique for fabricating and interrogating fiber-optic refractive index sensors based on etched MgO-based nanoparticle doped fibers is proposed and evaluated in this study. The method involves using light backscattered by the fiber for detection, with sensor performance monitored using distributed sensing. Sensitivities of different etched fibers are compared, with a maximum sensitivity achieved at 45.95 nm/RIU and the potential for temperature compensation.
Article
Chemistry, Multidisciplinary
Zhannat Ashikbayeva, Arman Aitkulov, Alexey Wolf, Alexander Dostovalov, Aida Amantayeva, Aliya Kurbanova, Vassilis J. Inglezakis, Daniele Tosi
Summary: The study examined the effect of iron oxide nanoparticles on temperature increment during radiofrequency ablation therapy of porcine liver, and experimentally evaluated the impact of solvents on temperature changes.
APPLIED SCIENCES-BASEL
(2021)
Article
Optics
Takhmina Ayupova, Madina Shaimerdenova, Marzhan Sypabekova, Luca Vangelista, Daniele Tosi
Summary: A ball resonator located on the tip of an optical fiber has been developed as a biosensor for detecting thrombin using a CO2 laser splicing method. The device, with high sensitivity, can measure protein concentrations in a wide range and has a detection limit of 1.56 pM in logarithmic response.
Article
Chemistry, Multidisciplinary
Zhannat Ashikbayeva, Arman Aitkulov, Timur Sh. Atabaev, Wilfried Blanc, Vassilis J. Inglezakis, Daniele Tosi
Summary: Thermal ablation therapy is an effective alternative to surgery, and the use of silver nanoparticles can improve heat propagation during the procedure. The study demonstrated that silver nanoparticles could increase the temperature during thermal therapies by propagating the heat.
Article
Biology
Nigara Yunussova, Marzhan Sypabekova, Zhazira Zhumabekova, Bakhyt Matkarimov, Damira Kanayeva
Summary: In this study, single-stranded DNA aptamers against carcinoembryonic antigen (CEA) were developed using SELEX and NGS methods. The selected aptamer showed high affinity and specificity for CEA and has the potential to be used in cancer diagnostics. The study provides valuable insights into the development of precise and sensitive techniques for early cancer diagnosis.
Article
Chemistry, Analytical
Madina Shaimerdenova, Takhmina Ayupova, Aliya Bekmurzayeva, Marzhan Sypabekova, Zhannat Ashikbayeva, Daniele Tosi
Summary: This study presents a spatial-division multiplexing method for fiber-optic ball resonators, which has been experimentally validated to be highly efficient and capable of designing a sensing network with reasonable penalties. The method enables simultaneous detection of different cancer biomarkers.
Review
Chemistry, Analytical
Marzhan Sypabekova, Aidan Hagemann, Donggee Rho, Seunghyun Kim
Summary: Surface functionalization and bioreceptor immobilization are crucial processes for developing a sensitive and selective biosensor. The silanization process using 3-aminopropyltriethoxysilane (APTES) on oxide surfaces is commonly used due to its bifunctional nature and low cost. This review provides an overview of APTES deposition methods, categorized into solution-phase and vapor-phase, and a comprehensive guide for creating stable APTES monolayers on oxide surfaces for biosensing applications.
Article
Engineering, Electrical & Electronic
Marzhan Sypabekova, Aidan Hagemann, Jenna Kleiss, Cooper Morlan, Seunghyun Kim
Summary: The rapid advancement of biosensor technology has revolutionized healthcare. In this study, an optical cavity-based biosensor (OCB) was developed, which offers label-free detection and high sensitivity. By optimizing the OCB and camera settings, and enhancing the differential detection approach, the limit of detection (LOD) was significantly improved.
IEEE SENSORS JOURNAL
(2023)
Proceedings Paper
Engineering, Biomedical
Takhmina Ayupova, Madina Shaimerdenova, Aliya Bekmurzayeva, Marzhan Sypabekova, Arman Aitkulov, Daniele Tosi
Summary: This study reports the investigation of thrombin concentration using a microresonator functionalized with a thiol-modified thrombin-binding aptamer (TBA). The sensitivity and reflectivity of the resonator were measured after calibration with sucrose and coating with gold. The resonator showed promising results in detecting thrombin protein at different concentrations.
DESIGN AND QUALITY FOR BIOMEDICAL TECHNOLOGIES XIV
(2021)
Article
Chemistry, Analytical
Madina Shaimerdenova, Takhmina Ayupova, Marzhan Sypabekova, Daniele Tosi
Proceedings Paper
Engineering, Biomedical
M. Shaimerdenova, A. Bekmurzayeva, T. Ayupova, M. Sypabekova, S. Korganbayev, K. Dukenbayev, W. Blanc, C. Molardi, D. Tosi
OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS XX
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
