Article
Engineering, Environmental
Sethupathi Velmurugan, Thomas C. -K. Yang, Shih-Wen Chen, Jyy-Ning Chen
Summary: This study presents an eco-friendly synthesis method for a metal oxide pn junction composite with high specific surface area, which has been successfully applied in photoelectrochemical monitoring. The ZnO-Co3O4 pn heterojunction composite exhibited high stability and conductivity for the detection of sulfadiazine.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Electrochemistry
Bingwang Yang, Ning Han, Shiyu Hu, Liying Zhang, Shasha Yi, Zongtao Zhang, Yu Wang, Deliang Chen, Yanfeng Gao
Summary: A Cu/ZnO nano-thorn array was presented for photoelectrochemical detection of glucose in neutral solution, showing excellent performance and high sensitivity in the detection process.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biotechnology & Applied Microbiology
Guangli He, Yue Zhou, Mifang Li, Yanzhen Guo, Hang Yin, Baocheng Yang, Shouren Zhang, Yibiao Liu
Summary: An ultrasensitive photoelectrochemical (PEC) sensor based on ZnO@polydopamine/Au nanocomposites was developed for quantitative detection of A beta, showing a wide linear range and low detection limit. Additionally, the sensor exhibited good selectivity, stability, and reproducibility, providing a promising method for advanced PEC immunoassays for AD biomarkers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Bairui Tao, Wenbo Yang, Fengjuan Miao, Yu Zang
Summary: In this study, Co3 O4/ZnO/CNTs electrodes were prepared and used for the sensitive detection of lactic acid (LA) in human fluids. The electrodes showed high sensitivity and low detection limits, making them suitable for enzyme-free, noninvasive, and real-time monitoring.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Engineering, Electrical & Electronic
Bairui Tao, Xiaoqin Li, Zhidong Ye, Fengjuan Miao, Yu Zang
Summary: Hybrid transition metal oxides and redox graphene nanocomposites are synthesized using a multistep hydrothermal method to improve the electrochemical properties of ZnO/MoS2/rGO nanocomposites. The resulting material shows excellent performance as a dual-function electrode in solid-state flexible supercapacitors and amperometric photochemical CO2 gas sensors, with a wide linear sensing range, high sensitivity, fast recovery and response time, and low detection limit. Additionally, the ZnO/MoS2/rGO electrodes exhibit high specific capacitance, significant rate performance, and long cycle life, making them promising for next-generation electrochemical gas sensors and high-performance energy storage.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Applied
Huafang Zhang, Qinghong Pan, Wanying Cai, Xiaowei Shi, Da-Peng Yang, Hetong Lin, Enhui Qiu
Summary: Antibiotic monitoring is crucial for ensuring human health and safety in the environment and food. Photoelectrochemical (PEC) sensor, as the most popular detection method, offers rapid and accurate antibiotic detection with high sensitivity, easy preparation process, and high selectivity. In this study, a highly efficient visible-light responsive ZnO/C nanocomposite combined with acetylene black was prepared to enhance electron migration efficiency. A molecularly imprinted polymer obtained by electrical agglomeration was conjugated as a specific recognition site for the target. The resulting rMIP-PEC sensor exhibited a low detection limit, wide linear detection range, excellent selectivity, and long-term stability for oxytetracycline (OTC). This work provides a novel approach of using C-doped ZnO semiconductor and molecularly imprinted polymer as photoelectrically active sensing materials for rapid and accurate analysis of antibiotics in food and the environment.
Article
Environmental Sciences
Huafang Zhang, Zewen Kang, Hu Zhu, Hetong Lin, Da-Peng Yang
Summary: Nanomaterials-based photoelectrochemical (PEC) detection is a rapidly-developing analytical technique in chemical and biological assays due to its advantages of easy miniaturization, high sensitivity, and rapid turn-around time. In this study, a molecularly imprinted polymer-assisted PEC sensor based on ZnO/C nanocomposite was successfully fabricated for the highly sensitive and selective determination of chloramphenicol (CAP). Under optimal conditions, the PEC sensor showed significant CAP detection performance and was successfully applied to the detection of CAP in milk sample. The results demonstrate that ZnO/C nanocomposite and MIP can be used as an efficient photo-responsible matrix to fabricate PEC sensor, with important application potentials for pollutants control in food and environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Songlong Jiao, Lei Liu, Youqiang Xing, Ze Wu, Bingjue Li, Peng Huang
Summary: The development of photoactive materials based on single-atom catalysts is crucial for improving the performance of PEC biosensors. By designing Pt atoms-anchored MoS2 nanotubes (PtMoS2NT), this study demonstrates the advantages of single-atom catalysts in achieving ultra-sensitive detection of miRNA-155.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Cheng Wang, Jialei Dai, Shufang Guo, Rui Sun, Chengyan Zhang, Xinhui Zhao, Lihua Zhou, Fan Zhang, Na Li, Mingyan Wang, Jun Chen
Summary: A novel ternary nanocomposite of CdSH/ZnO-GE was prepared for photoelectrochemical sensing of Cu2+, showing enhanced photoelectrical activity and wide linear concentration range for detection. The sensor exhibited low detection limit, high selectivity and stability, making it promising for detecting copper pollution in natural environments.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Delun Chen, Xue Zou, Fan Dong, Chao Zhen, Dan Xiao, Xiaohong Wang, Qiang Wu, Yang Cao, Jinchun Tu
Summary: Introducing the intramolecular donor-acceptor compensated semiconductor I-D/A ZnO with the assistance of ascorbic acid has been shown to enhance the carrier lifetime and reduce electron transfer resistance. The photoelectrochemical biosensor based on this material exhibited high sensitivity, low limit of detection, and excellent anti-interference properties when detecting glucose.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Zheng-Ying Yang, Jun Song, Ruo-Li Jiang, Jinyu Dai, Keqiang Xu, Xiu-Li Yang, Ming-Hua Xie
Summary: Photoelectrochemical sensing is a promising solution for health monitoring and food safety guarantee. In this work, a novel strategy for preparing TiO2 nanofibers threaded ZnO heterostructures and selectively detecting lactic acid using photoelectrochemistry is reported. The resulting heterostructures demonstrate enhanced charge transfer activity, photocurrent density, and excellent detection performance.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biophysics
Mingjun Xiao, Minghui Zhu, Ruo Yuan, Yali Yuan
Summary: In this work, an ultrasensitive PEC biosensor based on dual-sensitized PDA/ZnO@MoS2 QDs photoactive material was proposed for detection of miRNA-182-5p. The DSN-assisted target recycling amplification triggered a multilocus domino-like DNA cascade reaction on DNA nanonet, which significantly enhanced the detection sensitivity. The developed biosensor exhibited a low detection limit of 0.17 fM, providing a new avenue for sensitive, fast and reliable sensing of various DNA/RNA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Physics, Condensed Matter
Weiting Zhan, Wei Liu, Lu Han, Xu Liang, Rongsheng Chen, Hongwei Ni
Summary: Photoelectrochemical (PEC) detection technique using GO/Ag2S/ZnO nanorods coatings on stainless steel was utilized to monitor low concentration of glycine. The samples with a deposition time of 120 s displayed excellent photochemical properties compared to other samples. The GO/Ag2S/ZnO nanorods coatings demonstrated high sensitivity, wide linear range, and low detection limit for glycine detection, making them potential PEC sensors for clinical applications.
PHYSICA B-CONDENSED MATTER
(2023)
Article
Chemistry, Analytical
Jutao Hu, Xiaoyu Su, Lei Yuan, Kaiyi Zheng, Xiaobo Zou, Zongbao Sun, Xuechao Xu, Wen Zhang
Summary: Accurate and sensitive detection of chloramphenicol (CAP) in natural samples is achieved using an enzyme-regulated fluorescence sensor. A Fe3O4@COF/Fe3+ probe is developed, where Fe3O4@COF acts as a magnetic carrier and signal probe. The sensor demonstrates good stability, reusability, and a logarithmic linear relationship between CAP concentration and fluorescence intensity, providing a reliable method for CAP detection with a low limit of detection.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xue Dong, Hanyu Wang, Nuo Zhang, Xiang Ren, Dawei Fan, Hongmin Ma, Dan Wu, Qin Wei
Summary: This work introduces a photoelectrochemical (PEC) sensor based on the in situ generation of BiOBr/Bi2S3 by Cs3Bi2Br9 for detecting trenbolone (TB). The Cs3Bi2Br9/BiOBr/Bi2S3 heterojunction, a stable and large photocurrent producing material, is obtained through a two-step in situ growth method on the basis of Cs3Bi2Br9 perovskite. CdS and Au nanoparticles are used as TB antigen (Ag) markers, and their competitive combination with TB or Ag-Au/CdS reveals the association between TB concentration and output current. The competitive PEC sensor achieves reliable detection of TB with a low detection limit of 29.7 fg mL(-1).
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Mingliang Guo, Zijian Huang, Binbin Liu, Yanji Bao, Xiaohong Wang, Kexi Zhang, Qiang Wu, Yang Cao, Jinchun Tu, Lei Ding
Summary: The advanced structural design of Ni3S2/NiCo2S4/NF electrodes via a simple microwave-assisted method shows high specific capacitance, remarkable rate capacity, and cycling stability, making them promising anode materials in asymmetric SCs.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biophysics
Yanan Peng, Huajie Pang, Zhijun Gao, Dongxia Li, Xiangde Lai, Delun Chen, Rui Zhang, Xuan Zhao, Xinping Chen, Hua Pei, Jinchun Tu, Bin Qiao, Qiang Wu
Summary: This paper presents a novel approach to localize the catalytic hairpin assembly (CHA) system into the DNA tile self-assembly nanostructure, resulting in higher reaction concentration and enhanced reaction kinetics. Experimental results show that this method achieves faster reaction plateau and amplifies the effect of microRNA (miRNA) 1.57-6.99 times higher compared to the simple CHA system. Moreover, this strategy fulfills the requirement for one-step detection of miRNA in cell lysates at room temperature.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Wenxin Wu, Jie Wu, Hao Huang, Bin Qiao, Chenglong Jiang, Yao Shi, Chao Wang, Hua Pei, Qiqi Xu, Xiaotian Wu, Qiang Wu, Huangxian Ju
Summary: In this work, an electrochemiluminescence (ECL) biosensing strategy was proposed for sensitive detection of 5-methyl-cytosine (5mC) DNA methylation. The biosensor utilized encapsulated [Ru(byp)3]2+ in silica nanoparticles (Ru@SiO2) as labeling agents for signal amplification. By immobilizing biotinylated DNA on streptavidin-modified magnetic microbeads (S-MBs), sequentially methylated ssDNA, 5mC antibody, and Ru@SiO2 labeled antibody were captured and separated from other species. The biosensor demonstrated high sensitivity, convenience, automation, versatility, and potential for detecting important gene-specific methylation without nucleic acid amplification and sample pretreatment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Yanan Peng, Zhijun Gao, Bin Qiao, Dongxia Li, Huajie Pang, Xiangde Lai, Qiumei Pu, Rui Zhang, Xuan Zhao, Guangyuan Zhao, Dan Xu, Yuanyuan Wang, Yuxiang Ji, Hua Pei, Qiang Wu
Summary: In this study, size-controlled 9-tile nanoarrays were designed to achieve caveolae-mediated endocytosis and amplify the imaging of microRNAs (miRNAs). These nanoarrays showed high sensitivity and specificity for miRNAs, bypassing lysosomal traps and delivering miRNAs efficiently into the cytoplasm.
Article
Biotechnology & Applied Microbiology
Chao Liu, Kaili Ou, Ping Li, Yan Pang, Guangyuan Zhao, Qiang Wu
Summary: This study developed a rapid and low-cost method for virus detection in water using membrane separation virus enrichment and RT-ERA technique. The results showed that RT-ERA could detect samples with as few as 10 copies, while membrane separation could enrich various target viruses in water to concentrations 60-70 folds higher. The entire procedure can be completed in 30 min and the test is comparable to the laboratory methods in terms of enrichment and detection accuracy and sensitivity.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Chemistry, Multidisciplinary
Run Yuan, Bingdong Yan, Caiyan Lai, Xiaohong Wang, Yang Cao, Jinchun Tu, Yi Li, Qiang Wu
Summary: In this study, a visible light-driven PEC enzyme biosensor was proposed for the sensitive and rapid detection of glucose. The biosensor utilized CDs/branched TiO2 (B-TiO2) as the photoactive material and glucose oxidase (GOx) as the identification element. The biosensor showed good sensing performance with a detection range of 0 to 9.00 mM and a detection limit of 0.0430 mM for glucose under visible light.
Article
Engineering, Biomedical
Chang Liu, Quan Zou, Huixin Tang, Jia Liu, Shiqi Zhang, Caihong Fan, Junwei Zhang, Ruiqing Liu, Yashan Liu, Ruiyan Liu, Yan Zhao, Qiang Wu, Zhi Qi, Yanna Shen
Summary: Myocardial injury in sepsis is a severe complication resulting in increased morbidity and mortality. Recent studies have shown that reactive oxygen species (ROS)-mediated ferroptosis plays a crucial role in the development of heart diseases. In this study, the researchers demonstrated that a small biocompatible and MRI-visible melanin nanoparticles (MMPP) can improve myocardial function by inhibiting the ROS-related ferroptosis signaling pathway. Through various experiments, they showed that MMPP alleviated myocardial injury, suppressed iron-accumulation induced ferroptosis, and protected against sepsis-induced cardiac injury. These findings suggest that MMPP could be a potential novel therapeutic approach in the future.
BIOACTIVE MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Chicheng Ma, Weiwei Li, Dan Xu, Qiang Wu, Cong Li, Jinchun Tu, Kexi Zhang
Summary: A highly exposed MoS2 hybrid electrocatalyst with active edge sites is successfully prepared by employing a confined strategy of the pores of a 2D metal-organic framework (MOF). The hybrid electrocatalyst shows better hydrogen evolution reaction (HER) efficiency, with a low overpotential of 76 mV at 10 mA cm(-2) and a Tafel slope of 73 mV dec(-1), compared to pristine MoS2. The denotative growth of MoS2 from the internal pore of 2D MOF prevents stacking and exposes more active edge sites, while the incorporation of Co into MoS2 enhances the HER activity through strong electronic interaction.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Cell Biology
Shengyu Li, Lifeng Feng, Guangru Li, Ruiqing Liu, Changzhen Ma, Lin Wang, Aijiao Gao, Chang Liu, Yujie Cui, Zecheng Jiang, Yuhang Xie, Qiang Wu, Xia Wang, Liang Yang, Zhi Qi, Yanna Shen
Summary: Diabetic nephropathy (DN) is a serious complication of diabetes that significantly increases morbidity and mortality. This study found that the GSDME-dependent pyroptosis signaling pathway plays a crucial role in DN, providing important insights for potential therapeutic strategies.
CELL DEATH DISCOVERY
(2023)
Article
Nanoscience & Nanotechnology
Ting Wang, Mingliang Guo, Xiaolin Zhang, Yang Cao, Qiang Wu, Kexi Zhang, Jinchun Tu
Summary: Atomic-level defect engineering is employed to optimize the catalytic performance of transition metal-based materials. In this study, defect-rich ultrathin NiFeAl layered double hydroxide nanosheets were synthesized on nickel foam by microwave-assisted growth, exhibiting excellent oxygen evolution reaction catalytic performance. The introduction of abundant cation vacancies effectively modulates the electronic structure and enhances the adsorption strength of reaction intermediates, leading to improved catalytic performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Xuan Zhao, Xiangde Lai, Chenglong Jiang, Yanan Peng, Rui Zhang, Huajie Pang, Guangyuan Zhao, Hua Pei, Bin Qiao, Binwen Huang, Qiang Wu
Summary: This study developed a smartphone-assisted nucleic acid POCT method for rapid and accurate detection of viruses. The method utilized hybridization chain reaction, magnetic beads, and etching of gold nanorods to amplify nucleic acid signal and convert it into a visually semi-quantitative result. The method showed excellent specificity and fast detection time, making it suitable for clinical laboratory diagnosis and nucleic acid POCT research.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Bingrong Wang, Bingdong Yan, Run Yuan, Bin Qiao, Guangyuan Zhao, Jinchun Tu, Xiaohong Wang, Hua Pei, Qiang Wu
Summary: A photoelectrochemical detection platform was constructed based on the branched rutile/anatase titanium dioxide electrode. Theoretical calculations demonstrated the efficient charge separation enabled by the type-II band alignment of rutile and anatase. Carboxylated CdTe quantum dots were used for signal amplification, resulting in highly sensitive and specific detection of target DNA.
Article
Chemistry, Multidisciplinary
Yongtao Xu, Bingdong Yan, Caiyan Lai, Mingyu Wang, Yang Cao, Jinchun Tu, Delun Chen, Youbin Liu, Qiang Wu
Summary: In this study, a ZnO/ZnS nanocluster heterojunction photoelectrode with surface oxygen defects (Vo-ZnO/ZnS) was prepared using an in situ anion substitution and nitrogen atmosphere annealing method. The synergy between defect and surface engineering significantly improved the photocatalytic performance of Vo-ZnO/ZnS, allowing it to have a longer carrier lifetime, narrower band gap, higher carrier density, and better electron transfer under light conditions compared to ZnO. Vo-ZnO/ZnS also demonstrated excellent performance as a photocathode in a photoelectric sensor system for glucose detection, with a low detection limit, high sensitivity, and wide detection range.
Article
Chemistry, Multidisciplinary
Chenlong Jiang, Xiangde Lai, Feng Han, Zhijun Gao, Haixia Yang, Xuan Zhao, Huajie Pang, Bin Qiao, Hua Pei, Qiang Wu
Summary: Heart failure (HF) is a major public health problem caused by heart circulation disorders. Early detection and diagnosis are important for HF prevention and treatment, so it is necessary to establish a simple and sensitive method to monitor the diagnostic biomarkers of HF. In this study, a visual detection method using gold nanorods (AuNRs) and double-antibody-sandwich ELISA was developed for the detection of NT-proBNP, which is a sensitive biomarker for HF. The method showed a wide concentration range and low detection limit, with negligible cross-reactivity and high sample recovery rates.
Article
Nanoscience & Nanotechnology
Yuanyuan Wang, Li Yin, Jie Wu, Nan Li, Na He, Haixin Zhao, Xiaotian Li, Xiaoyong Lai, Qiang Wu
Summary: A photoelectrochemical electrode for glucose detection was developed using a polyaniline modified titanium dioxide heterojunction structure. The electrode exhibited excellent performance in detecting glucose, with a linear range of 0.2-1.0 mM and a sensitivity of 15.63 mu A mM(-1) cm(-2) in one range and a linear range of 1.0-15.0 mM with a sensitivity of 1.42 mu A mM(-1) cm(-2) in another range.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
