Article
Biochemistry & Molecular Biology
Andrea Barrientos-Riosalido, Monica Real, Laia Bertran, Carmen Aguilar, Salome Martinez, David Parada, Margarita Vives, Fatima Sabench, David Riesco, Daniel Del Castillo, Cristobal Richart, Teresa Auguet
Summary: This study analyzed the expression of ATG7 gene in obesity-associated NAFLD and found that ATG7 was highly expressed in NASH patients. ATG7 may play an important role in the pathogenesis of NAFLD, especially in NASH, possibly having a protective effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jaclyn S. Long, Elzbieta Kania, David G. McEwan, Valentin J. A. Barthet, Martina Brucoli, Marcus J. G. W. Ladds, Christoph Nossing, Kevin M. Ryan
Summary: Research findings show that the loss of Atg7 in a model of PDAC with mutant Kras(G12D) and mutant Trp53(172H/+) promotes tumor development and enhances metastasis, while reducing the occurrence of metastasis. Tumors with Atg7(+/-) have lower levels of succinate and lower invasion capabilities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Cell Biology
Jack J. Collier, Monika Olahova, Thomas G. McWilliams, Robert W. Taylor
Summary: ATG7 plays a crucial role in autophagy, and dysfunction of ATG7 may lead to neurological issues. Studies have identified patients with specific ATG7 variants suffering from neurodevelopmental disorders, with the pathology being linked to attenuated autophagy.
Article
Cardiac & Cardiovascular Systems
Yong Wang, Xiaoguang Lu, Xiaoping Wang, Qi Qiu, Ping Zhu, Lin Ma, Xiao Ma, Joerg Herrmann, Xueying Lin, Wei Wang, Xiaolei Xu
Summary: The study aimed to elucidate the dynamic autophagic defects in AIC and identify a mechanism-based therapy through genetic and pharmacological studies. Results showed that atg7-based autophagy activation is an effective therapeutic avenue to reverse the decline in cardiac function in AIC, highlighting the time-dependent nature of autophagy-based therapy.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Hui Liu, Jia-Yi Wei, Yuan Li, Meng Ban, Qi Sun, Hui-Jie Wang, Dan Zhao, Pai-Ge Tong, Li Wang, Kang-Ji Wang, Jin-Li Yue, Hong-Yan Zhang, Wen-Gang Fang, Dong-Xin Liu, De-Shu Shang, Bo Li, Ya-Ping Jin, Liu Cao, Wei-Dong Zhao, Yu-Hua Chen
Summary: Liu et al. have discovered that Atg7, regulated by endothelial cells, is necessary for the attachment of astrocytes to the microvascular wall. Deficiency of endothelial Atg7 suppresses fibronectin through PKA/CREB signaling. This study has revealed the autophagy-independent function of endothelial Atg7 in maintaining the integrity of the blood-brain barrier (BBB).
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Bora Lee, Hyejin Shin, Ji-Eun Oh, Jaekyoung Park, Mira Park, Seung Chel Yang, Jin-Hyun Jun, Seok-Ho Hong, Haengseok Song, Hyunjung Jade Lim
Summary: The study revealed that the deficit of autophagy in the uterine vessel microenvironment provokes hyperpermeability through the deregulation of VEGFA, NOS1, and CTNNB1, affecting the vascular stability and function.
Review
Medicine, Research & Experimental
Jack J. Collier, Fumi Suomi, Monika Olahova, Thomas G. McWilliams, Robert W. Taylor
Summary: ATG proteins are essential for macroautophagy and play important roles beyond autophagic elimination. Dysfunction of ATG7 is associated with diseases, but the mechanisms of how it contributes to these diseases remain unclear. Further research on the relationship between ATG7 dysfunction and diseases will help develop therapies for disorders involving ATG7 deficiency and impaired autophagy.
EMBO MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hu-Qiang He, Yuan-Qing Qu, Betty Yuen Kwan Law, Cong-Ling Qiu, Yu Han, Ivo Ricardo de Seabra Rodrigues Dias, Yong Liu, Jie Zhang, An-Guo Wu, Cheng-Wen Wu, Simon Wing Fai Mok, Xin Cheng, Yan-Zheng He, Vincent Kam Wai Wong
Summary: The study found that calcification was upregulated in HASMCs treated with AGEs when autophagy and apoptosis were activated. However, AGEs-activated calcification and apoptosis were suppressed in Atg7 knockout cells or pretreated with wortmannin (WM), an autophagy inhibitor. This suggests potential clinical applications for autophagy inhibitors in the treatment of diabetes-related vascular calcification.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xi Chen, Qingchun He, Shuangshuang Zeng, Zhijie Xu
Summary: This study suggests that nuclear division cycle 80 (NDC80) may serve as a novel prognostic indicator of lung cancer and promotes the development of lung cancer by regulating autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xingxia Wang, Wei Hu, Liqun Qu, Jian Wang, Anguo Wu, Hang Hong Lo, Jerome P. L. Ng, Yong Tang, Xiaoyun Yun, Jianhui Wu, Vincent Kam Wai Wong, Sookja Kim Chung, Linna Wang, Weidan Luo, Xiang Ji, Betty Yuen Kwan Law
Summary: Tricin, a natural compound, has been found to have antioxidant, anti-inflammatory, and autophagic effects. It can induce autophagy and lower the level of alpha-synuclein in a PD model. Tricin may serve as a potential adjuvant therapy or nutraceutical for the prevention and treatment of PD.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Plant Sciences
Wenxin Zhang, Zimei Wu, Huijie Qi, Lu Chen, Tianxiao Wang, Xiang Mao, Huanying Shi, Haifei Chen, Mingkang Zhong, Xiaojin Shi, Xinhai Wang, Qunyi Li
Summary: The study demonstrated that Celastrol induced apoptosis and autophagy in colorectal cancer cells, with Nur77 playing a crucial role in its anti-cancer effects and influencing the expression of ATG7.
Article
Physiology
Yushi Uchida, Kumiko Torisu, Kenji Ueki, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: The study showed that autophagy regulates albumin transcytosis in proximal tubule epithelial cells by modulating FcRn transport, and inhibition of autophagy leads to albumin accumulation and cytotoxicity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chong Wang, Zhao Tang, Ze Zhang, Tiantian Liu, Jingwei Zhang, Houbao Huang, Yawei Li
Summary: Bladder cancer is one of the most common cancers in men, and miR-7-5p acts as a tumor suppressor gene in its treatment by inhibiting migration, invasion, and autophagy, and improving chemosensitivity.
Article
Cell Biology
Zhenxuan Shao, Libin Ni, Sunli Hu, Tianzhen Xu, Zaher Meftah, Zupo Yu, Naifeng Tian, Yaosen Wu, Liaojun Sun, Aimin Wu, Zongyou Pan, Linwei Chen, Weiyang Gao, Yifei Zhou, Xiaolei Zhang, Xiangyang Wang
Summary: This study suggests that HuR may suppress senescence through autophagy activation via stabilizing Atg7 in diabetic NP cells. Overexpression of Atg7, but not HuR, may serve as a potential therapeutic target for DB-IVDD.
CELL PROLIFERATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiumei Zhuang, Xiaoxuan Lin, Ruogu Xu, Zhengchuan Zhang, Bin Zhou, Feilong Deng
Summary: Oral myofibroblasts resist apoptosis induced by irradiation through autophagy activation. Silencing ATG7 inhibits autophagy and promotes apoptosis of oral myofibroblasts.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
