Journal
BIOMICROFLUIDICS
Volume 14, Issue 4, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/5.0005373
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Funding
- Anhui Natural Science Foundation of China [1908085MF197]
- National Natural Science Foundation of China (NNSFC) [21904003]
- Natural Science Foundation of Anhui Province [1908085QB66]
- [2014M550794]
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Circulating tumor cells (CTCs) are tumor cells detached from the original lesion and getting into the blood and lymphatic circulation systems. They potentially establish new tumors in remote areas, namely, metastasis. Isolation of CTCs and following biological molecular analysis facilitate investigating cancer and coming out treatment. Since CTCs carry important information on the primary tumor, they are vital in exploring the mechanism of cancer, metastasis, and diagnosis. However, CTCs are very difficult to separate due to their extreme heterogeneity and rarity in blood. Recently, advanced technologies, such as nanosurfaces, quantum dots, and Raman spectroscopy, have been integrated with microfluidic chips. These achievements enable the next generation isolation technologies and subsequent biological analysis of CTCs. In this review, we summarize CTCs' separation with microfluidic chips based on the principle of immunomagnetic isolation of CTCs. Fundamental insights, clinical applications, and potential future directions are discussed.
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