Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kun Chen, Jian Wang, Shuai Li, Wen Zhou, Wengui Xu
Summary: The study aimed to develop and validate an F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) model for predicting the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients. Data pre-processing methods, including the elimination of batch effects and data discretization, were used to enhance the predictive effect of the model. Several excellent models were selected, and the optimal model predicted AUC values between 0.7 and 0.77 for four test groups, with statistically significant p-values from permutation tests.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Oncology
Chae Hong Lim, Joon Young Choi, Joon Ho Choi, Jun-Hee Lee, Jihyoun Lee, Cheol Wan Lim, Zisun Kim, Sang-Keun Woo, Soo Bin Park, Jung Mi Park
Summary: This study developed and validated a predictive model using F-18-FDG PET-derived radiomics to predict pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer. The model demonstrated satisfactory performance in training, internal validation, and external validation cohorts. The combination model incorporating human epidermal growth factor receptor 2 (HER2) status showed improved predictive performance compared to the radiomic-score model alone.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Thierry Galvez, Ikrame Berkane, Simon Thezenas, Marie-Claude Eberle, Nicolas Flori, Sophie Guillemard, Alina Diana Ilonca, Lore Santoro, Pierre-Olivier Kotzki, Pierre Senesse, Emmanuel Deshayes
Summary: F-18-FDG PET-CT is commonly used for the initial staging of various cancers. This study found a significant association between F-18-FDG uptake in the brain and initial weight loss in patients with esophageal cancer, providing new insights for the diagnosis and treatment of anorexia in cancer patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sameer Taywade, Tanisha Gupta, Rajesh Kumar, Rahul Choudhary, Deepak Kumar
Summary: Nuclear imaging plays a crucial role in evaluating cardiac diseases of infective, inflammatory, innervation, and infiltrative origins. We report a case of persistent pyrexia after percutaneous transluminal coronary angioplasty in a patient with a history of inferior wall myocardial infarction. Molecular imaging techniques, such as F-18-FDG PET/CT and Tc-99m-MIBI myocardial perfusion study, helped in narrowing the differentials and eventually diagnosing the patient with Dressler syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Jian-Wei Yang, Ling-Ling Yuan, Yan Gao, Xu-Sheng Liu, Yu-Jiao Wang, Lu-Meng Zhou, Xue-Yan Kui, Xiao-Hui Li, Chang-Bin Ke, Zhi-Jun Pei
Summary: The study found a correlation between the expression levels of EIF2S2 gene and F-18-FDG PET/CT metabolic parameters in CRC patients, and a positive correlation between EIF2S2 and GLUT1 expression. Overexpression of EIF2S2 in CRC can promote glycolysis.
Article
Medicine, General & Internal
Do-Hoon Kim, Junik Son, Chae Moon Hong, Ho-Sung Ryu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee
Summary: In this study, we developed a novel quantification method using PET/CT and shape feature to discriminate between Alzheimer's disease and mild cognitive impairment or other precursors dementia. We calculated the cerebral amyloid smoothing score and brain atrophy index using PET images, and gray and white matter from trained CT data. Our results showed that shape feature had similar accuracy to standard uptake values in ROC analysis, and correlated well with neuropsychological tests. This suggests that shape feature is useful in the diagnosis of Alzheimer's disease.
Article
Cardiac & Cardiovascular Systems
Sekeun Kim, Hyung-Bok Park, Jaeik Jeon, Reza Arsanjani, Ran Heo, Sang-Eun Lee, Inki Moon, Sun Kook Yoo, Hyuk-Jae Chang
Summary: This study aims to compare the segmentation performance of current prominent deep learning algorithms with ground-truth segmentations and validate the reproducibility of manually created four cardiac chamber ground-truth annotations in 2D echocardiography. The results show that the three current prominent DL-based fully automated methods are able to reliably perform four-chamber segmentation and quantification of clinical indices, with some degree of inter-observer variability.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Hyun Hwang, Hye-Suk Hong, Dongwoo Kim, Gyoung Min Kim, Hye Won Lee, Misu Lee, Do Young Kim, Mi-Ae Park, Mijin Yun
Summary: This study evaluated the prognostic value of metabolic parameters on F-18-FDG PET/CT and tumor dose (TD) on post-treatment Y-90 PET/CT in HCC patients undergoing Y-90 transarterial radioembolization (TARE). The results showed that TLG is a better prognostic factor for OS than TD in these patients.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Yusun Park, Yeonju Han, Dongwoo Kim, Sua Cho, WonJin Kim, Hyemin Hwang, Hye Won Lee, Dai Hoon Han, Kyung Sik Kim, Mijin Yun, Misu Lee
Summary: This study examined the use of exogenous histidine treatment to enhance tumor responses to sorafenib in patients with advanced hepatocellular carcinoma (HCC). Histidine treatment reduced the expression of tumor markers related to glycolysis, inflammation, angiogenesis, and stem cells in HCC cells. Combined treatment with sorafenib and histidine may be a novel therapeutic strategy to improve the sensitivity to sorafenib and enhance long-term survival in HCC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongwoo Kim, Joong Hyun Chun, Ju Hyeon Yi, Hae Young Ko, Jee-In Chung, Misu Lee, Yongmin Mason Park, Min-Ho Nam, Jisu Kim, Seon Yoo Kim, Youngjoo Park, Ju Hyung Moon, Seok-Gu Kang, Jong Hee Chang, C. Justin Lee, Se Hoon Kim, Mijin Yun
Summary: C-11-ACE PET/CT is an imaging biomarker that can characterize reactive astrogliosis in different types of gliomas. High C-11-ACE uptake is associated with high-grade IDH1-wt tumors, allowing differentiation from high-grade IDH1-mt and low-grade gliomas. Low C-11-ACE uptake in ODs is advantageous in overcoming the limitations of radiolabeled amino acid tracers.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Seon Yoo Kim, Dongwoo Kim, Jisu Kim, Hae Young Ko, Won Jin Kim, Youngjoo Park, Hye Won Lee, Dai Hoon Han, Kyung Sik Kim, Sunghyouk Park, Misu Lee, Mijin Yun
Summary: Patients with low-glycolytic hepatocellular carcinoma (HCC) have better clinical outcomes compared to those with hypoxic and high-glycolytic HCC. The study found that SLC13A5/NaCT is an important solute carrier (SLC) in low-glycolytic HCCs. Extracellular citrate treatment in HCCs with high SLC13A5/NaCT expression led to reduced glucose uptake and tumor growth inhibition. This research suggests that extracellular nutrient administration related to SLCs can prevent hypoxic tumor progression in low-glycolytic HCC.
Article
Engineering, Biomedical
JunHwan Kwon, Oyun Kwon, KyeongTeak Oh, Jeongmin Kim, Cheung Soo Shin, Sun K. Yoo
Summary: In this study, a model for calculating respiratory volume based on nasal cavity temperature changes was proposed and compared with a respiratory volume monitor for validation. The results suggest that the model is a feasible method for estimating relative tidal volume.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Yun Joong Kim, Hye Sun Lee, Seong Ho Jeong, Ji-Man Hong, Young H. Sohn, Mijin Yun, Yong Jeong, Phil Hyu Lee
Summary: Different patterns of striatal dopamine depletion are closely associated with WM structural alterations, which may contribute to heterogeneous cognitive profiles in individuals with PD.
Article
Clinical Neurology
Yae Ji Kim, Chan Wook Park, Hye Won Shin, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Yong Jeong, Seok Jong Chung
Summary: This study explored the white matter structural network associated with motor reserve in patients with newly diagnosed Parkinson's disease (PD). It found that higher network strength was associated with a slower longitudinal increase in levodopa-equivalent dose (LED) during a 3-year follow-up period.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Computer Science, Interdisciplinary Applications
Sekeun Kim, Zhenxiang Jiang, Byron A. A. Zambrano, Yeonggul Jang, Seungik Baek, Sunkook Yoo, Hyuk-Jae Chang
Summary: Prediction of abdominal aortic aneurysm (AAA) growth is crucial for early treatment and surgical intervention. By integrating physics-based knowledge with deep learning using a convolutional neural network (CNN) approach, important multiphysical features can be incorporated to enhance AAA growth prediction.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Clinical Neurology
Kyoungwon Baik, Seun Jeon, Soh-Jeong Yang, Yeona Na, Seok Jong Chung, Han Soo Yoo, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Byoung Seok Ye
Summary: This study aimed to investigate the impact of demographic factors on cortical thickness and brain glucose metabolism in healthy aging individuals. A total of 71 subjects were assessed using neurological examination, 3-tesla magnetic resonance imaging, 18F-fluorodeoxyglucose positron-emission tomography, and neuropsychological tests. Cortical thickness and brain metabolism were measured using vertex- and voxelwise analyses, respectively. General linear models were used to determine the effects of age, sex, and education on cortical thickness and brain glucose metabolism. The study found that age and sex have differential effects on cortical thickness and brain metabolism, highlighting the importance of considering demographic factors in the analysis.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Neurosciences
Seong Ho Jeong, Jungho Cha, Jin Ho Jung, Mijin Yun, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study found that additional occipital amyloid-beta deposition is associated with poor baseline language function and rapid cognitive deterioration in patients with Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Hyun Mok Park, Seungjae Ryu, Eunah Jo, Sun Kook Yoo, Young Wook Kim
Summary: Effective oral care is crucial for maintaining a high quality of life. A toothbrush using bioelectric effect has been developed, demonstrating higher efficiency in removing oral biofilms compared to traditional manual toothbrushes. Tests have shown significant biofilm removal effects in both saline and toothpaste conditions, with less dependence on toothpaste.
BIOENGINEERING-BASEL
(2023)
Article
Engineering, Biomedical
Junhwan Kwon, Oyun Kwon, Kyeong Taek Oh, Jeongmin Kim, Sun K. K. Yoo
Summary: Breathing can be measured in a non-contact method using a thermal camera. This study proposed a new algorithm that can extract stable breathing signals at various angles and views. The results showed an improvement in breathing cycle accuracy and correlation value compared to the previous method, allowing for monitoring in diverse environments.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Article
Computer Science, Information Systems
Jiwon Choi, Kyeong-Taek Oh, Oyun Kwon, Jun Hwan Kwon, Jeongmin Kim, Sun K. Yoo
Summary: This paper proposes a method for measuring human respiration using a thermal camera. The method utilizes a multi-resolution window and phase-sensitive processing to achieve accurate respiratory rate prediction in a non-contact manner. The results show high accuracy and potential for application in clinical environments.