Review
Immunology
Rebecca R. Crowther, Joseph E. Qualls
Summary: This article provides a summary of the current knowledge on anti-Mtb immunity, focusing on immune cell amino acid metabolism, specifically discussing the roles of L-arginine and L-tryptophan in TB patients. By uncovering the immune cell contribution during Mtb infection and how amino acid utilization regulates their functions, novel host-directed therapies may be developed and refined to help eradicate TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agronomy
Robert Rosa, Larysa Hajko, Jolanta Franczuk, Anna Zaniewicz-Bajkowska, Alena Andrejiova, Ivana Mezeyova
Summary: Amino acids used as plant stimulants have a positive impact on crop quality and yields, playing a crucial role in global food security. This study investigated the effects of two amino acids, L-tryptophan and L-glutamic acid, on carrot yield and quality, and found that the synergistic action of these two amino acids significantly increased carrot yield and improved protein and total soluble solids content.
Article
Multidisciplinary Sciences
Miku Sato, Narumi Harada-Shoji, Takafumi Toyohara, Tomoyoshi Soga, Masatoshi Itoh, Minoru Miyashita, Hiroshi Tada, Masakazu Amari, Naohiko Anzai, Shozo Furumoto, Takaaki Abe, Takashi Suzuki, Takanori Ishida, Hironobu Sasano
Summary: The study found that L-type amino acid transporter-1 (LAT1) plays an important role in therapeutic resistance and clinical outcomes of breast cancer. Glucose and amino acid metabolism were closely related, and in vitro experiments showed that LAT1 promoted amino acid uptake for energy production. Oncometabolites and branched-chain amino acids were also key players in energy production and drug resistance in chemotherapeutic-treated MCF-7 cells.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Bin Wang, Lili Jiang, Zhenlong Wu, Zhaolai Dai
Summary: This study investigated the effects of L-tryptophan (Trp) on lipopolysaccharide (LPS)-induced changes in glucose and amino acid transport in the rat jejunum. The results showed that Trp alleviated LPS-induced increase in permeability and decrease in short-circuit current of various nutrients. Trp also reversed the downregulation of certain transporters while increasing the expression of an acidic amino acid transporter. These findings have implications for nutritional interventions to improve gut function in the presence of inflammation.
Review
Biochemistry & Molecular Biology
Ancuta Dinu, Constantin Apetrei
Summary: In recent years, the development of sensors and biosensors has become a hot topic in interdisciplinary research, attracting researchers from various fields. This paper synthesizes the most relevant studies on the construction and functioning of versatile devices, as well as electrochemical sensors and biosensors. It focuses on the role and importance of the amino acids phenylalanine, tyrosine, and tryptophan in the central nervous system, and the application of conductor polymers and molecularly imprinted polymers in achieving electrochemical sensors and biosensors. The paper also analyzes the performance of sensors and biosensors developed so far for amino acid detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Rafael Massami Suzuki, Matheus de Paula Reis, Juliana Celia Denadai, Leticia Graziele Pacheco, Carolina Cardoso Nagib Nascimento, Nilva Kazue Sakomura
Summary: The study utilized L-[N-15] threonine to evaluate its incorporation rate and distribution among different tissues of broiler chickens at various ages. The results showed that the incorporation rate of L-[N-15] threonine decreased with age in most tissues, except for the jejunum. The study provides valuable insights into tissue-specific changes in amino acid requirements with age.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Food Science & Technology
Xitong Fei, Haichao Hu, Yingli Luo, Qianqian Shi, Anzhi Wei
Summary: This study evaluated the quality characteristics of amino acids in peppers using various methods and identified the key genes involved in amino acid synthesis. The findings have important implications for the development of pepper functional food.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Chemistry, Analytical
Hashmatullah Nasimi, Jonna Skov Madsen, Ahmed H. Zedan, Anders Malmendal, Palle Jorn Sloth Osther, Fatima AlZahra'a Alatraktchi
Summary: Amino acids such as tyrosine and tryptophan have attracted attention as potential biomarkers for various diseases. Electrochemical sensors offer a simple, cost-effective, and highly sensitive alternative to metabolomic methods for detecting these amino acids.
MICROCHEMICAL JOURNAL
(2023)
Article
Plant Sciences
Jinjing Cheng, Leilei Xiang, Meizhen Yang, Ying Liu, Luyi Pan, Zhenfei Guo, Shaoyun Lu
Summary: This study analyzed the transcriptomic profiling of Kentucky bluegrass cultivar 'Qinghai' in response to osmotic stress, and identified key genes involved in carbohydrate metabolism, polyamine and amino acid metabolism, and plant hormone signaling pathway. These findings provide promising candidate genes for studying drought mechanisms and improving drought tolerance in Kentucky bluegrass and drought-sensitive crops.
Article
Chemistry, Medicinal
Julien Graff, Jennifer Mueller, Anna Sadurni, Matthias Rubin, Ines Andre Canivete Cuissa, Claudia Keller, Marco Hartmann, Simon Singer, Jurg Gertsch, Karl-Heinz Altmann
Summary: A series of derivatives of the substrate amino acid l-tryptophan have been investigated for inhibition of the L-type amino acid transporter LAT1. The 5-substituted derivative showed the highest potency, while the replacement of the carboxy group led to a complete loss in potency. Increasing the steric bulk at the 5-position did not improve the inhibitory activity. None of these derivatives were found to be substrates for LAT1-mediated transport.
Article
Biochemistry & Molecular Biology
Ancuta Dinu, Constantin Apetrei
Summary: This research introduced the development of new electrochemical sensors modified with polypyrrole for selective and sensitive detection of Tyrosine. The sensors showed good sensitivity in detecting L-Tyr and demonstrated adequate selectivity for potential use in the pharmaceutical and medical fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Yaxian Gao, Jiaqing Li, Xinya Guo, Liru Guan, Jie Wang, Xiaochen Huang, Wenjuan Wang, Hua Yang
Summary: Amino acid L-tyrosine has been found to reduce the survival of Mycobacterium tuberculosis in animals and inhibit its replication within the host. This discovery may pave the way for the development of amino acid-based treatments for tuberculosis infections.
Article
Spectroscopy
Arul Pundi, Chi-Jung Chang, Yi-Shao Chen, Jem-Kun Chen, Jui-Ming Yeh, Cai-Shan Zhuang, Ming-Ching Lee
Summary: A novel multifunctional cation-amino acid sensor (CAS) was synthesized in this study for the detection of metal ions and amino acids, with low detection limits. The CAS-Cu2+ complex can act as a fluorescence sensor for L-tryptophan.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Dongmin Liu, Siyu Wang, Yaqing Liu, Yong Luo, Beibei Wen, Wenliang Wu, Hongliang Zeng, Jianan Huang, Zhonghua Liu
Summary: This study found that Fuzhuan brick tea (FBT) improved obesity, hepatic steatosis, and steatohepatitis induced by a high-fat diet by regulating gut microbiota and tryptophan metabolism. FBT increased the abundance of AhR-ligand producing bacteria and elevated the cecal contents of AhR-ligands, thereby regulating the expression of related genes in the liver. These findings highlight the beneficial effects of FBT on obesity-related hepatic steatosis and steatohepatitis through microbiota-derived AhR signaling.
Article
Plant Sciences
Yanmei Sun, Yiwen Lu, Haojie Xi, Bohao Geng, Haifan Shi, Na Zhao, Zhenfei Guo
Summary: This study investigates the transcriptomic profiling in response to cold in a mutant with reduced anthocyanin accumulation in common vetch. The mutant shows higher survival rate and biomass during overwintering, leading to increased forage production. Transcriptomic analysis revealed that reduced anthocyanin accumulation in the mutant is associated with altered metabolism and increased accumulation of free amino acids and polyamines, which contribute to improved cold tolerance.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Le Wang, Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian
ANALYTICA CHIMICA ACTA
(2015)
Article
Biochemistry & Molecular Biology
Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, Zhongmin Tian
Article
Cell Biology
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang, Zhongmin Tian
Article
Biochemical Research Methods
Entai Hou, Xian Li, Zerong Liu, Fuchang Zhang, Zhongmin Tian
BIOMEDICAL CHROMATOGRAPHY
(2018)
Article
Medicine, Research & Experimental
Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang
Article
Biochemistry & Molecular Biology
Le Wang, Entai Hou, Zhengjun Wang, Na Sun, Liqing He, Lan Chen, Mingyu Liang, Zhongmin Tian
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Peripheral Vascular Disease
Xuewei Zheng, Meng Chen, Xiaoxue Li, Pengfei Yang, Xinrui Zhao, Yanan Ouyang, Zhe Yang, Mingyu Liang, Entai Hou, Zhongmin Tian
HYPERTENSION RESEARCH
(2019)
Article
Cell Biology
Junsheng Li, Minzhen Lu, Puyao Zhang, Entai Hou, Tianjie Li, Xian Liu, Xiaofei Xu, Zhaohui Wang, Yong Fan, Xiumei Zhen, Rong Li, Ping Liu, Yang Yu, Jing Hang, Jie Qiao
Article
Biochemical Research Methods
Entai Hou, Jie Yan, Xiaohui Zhu, Jie Qiao
Summary: High-salt diets cause elevated levels of reactive oxygen species (ROS) in ovarian tissue, leading to increased oxidative stress. This study found that ROS and H2O2 levels significantly increased in the ovaries of mice on a high-salt diet, along with enhanced antioxidant enzyme activity. However, the activation of antioxidant defense appeared insufficient to counterbalance the increased oxidative stress. In addition, high-salt diets significantly altered the metabolic patterns of ovarian tissue, mainly affecting fatty acid metabolism.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Meeting Abstract
Peripheral Vascular Disease
Xue Hong, Cheng Yuan, Song Haiying, Pan Xiaoqing, Wan Yifei, Wang Tao, Tian Zhongmin, Hou Entai, Ian R. Lanza, Liu Pengyuan, Liu Yong, Purushottam W. Laud, Kristie Usa, He Yongcheng, Liang Mingyu
Article
Biochemical Research Methods
Zhongmin Tian, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou, Na Sun
CURRENT PROTEOMICS
(2014)
Meeting Abstract
Peripheral Vascular Disease
Le Wang, Entai Hou, Zhengjun Wang, Na Sun, Liqing He, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian
Meeting Abstract
Peripheral Vascular Disease
Zhongmin Tian, Le Wang, Entai Hou, Qiong Sun