Article
Cardiac & Cardiovascular Systems
Jesse D. Cochran, Yoshimitsu Yura, Mark C. Thel, Heather Doviak, Ariel H. Polizio, Yuka Arai, Yohei Arai, Keita Horitani, Eunbee Park, Nicholas W. Chavkin, Anupreet Kour, Soichi Sano, Nitin Mahajan, Megan Evans, Mahalia Huba, Nadia Martinez Naya, Hanna Sun, Young Ho Ban, Karen K. Hirschi, Stefano Toldo, Antonio Abbate, Todd E. Druley, Frederick L. Ruberg, Mathew S. Maurer, Justin A. Ezekowitz, Jason R. B. Dyck, Kenneth Walsh
Summary: The study identified an enrichment of TET2-mediated CH in patients with HFpEF, which was associated with exacerbated diastolic dysfunction. Patients with HFpEF, aged >= 70 years and CH, exhibited a worse prognosis in terms of 5-year cardiovascular-related hospitalization rate compared with those without CH.
Article
Peripheral Vascular Disease
Michael A. Francisco, Joshua F. Lee, Zachary Barrett-O'Keefe, H. Jonathan Groot, Stephen M. Ratchford, Kanokwan Bunsawat, Jeremy K. Alpenglow, John J. Ryan, Jose N. Nativi, Russell S. Richardson, D. Walter Wray
Summary: The study revealed a significant decline in lower limb microvascular function in patients with HFpEF compared to healthy controls, possibly associated with systemic inflammation and oxidative damage. However, disease-related biomarkers of inflammation and oxidative damage were not correlated with responses to passive leg movement.
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Walter J. Paulus, Michael R. Zile
Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.
CIRCULATION RESEARCH
(2021)
Review
Cell Biology
Thassio Mesquita, Yen-Nien Lin, Ahmed Ibrahim
Summary: HFpEF is the predominant form of heart failure with a significant increase in risk with age. Low-grade inflammation, termed inflammaging, is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated disease severity and improved outcomes in HFpEF. Inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression.
Review
Cardiac & Cardiovascular Systems
Francesca Graziani, Rosa Lillo, Filippo Crea
Summary: HFpEF is a significant public health issue with a lack of effective treatment. A new paradigm suggests that coexisting cardiovascular and non-cardiovascular comorbidities may lead to systemic inflammation, potentially resulting in myocardial fibrosis. Anti-fibrotic and anti-inflammatory drugs may play a role in treating HFpEF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Tiantian He, Chen Liu, Weihao Liang
Summary: This study aimed to explore the prognostic value of abnormal electrocardiogram (ECG) at baseline in patients with heart failure with preserved ejection fraction (HFpEF). The results showed that abnormal ECG was significantly associated with higher risks of cardiovascular events and HF hospitalization in HFpEF patients. Specific abnormalities like bundle branch block and atrial fibrillation were also found to be predictive of adverse outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Medicine, Research & Experimental
Min Zhang, Hongyang Shu, Chen Chen, Zuowen He, Zhou Zhou, Dao Wen Wang
Summary: Heart failure with preserved ejection fraction (HFpEF) has a negative impact on quality of life, requires significant medical resources, and has a high mortality rate. Currently, there is a lack of effective therapy for HFpEF due to limited knowledge of its mechanism. Epoxyeicosatrienoic acids (EETs) are endogenous cardioprotective factors that have inhibitory effects on the fundamental mechanisms of HFpEF, such as inflammation, endothelial dysfunction, cardiac remodeling, and fibrosis. Therefore, exploring the potential of EETs as a therapeutic target for HFpEF is crucial.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Javed Butler, Dimitrios Farmakis, Faiez Zannad, Anne Pernille Ofstad, Joao Pedro Ferreira, Jennifer B. Green, Julio Rosenstock, Sven Schnaidt, Martina Brueckmann, Stuart J. Pocock, Milton Packer, Stefan D. Anker
Summary: In patients with heart failure and preserved ejection fraction, empagliflozin significantly reduces the risk of heart failure outcomes, regardless of diabetes status at baseline.
Letter
Medicine, General & Internal
Elric Zweck, Ralf Westenfeld, Bjorn Redfors, Elmir Omerovic, Robin A. P. Weir, Domenico Gabrielli, Fabrizio Oliva, Giuseppe Zuccala, Scott D. Solomon, Muthiah Vaduganathan, John J. V. McMurray
Summary: Solomon et al. report on the DELIVER trial, which showed that dapagliflozin reduced risks of heart failure-related outcomes in patients with a mildly reduced or preserved left ventricular ejection fraction. These findings are expected to influence guidelines and clinical practice. The trial also confirmed dapagliflozin's efficacy in patients with a left ventricular ejection fraction of 60% or above.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Khaled Elkholey, Monika Niewiadomska, Lynsie Morris, Seabrook Whyte, Jeremy Houser, Mary Beth Humphrey, Stavros Stavrakis
Summary: This study found that low-level transcutaneous vagus nerve stimulation (LLTS) improved cardiac function in a rat model of heart failure with preserved ejection fraction (HFpEF) through its anti-inflammatory and antifibrotic effects.
CIRCULATION-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Karl-Patrik Kresoja, Karl-Philipp Rommel, Rolf Wachter, Sylvia Henger, Christian Besler, Nora Kloeting, Moritz Schnelle, Anne Hoffmann, Petra Buettner, Uta Ceglarek, Holger Thiele, Markus Scholz, Frank Edelmann, Matthias Blueher, Philipp Lurz
Summary: This study aimed to investigate circulating biomarkers in obese HFpEF patients and found that they exhibit higher levels of biomarkers related to volume expansion, myocardial fibrosis, and systemic inflammation compared to non-HFpEF or lean HFpEF patients. These findings support the clinical definition of a distinct obese HFpEF phenotype and may warrant further investigation.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Besler, Karl-Philipp Rommel, Karl-Patrik Kresoja, Justus Moerbitz, Holger Kirsten, Markus Scholz, Karin Klingel, Joachim Thiery, Ralph Burkhardt, Petra Buettner, Volker Adams, Holger Thiele, Philipp Lurz
Summary: PDE9A expression is increased in endomyocardial biopsies and peripheral blood mononuclear cells from patients with HFpEF, and correlates with inflammatory cell count in EMBs and high-sensitivity C-reactive protein levels in PBMNCs. Additionally, lower PDE9A expression in PBMNCs is associated with worse survival in HFpEF patients after age adjustment.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Kavita Sharma, Sanjiv J. Shah, Jennifer E. Ho
Summary: The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing due to aging, obesity, sedentariness, and cardiometabolic disorders. Despite recent advances in understanding its pathophysiological effects and introduction of new diagnosis approaches, HFpEF remains under-recognized. This is concerning as effective treatments have been identified. This article provides an in-depth examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF. (J Am Coll Cardiol 2023;81:1810-1834) (c) 2023 by the American College of Cardiology Foundation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Letter
Medicine, General & Internal
Debdatta Bhattacharyya, Ayan Kar, Saurabh Dhumale, Filippos K. Triposkiadis, Andrew Xanthopoulos, Efstathios K. Iliodromitis, James Amato, Hiddo J. L. Heerspink, Lesley Inker, Tom Greene, Stefan D. Anker, Javed Butler, Milton Packer
Summary: In patients with heart failure and preserved ejection fraction, Empagliflozin reduced the incidence of primary outcome events compared to other drugs, but had higher rates of cardiovascular death, death from any cause, and hospitalization for heart failure compared to spironolactone.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alice Wood, Alexios Antonopoulos, Surawee Chuaiphichai, Theodosios Kyriakou, Rebeca Diaz, Abtehale Al Hussaini, Anna Marie Marsh, Manjit Sian, Mitul Meisuria, Gerry McCann, Victoria S. Rashbrook, Edward Drydale, Sally Draycott, Murray David Polkinghorne, Ioannis Akoumianakis, Charalambos Antoniades, Hugh Watkins, Keith M. Channon, David Adlam, Gillian Douglas
Summary: The aim of this study was to investigate the role of PHACTR1 in vascular function. It was found that the PHACTR1 locus was significantly associated with changes in distensibility in the ascending aorta and carotid artery. However, no association was observed in the descending aorta or in SCAD patients. Additionally, no association was found between the PHACTR1 locus and endothelial cell function. A murine model also confirmed these findings.
CARDIOVASCULAR RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah L. Ayton, Aseel Alfuhied, Gaurav S. Gulsin, Kelly S. Parke, Joanne Wormleighton, J. Ranjit Arnold, Alastair J. Moss, Anvesha Singh, Hui Xue, Peter Kellman, Matthew P. M. Graham-Brown, Gerry P. McCann
Summary: The study compared the agreement of left ventricular strain measurements at 1.5 T and 3 T, finding that measurements derived from short-axis images had better agreement, while global longitudinal shortening showed good agreement.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Eva M. Boorsma, Jozine M. Ter Maaten, Kevin Damman, Bart J. van Essen, Faiez Zannad, Dirk J. van Veldhuisen, Nilesh J. Samani, Kenneth Dickstein, Marco Metra, Gerasimos Filippatos, Chim C. Lang, Leong Ng, Stefan D. Anker, John G. Cleland, Pierpaolo Pellicori, Ron T. Gansevoort, Hiddo J. L. Heerspink, Adriaan A. Voors, Johanna E. Emmens
Summary: Albuminuria is common in patients with heart failure and is associated with clinical symptoms and biomarkers of congestion. It is also related to the severity and prognosis of heart failure.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Eerde H. Weening, Ali A. Al-Mubarak, Martin M. Dokter, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Marco Metra, Dirk J. van Veldhuisen, Daan J. Touw, Rudolf A. de Boer, Ron T. Gansevoort, Adriaan A. Voors, Stephan J. L. Bakker, Peter van der Meer, Nils Bomer
Summary: The study found that serum selenium levels are associated with the incidence of heart failure and metabolic syndrome. There are notable differences between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medical Laboratory Technology
Jenny Hallqvist, Dan Lane, Andrew Shapanis, Kayleigh Davis, Wendy E. Heywood, Ivan Doykov, Nana Ghansah, Brian Keevil, Pankaj Gupta, Rebekah Jukes-Jones, Raj Singh, Dominic Foley, Johannes P. C. Vissers, Rebecca Pattison, Samantha Ferries, Robert Wardle, Amy Bartlett, Lisa J. Calton, Leigh Anderson, Morteza Razavi, Terry Pearson, Matt Pope, Richard Yip, Leong L. Ng, Benjamin Nicholas, Alistair Bailey, Dan Noel, R. Neil Dalton, Simon Heales, Christopher Hopley, Andrew R. Pitt, Perdita Barran, Kevin Mills, Paul Skipp, Rachel S. Carling
Summary: The UK's Department of Health and Social Care established the Moonshot programme in 2020 to fund diagnostic approaches for detecting SARS-CoV-2. This study presents a targeted protein assay that utilizes mass spectrometry to accurately detect the virus in nasopharyngeal swabs. The assay shows high sensitivity and specificity compared to the commonly used RT-qPCR method.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Camilla C. S. van Der Hoef, Eva M. M. Boorsma, Johanna E. E. Emmens, Bart J. J. van Essen, Marco Metra, Leong L. L. Ng, Stefan D. D. Anker, Kenneth Dickstein, Ify R. R. Mordi, Adel Dihoum, Chim C. C. Lang, Dirk J. J. van Veldhuisen, Carolyn S. P. Lam, Adriaan A. A. Voors
Summary: This study investigated the clinical and biomarker correlates of metabolic syndrome in patients with heart failure. It found that metabolic syndrome is associated with obesity, lipid metabolism, and chronic inflammation-related biomarkers and pathways underlying heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Louise A. E. Brown, Gaurav S. Gulsin, Sebastian C. Onciul, David A. Broadbent, Jian L. Yeo, Alice L. Wood, Christopher E. D. Saunderson, Arka Das, Nicholas Jex, Amrit Chowdhary, Sharmaine Thirunavukarasu, Noor Sharrack, Kristopher D. Knott, Eylem Levelt, Peter P. Swoboda, Hui Xue, John P. Greenwood, James C. Moon, David Adlam, Gerry P. McCann, Peter Kellman, Sven Plein
Summary: This study aimed to establish sex- and age-specific normal values for myocardial blood flow (MBF) in healthy volunteers. The results showed differences in MBF between males and females, and a decrease in MBF and myocardial perfusion reserve with advancing age.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
George Markousis-Mavrogenis, Waldemar B. Minich, Ali A. Al-Mubarak, Stefan D. Anker, John G. F. Cleland, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Nilesh J. Samani, Faiez Zannad, Marco Metra, Petra Seemann, Antonia Hoeg, Patricio Lopez, Dirk J. van Veldhuisen, Rudolf A. de Boer, Adriaan A. Voors, Peter van der Meer, Lutz Schomburg, Nils Bomer
Summary: The study examined the importance of autoantibodies against adrenergic/muscarinic receptors in heart failure. The findings suggest that anti-beta 1 AABs are independently associated with HF rehospitalization, while other AABs are mainly related to comorbidities and medication use.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Marie-Sophie L. Y. de Koning, Johanna E. Emmens, Esteban Romero-Hernandez, Arno R. Bourgonje, Solmaz Assa, Sylwia M. Figarska, John G. F. Cleland, Nilesh J. Samani, Leong L. Ng, Chim C. Lang, Marco Metra, Gerasimos S. Filippatos, Dirk J. van Veldhuisen, Stefan D. Anker, Kenneth Dickstein, Adriaan A. Voors, Erik Lipsic, Harry van Goor, Pim van der Harst
Summary: This study investigated the associations between serum-free thiol concentrations and disease severity and clinical outcome in patients with heart failure. The results showed that lower serum-free thiol concentrations were associated with higher oxidative stress, increased HF severity, and poorer prognosis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gaurav S. Gulsin, Alastair James Moss
Editorial Material
Cardiac & Cardiovascular Systems
Gerry P. McCann, Gaurav S. Gulsin
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Koen W. Streng, Hans L. Hillege, Jozine M. ter Maaten, Dirk J. van Veldhuisen, Kenneth Dickstein, Nilesh J. Samani, Leong L. Ng, Marco Metra, Gerasimos S. Filippatos, Piotr Ponikowski, Faiez Zannad, Stefan D. Anker, Peter van der Meer, Chim C. Lang, Adriaan A. Voors, Kevin Damman
Summary: A study found that the causes of renal dysfunction differ between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). The study measured various urinary markers reflecting different nephron segments in heart failure patients and found that HFpEF patients showed more evidence of tubular damage and/or dysfunction, especially when glomerular function was preserved.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Colin C. Everett, Colin Berry, Gerry P. McCann, Catherine Fernandez, Catherine Reynolds, Chiara Bucciarelli-Ducci, Erica Dall'Armellina, Abhiram Prasad, James R. Foley, Kenneth Mangion, Petra Bijsterveld, Julia Brown, Deborah Stocken, Simon Walker, Mark Sculpher, Sven Plein, John P. Greenwood
Summary: Different strategies for managing suspected stable angina did not significantly reduce 3-year cardiovascular event rates or improve quality of life for patients.
Article
Cardiac & Cardiovascular Systems
Saadia Aslam, Michalis A. Patsalides, Svetlana Stoma, Aseel Alfuhied, Christopher P. Nelson, Iain B. Squire, Claire A. Lawson, Kamlesh Khunti, Gerry P. McCann, Anvesha Singh
Summary: This study aimed to explore the ethnic differences in patients undergoing aortic valve intervention for severe aortic stenosis in Leicestershire, UK. The results showed that Asian patients had lower rates of SAVR and TAVI, were younger in age, had more comorbidities, and worse functional status. However, the age-adjusted rates did not show significant differences in ethnicities.
Article
Cardiac & Cardiovascular Systems
Marc R. Dweck, Krithika Loganath, Rong Bing, Thomas A. Treibel, Gerry P. McCann, David E. Newby, Jonathon Leipsic, Chiara Fraccaro, Pasquale Paolisso, Bernard Cosyns, Gilbert Habib, Joao Cavalcante, Erwan Donal, Patrizio Lancellotti, Marie-Annick Clavel, Catherine M. Otto, Phillipe Pibarot
Summary: In this article, the current use of multi-modality imaging in the diagnosis, risk stratification, and follow-up of patients with aortic stenosis is explored. Echocardiography is the key method of diagnosis and surveillance, while computed tomography is increasingly used for planning and clarifying disease severity. Improved assessments of myocardial decompensation with various imaging techniques will become more common, and artificial intelligence will play a significant role. Overall, this new era of multi-modality imaging is expected to improve the management of aortic stenosis and potentially accelerate the development of novel treatments.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)