Article
Chemistry, Medicinal
Yingyu Zhang, Yuan Sun, Yupei Liu, Jiameng Liu, Jing Sun, Xinmin Liu, Bei Fan, Cong Lu, Fengzhong Wang
Summary: The study found that Polygonum sibiricum polysaccharides (PSP) exerted antidepressant-like effects via the microbiota-gut-brain (MGB) axis. Transplantation of fecal microbiota (FMT) from PSP administration mice significantly reversed depressive-like behaviors in CUMS-induced mice and influenced neurotransmitter levels and inflammation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ming Zhang, Aoqiang Li, Qifang Yang, Jingyi Li, Lihua Zheng, Guannan Wang, Ying Sun, Yanxin Huang, Muqing Zhang, Zhenbo Song, Lei Liu
Summary: By modulating the microbiota-gut-brain axis, matrine can alleviate depression, reduce inflammation, and increase the levels of brain-derived neurotrophic factor (BDNF).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kristopher D. Parker, Akhilendra K. Maurya, Hend Ibrahim, Sangeeta Rao, Petronella R. Hove, Dileep Kumar, Rama Kant, Bupinder Raina, Rajesh Agarwal, Kristine A. Kuhn, Komal Raina, Elizabeth P. Ryan
Summary: The study demonstrates that modified gut microbiota from humans consuming rice bran can protect mice from colon carcinogenesis, with specific microbial communities associated with colon health. The findings suggest that integrated dietary-FMT intervention strategies could be effective for colorectal cancer control, treatment, and prevention.
Review
Nutrition & Dietetics
Ewelina Mlynarska, Joanna Gadzinowska, Julita Tokarek, Joanna Forycka, Aleksandra Szuman, Beata Franczyk, Jacek Rysz
Summary: This review investigates the impact of gut microbiota on the development of depression and the underlying molecular mechanisms. There are two possible pathways in which this interaction might occur, one suggesting that depressive disorder could lead to dysbiosis and the other considering if changes in gut microbiota might cause depressive disorder. The mechanisms responsible for this interaction include the secretion of neurotransmitters, gut peptides, and the activation of the immune system. However, more research is needed to explore the direct mechanisms of the interaction between gut microbiota and mental health.
Review
Microbiology
Xuan Fu, Ti Chen, Jingda Cai, Bo Liu, Yaohui Zeng, Xiaojie Zhang
Summary: Substance addiction is a complex worldwide public health issue that endangers both individuals and society, while the gut microbiome may play a crucial role in the pathogenesis of substance-related disorders.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yingli Jing, Yan Yu, Fan Bai, Limiao Wang, Degang Yang, Chao Zhang, Chuan Qin, Mingliang Yang, Dong Zhang, Yanbing Zhu, Jianjun Li, Zhiguo Chen
Summary: Fecal microbiota transplantation (FMT) from healthy uninjured mice into SCI mice was found to improve locomotor and GI functions through promoting neuronal axonal regeneration, enhancing intestinal barrier integrity and modifying gut microbiome composition. Additionally, FMT increased levels of short-chain fatty acids (SCFAs) in feces and downregulated inflammatory signaling pathways in the spinal cord and gut of SCI mice. These findings suggest that FMT may have a neuroprotective effect on SCI.
Article
Oncology
Yiqi Fan, Qing Su, Junxiao Chen, Yong Wang, Shuai He
Summary: This study evaluated the relationship between gut microbiome (GM) and glioma and found that an imbalance in GM promotes glioma growth, while a balanced GM can delay glioma development. In particular, an increased abundance of Bacteroidia is associated with accelerated glioma progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Ylaine Gerardin, Sonia Timberlake, Jessica R. Allegretti, Mark B. Smith, Zain Kassam
Summary: The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Oncology
Mong-Hong Lee
Summary: Research has shown that gut microbiota dysbiosis is linked to physiological changes and various diseases, including cancers. Advances in metagenome sequencing and multiomics studies have provided insights into the composition, taxonomic alterations, and host interactions of gut microbiota during tumorigenesis. However, the complexity of gut microbiota interactions still presents challenges in fully understanding the microbiota-cancer connections and their implications for cancer diagnosis, treatment, and prevention.
CANCER COMMUNICATIONS
(2021)
Review
Microbiology
Xianzhuo Zhang, Xufei Luo, Liang Tian, Ping Yue, Mengyao Li, Kefeng Liu, Daoming Zhu, Chongfei Huang, Qianling Shi, Liping Yang, Zhili Xia, Jinyu Zhao, Zelong Ma, Jianlong Li, Joseph W. Leung, Yanyan Lin, Jinqiu Yuan, Wenbo Meng, Xun Li, Yaolong Chen
Summary: This study summarized the associations between gut microbiome dysbiosis and various diseases, and conducted an umbrella review to determine the efficacy and safety of fecal microbiota transplantation (FMT) in treating these diseases. The research found that FMT was effective for recurrent Clostridium difficile infection (rCDI) with a high cure rate, and had moderate to high quality evidence for ulcerative colitis and Crohn's disease, but low to very low quality evidence for other diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Psychiatry
Xiangzhao Xu, Lixia Zhuo, Linjuan Zhang, Huan Peng, Yixuan Lyu, Huan Sun, Yifang Zhai, Danlei Luo, Xiaodan Wang, Xinyang Li, Liya Li, Ying Zhang, Xiancang Ma, Qiang Wang, Yan Li
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder that affects children and continues into adulthood. Dexmedetomidine (DEX), a short-term sedative, has shown potential as a treatment for ADHD by improving ADHD-like behavior and normalizing brain rhythms in an animal model of ADHD. DEX treatment also alters the gut microbiota and reduces inflammation in the gut and brain, suggesting its therapeutic effects are mediated by reshaping the gut microbiota.
PSYCHIATRY RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Ziyu Huang, Yue Li, Heekuk Park, Martin Ho, Kanchan Bhardwaj, Naoki Sugimura, Hye Won Lee, Huicui Meng, Matthias P. Ebert, Kang Chao, Elke Burgermeister, Aadra P. Bhatt, Sudarshan A. Shetty, Kai Li, Weiping Wen, Tao Zuo
Summary: The urban population is growing globally, especially in developing Asian and African countries, leading to an increase in the burden of non-communicable diseases (NCDs). The gut microbiome plays a significant role in regulating the host's immune and metabolic homeostasis, linking external factors to host physiology. This review discusses the relationship between urbanization, dysbiosis of the gut microbiome, and the rising incidence of NCDs, as well as potential microbiome-inspired approaches to counteract NCDs.
Article
Microbiology
Yi Zhang, Jing Zhang, Jianmin Wu, Qinwen Zhu, Changrong Chen, Yanning Li
Summary: Psychological stress can lead to affective disorders. The study shows that gut microbiota is involved in regulating emotional function, and that there is a relationship between gut microbiota and psychological stress.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)