Article
Environmental Sciences
Huishan Zhang, Hemin Lu, Lin Yu, Jiexin Yuan, Shan Qin, Cong Li, Ren-Shan Ge, Haolin Chen, Leping Ye
Summary: The study suggests that gestational exposure to PFOS may impact lung development in offspring by reducing alveolar numbers, causing simplified alveolar structure and thickened alveolar septa. PFOS-treated animals also showed increased lung inflammation and up-regulated inflammasome associated proteins, as well as raised inflammatory cytokines, while down-regulating critical factors promoting alveolar development and pulmonary angiogenesis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Baiping Mao, Chao Li, Zina Wen, Huitao Li, Yiyan Wang, Lanlan Chen, Qingquan Lian, Ren-Shan Ge
Summary: Short-term exposure to perfluorooctane sulfonate inhibits Leydig cell regeneration in rats by suppressing the development of stem Leydig cells and the Hedgehog signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ling Chen, Yafeng Liu, Hongxin Mu, Huan Li, Su Liu, Mengyuan Zhu, Yuanqing Bu, Bing Wu
Summary: This study investigated the toxicity of low-dose PFBS on liver and compared it with PFOS. The results showed that PFBS exposure induced cell apoptosis and decreased CAT activities, while PFOS exposure led to accumulation of lipid droplets, increase of CAT activities, and TAG levels. Lipidomics analysis revealed similar global lipid changes in the two PFBS-treated groups, distinct from PFOS.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Multidisciplinary
Mengke Song, Longfei Jiang, Dayi Zhang, Zilin Huang, Shaorui Wang, Weiping Mei, Chunling Luo, Gan Zhang
Summary: The study found that the presence of different concentrations of copper (Cu) had varying effects on PFOS, with low concentrations causing an increase in PFOS concentration in roots and high concentrations damaging root cell membranes and increasing root permeability. It was also observed that Cu inhibition of carrier proteins could lead to the suppression of acropetal translocation of PFOS, and the presence of a protein-mediated uptake pathway was evidenced by enantiomer fraction (EF) results.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Haijing Zhang, Chao Zhang, Donggang Xu, Qin Wang, Dongqun Xu
Summary: This study investigated the impact of PFOS on cognitive function and the underlying mechanisms using a C57BL/6J mouse model. The results showed that exposure to PFOS for 6 months caused a decline in object recognition ability, learning, and spatial memory. Furthermore, PFOS selectively increased apoptosis in neurons of the cerebral cortex and activated the endoplasmic reticulum stress PERK/CHOP signaling pathway. These findings suggest that subchronic exposure to PFOS can lead to cognitive impairment in mice, which may be associated with the specific activation of an endoplasmic reticulum stress-induced pro-apoptosis pathway in cerebral cortex neurons.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Bianhe Lu, Jin Qian, Fei He, Peifang Wang, Yuxuan He, Sijing Tang, Xin Tian
Summary: This study investigated the impact of perfluorooctane sulfonate (PFOS) on the performance and microbial community of activated sludge. The results showed that the presence of PFOS reduced the removal efficiency of total nitrogen and improved the removal efficiency of total phosphorus, while also leading to the deterioration of activated sludge's dewatering performance.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Pingwei Wang, Dongge Liu, Shuqi Yan, Jiajing Cui, Yujun Liang, Shuping Ren
Summary: This study reviews the adverse effects of PFOS on liver tissue and function, providing a reference for further research on the toxicity of PFOS and liver injury caused by PFOS.
Article
Environmental Sciences
Md Nur Alam, Xuejingping Han, Bingru Nan, Liangpo Liu, Meiping Tian, Heqing Shen, Qingyu Huang
Summary: The study revealed that chronic low-level PFOS exposure can activate key steroidogenic gene expression in male rats by enhancing histone acetylation, ultimately stimulating steroid hormone biosynthesis in rat testis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yongjie Liu, Guoqi Yu, Ruiyuan Zhang, Liping Feng, Jun Zhang
Summary: PFOS exposure during pregnancy affects intestinal immune homeostasis in rats and leads to decreased body weight in offspring. It also alters the composition of gut microbiota and blood metabolome, resulting in increased proinflammatory cytokines.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
V. N. Bednarz, S. Choyke, L. F. B. Marangoni, E. I. Otto, E. Beraud, M. Metian, I. Tolosa, C. Ferrier-Pages
Summary: This study investigated the effects of PFOS on corals, demonstrating that corals can rapidly bioconcentrate and eliminate PFOS. Additionally, an antagonistic effect between elevated temperature and PFOS exposure was observed.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Weichuan Qiao, Rong Li, Tianhao Tang, Achuo Anitta Zuh
Summary: The vertical-flow constructed wetland effectively removed PFOS from simulated domestic sewage through soil adsorption and plant uptake. Soil adsorption played a key role in PFOS removal, with a higher percentage compared to plant uptake.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2021)
Article
Environmental Sciences
Chunqing Bi, Muhammad Junaid, Yan Liu, Wenjing Guo, Xilin Jiang, Baozhu Pan, Zhengguoshen Li, Nan Xu
Summary: The presence of graphene oxide (GO) increases the bioaccumulation of perfluorooctane sulfonate (PFOS) in Asian clams, leading to oxidative stress and various negative effects at the behavioral and molecular levels, as well as histopathological changes.
Article
Environmental Sciences
Kurt A. Gust, J. Erik Mylroie, Ashley N. Kimble, Mitchell S. Wilbanks, Catherine S. C. Steward, Kacy A. Chapman, Kathleen M. Jensen, Alan J. Kennedy, Paige M. Krupa, Scott A. Waisner, Zacharias Pandelides, Natalia Garcia-Reyero, Russell J. Erickson, Gerald T. Ankley, Jason Conder, David W. Moore
Summary: This study investigated the multigenerational effects of perfluorooctane sulfonic acid (PFOS) exposure in zebrafish. Results showed that the adverse effects reported at concentrations lower than 1 μg/L in previous research were difficult to replicate. However, adverse effects at concentrations below 117 μg/L were observed, indicating an ecologically relevant threshold.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Yanhui Ge, Zhan Wang, Xuelu Chen, Wen Wang, Zhenying Liu, Hongwen Sun, Lianying Zhang
Summary: The toxicity of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and perfluorooctane sulfonate (PFOS) to earthworms was compared in this study. F-53B was found to be more toxic to earthworms, causing higher oxidative stress and disruption of metabolic processes, particularly in extracellular matrix destruction, apoptosis and ferroptosis induction.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Shengzhong Su, Laura J. Billy, Sue Chang, Frank J. Gonzalez, Andrew D. Patterson, Jeffrey M. Peters
Summary: This study examined the effects of PFOS on mouse and human livers and the role of PPAR-α. The results showed that PFOS can induce peroxisome proliferation in mouse liver by activating mouse PPAR-α and increasing the expression of Acoxl and Cyp4a10. In contrast, human PPAR-α is less responsive to PFOS, and PFOS-induced hepatomegaly may be due to the activation of CAR and/or PXR.
Article
Environmental Sciences
Sarah-Marie E. Baxter, Marie E. DeLorenzo, Peter B. Key, Katy W. Chung, Emily Pisarski, Barbara Beckingham, Michael H. Fulton
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Environmental Sciences
Jennifer M. Lynch, Jared M. Ragland, William K. Reagen, Susan T. Wolf, Michelle D. Malinsky, Michael B. Ellisor, Amanda J. Moors, Rebecca S. Pugh, Jessica L. Reiner
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Environmental Sciences
Jacqueline T. Bangma, Jessica L. Reiner, Russell H. Lowers, Theresa M. Cantu, Jacob Scott, Jeffrey E. Korte, Doug M. Scheidt, Chris McDonough, Jonathan Tucker, Brenton Back, Douglas H. Adams, John A. Bowden
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Environmental Sciences
Jacqueline T. Bangma, Jared M. Ragland, Thomas R. Rainwater, John A. Bowden, J. Whitfield Gibbons, Jessica L. Reiner
Article
Engineering, Environmental
Adam E. Kurtz, Jessica L. Reiner, Kristi L. West, Brenda A. Jensen
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Environmental Sciences
Kady Palmer, Jacqueline T. Bangma, Jessica L. Reiner, Robert K. Bonde, Jeffrey E. Korte, Ashley S. P. Boggs, John A. Bowden
MARINE POLLUTION BULLETIN
(2019)
Article
Engineering, Environmental
Jacqueline Bangma, Lauren A. Eaves, Kirsi Oldenburg, Jessica L. Reiner, Tracy Manuck, Rebecca C. Fry
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Environmental Sciences
Abby G. Wenzel, Jessica L. Reiner, Satomi Kohno, Bethany J. Wolf, John W. Brock, Lori Cruze, Roger B. Newman, John R. Kucklick
Summary: The study conducted urine samples testing on pregnant women in Charleston, SC, discovering that the DINCH metabolite OH-MINCH was detected in 98% of samples, with concentrations significantly higher in African American women compared to Caucasian women. In vitro assays showed that DINCH metabolites did not exhibit estrogenic or progestogenic activity, suggesting the need for continued monitoring of human exposure to these emerging compounds.
Article
Biochemical Research Methods
Alix E. Rodowa, Jessica L. Reiner
Summary: NIST produces and maintains a wide range of SRMs to serve global commerce, with SRM 1957 being a key material widely utilized in the analytical chemistry community. This material has been used for various analytical purposes, including quality control, interlaboratory comparison, and measurement accuracy, among others.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Marie E. DeLorenzo, Peter B. Key, Katy W. Chung, Kaitlin Aaby, Deanna Hausman, Cheldina Jean, Paul L. Pennington, Emily C. Pisarski, Edward F. Wirth
Summary: When oil is spilled into the environment, its toxicity is influenced by abiotic conditions and multiple stressors. Changes in oil toxicity occur with different temperatures, salinities, and UV light exposure.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Engineering, Environmental
Devin K. Jones, Kathryn A. Quinlin, Maggie A. Wigren, Youn J. Choi, Maria S. Sepulveda, Linda S. Lee, David L. Haskins, Guilherme R. Lotufo, Alan Kennedy, Lauren May, Ashley Harmon, Thomas Biber, Nicolas Melby, Michael K. Chanov, Michelle L. Hudson, Peter B. Key, Katy W. Chung, David W. Moore, Jamie G. Suski, Edward F. Wirth, Jason T. Hoverman
Summary: Researchers have found it crucial to further explore the potential toxic effects of PFAS-free AFFF as a substitute for PFAS-containing AFFF. The study reveals variations in the toxicity of different chemical formulations on aquatic species, with some formulas being more toxic than others.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Marine & Freshwater Biology
Peter B. Key, Katy W. Chung, J. Blaine West, Paul L. Pennington, Marie E. DeLorenzo
AQUATIC TOXICOLOGY
(2020)
Article
Environmental Sciences
M. E. DeLorenzo, P. B. Key, K. W. Chung, E. Pisarski, B. Shaddrix, E. F. Wirth, P. L. Pennington, J. Wade, M. Franco, M. H. Fulton
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2018)