Review
Medicine, Research & Experimental
Weihang Gao, Chen Liang, Ke Zhao, Mingming Hou, Yinxian Wen
Summary: Osteoporosis is a common bone disorder worldwide, and the traditional clinical treatments face challenges. Gold nanoparticles (AuNPs) with unique optical properties and good biocompatibility have shown promise in osteoporosis research. This review summarizes the advances and drawbacks of AuNPs in bone formation and resorption mechanisms, and discusses important directions for future studies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Archita Gupta, Sneha Singh
Summary: Osseous tissue repair has advanced with the introduction of tissue engineering, with gold nanoparticles playing a significant role in bone tissue regeneration. Gold nanoparticles modulate the properties of scaffolds and osteogenic cells, influence bone regeneration mechanisms, and have potential toxicity.
Review
Medicine, Research & Experimental
Yaosheng Xiao, Xunlu Xie, Zhixi Chen, Guoqiang Yin, Weihao Kong, Jianguo Zhou
Summary: ATF4 plays a crucial role in maintaining bone homeostasis and inhibiting the development of osteoporosis. It promotes bone formation and inhibits bone resorption.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Seong Cheol Kim, Hyeon Jeong Kim, Gi Eun Park, Ramesh Prasad Pandey, Jisun Lee, Jae Kyung Sohng, Yong Il Park
Summary: This study demonstrated that Tri inhibits osteoclastic cell differentiation and bone resorption by down-regulating the expression of osteoclastogenic marker genes and signalling proteins, bone resorptive proteins, and by augmenting serum OPG/RANKL ratio, suggesting that Tri can be a novel anti-osteoporotic compound for treating senile and postmenopausal OP.
Article
Engineering, Biomedical
Xiao Sheng, Chen Li, Zhonghan Wang, Yu Xu, Yang Sun, Weimin Zhang, He Liu, Jincheng Wang
Summary: This review provides a comprehensive overview of strontium-containing biomaterials and their current clinical use. Different types of biomaterials, including calcium phosphate, bioactive glass, and polymers, are discussed, and future outlook on the fabrication of the next-generation multifunctional and smart biomaterials is provided.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Yongbo Li, Zhe Tan, Jixiang Zhang, Junhan Mu, Han Wu
Summary: In this study, nano-deer bone meal was successfully prepared and found to have a higher Ca/P ratio and enriched beneficial trace elements compared to cow bone. The nano-deer bone meal showed good biocompatibility and met the standards of medical biomaterials. Cell function studies demonstrated its excellent performance in the proliferation and differentiation of bone marrow mesenchymal stem cells. These findings suggest the potential use of nano-deer bone meal as an active nanomaterial in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Kaveh Roshanbinfar, Maria Kolesnik-Gray, Miriam Angeloni, Stefan Schruefer, Maren Fiedler, Dirk W. Schubert, Fulvia Ferrazzi, Vojislav Krstic, Felix B. Engel
Summary: Cardiac tissue engineering is a promising strategy to prevent heart failure, but several issues remain unsolved. This study develops a biohybrid hydrogel that enhances the beating properties of engineered cardiac tissues and allows for concurrent drug release.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Daye Lee, Wan-Kyu Ko, Seong Jun Kim, In-Bo Han, Je Beom Hong, Seung Hun Sheen, Seil Sohn
Summary: Silver nanoparticles (SNPs) were found to have a strong inhibitory effect on differentiation into osteoclasts, significantly reducing the formation of TRAP positive multinuclear cells and actin ring structure. Compared to gold nanoparticles (GNPs), SNPs exhibited a more significant inhibitory effect on genes related to the differentiation into osteoclasts, making them a promising material for treating osteoporosis patients.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Engineering, Environmental
Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo, Yan Hu
Summary: This study presents a bone-targeted nanoformulation based on CaCO3 nanomaterials, which can be activated in the acidic microenvironment of osteoporosis and regulate the activity of osteoclasts and osteoblasts to reverse bone deterioration. The study provides an effective approach for the treatment of osteoporosis in clinics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Huey-Shan Hung, Yi-Chin Yang, Chih-Hsuan Chang, Kai-Bo Chang, Chiung-Chyi Shen, Chien-Lun Tang, Szu-Yuan Liu, Chung-Hsin Lee, Chun-Ming Yen, Meng-Yin Yang
Summary: The study demonstrates that the composite material of chitosan and gold nanoparticles can enhance the neural differentiation of mesenchymal stem cells and has the potential as a biosafe nanomaterial for neural tissue engineering.
Article
Biochemistry & Molecular Biology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amelie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D. Zajac, Rachel A. Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J. M. Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
Summary: The anti-inflammatory protein A20 plays a critical role in inhibiting NF-kappa B signaling and inflammation. Deficiency of A20 can lead to osteoporosis without causing inflammatory arthritis. A20 regulates RANK-induced NF-kappa B signaling through its specific domains, controlling osteoclast differentiation and bone development.
Article
Engineering, Biomedical
Mattia Vitale, Cosimo Ligorio, Bethan McAvan, Nigel W. Hodson, Chris Allan, Stephen M. Richardson, Judith A. Hoyland, Jordi Bella
Summary: Hydrogels have great potential for tissue engineering applications, but their use in bone regeneration is often hindered by poor mineralization and mechanical properties. Osteoclasts (OCs), which play a pivotal role in bone homeostasis, are often overlooked. This study aims to develop customized, reinforced hydrogels as a platform for studying OC function and differentiation.
ACTA BIOMATERIALIA
(2022)
Article
Endocrinology & Metabolism
Iryna Khrystoforova, Chen Shochat-Carvalho, Ram Harari, Katrin Henke, Katherine Woronowicz, Matthew P. P. Harris, David Karasik
Summary: This study investigated the role of LRP5 in skeletal development and homeostasis using a gene knockout zebrafish model. Transcriptome analysis revealed upregulation of genes associated with hydrolase activity in lrp5 mutants, indicating changes in osteoclast differentiation. Functional analysis showed increased resorptive activity in the absence of Lrp5 signaling, potentially leading to skeletal dysmorphologies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Akshith Dasari, Jingyi Xue, Sanjukta Deb
Summary: Tissue engineering approaches offer the possibility to induce new functional bone regeneration by creating a regenerative niche at the site of damage. Magnetic nanoparticles, as a potential tool in bone tissue engineering, leverage the inherent magnetism to enhance the properties of osteoinduction, osteoconduction, and angiogenesis in scaffold design.
Article
Materials Science, Multidisciplinary
Haram Nah, Donghyun Lee, Min Heo, Jae Seo Lee, Sang Jin Lee, Dong Nyoung Heo, Jeongmin Seong, Ho-Nam Lim, Yeon-Hee Lee, Ho-Jin Moon, Yu-Shik Hwang, Il Keun Kwon
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2019)
Article
Chemistry, Physical
Jae Seo Lee, Sang Jin Lee, Seok Bin Yang, Donghyun Lee, Haram Nah, Dong Nyoung Heo, Ho-Jin Moon, Yu-Shik Hwang, Rui L. Reis, Ji-Hoi Moon, Il Keun Kwon
APPLIED SURFACE SCIENCE
(2019)
Review
Biochemistry & Molecular Biology
Yeon-Hee Lee, Hee-Kyung Park, Q-Schick Auh, Haram Nah, Jae Seo Lee, Ho-Jin Moon, Dong Nyoung Heo, In San Kim, Il Keun Kwon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Physical
Sang Jin Lee, Haram Nah, Dong Nyoung Heo, Kyoung-Hwa Kim, Ji Min Seok, Min Heo, Ho-Jin Moon, Donghyun Lee, Jae Seo Lee, Seong Yeong An, Yu-Shik Hwang, Wan-Kyu Ko, Seong Jun Kim, Seil Sohn, Su A. Park, Shin-Young Park, Il Keun Kwon
Article
Materials Science, Biomaterials
Karan Gulati, Ho-Jin Moon, P. T. Sudheesh Kumar, Pingping Han, Saso Ivanovski
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Physical
Jae Seo Lee, Haram Nah, Ho-Jin Moon, Sang Jin Lee, Dong Nyoung Heo, Il Keun Kwon
APPLIED SURFACE SCIENCE
(2020)
Article
Engineering, Biomedical
Ryan S. B. Lee, Stephen M. Hamlet, Ho-Jin Moon, Saso Ivanovski
Summary: Immune modulation mediated by titanium surface can enhance bone healing after implantation in diabetic patients by alleviating inflammatory response, promoting M2 macrophage activity, and stimulating osteogenesis.
Article
Engineering, Biomedical
Sung Jun Min, Jae Seo Lee, Haram Nah, Seung Hyeon Kim, Ho-Jin Moon, Rui L. Reis, Il Keun Kwon, Dong Nyoung Heo
Summary: This study introduces a 3D-printable platelet lysate-based hydrogel that can mimic the 3D structure of tissues, improve cell diffusion and proliferation, and be used for various tissue repairs.
Article
Chemistry, Multidisciplinary
Sang Jin Lee, Haram Nah, Wan-Kyu Ko, Donghyun Lee, Ho-Jin Moon, Jae Seo Lee, Min Heo, Yu-Shik Hwang, Jae Beum Bang, Sang-Hyun An, Dong Nyoung Heo, Il Keun Kwon
Summary: This study successfully developed chitosan electrospun nanofibers modified with succinyl-beta-cyclodextrin for stable and sustained release of hydrophobic drugs. The modified nanofibers showed increased hydrophobicity and reduced amine content while maintaining good cell viability and proliferation. The material and strategies have potential applications as drug carriers in tissue engineering.
Article
Biochemistry & Molecular Biology
Jae Seo Lee, Hyo-Sung Kim, Haram Nah, Sang Jin Lee, Ho-Jin Moon, Jae Beum Bang, Jung Bok Lee, Sun Hee Do, Il Keun Kwon, Dong Nyoung Heo
Summary: This study synthesized succinylated chitosan (SCS)-based hydrogels with high decomposition rate and excellent biocompatibility, confirming well distributed Bone Graft Materials (BGMs) inside the SCS hydrogel. Increasing succinylation rate in SCS-B hydrogels led to a decrease in mechanical properties, such as compressive strength and Young's modulus, while also exhibiting high cell growth rate and bone differentiation rate. In vivo results showed that the SCS hydrogel could resorb into surrounding tissues while maintaining BGMs in the transplantation area for up to 6 weeks, indicating potential as a bioactive drug carrier for various biomedical applications.
Article
Cell Biology
Kyung-Ran Park, Bomi Kim, Joon Yeop Lee, Ho-Jin Moon, Il Keun Kwon, Hyung-Mun Yun
Summary: This study investigated the effects of scoparone (SCOP), derived from Artemisia capillaris Thunb, on osteogenic processes using MC3T3-E1 pre-osteoblasts. SCOP showed no cytotoxic effects and promoted alkaline phosphatase staining, mineralized nodule formation, and osteogenic signals. SCOP also induced autophagy, migration, and adhesion. Overall, SCOP has osteogenic effects associated with cell differentiation, adhesion, migration, autophagy, and mineralization.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Sung Jun Min, Jae Seo Lee, Haram Nah, Ho-Jin Moon, Sang Jin Lee, Hyeon Jeong Kang, Yu-Shik Hwang, Il Keun Kwon, Dong Nyoung Heo
Summary: Biodegradable hydrogels have great potential as biomaterials for controlled-release systems in skin tissue regeneration. In this study, keratin-based hydrogels were synthesized and their properties were investigated for controllable protein delivery. The results showed that these hydrogels exhibited promising biological performance and could serve as suitable carriers for controlled protein delivery.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Engineering, Biomedical
Seung Hyeon Kim, Jae Seo Lee, Sang Jin Lee, Haram Nah, Sung Jun Min, Ho Jin Moon, Jae Beum Bang, Han-Jun Kim, Won Jong Kim, Il Keun Kwon, Dong Nyoung Heo
Summary: In this study, plasma treatment was used to enhance the biocompatibility of 3D-printed scaffolds. The wettability, roughness, and protein adsorption capability of the scaffolds significantly increased with the plasma treatment. The plasma-treated scaffolds exhibited enhanced cell adhesion and proliferation in vitro, as well as higher tissue infiltration and lower collagen encapsulation in vivo.
Article
Chemistry, Multidisciplinary
Kwansung Seo, Ji Hye Yoo, Jisu Kim, Sung Jun Min, Dong Nyoung Heo, Il Keun Kwon, Ho-Jin Moon
Summary: Ginseng-derived extracellular nanovesicles (GDNs) have the potential to inhibit osteoclast differentiation and may be used for the prevention and treatment of bone loss diseases.
Article
Chemistry, Physical
Qi-Wen Chen, Ze-Qing Guo, Jian-Ping Zhou
Summary: Multifunctional continuous solid solutions NFMTO-x were successfully synthesized via a one-step hydrothermal method by controlling the ratio of Mg and Fe. The NFMTO-x materials exhibited enhanced visible light response, effective adsorption and photocatalytic degradation of organic pollutants, CO2 methanation capability, and easy recyclability due to their magnetic properties. This research provides a significant multifunctional material for water purification.
APPLIED SURFACE SCIENCE
(2024)
Review
Chemistry, Physical
George E. Stan, Maziar Montazerian, Adam Shearer, Bryan W. Stuart, Francesco Baino, John C. Mauro, Jose M. F. Ferreira
Summary: Bioactive glasses have the ability to form strong bonds with tissues and release therapeutic ions. However, their biomechanical compatibility limits their use in load-bearing applications. The use of magnetron sputtering technology to fabricate BG coatings shows promise in improving their efficacy and potential for application.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Zhaoxuan Wang, Zhicheng Yan, Zhigang Qi, Yu Feng, Qi Chen, Ziqi Song, Meng Huang, Peng Jia, Ki Buem Kim, Weimin Wang
Summary: The corrosion behavior of Fe-60 and Fe-83 ribbons in 0.6 M NaCl was studied. Fe-60 exhibited a local corrosion mode and formed a stable passivation film with higher corrosion resistance, while Fe-83 showed a combination of local and global corrosion modes and had lower corrosion resistance. Controlling the precipitation of nanocrystalline phases and increasing the POx content in the passivation film significantly improved the corrosion resistance of Fe-based glassy alloys.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Hao-Kai Peng, Sheng-Yen Zheng, Wei-Ning Kao, Ting-Chieh Lai, Kai-Sheun Lee, Yung- Hsien Wu
Summary: This study investigates the effects of high energy/fluence proton radiation on the performance of HfZrOx-based FeFETs memory with different Zr content. The results show that the characteristics of FeFETs are influenced by proton radiation, and the extent of the influence depends on the Zr content. FeFETs with 50% Zr content exhibit minimal changes in memory window and demonstrate good endurance and retention performance.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Zongyi Yue, Guangyi Wang, Zengguang Huang, Sihua Zhong
Summary: In this study, AZO and ITO films were successfully tuned as excellent passivation layers for c-Si surfaces, achieving effective minority carrier lifetime and outstanding optical properties through the optimization of annealing temperature and interfacial silicon oxide.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Martin Hruska, Jan Kejzlar, Jaroslav Otta, Premysl Fitl, Michal Novotny, Jakub Cizek, Oksana Melikhova, Matej Micusik, Peter Machata, Martin Vrnata
Summary: This paper presents a detailed study on the hydrogen sensing capabilities of highly nanoporous black gold films. The films exhibit fast response and recovery times at low temperatures. Different levels of nanoporosity were prepared and tested to investigate the sensing properties, and it was found that nanoporous black gold is suitable for hydrogen sensing. The sensitivity of the film depends on its nanoporosity.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yupu Wang, Gaofeng Teng, Chun To Yiu, Junyi Zhu
Summary: In the study of BM-SCO and HSCO thin films, it was found that H vacancies tend to prefer sites near the external surface or oxygen vacancy channels (OVCs), while H interstitials prefer sites of oxygen on a layer that contains six-fold coordinated Co. These findings not only enrich the understanding of complex surface phenomena of defect formation but also provide an explanation for the reversibility during phase transformation.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Jiafeng Lu, Linping Teng, Qinxiao Zhai, Chunhua Wang, Matthieu Lancry, Ye Dai, Xianglong Zeng
Summary: In this study, we achieved full control of fiber nanograting orientation by manipulating laser polarization, and tailored space variant fiber nanogratings, which expanded the diversity in fiber nanograting engineering.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yibo Liu, Yujie Tao, Yue Liu, Qi Sun, Qinrong Lin, Kexin Kang, Qinghua Zhang, Qingjie Sun
Summary: This study investigates the wettability of the Ti-Cu-Fe multi-metal system, specifically the wetting behaviors of CuSi3 droplets on TC4 and 304SS plates. The results show that the CO2 + Ar gas atmosphere significantly affects interfacial mass transfer, thus influencing the wettability of the systems.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Jimei Liu, Fei Wang, Rong Guo, Yuqi Liu, Mengyu Zhang, Jaka Sunarso, Dong Liu
Summary: This study developed Co/MXene composites with anti-corrosion properties by varying the cobalt content. These composites exhibited remarkable electromagnetic absorption performance and high resistance to corrosion under various corrosive conditions. The study also revealed the mechanism of electron transfer from cobalt to MXene and the electromagnetic dissipation behavior originated from polarization loss alone.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Moujie Huang, Yongsong Ma, Jingbo Yang, Lingyun Xu, Hangqi Yang, Miao Wang, Xin Ma, Xin Xia, Junhao Yang, Deli Wang, Chuang Peng
Summary: Strong metal-support interactions (SMSIs) are important for enhancing catalytic activities and stability in thermal catalysis. This study demonstrates a method to create SMSIs in electrocatalysis using carbon nanotubes and Ru nanoparticles, resulting in excellent catalytic activity and stability.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Ravi Trivedi, Brinti Mondal, Nandini Garg, Brahmananda Chakraborty
Summary: This study explores the potential of biphenylene as a nanocarrier for the delivery of the anticancer drug cisplatin. It is found that biphenylene offers physical stability, rapid release rate, solubility, and bio-compatibilities compared to other nanocarriers. The adsorption of cisplatin on the surface of biphenylene involves charge transfer from cisplatin to biphenylene. The drug is shown to be released at body temperature in an acidic environment. Biphenylene also exhibits excellent cytotoxicity activity and cellular uptake of the drug. Overall, biphenylene shows promise as a potential nanocarrier for cisplatin delivery.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Hyun Jeong, Hyeong Chan Suh, Ga Hyun Cho, Rafael Salas-Montiel, Hayoung Ko, Ki Kang Kim, Mun Seok Jeong
Summary: In this study, a potential platform to enhance Raman scattering and increase the number of observable Raman modes in monolayer transition metal dichalcogenides (TMDs) was proposed. The platform consisted of large-scale arrays of gold micropillars (MPs), which were able to enhance the Raman intensity of TMDs and make difficult-to-detect Raman modes observable. The platform showed great industrial advantages and wide applicability due to its low cost, simple process, large controllable area, and short process time.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Yasir Abbas, Shafqat Ali, Sajjad Ali, Waqar Azeem, Zareen Zuhra, Haoliang Wang, Mohamed Bououdina, Zhenzhong Sun
Summary: In this study, FeOx@SPNO-C core-shell nanospheres as a catalyst for degradation of sulfamethoxazole (SMX) were successfully synthesized. The synergistic interaction between FeOx and SPNO-C, high carbon charge density, and the presence of C = O groups and N/Fe-Nx sites were found to be key factors for the enhanced degradation of SMX.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Physical
Qiaoting Yang, Yuxiao Gong, Yan Qian, Zhou-Qing Xiao, Serge Cosnier, Xue-Ji Zhang, Robert S. Marks, Dan Shan
Summary: This study proposes a hierarchical confinement strategy to design Prussian blue nanoparticles (PB NPs) with satisfactory electrocatalytic ability and stability. The catalytic synthesis of PB NPs is achieved through a hydrothermal process, and the as-prepared PB@NH2MIL exhibits efficient electronic transmission and enhanced electrocatalytic properties.
APPLIED SURFACE SCIENCE
(2024)